Found: 31

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  • An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.

    Published in:
    Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-31659-0
    By:
    • Collord, Grace;
    • Tarpey, Patrick;
    • Kurbatova, Natalja;
    • Martincorena, Inigo;
    • Moran, Sebastian;
    • Castro, Manuel;
    • Nagy, Tibor;
    • Bignell, Graham;
    • Maura, Francesco;
    • Young, Matthew D.;
    • Berna, Jorge;
    • Tubio, Jose M. C.;
    • McMurran, Chris E.;
    • Young, Adam M. H.;
    • Sanders, Mathijs;
    • Noorani, Imran;
    • Price, Stephen J.;
    • Watts, Colin;
    • Leipnitz, Elke;
    • Kirsch, Matthias
    Publication type:
    Article

  • Pathway-based dissection of the genomic heterogeneity of cancer hallmarks' acquisition with SLAPenrich.

    Published in:
    Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-25076-6
    By:
    • Iorio, Francesco;
    • Garcia-Alonso, Luz;
    • Brammeld, Jonathan S.;
    • Martincorena, Iňigo;
    • Wille, David R.;
    • McDermott, Ultan;
    • Saez-Rodriguez, Julio
    Publication type:
    Article

  • The driver landscape of sporadic chordoma.

    Published in:
    Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01026-0
    By:
    • Tarpey, Patrick S.;
    • Behjati, Sam;
    • Young, Matthew D.;
    • Martincorena, Inigo;
    • Alexandrov, Ludmil B.;
    • Farndon, Sarah J.;
    • Guzzo, Charlotte;
    • Hardy, Claire;
    • Latimer, Calli;
    • Butler, Adam P.;
    • Teague, Jon W.;
    • Shlien, Adam;
    • Futreal, P. Andrew;
    • Shah, Sohrab;
    • Bashashati, Ali;
    • Jamshidi, Farzad;
    • Nielsen, Torsten O.;
    • Huntsman, David;
    • Baumhoer, Daniel;
    • Brandner, Sebastian
    Publication type:
    Article

  • Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

    Published in:
    Nature Communications, 2017, v. 8, n. 6, p. 15936, doi. 10.1038/ncomms15936
    By:
    • Behjati, Sam;
    • Tarpey, Patrick S.;
    • Haase, Kerstin;
    • Ye, Hongtao;
    • Young, Matthew D.;
    • Alexandrov, Ludmil B.;
    • Farndon, Sarah J.;
    • Collord, Grace;
    • Wedge, David C.;
    • Martincorena, Inigo;
    • Cooke, Susanna L.;
    • Davies, Helen;
    • Mifsud, William;
    • Lidgren, Mathias;
    • Martin, Sancha;
    • Latimer, Calli;
    • Maddison, Mark;
    • Butler, Adam P.;
    • Teague, Jon W.;
    • Pillay, Nischalan
    Publication type:
    Article

  • Processed pseudogenes acquired somatically during cancer development.

    Published in:
    Nature Communications, 2014, v. 5, n. 4, p. 3644, doi. 10.1038/ncomms4644
    By:
    • Cooke, Susanna L.;
    • Shlien, Adam;
    • Marshall, John;
    • Pipinikas, Christodoulos P.;
    • Martincorena, Inigo;
    • Tubio, Jose M.C.;
    • Li, Yilong;
    • Menzies, Andrew;
    • Mudie, Laura;
    • Ramakrishna, Manasa;
    • Yates, Lucy;
    • Davies, Helen;
    • Bolli, Niccolo;
    • Bignell, Graham R.;
    • Tarpey, Patrick S.;
    • Behjati, Sam;
    • Nik-Zainal, Serena;
    • Papaemmanuil, Elli;
    • Teixeira, Vitor H.;
    • Raine, Keiran
    Publication type:
    Article

  • Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.

    Published in:
    Nature Communications, 2014, v. 5, n. 1, p. 2997, doi. 10.1038/ncomms3997
    By:
    • Bolli, Niccolo;
    • Avet-Loiseau, Hervé;
    • Wedge, David C.;
    • Van Loo, Peter;
    • Alexandrov, Ludmil B.;
    • Martincorena, Inigo;
    • Dawson, Kevin J.;
    • Iorio, Francesco;
    • Nik-Zainal, Serena;
    • Bignell, Graham R.;
    • Hinton, Jonathan W.;
    • Li, Yilong;
    • Tubio, Jose M.C.;
    • McLaren, Stuart;
    • O' Meara, Sarah;
    • Butler, Adam P.;
    • Teague, Jon W.;
    • Mudie, Laura;
    • Anderson, Elizabeth;
    • Rashid, Naim
    Publication type:
    Article

  • Somatic mutation and clonal expansions in human tissues.

    Published in:
    Genome Medicine, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13073-019-0648-4
    By:
    • Martincorena, Inigo
    Publication type:
    Article

  • Evidence of non-random mutation rates suggests an evolutionary risk management strategy.

    Published in:
    Nature, 2012, v. 485, n. 7396, p. 95, doi. 10.1038/nature10995
    By:
    • Martincorena, Iñigo;
    • Seshasayee, Aswin S. N.;
    • Luscombe, Nicholas M.
    Publication type:
    Article

  • Next Generation Sequencing Workshop at the Royal Society of Medicine (London, May 2022): how genomics is on the path to modernizing genetic toxicology.

    Published in:
    Mutagenesis, 2023, v. 38, n. 4, p. 192, doi. 10.1093/mutage/gead012
    By:
    • Lynch, Anthony M;
    • Zanoni, Thalita B;
    • Salk, Jesse J;
    • Martincorena, Inigo;
    • Young, Robert R;
    • Kucab, Jill;
    • Valentine, Charles C;
    • Yauk, Carole;
    • Escobar, Patricia A;
    • Witt, Kristine L;
    • Frötschl, Roland;
    • Reed, Simon H;
    • Ashford, Anne
    Publication type:
    Article

  • Patterns of within-host genetic diversity in SARS-CoV-2.

    Published in:
    eLife, 2021, p. 1, doi. 10.7554/eLife.66857
    By:
    • Tonkin-Hill, Gerry;
    • Martincorena, Inigo;
    • Amato, Roberto;
    • Lawson, Andrew R. J.;
    • Gerstrung, Moritz;
    • Johnston, Ian;
    • Jackson, David K.;
    • Park, Naomi;
    • Lensing, Stefanie V.;
    • Quail, Michael A.;
    • Gonc¸alves, Sonia;
    • Ariani, Cristina;
    • Chapman, Michael Spencer;
    • Hamilton, William L.;
    • Meredith, Luke W.;
    • Hall, Grant;
    • Jahun, Aminu S.;
    • Chaudhry, Yasmin;
    • Hosmillo, Myra;
    • Pinckert, Malte L.
    Publication type:
    Article

  • Recurrent PTPRB and PLCG1 mutations in angiosarcoma.

    Published in:
    Nature Genetics, 2014, v. 46, n. 4, p. 376, doi. 10.1038/ng.2921
    By:
    • Behjati, Sam;
    • Tarpey, Patrick S;
    • Sheldon, Helen;
    • Martincorena, Inigo;
    • Van Loo, Peter;
    • Gundem, Gunes;
    • Wedge, David C;
    • Ramakrishna, Manasa;
    • Cooke, Susanna L;
    • Pillay, Nischalan;
    • Vollan, Hans Kristian M;
    • Papaemmanuil, Elli;
    • Koss, Hans;
    • Bunney, Tom D;
    • Hardy, Claire;
    • Joseph, Olivia R;
    • Martin, Sancha;
    • Mudie, Laura;
    • Butler, Adam;
    • Teague, Jon W
    Publication type:
    Article

  • RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.

    Published in:
    Nature Genetics, 2014, v. 46, n. 2, p. 116, doi. 10.1038/ng.2874
    By:
    • Papaemmanuil, Elli;
    • Rapado, Inmaculada;
    • Li, Yilong;
    • Potter, Nicola E;
    • Wedge, David C;
    • Tubio, Jose;
    • Alexandrov, Ludmil B;
    • Van Loo, Peter;
    • Cooke, Susanna L;
    • Marshall, John;
    • Martincorena, Inigo;
    • Hinton, Jonathan;
    • Gundem, Gunes;
    • van Delft, Frederik W;
    • Nik-Zainal, Serena;
    • Jones, David R;
    • Ramakrishna, Manasa;
    • Titley, Ian;
    • Stebbings, Lucy;
    • Leroy, Catherine
    Publication type:
    Article

  • Inactivating CUX1 mutations promote tumorigenesis.

    Published in:
    Nature Genetics, 2014, v. 46, n. 1, p. 33, doi. 10.1038/ng.2846
    By:
    • Wong, Chi C;
    • Martincorena, Inigo;
    • Rust, Alistair G;
    • Rashid, Mamunur;
    • Alifrangis, Constantine;
    • Alexandrov, Ludmil B;
    • Tiffen, Jessamy C;
    • Kober, Christina;
    • Green, Anthony R;
    • Massie, Charles E;
    • Nangalia, Jyoti;
    • Lempidaki, Stella;
    • Döhner, Hartmut;
    • Döhner, Konstanze;
    • Bray, Sarah J;
    • McDermott, Ultan;
    • Papaemmanuil, Elli;
    • Campbell, Peter J;
    • Adams, David J
    Publication type:
    Article

  • Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma.

    Published in:
    Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08081-1
    By:
    • Wong, Kim;
    • van der Weyden, Louise;
    • Schott, Courtney R.;
    • Foote, Alastair;
    • Constantino-Casas, Fernando;
    • Smith, Sionagh;
    • Dobson, Jane M.;
    • Murchison, Elizabeth P.;
    • Wu, Hong;
    • Yeh, Iwei;
    • Fullen, Douglas R.;
    • Joseph, Nancy;
    • Bastian, Boris C.;
    • Patel, Rajiv M.;
    • Martincorena, Inigo;
    • Robles-Espinoza, Carla Daniela;
    • Iyer, Vivek;
    • Kuijjer, Marieke L.;
    • Arends, Mark J.;
    • Brenn, Thomas
    Publication type:
    Article

  • Genomic patterns of progression in smoldering multiple myeloma.

    Published in:
    Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-05058-y
    By:
    • Bolli, Niccolò;
    • Maura, Francesco;
    • Minvielle, Stephane;
    • Gloznik, Dominik;
    • Szalat, Raphael;
    • Fullam, Anthony;
    • Martincorena, Inigo;
    • Dawson, Kevin J.;
    • Samur, Mehmet Kemal;
    • Zamora, Jorge;
    • Tarpey, Patrick;
    • Davies, Helen;
    • Fulciniti, Mariateresa;
    • Shammas, Masood A.;
    • Yu Tzu Tai;
    • Magrangeas, Florence;
    • Moreau, Philippe;
    • Corradini, Paolo;
    • Anderson, Kenneth;
    • Alexandrov, Ludmil
    Publication type:
    Article

  • Reconstructing phylogenetic trees from genome-wide somatic mutations in clonal samples.

    Published in:
    Nature Protocols, 2024, v. 19, n. 6, p. 1866, doi. 10.1038/s41596-024-00962-8
    By:
    • Coorens, Tim H. H.;
    • Spencer Chapman, Michael;
    • Williams, Nicholas;
    • Martincorena, Inigo;
    • Stratton, Michael R.;
    • Nangalia, Jyoti;
    • Campbell, Peter J.
    Publication type:
    Article

  • Author Correction: Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing.

    Published in:
    2023
    By:
    • Ellis, Peter;
    • Moore, Luiza;
    • Sanders, Mathijs A.;
    • Butler, Timothy M.;
    • Brunner, Simon F.;
    • Lee-Six, Henry;
    • Osborne, Robert;
    • Farr, Ben;
    • Coorens, Tim H. H.;
    • Lawson, Andrew R. J.;
    • Cagan, Alex;
    • Stratton, Mike R.;
    • Martincorena, Inigo;
    • Campbell, Peter J.
    Publication type:
    Correction Notice

  • Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing.

    Published in:
    Nature Protocols, 2021, v. 16, n. 2, p. 841, doi. 10.1038/s41596-020-00437-6
    By:
    • Ellis, Peter;
    • Moore, Luiza;
    • Sanders, Mathijs A.;
    • Butler, Timothy M.;
    • Brunner, Simon F.;
    • Lee-Six, Henry;
    • Osborne, Robert;
    • Farr, Ben;
    • Coorens, Tim H. H.;
    • Lawson, Andrew R. J.;
    • Cagan, Alex;
    • Stratton, Mike R.;
    • Martincorena, Inigo;
    • Campbell, Peter J.
    Publication type:
    Article

  • Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids.

    Published in:
    BMC Developmental Biology, 2020, v. 20, n. 1, p. 1, doi. 10.1186/s12861-020-0209-5
    By:
    • Georgakopoulos, Nikitas;
    • Prior, Nicole;
    • Angres, Brigitte;
    • Mastrogiovanni, Gianmarco;
    • Cagan, Alex;
    • Harrison, Daisy;
    • Hindley, Christopher J.;
    • Arnes-Benito, Robert;
    • Liau, Siong-Seng;
    • Curd, Abbie;
    • Ivory, Natasha;
    • Simons, Benjamin D.;
    • Martincorena, Inigo;
    • Wurst, Helmut;
    • Saeb-Parsy, Kourosh;
    • Huch, Meritxell
    Publication type:
    Article

  • The Organization of Local and Distant Functional Connectivity in the Human Brain.

    Published in:
    PLoS Computational Biology, 2010, v. 6, n. 6, p. 1, doi. 10.1371/journal.pcbi.1000808
    By:
    • Sepulcre, Jorge;
    • Hesheng Liu;
    • Talukdar, Tanveer;
    • Martincorena, Iñigo;
    • Thomas Yeo, B. T.;
    • Buckner, Randy L.
    Publication type:
    Article

  • Recurrent histone mutations in T‐cell acute lymphoblastic leukaemia.

    Published in:
    British Journal of Haematology, 2019, v. 184, n. 4, p. 676, doi. 10.1111/bjh.15155
    By:
    • Collord, Grace;
    • Martincorena, Inigo;
    • Young, Matthew D.;
    • Foroni, Letizia;
    • Bolli, Niccolo;
    • Stratton, Michael R.;
    • Vassiliou, George S.;
    • Campbell, Peter J.;
    • Behjati, Sam
    Publication type:
    Article

  • Genome sequencing of normal cells reveals developmental lineages and mutational processes.

    Published in:
    Nature, 2014, v. 513, n. 7518, p. 422, doi. 10.1038/nature13448
    By:
    • Behjati, Sam;
    • Huch, Meritxell;
    • van Boxtel, Ruben;
    • Karthaus, Wouter;
    • Wedge, David C.;
    • Martincorena, Iñigo;
    • Petljak, Mia;
    • Alexandrov, Ludmil B.;
    • Gundem, Gunes;
    • Tarpey, Patrick S.;
    • Roerink, Sophie;
    • Maddison, Mark;
    • Mudie, Laura;
    • Robinson, Ben;
    • Campbell, Peter;
    • Stratton, Michael R.;
    • Tamuri, Asif U.;
    • Goldman, Nick;
    • Blokker, Joyce;
    • van de Wetering, Marc
    Publication type:
    Article

  • Mutational landscape of normal epithelial cells in Lynch Syndrome patients.

    Published in:
    Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29920-2
    By:
    • Lee, Bernard C. H.;
    • Robinson, Philip S.;
    • Coorens, Tim H. H.;
    • Yan, Helen H. N.;
    • Olafsson, Sigurgeir;
    • Lee-Six, Henry;
    • Sanders, Mathijs A.;
    • Siu, Hoi Cheong;
    • Hewinson, James;
    • Yue, Sarah S. K.;
    • Tsui, Wai Yin;
    • Chan, Annie S. Y.;
    • Chan, Anthony K. W.;
    • Ho, Siu Lun;
    • Campbell, Peter J.;
    • Martincorena, Inigo;
    • Buczacki, Simon J. A.;
    • Yuen, Siu Tsan;
    • Leung, Suet Yi;
    • Stratton, Michael R.
    Publication type:
    Article

  • The semantic organization of the animal category: evidence from semantic verbal fluency and network theory.

    Published in:
    2011
    By:
    • Goñi, Joaquín;
    • Arrondo, Gonzalo;
    • Sepulcre, Jorge;
    • Martincorena, Iñigo;
    • Vélez de Mendizábal, Nieves;
    • Corominas-Murtra, Bernat;
    • Bejarano, Bartolomé;
    • Ardanza-Trevijano, Sergio;
    • Peraita, Herminia;
    • Wall, Dennis;
    • Villoslada, Pablo
    Publication type:
    Report

  • SWITCHER-RANDOM-WALKS:: A COGNITIVE-INSPIRED MECHANISM FOR NETWORK EXPLORATION.

    Published in:
    International Journal of Bifurcation & Chaos in Applied Sciences & Engineering, 2010, v. 20, n. 3, p. 913, doi. 10.1142/S0218127410026204
    By:
    • GOÑI, JOAQUÍN;
    • MARTINCORENA, IÑIGO;
    • COROMINAS-MURTRA, BERNAT;
    • ARRONDO, GONZALO;
    • ARDANZA-TREVIJANO, SERGIO;
    • VILLOSLADA, PABLO
    Publication type:
    Article

  • GOTHiC, a probabilistic model to resolve complex biases and to identify real interactions in Hi-C data.

    Published in:
    PLoS ONE, 2017, v. 12, n. 4, p. 1, doi. 10.1371/journal.pone.0174744
    By:
    • Martincorena, Inigo;
    • Darbo, Elodie;
    • Sugar, Robert;
    • Mifsud, Borbala;
    • Luscombe, Nicholas M.;
    • Schoenfelder, Stefan;
    • Fraser, Peter
    Publication type:
    Article

  • Mutational signatures are jointly shaped by DNA damage and repair.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15912-7
    By:
    • Volkova, Nadezda V.;
    • Meier, Bettina;
    • González-Huici, Víctor;
    • Bertolini, Simone;
    • Gonzalez, Santiago;
    • Vöhringer, Harald;
    • Abascal, Federico;
    • Martincorena, Iñigo;
    • Campbell, Peter J.;
    • Gartner, Anton;
    • Gerstung, Moritz
    Publication type:
    Article

  • Genomic landscape and chronological reconstruction of driver events in multiple myeloma.

    Published in:
    Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11680-1
    By:
    • Maura, Francesco;
    • Bolli, Niccoló;
    • Angelopoulos, Nicos;
    • Dawson, Kevin J.;
    • Leongamornlert, Daniel;
    • Martincorena, Inigo;
    • Mitchell, Thomas J.;
    • Fullam, Anthony;
    • Gonzalez, Santiago;
    • Szalat, Raphael;
    • Abascal, Federico;
    • Rodriguez-Martin, Bernardo;
    • Samur, Mehmet Kemal;
    • Glodzik, Dominik;
    • Roncador, Marco;
    • Fulciniti, Mariateresa;
    • Tai, Yu Tzu;
    • Minvielle, Stephane;
    • Magrangeas, Florence;
    • Moreau, Philippe
    Publication type:
    Article

  • The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.

    Published in:
    Genome Biology, 2013, v. 14, n. 10, p. 3, doi. 10.1186/gb-2013-14-10-r113
    By:
    • Yen, Jennifer;
    • White, Richard M.;
    • Wedge, David C.;
    • Loo, Peter Van;
    • Ridder, Jeroen de;
    • Capper, Amy;
    • Richardson, Jennifer;
    • Jones, David;
    • Raine, Keiran;
    • Watson, Ian R.;
    • Chang-Jiun Wu;
    • Jiqiu Cheng;
    • Martincorena, Iñigo;
    • Nik-Zainal, Serena;
    • Mudie, Laura;
    • Moreau, Yves;
    • Marshall, John;
    • Ramakrishna, Manasa;
    • Tarpey, Patrick;
    • Shlien, Adam
    Publication type:
    Article

  • Generating realistic null hypothesis of cancer mutational landscapes using SigProfilerSimulator.

    Published in:
    BMC Bioinformatics, 2020, v. 21, n. 1, p. N.PAG, doi. 10.1186/s12859-020-03772-3
    By:
    • Bergstrom, Erik N.;
    • Barnes, Mark;
    • Martincorena, Iñigo;
    • Alexandrov, Ludmil B.
    Publication type:
    Article

  • Non-random mutation: The evolution of targeted hypermutation and hypomutation.

    Published in:
    BioEssays, 2013, v. 35, n. 2, p. 123, doi. 10.1002/bies.201200150
    By:
    • Martincorena, Iñigo;
    • Luscombe, Nicholas M.
    Publication type:
    Article