Works by Marrazzo, Agostino

Results: 41

Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain.

Published in:

Inflammation, 2014, v. 37, n. 1, p. 261, doi. 10.1007/s10753-013-9736-6

By:

Parenti, Carmela;
Marrazzo, Agostino;
Aricò, Giuseppina;
Cantarella, Giuseppina;
Prezzavento, Orazio;
Ronsisvalle, Simone;
Scoto, Giovanna;
Ronsisvalle, Giuseppe

Publication type:

Article

Erratum to: Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain.

Published in:

2014

By:

Parenti, Carmela;
Marrazzo, Agostino;
Aricò, Giuseppina;
Cantarella, Giuseppina;
Prezzavento, Orazio;
Ronsisvalle, Simone;
Scoto, Giovanna;
Ronsisvalle, Giuseppe

Publication type:

Correction Notice

Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries.

Published in:

Clinical Science, 2017, v. 131, n. 14, p. 1701, doi. 10.1042/CS20170157

By:

Amata, Emanuele;
Pittalà, Valeria;
Marrazzo, Agostino;
Parenti, Carmela;
Prezzavento, Orazio;
Arena, Emanuela;
Nabavi, Seyed Mohammad;
Salerno, Loredana

Publication type:

Article

HDAC/σ1R Dual-Ligand as a Targeted Melanoma Therapeutic.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 2, p. 179, doi. 10.3390/ph18020179

By:

Leotta, Claudia Giovanna;
Barbaraci, Carla;
Fiorito, Jole;
Coco, Alessandro;
di Giacomo, Viviana;
Amata, Emanuele;
Marrazzo, Agostino;
Pitari, Giovanni Mario

Publication type:

Article

Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 11, p. 5864, doi. 10.3390/ijms23115864

By:

Vicario, Nunzio;
Denaro, Simona;
Turnaturi, Rita;
Longhitano, Lucia;
Spitale, Federica Maria;
Spoto, Salvatore;
Marrazzo, Agostino;
Zappalà, Agata;
Tibullo, Daniele;
Li Volti, Giovanni;
Chiechio, Santina;
Pasquinucci, Lorella;
Parenti, Rosalba;
Parenti, Carmela

Publication type:

Article

New Arylethanolimidazole Derivatives as HO-1 Inhibitors with Cytotoxicity against MCF-7 Breast Cancer Cells.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 6, p. 1923, doi. 10.3390/ijms21061923

By:

Ciaffaglione, Valeria;
Intagliata, Sebastiano;
Pittalà, Valeria;
Marrazzo, Agostino;
Sorrenti, Valeria;
Vanella, Luca;
Rescifina, Antonio;
Floresta, Giuseppe;
Sultan, Ameera;
Greish, Khaled;
Salerno, Loredana

Publication type:

Article

Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 3, p. 488, doi. 10.3390/ijms20030488

By:

Floresta, Giuseppe;
Dichiara, Maria;
Gentile, Davide;
Prezzavento, Orazio;
Marrazzo, Agostino;
Rescifina, Antonio;
Amata, Emanuele

Publication type:

Article

The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling.

Published in:

Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.749365

By:

Fidilio, Annamaria;
Grasso, Margherita;
Turnaturi, Rita;
Caruso, Giuseppe;
Spitale, Federica Maria;
Vicario, Nunzio;
Parenti, Rosalba;
Spoto, Salvatore;
Musso, Nicolò;
Marrazzo, Agostino;
Chiechio, Santina;
Caraci, Filippo;
Pasquinucci, Lorella;
Parenti, Carmela

Publication type:

Article

Identification of Potentially Potent Heme Oxygenase 1 Inhibitors through 3D‐QSAR Coupled to Scaffold‐Hopping Analysis.

Published in:

ChemMedChem, 2018, v. 13, n. 13, p. 1336, doi. 10.1002/cmdc.201800176

By:

Floresta, Giuseppe;
Amata, Emanuele;
Dichiara, Maria;
Marrazzo, Agostino;
Salerno, Loredana;
Romeo, Giuseppe;
Prezzavento, Orazio;
Pittalà, Valeria;
Rescifina, Antonio

Publication type:

Article

Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors.

Published in:

ChemMedChem, 2017, v. 12, n. 22, p. 1873, doi. 10.1002/cmdc.201700321

By:

Amata, Emanuele;
Marrazzo, Agostino;
Dichiara, Maria;
Modica, Maria N.;
Salerno, Loredana;
Prezzavento, Orazio;
Nastasi, Giovanni;
Rescifina, Antonio;
Romeo, Giuseppe;
Pittalà, Valeria

Publication type:

Article

Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases.

Published in:

ChemMedChem, 2017, v. 12, n. 16, p. 1235, doi. 10.1002/cmdc.201700259

By:

Dichiara, Maria;
Marrazzo, Agostino;
Prezzavento, Orazio;
Collina, Simona;
Rescifina, Antonio;
Amata, Emanuele

Publication type:

Article

Synthetic approaches to bridgehead nitrogen methanesulfonamide derivatives of 3-amino-2-thioxo-2,3-dihydrothieno[2,3- d]pyrimidin-4(1 H)-ones, potential cox-2 selective inhibitors.

Published in:

Journal of Heterocyclic Chemistry, 2006, v. 43, n. 4, p. 1099, doi. 10.1002/jhet.5570430443

By:

Granata, Giuseppe;
Barbagallo, Salvatore;
Perdicaro, Antonio;
Marrazzo, Agostino;
Santagati, Andrea;
Lombardo, Laura;
Cardile, Venera

Publication type:

Article

Synthesis of potential selective cox-2 enzyme inhibitors derived from ethyl ester of 2-isothiocyanato-5-phenyl-3-thiophenecarboxylic acid.

Published in:

Journal of Heterocyclic Chemistry, 2003, v. 40, n. 5, p. 869, doi. 10.1002/jhet.5570400519

By:

Santagati, Andrea;
Marrazzo, Agostino;
Granata, Giuseppe

Publication type:

Article

Anti-Amnesic and Neuroprotective Actions of the Sigma-1 Receptor Agonist (-)-MR22 in Rats with Selective Cholinergic Lesion and Amyloid Infusion.

Published in:

Journal of Alzheimer's Disease, 2011, v. 24, n. 3, p. 569, doi. 10.3233/JAD-2011-101794

By:

Antonini, Vuokko;
Marrazzo, Agostino;
Kleiner, Giulio;
Coradazzi, Marino;
Ronsisvalle, Simone;
Prezzavento, Orazio;
Ronsisvalle, Giuseppe;
Leanza, Giampiero

Publication type:

Article

Mechanisms of the Antineoplastic Effects of New Fluoroquinolones in 2D and 3D Human Breast and Bladder Cancer Cell Lines.

Published in:

Cancers, 2024, v. 16, n. 12, p. 2227, doi. 10.3390/cancers16122227

By:

Ferrario, Nicole;
Marras, Emanuela;
Vivona, Veronica;
Randisi, Federica;
Fallica, Antonino Nicolò;
Marrazzo, Agostino;
Perletti, Gianpaolo;
Gariboldi, Marzia Bruna

Publication type:

Article

Designing drugs optimized for both blood–brain barrier permeation and intra-cerebral partition.

Published in:

Expert Opinion on Drug Discovery, 2024, v. 19, n. 3, p. 317, doi. 10.1080/17460441.2023.2294118

By:

Dichiara, Maria;
Cosentino, Giuseppe;
Giordano, Giorgia;
Pasquinucci, Lorella;
Marrazzo, Agostino;
Costanzo, Giuliana;
Amata, Emanuele

Publication type:

Article

Anti-amnesic properties of (±)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats.

Published in:

Journal of Neurochemistry, 2009, v. 109, n. 3, p. 744, doi. 10.1111/j.1471-4159.2009.06000.x

By:

Antonini, Vuokko;
Prezzavento, Orazio;
Coradazzi, Marino;
Marrazzo, Agostino;
Ronsisvalle, Simone;
Arena, Emanuela;
Leanza, Giampiero

Publication type:

Article

Sigma-1 receptor targeting inhibits connexin 43 based intercellular communication in chronic neuropathic pain.

Published in:

Inflammation Research, 2024, v. 73, n. 10, p. 1711, doi. 10.1007/s00011-024-01926-0

By:

Denaro, Simona;
D'Aprile, Simona;
Torrisi, Filippo;
Zappalà, Agata;
Marrazzo, Agostino;
Al-Khrasani, Mahmoud;
Pasquinucci, Lorella;
Vicario, Nunzio;
Parenti, Rosalba;
Parenti, Carmela

Publication type:

Article

The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation.

Published in:

Inflammation Research, 2014, v. 63, n. 3, p. 231, doi. 10.1007/s00011-013-0692-2

By:

Parenti, Carmela;
Marrazzo, Agostino;
Aricò, Giuseppina;
Parenti, Rosalba;
Pasquinucci, Lorella;
Ronsisvalle, Simone;
Ronsisvalle, Giuseppe;
Scoto, Giovanna

Publication type:

Article

Enhancing HDAC Inhibitor Screening: Addressing Zinc Parameterization and Ligand Protonation in Docking Studies.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 2, p. 850, doi. 10.3390/ijms26020850

By:

Buccheri, Rocco;
Coco, Alessandro;
Pasquinucci, Lorella;
Amata, Emanuele;
Marrazzo, Agostino;
Rescifina, Antonio

Publication type:

Article

Synthesis and biological evaluation of new benzo-thieno[3,2-d]pyrimidin-4-one sulphonamide thio-derivatives as potential selective cyclooxygenase-2 inhibitors.

Published in:

Molecular Diversity, 2013, v. 17, n. 3, p. 445, doi. 10.1007/s11030-013-9443-0

By:

Barone, Mariarita;
Graziano, Adriana;
Marrazzo, Agostino;
Gemmellaro, Pietro;
Santagati, Andrea;
Cardile, Venera

Publication type:

Article

Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands.

Published in:

ChemMedChem, 2025, v. 20, n. 9, p. 1, doi. 10.1002/cmdc.202401015

By:

Cosentino, Giuseppe;
Dichiara, Maria;
Costanzo, Giuliana;
Coco, Alessandro;
Pasquinucci, Lorella;
Marrazzo, Agostino;
Rescifina, Antonio;
Amata, Emanuele

Publication type:

Article

Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5‐Fluorouracil and Imidazole‐Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells.

Published in:

ChemMedChem, 2023, v. 18, n. 8, p. 1, doi. 10.1002/cmdc.202300047

By:

Salerno, Loredana;
Sorrenti, Valeria;
Pittalà, Valeria;
Consoli, Valeria;
Modica, Maria N.;
Romeo, Giuseppe;
Marrazzo, Agostino;
Giuliano, Michela;
Zajdel, Paweł;
Vanella, Luca;
Intagliata, Sebastiano

Publication type:

Article

Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products.

Published in:

Marine Drugs, 2019, v. 17, n. 2, p. 113, doi. 10.3390/md17020113

By:

Floresta, Giuseppe;
Amata, Emanuele;
Gentile, Davide;
Romeo, Giuseppe;
Marrazzo, Agostino;
Pittalà, Valeria;
Salerno, Loredana;
Rescifina, Antonio

Publication type:

Article

A Structure- and Ligand-Based Virtual Screening of a Database of "Small" Marine Natural Products for the Identification of "Blue" Sigma-2 Receptor Ligands.

Published in:

Marine Drugs, 2018, v. 16, n. 10, p. 384, doi. 10.3390/md16100384

By:

Barbaraci, Carla;
Gentile, Davide;
Turnaturi, Rita;
Marrazzo, Agostino;
Rescifina, Antonio;
Floresta, Giuseppe;
Amata, Emanuele

Publication type:

Article

Synthesis and Effects on the COX-1 and COX-2 Activity in Human Whole Blood ex vivo of Derivatives Containing the [1]Benzothienol-[3, 2-d]pyrimidin-4-one Heterocyclic System.

Published in:

Archiv der Pharmazie, 2003, v. 336, n. 9, p. 429, doi. 10.1002/ardp.200300753

By:

Andrea Santagati;
Giuseppe Granata;
Agostino Marrazzo;
Maria Santagati

Publication type:

Article

Sigma Receptor Binding Profile of a Series of Analgesic Tropane Derivatives.

Published in:

Archiv der Pharmazie, 2002, v. 335, n. 1, p. 39, doi. 10.1002/1521-4184(200201)335:1<39::AID-ARDP39>3.0.CO;2-H

By:

Prezzavento, Orazio;
Gualtieri, Fulvio;
Marrazzo, Agostino;
Romanelli, Maria Novella;
Ronsisvalle, Giuseppe;
Teodori, Elisabetta

Publication type:

Article

Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors.

Published in:

Molecules, 2024, v. 29, n. 11, p. 2697, doi. 10.3390/molecules29112697

By:

Zampieri, Daniele;
Romano, Maurizio;
Fortuna, Sara;
Amata, Emanuele;
Dichiara, Maria;
Cosentino, Giuseppe;
Marrazzo, Agostino;
Mamolo, Maria Grazia

Publication type:

Article

New Insights into the Opioid Analgesic Profile of cis -(−)- N -Normetazocine-derived Ligands.

Published in:

Molecules, 2023, v. 28, n. 12, p. 4827, doi. 10.3390/molecules28124827

By:

Costanzo, Giuliana;
Turnaturi, Rita;
Parenti, Carmela;
Spoto, Salvatore;
Piana, Silvia;
Dichiara, Maria;
Zagni, Chiara;
Galambos, Anna Rita;
Essmat, Nariman;
Marrazzo, Agostino;
Amata, Emanuele;
Al-Khrasani, Mahmoud;
Pasquinucci, Lorella

Publication type:

Article

Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands.

Published in:

Molecules, 2023, v. 28, n. 8, p. 3431, doi. 10.3390/molecules28083431

By:

Zampieri, Daniele;
Calabretti, Antonella;
Romano, Maurizio;
Fortuna, Sara;
Collina, Simona;
Amata, Emanuele;
Dichiara, Maria;
Marrazzo, Agostino;
Mamolo, Maria Grazia

Publication type:

Article

Novel N -normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain.

Published in:

Molecules, 2022, v. 27, n. 16, p. 5135, doi. 10.3390/molecules27165135

By:

Turnaturi, Rita;
Chiechio, Santina;
Pasquinucci, Lorella;
Spoto, Salvatore;
Costanzo, Giuliana;
Dichiara, Maria;
Piana, Silvia;
Grasso, Margherita;
Amata, Emanuele;
Marrazzo, Agostino;
Parenti, Carmela

Publication type:

Article

Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia.

Published in:

Molecules, 2022, v. 27, n. 10, p. 3220, doi. 10.3390/molecules27103220

By:

Ciaffaglione, Valeria;
Consoli, Valeria;
Intagliata, Sebastiano;
Marrazzo, Agostino;
Romeo, Giuseppe;
Pittalà, Valeria;
Greish, Khaled;
Vanella, Luca;
Floresta, Giuseppe;
Rescifina, Antonio;
Salerno, Loredana;
Sorrenti, Valeria

Publication type:

Article

Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands.

Published in:

Molecules, 2020, v. 25, n. 8, p. 1851, doi. 10.3390/molecules25081851

By:

Intagliata, Sebastiano;
Helal, Mohamed A.;
Materia, Luisa;
Pittalà, Valeria;
Salerno, Loredana;
Marrazzo, Agostino;
Cagnotto, Alfredo;
Salmona, Mario;
Modica, Maria N.;
Romeo, Giuseppe

Publication type:

Article

A Pseudouridine Isoxazolidinyl Nucleoside Analogue Structural Analysis: A Morphological Approach.

Published in:

Molecules, 2018, v. 23, n. 12, p. 3381, doi. 10.3390/molecules23123381

By:

Floresta, Giuseppe;
Pistarà, Venerando;
Christensen, Kirsten E.;
Amata, Emanuele;
Marrazzo, Agostino;
Gentile, Davide;
Rescifina, Antonio;
Punzo, Francesco

Publication type:

Article

Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation.

Published in:

Molecules, 2018, v. 23, n. 5, p. 1209, doi. 10.3390/molecules23051209

By:

Greish, Khaled F.;
Salerno, Loredana;
Al Zahrani, Reem;
Amata, Emanuele;
Modica, Maria N.;
Romeo, Giuseppe;
Marrazzo, Agostino;
Prezzavento, Orazio;
Sorrenti, Valeria;
Rescifina, Antonio;
Floresta, Giuseppe;
Intagliata, Sebastiano;
Pittalà, Valeria

Publication type:

Article

Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists.

Published in:

Molecules, 2018, v. 23, n. 3, p. 677, doi. 10.3390/molecules23030677

By:

Turnaturi, Rita;
Parenti, Carmela;
Prezzavento, Orazio;
Marrazzo, Agostino;
Pallaki, Paschalina;
Georgoussi, Zafiroula;
Amata, Emanuele;
Pasquinucci, Lorella

Publication type:

Article

S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands.

Published in:

Journal of Cheminformatics, 2017, v. 9, n. 1, p. 1, doi. 10.1186/s13321-017-0191-5

By:

Nastasi, Giovanni;
Miceli, Carla;
Pittalà, Valeria;
Modica, Maria;
Prezzavento, Orazio;
Romeo, Giuseppe;
Rescifina, Antonio;
Marrazzo, Agostino;
Amata, Emanuele

Publication type:

Article

Copper-Catalyzed Coupling Reaction of 2-Thioxo-4-quinazolinone and Thieno[3,2-d]pyrimidin-4-one Methane Sulphonamide with Aryl Iodides: Preparation of Potential COX-2 Selective Inhibitors.

Published in:

Synthetic Communications, 2008, v. 38, n. 5, p. 723, doi. 10.1080/00397910701820236

By:

Perdicaro, Antonio;
Granata, Giuseppe;
Marrazzo, Agostino;
Santagati, Andrea

Publication type:

Article

Design, Synthesis, and Evaluation of Novel (−)‐cis‐N‐Normetazocine Derivatives: In Vitro and Molecular Modeling Insights.

Published in:

Chemical Biology & Drug Design, 2024, v. 104, n. 6, p. 1, doi. 10.1111/cbdd.70037

By:

Costanzo, Giuliana;
Coco, Alessandro;
Cosentino, Giuseppe;
Patamia, Vincenzo;
Parenti, Carmela;
Amata, Emanuele;
Marrazzo, Agostino;
Rescifina, Antonio;
Pasquinucci, Lorella

Publication type:

Article

Design, synthesis, in vitro evaluation, and molecular modeling studies of N‐substituted benzomorphans, analogs of LP2, as novel MOR ligands.

Published in:

Chemical Biology & Drug Design, 2023, v. 101, n. 6, p. 1382, doi. 10.1111/cbdd.14220

By:

Costanzo, Giuliana;
Patamia, Vincenzo;
Turnaturi, Rita;
Parenti, Carmela;
Zagni, Chiara;
Lombino, Jessica;
Amata, Emanuele;
Marrazzo, Agostino;
Pasquinucci, Lorella;
Rescifina, Antonio

Publication type:

Article

Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5ʹ‐monophosphate glycosidase.

Published in:

Chemical Biology & Drug Design, 2018, v. 91, n. 2, p. 519, doi. 10.1111/cbdd.13113

By:

Pistarà, Venerando;
Amata, Emanuele;
Dichiara, Maria;
Damigella, Arcangelo;
Marrazzo, Agostino;
Prezzavento, Orazio;
Punzo, Francesco;
Rescifina, Antonio;
Floresta, Giuseppe

Publication type:

Article