Works by Masahiro Hirama

Results: 47

Total Syntheses of Complanadines A and B.

Published in:

Angewandte Chemie, 2013, v. 125, n. 6, p. 1766, doi. 10.1002/ange.201208297

By:

Zhao, Le;
Tsukano, Chihiro;
Kwon, Eunsang;
Takemoto, Yoshiji;
Hirama, Masahiro

Publication type:

Article

Asymmetric Total Synthesis of (-)-Merrilactone A: Use of a Bulky Protecting Group as Long-Range Stereocontrolling Element.

Published in:

Angewandte Chemie, 2006, v. 118, n. 29, p. 4961, doi. 10.1002/ange.200601358

By:

Masayuki Inoue;
Takaaki Sato;
Masahiro Hirama

Publication type:

Article

Total synthesis and related studies of large, strained, and bioactive natural products.

Published in:

Proceedings of the Japan Academy, Series B Physical & biological sciences, 2016, v. 92, n. 8, p. 290, doi. 10.2183/pjab.92.290

By:

Masahiro HIRAMA

Publication type:

Article

A Formal Total Synthesis of (+)-Pinnatoxin AThis work was supported by CREST, Japan Science and Technology Agency (JST). A fellowship to H.S. from the Japan Society for the Promotion of Science (JSPS) is gratefully acknowledged. We thank Professor Y. Kishi (Harvard University) for providing NMR spectra of synthetic intermediates, Professor D. Uemura (Nagoya University) for providing natural pinnatoxin A, and Professor K. Nagasawa (Tokyo University of Agriculture and Technology) for helpful discussions.

Published in:

Angewandte Chemie, 2004, v. 116, n. 47, p. 6667, doi. 10.1002/ange.200461802

By:

Satoshi Sakamoto;
Hayato Sakazaki;
Koji Hagiwara;
Kei Kamada;
Kento Ishii;
Takeshi Noda;
Masayuki Inoue;
Masahiro Hirama

Publication type:

Article

Synthesis of the C-1027 Chromophore Framework through Atropselective MacrolactonizationThis work was supported by CREST, Japan Science and Technology Agency (JST). A fellowship to T.S. from the Japanese Society for the Promotion of Science (JSPS) is gratefully acknowledged.

Published in:

Angewandte Chemie, 2004, v. 116, n. 47, p. 6662, doi. 10.1002/ange.200461428

By:

Masayuki Inoue;
Takeo Sasaki;
Suguru Hatano;
Masahiro Hirama

Publication type:

Article

Spin Trapping of 13C-Labeled p-Benzynes Generated by Masamune–Bergman Cyclization of Bicyclic Nine-Membered EnediynesThis work was supported by CREST (Core Research for Evolutional Science and Technology), the Japan Science and Technology Agency (postdoctoral fellowship to P.D.), and the Ministry of Education, Culture, Sports, Science and Technology. We are grateful for three Research Fellowships for Young Scientists (T.U., T.M., and F.Y.) from the Japanese Society for the Promotion of Science. We thank Dr. Jonathan Hobley, Tohoku University, for many insightful comments and fruitful discussions.

Published in:

Angewandte Chemie, 2004, v. 116, n. 39, p. 5361, doi. 10.1002/ange.200454133

By:

Toyonobu Usuki;
Takashi Mita;
Martin J. Lear;
Parthasarathi Das;
Fumihiko Yoshimura;
Masayuki Inoue;
Masahiro Hirama;
Kimio Akiyama;
Shozo Tero-Kubota

Publication type:

Article

Total Synthesis of TMC-95A ( Dr. Jun Kohno, Tanabe Seiyaku Co. (Japan), is gratefully acknowledged for providing natural TMC-95A for comparative analysis. ).

Published in:

Angewandte Chemie, 2003, v. 115, n. 23, p. 2758, doi. 10.1002/ange.200351130

By:

Masayuki Inoue;
Hayato Sakazaki;
Hidetomo Furuyama;
Masahiro Hirama

Publication type:

Article

Sensitive Detection of Ciguatoxins Using a Neuroblastoma Cell-Based Assay with Voltage-Gated Potassium Channel Inhibitors.

Published in:

Toxins, 2024, v. 16, n. 3, p. 118, doi. 10.3390/toxins16030118

By:

Yokozeki, Toshiaki;
Kawabata, Madoka;
Fujita, Kazuhiro;
Hirama, Masahiro;
Tsumuraya, Takeshi

Publication type:

Article

Rationally Designed Synthetic Haptens to Generate Anti-Ciguatoxin Monoclonal Antibodies, and Development of a Practical Sandwich ELISA to Detect Ciguatoxins.

Published in:

Toxins, 2019, v. 11, n. 9, p. 533, doi. 10.3390/toxins11090533

By:

Tsumuraya, Takeshi;
Hirama, Masahiro

Publication type:

Article

Transcriptomic Analysis of Ciguatoxin-Induced Changes in Gene Expression in Primary Cultures of Mice Cortical Neurons.

Published in:

Toxins, 2018, v. 10, n. 5, p. 192, doi. 10.3390/toxins10050192

By:

Rubiolo, Juan Andrés;
Vale, Carmen;
Boente-Juncal, Andrea;
Hirama, Masahiro;
Yamashita, Shuji;
Camiña, Mercedes;
Vieytes, Mercedes R.;
Botana, Luis M.

Publication type:

Article

Total Synthesis of Limonin.

Published in:

Angewandte Chemie International Edition, 2015, v. 54, n. 29, p. 8538, doi. 10.1002/anie.201503794

By:

Yamashita, Shuji;
Naruko, Akito;
Nakazawa, Yuki;
Zhao, Le;
Hayashi, Yujiro;
Hirama, Masahiro

Publication type:

Article

Biomimetic Total Synthesis of Cyanosporaside Aglycons from a Single Enediyne Precursor through Site-Selective p-Benzyne Hydrochlorination.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 50, p. 13902, doi. 10.1002/anie.201408416

By:

Yamada, Kei;
Lear, Martin J.;
Yamaguchi, Takaya;
Yamashita, Shuji;
Gridnev, Ilya D.;
Hayashi, Yujiro;
Hirama, Masahiro

Publication type:

Article

Solvent-mediated Tuning of the Regioselectivity of Intramolecular Diaryl Ether Formation: Total Synthesis of (+)-Aspercyclide C.

Published in:

Chemistry Letters, 2014, v. 43, n. 3, p. 349, doi. 10.1246/cl.131045

By:

Tatsuya Yoshino;
Shuji Yamashita;
Itaru Sato;
Yujiro Hayashi;
Masahiro Hirama

Publication type:

Article

Concise Synthesis of the Tetracyclic Framework of Azadiradione: Tandem Radical Cyclization Route.

Published in:

Chemistry Letters, 2013, v. 42, n. 3, p. 220, doi. 10.1246/cl.2013.220

By:

Shuji Yamashita;
Akito Naruko;
Takahiro Yamada;
Yujiro Hayashi;
Masahiro Hirama

Publication type:

Article

The First Total Synthesis of Gravicycle.

Published in:

Chemistry Letters, 2012, v. 41, n. 1, p. 87, doi. 10.1246/cl.2012.87

By:

Katsuaki Ueda;
Itaru Sato;
Masahiro Hirama

Publication type:

Article

Remarkable Selectivity in Derivatization and Protection of Hydroxy Groups of 51-hydroxyCTX3C: Chemoselective Synthesis of Biotin-conjugated Ciguatoxin Derivatives.

Published in:

Chemistry Letters, 2009, v. 38, n. 9, p. 7, doi. 10.1246/cl.2009.886

By:

Ishihara, Yuuki;
Miyazaki, Keisuke;
Yamashita, Shuji;
Hirama, Masahiro

Publication type:

Article

Glycoglycerolipid from the Membranes of Acholeplasma laidlawii Binds to Human Immunodeficiency Virus-1 (HIV-1) and Accelerates Its Entry into Cells.

Published in:

Current Microbiology, 2004, v. 48, n. 3, p. 182, doi. 10.1007/s00284-003-4101-x

By:

Shimizu, Takashi;
Arai, Sumio;
Imai, Hiroto;
Oishi, Tohru;
Hirama, Masahiro;
Koito, Atsushi;
Kida, Yutaka;
Kuwano, Koichi

Publication type:

Article

Photochemical Cycloaromatization of Non-Benzenoid Enediynes.

Published in:

Angewandte Chemie International Edition, 1999, v. 38, n. 9, p. 1267, doi. 10.1002/(SICI)1521-3773(19990503)38:9<1267::AID-ANIE1267>3.0.CO;2-F

By:

Kaneko, Toshio;
Takahashi, Miki;
Hirama, Masahiro

Publication type:

Article

Friedel-Crafts β-Silylvinylations.

Published in:

Angewandte Chemie International Edition, 1997, v. 36, n. 12, p. 1313, doi. 10.1002/anie.199713131

By:

Yamaguchi, Masahiko;
Kido, Yoshiyuki;
Hayashi, Akio;
Hirama, Masahiro

Publication type:

Article

A Catalytic Enantioselective Michael Addition of a Simple Malonate to Prochiral α,β-Unsaturated Ketoses and Aldehydes.

Published in:

Angewandte Chemie International Edition, 1993, v. 32, n. 8, p. 1176, doi. 10.1002/anie.199311761

By:

Yamaguchi, Masahiko;
Shiraishi, Tai;
Hirama, Masahiro

Publication type:

Article

Oxidation of Benzyl Ether to Benzoate by Ozone.

Published in:

Synthetic Communications, 1983, v. 13, n. 9, p. 781, doi. 10.1080/00397918308063710

By:

Hirama, Masahiro;
Shimizu, Mitsuaki

Publication type:

Article

Total Synthesis of Limonin.

Published in:

Angewandte Chemie, 2015, v. 127, n. 29, p. 8658, doi. 10.1002/ange.201503794

By:

Yamashita, Shuji;
Naruko, Akito;
Nakazawa, Yuki;
Zhao, Le;
Hayashi, Yujiro;
Hirama, Masahiro

Publication type:

Article

Biomimetic Total Synthesis of Cyanosporaside Aglycons from a Single Enediyne Precursor through Site-Selective p-Benzyne Hydrochlorination.

Published in:

Angewandte Chemie, 2014, v. 126, n. 50, p. 14122, doi. 10.1002/ange.201408416

By:

Yamada, Kei;
Lear, Martin J.;
Yamaguchi, Takaya;
Yamashita, Shuji;
Gridnev, Ilya D.;
Hayashi, Yujiro;
Hirama, Masahiro

Publication type:

Article

A quantitative and comparative study of the effects of a synthetic ciguatoxin CTX3C on the kinetic properties of voltage-dependent sodium channels.

Published in:

British Journal of Pharmacology, 2004, v. 142, n. 5, p. 879, doi. 10.1038/sj.bjp.0705852

By:

Yamaoka, Kaoru;
Inoue, Masayuki;
Miyahara, Hidemichi;
Miyazaki, Keisuke;
Hirama, Masahiro

Publication type:

Article

Total Syntheses of Complanadines A and B.

Published in:

Angewandte Chemie International Edition, 2013, v. 52, n. 6, p. 1722, doi. 10.1002/anie.201208297

By:

Zhao, Le;
Tsukano, Chihiro;
Kwon, Eunsang;
Takemoto, Yoshiji;
Hirama, Masahiro

Publication type:

Article

Total Synthesis of a Protected Aglycon of the Kedarcidin Chromophore.

Published in:

Angewandte Chemie International Edition, 2009, v. 48, n. 6, p. 1110, doi. 10.1002/anie.200805518

By:

Ogawa, Kouki;
Koyama, Yasuhito;
Ohashi, Isao;
Sato, Itaru;
Hirama, Masahiro

Publication type:

Article

Critical Importance of the Nine-Membered F Ring of Ciguatoxin for Potent Bioactivity: Total Synthesis and Biological Evaluation of F-Ring-Modified Analogues.

Published in:

Angewandte Chemie International Edition, 2008, v. 47, n. 45, p. 8611, doi. 10.1002/anie.200803921

By:

Inoue, Masayuki;
Lee, Nayoung;
Miyazaki, Keisuke;
Usuki, Toyonobu;
Matsuoka, Shigeru;
Hirama, Masahiro

Publication type:

Article

Total Synthesis of the C-1027 Chromophore Core: Extremely Facile Enediyne Formation through SmI<sub>2</sub>-Mediated 1,2-Elimination.

Published in:

Angewandte Chemie International Edition, 2008, v. 47, n. 9, p. 1777, doi. 10.1002/anie.200704842

By:

Inoue, Masayuki;
Ohashi, Isao;
Kawaguchi, Teruko;
Hirama, Masahiro

Publication type:

Article

Design, Production, and Characterization of Recombinant Neocarzinostatin Apoprotein in Escherichia coli1.

Published in:

Journal of Biochemistry, 2002, v. 131, n. 5, p. 729, doi. 10.1093/oxfordjournals.jbchem.a003158

By:

Nozaki, Seishiro;
Tomioka, Yoshihisa;
Hishinuma, Takanori;
Inoue, Masayuki;
Nagum, Yoko;
Tsuruta, Lilian R.;
Hayashi, Katsuhiro;
Matsumoto, Toshiki;
Kato, Yoshinori;
Ishiwata, Shunji;
Itoh, Kunihiko;
Suzuki, Toshio;
Hirama, Masahiro;
Mizugaki, Michinao

Publication type:

Article

Effect of Ciguatoxin 3C on Voltage-Gated Na+ and K+ Currents in Mouse Taste Cells.

Published in:

Chemical Senses, 2006, v. 31, n. 7, p. 673, doi. 10.1093/chemse/bjl008

By:

Ghiaroni, Valeria;
Fuwa, Haruhiko;
Inoue, Masayuki;
Sasaki, Makoto;
Miyazaki, Keisuke;
Hirama, Masahiro;
Yasumoto, Takeshi;
Rossini, Gian Paolo;
Scalera, Giuseppe;
Bigiani, Albertino

Publication type:

Article

Competent Route to Unsymmetric Dimer Architectures: Total Syntheses of (−)-Lycodine and (−)-Complanadines A and B, and Evaluation of Their Neurite Outgrowth Activities.

Published in:

Chemistry - A European Journal, 2017, v. 23, n. 4, p. 802, doi. 10.1002/chem.201604647

By:

Zhao, Le;
Tsukano, Chihiro;
Kwon, Eunsang;
Shirakawa, Hisashi;
Kaneko, Shuji;
Takemoto, Yoshiji;
Hirama, Masahiro

Publication type:

Article

Frontispiece: Competent Route to Unsymmetric Dimer Architectures: Total Syntheses of (−)-Lycodine and (−)-Complanadines A and B, and Evaluation of Their Neurite Outgrowth Activities.

Published in:

Chemistry - A European Journal, 2017, v. 23, n. 4, p. n/a, doi. 10.1002/chem.201604647

By:

Zhao, Le;
Tsukano, Chihiro;
Kwon, Eunsang;
Shirakawa, Hisashi;
Kaneko, Shuji;
Takemoto, Yoshiji;
Hirama, Masahiro

Publication type:

Article

Practical Route to the Left Wing of CTX1B and Total Syntheses of CTX1B and 54-deoxyCTX1B.

Published in:

Chemistry - A European Journal, 2015, v. 21, n. 6, p. 2621, doi. 10.1002/chem.201405629

By:

Yamashita, Shuji;
Takeuchi, Katsutoshi;
Koyama, Takuya;
Inoue, Masayuki;
Hayashi, Yujiro;
Hirama, Masahiro

Publication type:

Article

Preparation of Anti-Ciguatoxin Monoclonal Antibodies Using Synthetic Haptens: Sandwich ELISA Detection of Ciguatoxins.

Published in:

Journal of AOAC International, 2014, v. 97, n. 2, p. 373, doi. 10.5740/jaoacint.SGETsumuraya

By:

TAKESHI TSUMURAYA;
IKUO FUJII;
MASAHIRO HIRAMA

Publication type:

Article

Asymmetric Total Synthesis of (−)-Merrilactone A: Use of a Bulky Protecting Group as Long-Range Stereocontrolling Element.

Published in:

Angewandte Chemie International Edition, 2006, v. 45, n. 29, p. 4843, doi. 10.1002/anie.200601358

By:

Inoue, Masayuki;
Sato, Takaaki;
Hirama, Masahiro

Publication type:

Article

A Formal Total Synthesis of (+)-Pinnatoxin AThis work was supported by CREST, Japan Science and Technology Agency (JST). A fellowship to H.S. from the Japan Society for the Promotion of Science (JSPS) is gratefully acknowledged. We thank Professor Y. Kishi (Harvard University) for providing NMR spectra of synthetic intermediates, Professor D. Uemura (Nagoya University) for providing natural pinnatoxin A, and Professor K. Nagasawa (Tokyo University of Agriculture and Technology) for helpful discussions.

Published in:

Angewandte Chemie International Edition, 2004, v. 43, n. 47, p. 6505, doi. 10.1002/anie.200461802

By:

Satoshi Sakamoto;
Hayato Sakazaki;
Koji Hagiwara;
Kei Kamada;
Kento Ishii;
Takeshi Noda;
Masayuki Inoue;
Masahiro Hirama

Publication type:

Article

Synthesis of the C-1027 Chromophore Framework through Atropselective MacrolactonizationThis work was supported by CREST, Japan Science and Technology Agency (JST). A fellowship to T.S. from the Japanese Society for the Promotion of Science (JSPS) is gratefully acknowledged.

Published in:

Angewandte Chemie International Edition, 2004, v. 43, n. 47, p. 6500, doi. 10.1002/anie.200461428

By:

Masayuki Inoue;
Takeo Sasaki;
Suguru Hatano;
Masahiro Hirama

Publication type:

Article

Spin Trapping of 13C-Labeled p-Benzynes Generated by Masamune–Bergman Cyclization of Bicyclic Nine-Membered EnediynesThis work was supported by CREST (Core Research for Evolutional Science and Technology), the Japan Science and Technology Agency (postdoctoral fellowship to P.D.), and the Ministry of Education, Culture, Sports, Science and Technology. We are grateful for three Research Fellowships for Young Scientists (T.U., T.M., and F.Y.) from the Japanese Society for the Promotion of Science. We thank Dr. Jonathan Hobley, Tohoku University, for many insightful comments and fruitful discussions.

Published in:

Angewandte Chemie International Edition, 2004, v. 43, n. 39, p. 5249, doi. 10.1002/anie.200454133

By:

Toyonobu Usuki;
Takashi Mita;
Martin J. Lear;
Parthasarathi Das;
Fumihiko Yoshimura;
Masayuki Inoue;
Masahiro Hirama;
Kimio Akiyama;
Shozo Tero-Kubota

Publication type:

Article

Total Synthesis of TMC-95A ( Dr. Jun Kohno, Tanabe Seiyaku Co. (Japan), is gratefully acknowledged for providing natural TMC-95A for comparative analysis. ).

Published in:

Angewandte Chemie International Edition, 2003, v. 42, n. 23, p. 2654, doi. 10.1002/anie.200351130

By:

Masayuki Inoue;
Hayato Sakazaki;
Hidetomo Furuyama;
Masahiro Hirama

Publication type:

Article

A Direct and Efficient α-Selective Glycosylation Protocol for the Kedarcidin Sugar,.

Published in:

Angewandte Chemie International Edition, 2001, v. 40, n. 5, p. 946, doi. 10.1002/1521-3773(20010302)40:5<946::AID-ANIE946>3.0.CO;2-G

By:

Lear, Martin J.;
Yoshimura, Fumihiko;
Hirama, Masahiro

Publication type:

Article

A Three-Step Synthesis of Halomon.

Published in:

Angewandte Chemie International Edition, 2000, v. 39, n. 19, p. 3430, doi. 10.1002/1521-3773(20001002)39:19<3430::AID-ANIE3430>3.0.CO;2-3

By:

Sotokawa, Takayuki;
Noda, Takeshi;
Pi, Sun;
Hirama, Masahiro

Publication type:

Article

Total synthesis of ciguatoxin CTX3C: a venture into the problems of ciguatera seafood poisoning.

Published in:

Chemical Record, 2005, v. 5, n. 4, p. 240, doi. 10.1002/tcr.20049

By:

Hirama, Masahiro

Publication type:

Article

Enantioselective Synthesis of the Fully Functionalized ABC Ring of Zoanthenol.

Published in:

Chemistry - An Asian Journal, 2008, v. 3, n. 8/9, p. 1549, doi. 10.1002/asia.200800079

By:

Sugano, Naoki;
Koizumi, Yuuki;
Hirai, Go;
Oguri, Hiroki;
Kobayashi, Shoji;
Yamashita, Shuji;
Hirama, Masahiro

Publication type:

Article

Synthesis of the Bicyclo[7.3.0]dodecadiyne Core of the Maduropeptin Chromophore.

Published in:

Chemistry - An Asian Journal, 2008, v. 3, n. 2, p. 447, doi. 10.1002/asia.200700310

By:

Iso, Kentaro;
Inoue, Masayuki;
Kato, Nobuki;
Hirama, Masahiro

Publication type:

Article

Glancing at the birth of a galaxy of scientists from Riko Majima.

Published in:

Proceedings of the Japan Academy, Series B Physical & biological sciences, 2023, v. 99, n. 9, p. 335, doi. 10.2183/pjab.99.019

By:

Hiroyuki ISOBE;
Masahiro HIRAMA

Publication type:

Article

A convergent total synthesis of the kedarcidin chromophore: 20-years in the making.

Published in:

Journal of Antibiotics, 2019, v. 72, n. 6, p. 350, doi. 10.1038/s41429-019-0175-y

By:

Lear, Martin J.;
Hirai, Keiichiro;
Ogawa, Kouki;
Yamashita, Shuji;
Hirama, Masahiro

Publication type:

Article

Total synthesis of avermectin B<sub>1a</sub> revisited.

Published in:

Journal of Antibiotics, 2016, v. 69, n. 1, p. 31, doi. 10.1038/ja.2015.47

By:

Yamashita, Shuji;
Hayashi, Daisuke;
Nakano, Aoi;
Hayashi, Yujiro;
Hirama, Masahiro

Publication type:

Article