Works by Marugan, Juan J

Results: 29

Disease models for the development of therapies for lysosomal storage diseases.

Published in:

Annals of the New York Academy of Sciences, 2016, v. 1371, n. 1, p. 15, doi. 10.1111/nyas.13052

By:

Xu, Miao;
Motabar, Omid;
Ferrer, Marc;
Marugan, Juan J.;
Zheng, Wei;
Ottinger, Elizabeth A.

Publication type:

Article

Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

Published in:

2018

By:

Rolt, Adam;
Le, Derek;
Zongyi Hu;
Wang, Amy Q.;
Shah, Pranav;
Singleton, Marc;
Hughes, Emma;
Dulcey, Andrés E.;
He, Shanshan;
Michio Imamura;
Takuro Uchida;
Kazuaki Chayama;
Xin Xu;
Marugan, Juan J.;
Liang, T. Jake;
Hu, Zongyi;
Imamura, Michio;
Uchida, Takuro;
Chayama, Kazuaki;
Xu, Xin

Publication type:

journal article

Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus.

Published in:

PLoS Pathogens, 2016, v. 12, n. 6, p. 1, doi. 10.1371/journal.ppat.1005717

By:

Mukhopadhyay, Rupkatha;
Roy, Sujayita;
Venkatadri, Rajkumar;
Su, Yu-Pin;
Ye, Wenjuan;
Barnaeva, Elena;
Mathews Griner, Lesley;
Southall, Noel;
Hu, Xin;
Wang, Amy Q.;
Xu, Xin;
Dulcey, Andrés E.;
Marugan, Juan J.;
Ferrer, Marc;
Arav-Boger, Ravit

Publication type:

Article

Teaching principles of translational science to a broad scientific audience using a case study approach: A pilot course from the National Center for Advancing Translational Sciences.

Published in:

Journal of Clinical & Translational Science, 2022, v. 6, n. 1, p. 1, doi. 10.1017/cts.2022.374

By:

Faupel-Badger, Jessica M.;
Vogel, Amanda L.;
Hussain, Shadab F.;
Austin, Christopher P.;
Hall, Matthew D.;
Ness, Elizabeth;
Sanderson, Philip;
Terse, Pramod S.;
Xu, Xin;
Balakrishnan, Krishna;
Patnaik, Samarjit;
Marugan, Juan J.;
Rudloff, Udo;
Ferrer, Marc

Publication type:

Article

combinatorial approach increases SMN level in SMA model mice.

Published in:

Human Molecular Genetics, 2022, v. 31, n. 17, p. 2989, doi. 10.1093/hmg/ddac068

By:

Dumas, Samantha A;
Villalón, Eric;
Bergman, Elizabeth M;
Wilson, Kenneth J;
Marugan, Juan J;
Lorson, Christian L;
Burnett, Barrington G

Publication type:

Article

Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 29, p. 7693, doi. 10.1523/JNEUROSCI.0628-16.2016

By:

Mazzulli, Joseph R.;
Zunke, Friederike;
Tsunemi, Taiji;
Toker, Nicholas J.;
Jeon, Sohee;
Burbulla, Lena F.;
Patnaik, Samarjit;
Sidransky, Ellen;
Marugan, Juan J.;
Sue, Carolyn M.;
Krainc, Dimitri

Publication type:

Article

An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2024, v. 109, n. 9, p. 2306, doi. 10.1210/clinem/dgae114

By:

Sarkar, Rhitajit;
Bolel, Priyanka;
Kapoor, Abhijeet;
Eliseeva, Elena;
Dulcey, Andrés E;
Templin, Jay S;
Wang, Amy Q;
Xu, Xin;
Southall, Noel;
Klubo-Gwiezdzinska, Joanna;
Neumann, Susanne;
Marugan, Juan J;
Gershengorn, Marvin C

Publication type:

Article

c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration.

Published in:

Antioxidants, 2023, v. 12, n. 11, p. 2007, doi. 10.3390/antiox12112007

By:

Martinez, Alexis;
Lamaizon, Cristian M.;
Valls, Cristian;
Llambi, Fabien;
Leal, Nancy;
Fitzgerald, Patrick;
Guy, Cliff;
Kamiński, Marcin M.;
Inestrosa, Nibaldo C.;
van Zundert, Brigitte;
Cancino, Gonzalo I.;
Dulcey, Andrés E.;
Zanlungo, Silvana;
Marugan, Juan J.;
Hetz, Claudio;
Green, Douglas R.;
Alvarez, Alejandra R.

Publication type:

Article

Plasma and Tissue Concentrations of α-Tocopherol and δ-Tocopherol Following High Dose Dietary Supplementation in Mice.

Published in:

2012

By:

Baxter, Laura L.;
Marugan, Juan J.;
Jingbo Xiao;
Incao, Art;
McKew, John C.;
Wei Zheng;
Pavan, William J.

Publication type:

Journal Article

Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease.

Published in:

2018

By:

Vu, Mylinh;
Li, Rong;
Baskfield, Amanda;
Lu, Billy;
Farkhondeh, Atena;
Gorshkov, Kirill;
Motabar, Omid;
Beers, Jeanette;
Chen, Guokai;
Zou, Jizhong;
Espejo-Mojica, Angela J.;
Rodríguez-López, Alexander;
Alméciga-Díaz, Carlos J.;
Barrera, Luis A.;
Jiang, Xuntian;
Ory, Daniel S.;
Marugan, Juan J.;
Zheng, Wei;
Rodríguez-López, Alexander;
Alméciga-Díaz, Carlos J

Publication type:

journal article

Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses.

Published in:

2018

By:

Sima, Ni;
Li, Rong;
Huang, Wei;
Xu, Miao;
Beers, Jeanette;
Zou, Jizhong;
Titus, Steven;
Ottinger, Elizabeth A.;
Marugan, Juan J.;
Xie, Xing;
Zheng, Wei

Publication type:

journal article

Analytical Characterization of Methyl-β-Cyclodextrin for Pharmacological Activity to Reduce Lysosomal Cholesterol Accumulation in Niemann-Pick Disease Type C1 Cells.

Published in:

Assay & Drug Development Technologies, 2017, v. 15, n. 4, p. 154, doi. 10.1089/adt.2017.774

By:

Rong Li;
Jon Hao;
Hideji Fujiwara;
Miao Xu;
Shu Yang;
Sheng Dai;
Yan Long;
Swaroop, Manju;
Changhui Li;
Mylinh Vu;
Marugan, Juan J.;
Ory, Daniel S.;
Wei Zheng

Publication type:

Article

Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-04143-9

By:

Esteban-Lopez, Maria;
Wilson, Kenneth J.;
Myhr, Courtney;
Kaftanovskaya, Elena M.;
Henderson, Mark J.;
Southall, Noel T.;
Xu, Xin;
Wang, Amy;
Hu, Xin;
Barnaeva, Elena;
Ye, Wenjuan;
George, Emmett R.;
Sherrill, John T.;
Ferrer, Marc;
Morello, Roy;
Agoulnik, Irina U.;
Marugan, Juan J.;
Agoulnik, Alexander I.

Publication type:

Article

c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer's disease.

Published in:

Frontiers in Aging Neuroscience, 2023, p. 1, doi. 10.3389/fnagi.2023.1180987

By:

León, Rilda;
Gutiérrez, Daniela A.;
Pinto, Claudio;
Morales, Cristian;
de la Fuente, Catalina;
Riquelme, Cristóbal;
Cortés, Bastián I.;
González-Martin, Adrián;
Chamorro, David;
Espinosa, Nelson;
Fuentealba, Pablo;
Cancino, Gonzalo I.;
Zanlungo, Silvana;
Dulcey, Andrés E.;
Marugan, Juan J.;
Álvarez Rojas, Alejandra

Publication type:

Article

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.

Published in:

Science Translational Medicine, 2015, v. 7, n. 282, p. 1, doi. 10.1126/scitranslmed.3010286

By:

Shanshan He;
Billy Lin;
Chu, Virginia;
Zongyi Hu;
Xin Hu;
Jingbo Xiao;
Wang, Amy Q.;
Schweitzer, Cameron J.;
Qisheng Li;
Michio Imamura;
Nobuhiko Hiraga;
Southall, Noel;
Ferrer, Marc;
Wei Zheng;
Kazuaki Chayama;
Marugan, Juan J.;
Liang, T. Jake

Publication type:

Article

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

Published in:

Science Translational Medicine, 2014, v. 6, n. 268, p. 1, doi. 10.1126/scitranslmed.3010523

By:

Xiao-Hong Lu;
Mattis, Virginia B.;
Nan Wang;
Al-Ramahi, Ismael;
van den Berg, Nick;
Fratantoni, Silvina A.;
Waldvogel, Henry;
Greiner, Erin;
Osmand, Alex;
Elzein, Karla;
Jingbo Xiao;
Dijkstra, Sipke;
de Pril, Remko;
Vinters, Harry V.;
Faull, Richard;
Signer, Ethan;
Seung Kwak;
Marugan, Juan J.;
Botas, Juan;
Fischer, David F.

Publication type:

Article

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 10, p. 6591, doi. 10.1093/nar/gku275

By:

Hoskins, Jason W.;
Ofori, Leslie O.;
Chen, Catherine Z.;
Kumar, Amit;
Sobczak, Krzysztof;
Nakamori, Masayuki;
Southall, Noel;
Patnaik, Samarjit;
Marugan, Juan J.;
Zheng, Wei;
Austin, Christopher P.;
Disney, Matthew D.;
Miller, Benjamin L.;
Thornton, Charles A.

Publication type:

Article

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.

Published in:

Nature Communications, 2013, v. 4, n. 6, p. 1953, doi. 10.1038/ncomms2953

By:

Xiao, Jingbo;
Huang, Zaohua;
Chen, Catherine Z.;
Agoulnik, Irina U.;
Southall, Noel;
Hu, Xin;
Jones, Raisa E.;
Ferrer, Marc;
Zheng, Wei;
Agoulnik, Alexander I.;
Marugan, Juan J.

Publication type:

Article

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

Published in:

Nature Communications, 2013, v. 4, n. 6, p. 2044, doi. 10.1038/ncomms3044

By:

Childs-Disney, Jessica L.;
Stepniak-Konieczna, Ewa;
Tran, Tuan;
Yildirim, Ilyas;
Park, HaJeung;
Chen, Catherine Z.;
Hoskins, Jason;
Southall, Noel;
Marugan, Juan J.;
Patnaik, Samarjit;
Zheng, Wei;
Austin, Chris P.;
Schatz, George C.;
Sobczak, Krzysztof;
Thornton, Charles A.;
Disney, Matthew D.

Publication type:

Article

Activation of relaxin family receptor 1 from different mammalian species by relaxin peptide and small-molecule agonist ML290.

Published in:

Frontiers in Endocrinology, 2015, p. 1, doi. 10.3389/fendo.2015.00128

By:

Zaohua Huang;
Myhr, Courtney;
Ho, Brian A.;
Bueno, Amaya;
Agoulnik, Alexander I.;
Bathgate, Ross A. D.;
Xin Hu;
Jingbo Xiao;
Southall, Noel;
Barnaeva, Elena;
Marugan, Juan J.;
Ferrer, Marc;
Agoulnik, Irina U.

Publication type:

Article

Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction.

Published in:

Frontiers in Physiology, 2021, v. 12, p. 1, doi. 10.3389/fphys.2021.650769

By:

Ng, Hooi Hooi;
Soula, Mariluz;
Rivas, Bryan;
Wilson, Kenneth J.;
Marugan, Juan J.;
Agoulnik, Alexander I.

Publication type:

Article

In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.

Published in:

Viruses (1999-4915), 2023, v. 15, n. 7, p. 1503, doi. 10.3390/v15071503

By:

Hu, Xin;
Morazzani, Elaine;
Compton, Jaimee R.;
Harmon, Moeshia;
Soloveva, Veronica;
Glass, Pamela J.;
Garcia, Andres Dulcey;
Marugan, Juan J.;
Legler, Patricia M.

Publication type:

Article

A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of <i>gsp</i>.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090766

By:

Bhattacharyya, Nisan;
Hu, Xin;
Chen, Catherine Z.;
Mathews Griner, Lesley A.;
Zheng, Wei;
Inglese, James;
Austin, Christopher P.;
Marugan, Juan J.;
Southall, Noel;
Neumann, Susanne;
Northup, John K.;
Ferrer, Marc;
Collins, Michael T.

Publication type:

Article

Novel Patient Cell-Based HTS Assay for Identification of Small Molecules for a Lysosomal Storage Disease.

Published in:

PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0029504

By:

Haifeng Geng;
Whiteley, Grace;
Ribbens, Jameson;
Wei Zheng;
Southall, Noel;
Xin Hu;
Marugan, Juan J.;
Ferrer, Marc;
Maegawa, Gustavo H. B.

Publication type:

Article

Analytical Characterization of Methyl-β-Cyclodextrin for Pharmacological Activity to Reduce Lysosomal Cholesterol Accumulation in Niemann-Pick Disease Type C1 Cells.

Published in:

Assay & Drug Development Technologies, 2017, v. 15, n. 4, p. 154, doi. 10.1089/adt.2017.774

By:

Li, Rong;
Hao, Jon;
Fujiwara, Hideji;
Xu, Miao;
Yang, Shu;
Dai, Sheng;
Long, Yan;
Swaroop, Manju;
Li, Changhui;
Vu, Mylinh;
Marugan, Juan J.;
Ory, Daniel S.;
Zheng, Wei

Publication type:

Article

Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A.

Published in:

Stem Cells Translational Medicine, 2016, v. 5, n. 12, p. 1644, doi. 10.5966/sctm.2015-0373

By:

Long, Yan;
Xu, Miao;
Li, Rong;
Dai, Sheng;
Beers, Jeanette;
Chen, Guokai;
Soheilian, Ferri;
Baxa, Ulrich;
Wang, Mengqiao;
Marugan, Juan J.;
Muro, Silvia;
Li, Zhiyuan;
Brady, Roscoe;
Zheng, Wei

Publication type:

Article

Characterization and Chemical Optimization of the D2 Dopamine Receptor‐Selective Antagonist, ML321, Identifies Lead Compounds for the Clinical Treatment of Neuropsychiatric Disorders.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2720

By:

Nilson, Ashley N.;
Dulcey Garcia, Andres;
Free, R. B.;
Boldizsar, Noelia;
Pearlstein, Hannah;
Rocereta, Julia A.;
Rodriguiz, Ramona M.;
Lane, J. R.;
Lee, Kuo H.;
Shi, Lei;
Wetsel, William C.;
Marugan, Juan J.;
Sibley, David R.

Publication type:

Article

Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis.

Published in:

FASEB Journal, 2019, v. 33, n. 11, p. 12435, doi. 10.1096/fj.201901046R

By:

Kaftanovskaya, Elena M.;
Hooi Hooi Ng;
Soula, Mariluz;
Rivas, Bryan;
Myhr, Courtney;
Ho, Brian A.;
Cervantes, Briana A.;
Shupe, Thomas D.;
Devarasetty, Mahesh;
Xin Hu;
Xin Xu;
Patnaik, Samarjit;
Wilson, Kenneth J.;
Barnaeva, Elena;
Ferrer, Marc;
Southall, Noel T.;
Marugan, Juan J.;
Bishop, Colin E.;
Agoulnik, Irina U.;
Agoulnik, Alexander I.

Publication type:

Article

Discovery, characterization, and optimization of highly selective D<sub>2</sub> dopaminergic antagonists.

Published in:

FASEB Journal, 2013, v. 27, p. 655.7, doi. 10.1096/fasebj.27.1_supplement.655.7

By:

Free, R. Benjamin;
Xiao, Jingbo;
Doyle, Trevor;
Conroy, Jennie;
Titus, Steve;
Bryant‐Genevier, Melanie;
Southall, Noel;
Hu, Xin;
Ferrer, Marc;
Javitch, Jonathan A;
Marugan, Juan J;
Sibley, David R

Publication type:

Article