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Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphoma.
Published in:
Molecular Oncology, 2022, v. 16, n. 5, p. 1132, doi. 10.1002/1878-0261.13115
By:
- Donati, Giulio;
- Ravà, Micol;
- Filipuzzi, Marco;
- Nicoli, Paola;
- Cassina, Laura;
- Verrecchia, Alessandro;
- Doni, Mirko;
- Rodighiero, Simona;
- Parodi, Federica;
- Boletta, Alessandra;
- Vellano, Christopher P.;
- Marszalek, Joseph R.;
- Draetta, Giulio F.;
- Amati, Bruno
Publication type:
Article
The Combined Treatment With the FLT3-Inhibitor AC220 and the Complex I Inhibitor IACS-010759 Synergistically Depletes Wt- and FLT3-Mutated Acute Myeloid Leukemia Cells.
Published in:
Frontiers in Oncology, 2021, v. 11, p. 1, doi. 10.3389/fonc.2021.686765
By:
- Lu, Xiyuan;
- Han, Lina;
- Busquets, Jonathan;
- Collins, Meghan;
- Lodi, Alessia;
- Marszalek, Joseph R.;
- Konopleva, Marina;
- Tiziani, Stefano
Publication type:
Article
Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery.
Published in:
Epigenetics & Chromatin, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13072-015-0026-4
By:
- Zhan, Yanai;
- Kost-Alimova, Maria;
- Xi Shi;
- Leo, Elisabetta;
- Bardenhagen, Jennifer P.;
- Shepard, Hannah E.;
- Appikonda, Srikanth;
- Vangamudi, Bhavatarini;
- Zhao, Shuping;
- Tieu, Trang N.;
- Jiang, Shiming;
- Heffernan, Timothy P.;
- Marszalek, Joseph R.;
- Toniatti, Carlo;
- Draetta, Giulio;
- Tyler, Jessica;
- Barton, Michelle;
- Jones, Philip;
- Palmer, Wylie S.;
- Geck Do, Mary K.
Publication type:
Article
Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery.
Published in:
Epigenetics & Chromatin, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13072-015-0026-4
By:
- Zhan, Yanai;
- Kost-Alimova, Maria;
- Xi Shi;
- Leo, Elisabetta;
- Bardenhagen, Jennifer P.;
- Shepard, Hannah E.;
- Appikonda, Srikanth;
- Vangamudi, Bhavatarini;
- Shuping Zhao;
- Tieu, Trang N.;
- Shiming Jiang;
- Heffernan, Timothy P.;
- Marszalek, Joseph R.;
- Toniatti, Carlo;
- Draetta, Giulio;
- Tyler, Jessica;
- Barton, Michelle;
- Jones, Philip;
- Palmer, Wylie S.;
- Geck Do, Mary K.
Publication type:
Article
Targeting the Mitochondria Metabolism of T-ALL with Novel Mitochondrial Complex I Inhibitor IACS-010759.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2017, v. 17, p. S1, doi. 10.1016/j.clml.2017.09.024
By:
- Baran, Natalia;
- Lodi, Alessia;
- Sweeney, Shannon;
- Kuruvilla, Vinitha Mary;
- Cavazos, Antonio;
- Velandy, Sriram Shanmuga;
- Harutyunyan, Karine;
- Ningping Feng;
- Gay, Jason;
- Kaminski, Marcin;
- Jabbour, Elias J.;
- Ferrando, Adolfo;
- Di Francesco, M. Emilia;
- Tiziani, Stefano;
- Marszalek, Joseph R.;
- Konopleva, Marina
Publication type:
Article
Novel Complex I inhibitor IACS-010759 Targets Leukemia Initiating Cells (LICs) in AML Patients.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2017, v. 17, p. S297, doi. 10.1016/j.clml.2017.07.089
By:
- Baran, Natalia;
- Han, Lina;
- Herbrich, Shelley;
- Sweeney, Shannon Renee;
- Lodi, Alessia;
- Gay, Jason;
- Feng, Ningping;
- Molina, Jennifer R.;
- Kaminski, Marcin;
- Guzman, Monica L.;
- Al-Atrash, Gheath;
- Tiziani, Stefano;
- Marszalek, Joseph R.;
- Konopleva, Marina
Publication type:
Article
Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma.
Published in:
British Journal of Cancer, 2022, v. 127, n. 5, p. 937, doi. 10.1038/s41416-022-01848-w
By:
- Noble, Richard A.;
- Thomas, Huw;
- Zhao, Yan;
- Herendi, Lili;
- Howarth, Rachel;
- Dragoni, Ilaria;
- Keun, Hector C.;
- Vellano, Christopher P.;
- Marszalek, Joseph R.;
- Wedge, Stephen R.
Publication type:
Article
Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma.
Published in:
2022
By:
- Noble, Richard A;
- Thomas, Huw;
- Zhao, Yan;
- Herendi, Lili;
- Howarth, Rachel;
- Dragoni, Ilaria;
- Keun, Hector C;
- Vellano, Christopher P;
- Marszalek, Joseph R;
- Wedge, Stephen R
Publication type:
journal article
Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo.
Published in:
Cells (2073-4409), 2019, v. 8, n. 12, p. 1487, doi. 10.3390/cells8121487
By:
- Gammon, Seth T.;
- Pisaneschi, Federica;
- Bandi, Madhavi L.;
- Smith, Melinda G.;
- Sun, Yuting;
- Rao, Yi;
- Muller, Florian;
- Wong, Franklin;
- De Groot, John;
- Ackroyd, Jeffrey;
- Mawlawi, Osama;
- Davies, Michael A.;
- Vashisht Gopal, Y.N.;
- Di Francesco, M. Emilia;
- Marszalek, Joseph R.;
- Dewhirst, Mark;
- Piwnica-Worms, David
Publication type:
Article
Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-38534-6
By:
- Wang, Zebin;
- Sun, Kaiming;
- Xiao, Yonghong;
- Feng, Bin;
- Mikule, Keith;
- Ma, XiaoYan;
- Feng, Ningping;
- Vellano, Christopher P.;
- Federico, Lorenzo;
- Marszalek, Joseph R.;
- Mills, Gordon B.;
- Hanke, Jeffrey;
- Ramaswamy, Sridhar;
- Wang, Jing
Publication type:
Article
Inhibition of Oxidative Phosphorylation Reverses Bone Marrow Hypoxia Visualized in Imageable Syngeneic B-ALL Mouse Model.
Published in:
Frontiers in Oncology, 2020, p. 1, doi. 10.3389/fonc.2020.00991
By:
- Rytelewski, Mateusz;
- Harutyunyan, Karine;
- Baran, Natalia;
- Mallampati, Saradhi;
- Zal, M. Anna;
- Cavazos, Antonio;
- Butler, Jason M.;
- Konoplev, Sergej;
- El Khatib, Mirna;
- Plunkett, Shane;
- Marszalek, Joseph R.;
- Andreeff, Michael;
- Zal, Tomasz;
- Konopleva, Marina
Publication type:
Article

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