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  • β-secretase inhibitors for treatment of Alzheimer's disease

    Published in:
    2010
    By:
    • O'Neill, Brian T.;
    • Brodney, Michael A.;
    • Ambroise, Claude;
    • Borzilleri, Kris;
    • Coffman, Karen;
    • Efremov, Ivan;
    • Hajos-Korcsok, Eva;
    • Helal, Christopher;
    • Kauffman, Gregory;
    • Lanyon, Lorraine;
    • Liston, Dane;
    • JianHua Liu;
    • Lu, Yasong;
    • Martinez-Alsina, Luis;
    • Murray, John;
    • Nelson, Frederick R.;
    • Noell, Stephen;
    • Nolan, Charles;
    • Oborski, Christine;
    • Ogilvie, Kevin
    Publication type:
    Abstract

  • Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.

    Published in:
    Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40536-y
    By:
    • Roth Flach, Rachel J.;
    • Bollinger, Eliza;
    • Reyes, Allan R.;
    • Laforest, Brigitte;
    • Kormos, Bethany L.;
    • Liu, Shenping;
    • Reese, Matthew R.;
    • Martinez Alsina, Luis A.;
    • Buzon, Leanne;
    • Zhang, Yuan;
    • Bechle, Bruce;
    • Rosado, Amy;
    • Sahasrabudhe, Parag V.;
    • Knafels, John;
    • Bhattacharya, Samit K.;
    • Omoto, Kiyoyuki;
    • Stansfield, John C.;
    • Hurley, Liam D.;
    • Song, LouJin;
    • Luo, Lina
    Publication type:
    Article

  • Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.

    Published in:
    Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40536-y
    By:
    • Roth Flach, Rachel J.;
    • Bollinger, Eliza;
    • Reyes, Allan R.;
    • Laforest, Brigitte;
    • Kormos, Bethany L.;
    • Liu, Shenping;
    • Reese, Matthew R.;
    • Martinez Alsina, Luis A.;
    • Buzon, Leanne;
    • Zhang, Yuan;
    • Bechle, Bruce;
    • Rosado, Amy;
    • Sahasrabudhe, Parag V.;
    • Knafels, John;
    • Bhattacharya, Samit K.;
    • Omoto, Kiyoyuki;
    • Stansfield, John C.;
    • Hurley, Liam D.;
    • Song, LouJin;
    • Luo, Lina
    Publication type:
    Article