Works matching AU Margison, G. P.

Results: 31

Exploring molecular mechanisms in chemically induced cancer: Complementation of mammalian DNA repair defects by a prokaryotic gene.

Published in:

BioEssays, 1987, v. 6, n. 4, p. 151, doi. 10.1002/bies.950060402

By:

Margison, G. P.;
Brennand, J.;
Ockey, C. H.;
O'Connor, P. J.

Publication type:

Article

A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours.

Published in:

2011

By:

Khan, O. A.;
Gore, M.;
Lorigan, P.;
Stone, J.;
Greystoke, A.;
Burke, W.;
Carmichael, J.;
Watson, A. J.;
McGown, G.;
Thorncroft, M.;
Margison, G. P.;
Califano, R.;
Larkin, J.;
Wellman, S.;
Middleton, M. R.

Publication type:

journal article

PON1 increases cellular DNA damage by lactone substrates.

Published in:

Archives of Toxicology, 2019, v. 93, n. 7, p. 2035, doi. 10.1007/s00204-019-02475-w

By:

Shangula, S.;
Noori, M.;
Ahmad, I.;
Margison, G. P.;
Liu, Y.;
Siahmansur, T.;
Soran, H.;
Povey, A. C.

Publication type:

Article

Development of a novel rapid assay to assess the fidelity of DNA double-strand-break repair in human tumour cells.

Published in:

Nucleic Acids Research, 2002, v. 30, n. 2, p. e1, doi. 10.1093/nar/30.2.e1

By:

Collis, S. J.;
Sangar, V. K.;
Tighe, A.;
Roberts, S. A.;
Clarke, N. W.;
Hendry, J. H.;
Margison, G. P.

Publication type:

Article

Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells.

Published in:

Nucleic Acids Research, 2001, v. 29, n. 7, p. 1534, doi. 10.1093/nar/29.7.1534

By:

Collis, S. J.;
Tighe, A.;
Scott, S. D.;
Roberts, S. A.;
Hendry, J. H.;
Margison, G. P.

Publication type:

Article

A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.

Published in:

2009

By:

Khan, O A;
Ranson, M;
Michael, M;
Olver, I;
Levitt, N C;
Mortimer, P;
Watson, A J;
Margison, G P;
Midgley, R;
Middleton, M R

Publication type:

Correction Notice

A phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma.

Published in:

2009

By:

Kefford, R. F.;
Thomas, N. P. B.;
Corrie, P. G.;
Palmer, C.;
Abdi, E.;
Kotasek, D.;
Beith, J.;
Ranson, M.;
Mortimer, P.;
Watson, A. J.;
Margison, G. P.;
Middleton, M. R.

Publication type:

journal article

A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.

Published in:

2008

By:

Khan, O. A.;
Ranson, M.;
Michael, M.;
Olver, I.;
Levitt, N. C.;
Mortimer, P.;
Watson, A. J.;
Margison, G. P.;
Midgley, R.;
Middleton, M. R.

Publication type:

journal article

Phase II study of SPI-77 (sterically stabilised liposomal cisplatin) in advanced non-small-cell lung cancer.

Published in:

2006

By:

White, S. C.;
Lorigan, P.;
Margison, G. P.;
Margison, J. M.;
Martin, F.;
Thatcher, N.;
Anderson, H.;
Ranson, M.

Publication type:

journal article

O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts.

Published in:

2005

By:

Clemons, M.;
Kelly, J.;
Watson, A. J.;
Howell, A.;
McElhinney, R. S.;
McMurry, T. B. H.;
Margison, G. P.

Publication type:

journal article

Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies.

Published in:

2005

By:

Geoerger, B.;
Vassal, G.;
Doz, F.;
O'Quigley, J.;
Wartelle, M.;
Watson, A. J.;
Raquin, M.-A.;
Frappaz, D.;
Chastagner, P.;
Gentet, J.-C.;
Rubie, H.;
Couanet, D.;
Geoffray, A.;
Djafari, L.;
Margison, G. P.;
Pein, F.

Publication type:

journal article

Differential radiosensitisation by ZD1839 (Iressa), a highly selective epidermal growth factor receptor tyrosine kinase inhibitor in two related bladder cancer cell lines.

Published in:

2005

By:

Maddineni, S. B.;
Sangar, V. K.;
Hendry, J. H.;
Margison, G. P.;
Clarke, N. W.

Publication type:

journal article

Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum.

Published in:

2002

By:

Lees, N P;
Harrison, K L;
Hill, E;
Hall, C N;
Margison, G P;
Povey, A C

Publication type:

journal article

Heterogeneity of O6-alkylguanine DNA-alkyltransferase expression in human breast tumours.

Published in:

2002

By:

Clemons, M J;
Bibby, M C;
El Teraifi, H;
Forster, G;
Kelly, J;
Banerjee, S;
Cadman, B;
Ryder, W D J;
Howell, A;
Margison, G P

Publication type:

journal article

Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer.

Published in:

British Journal of Cancer, 2001, v. 84, n. 3, p. 321, doi. 10.1054/bjoc.2000.1595

By:

Kassem, H Sh;
Varley, J M;
Hamam, S M;
Margison, G P

Publication type:

Article

Expression of Ku70 correlates with survival in carcinoma of the cervix.

Published in:

2000

By:

Wilson, C R;
Davidson, S E;
Margison, G P;
Jackson, S P;
Hendry, J H;
West, C M L;
West, C M

Publication type:

journal article

Fern spore extracts can damage DNA.

Published in:

British Journal of Cancer, 2000, v. 83, n. 1, p. 69

By:

Simán, S E;
Povey, A C;
Ward, T H;
Margison, G P;
Sheffield, E

Publication type:

Article

A phase I trial of lomeguatrib and irinotecan in metastatic colorectal cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 5, p. 829, doi. 10.1007/s00280-009-1225-0

By:

Sabharwal, A.;
Corrie, P. G.;
Midgley, R. S.;
Palmer, C.;
Brady, J.;
Mortimer, P.;
Watson, A. J.;
Margison, G. P.;
Middleton, M. R.

Publication type:

Article

Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts.

Published in:

2000

By:

Middleton, Mark R.;
Kelly, Jane;
Goodger, Sarah;
Thatcher, Nicholas;
Margison, Geoffrey P.;
Middleton, M R;
Kelly, J;
Goodger, S;
Thatcher, N;
Margison, G P

Publication type:

journal article

Effect of expression of the Escherichia coli nth gene in Saccharomyces cerevisiae on the toxicity of ionizing radiation and hydrogen peroxide.

Published in:

International Journal of Radiation Biology, 2003, v. 79, n. 9, p. 747

By:

Škorvaga, M.;
Černáková, L.;
Chovanec, M.;
Vlasáková, D.;
Kleibl, K.;
Hendry, J. H.;
Margison, G. P.;
Brozmanová, J.

Publication type:

Article

Relationships between the Cytotoxic Effects of Restriction Endonucleases and Radiation on Mammalian Cells.

Published in:

International Journal of Radiation Biology, 1995, v. 67, n. 3, p. 327, doi. 10.1080/09553009514550381

By:

Price, R. C.;
Margison, G. P.;
Hendry, J. H.;
West, C. M. L.

Publication type:

Article

Bacterial and mammalian DNA alkyltransferases sensitize Escherichia coli to the lethal and mutagenic effects of dibromoalkanes.

Published in:

Carcinogenesis, 1997, v. 18, n. 10, p. 1883, doi. 10.1093/carcin/18.10.1883

By:

Abril, N;
Luque-Romero, F L;
Prieto-Alamo, M J;
Rafferty, J A;
Margison, G P;
Pueyo, C

Publication type:

Article

Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene.

Published in:

Carcinogenesis, 1997, v. 18, n. 7, p. 1299, doi. 10.1093/carcin/18.7.1299

By:

Jackson, P E;
Hall, C N;
O'Connor, P J;
Cooper, D P;
Margison, G P;
Povey, A C

Publication type:

Article

Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy.

Published in:

1999

By:

Chinnasamy, N;
Rafferty, J A;
Lashford, L S;
Chinnasamy, D;
Margison, G P;
Thatcher, N;
Dexter, T M;
Fairbairn, L J;
Rafferty, J;
Lashford, L;
Margison, G;
Dexter, T;
Fairbairn, L

Publication type:

journal article

Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus.

Published in:

Gene Therapy, 2006, v. 13, n. 13, p. 1037, doi. 10.1038/sj.gt.3302755

By:

Schambach, A;
Schiedlmeier, B;
Kühlcke, K;
Verstegen, M;
Margison, G P;
Li, Z;
Kamino, K;
Bohne, J;
Alexandrov, A;
Hermann, F G;
von Laer, D;
Baum, C

Publication type:

Article

A radiation-controlled molecular switch for use in gene therapy of cancer.

Published in:

Gene Therapy, 2000, v. 7, n. 13, p. 1121, doi. 10.1038/sj.gt.3301223

By:

Scott, S D;
Marples, B;
Hendry, J H;
Lashford, L S;
Embleton, M J;
Hunter, R D;
Howell, A;
Margison, G P

Publication type:

Article

Development of synthetic promoters for radiation-mediated gene therapy.

Published in:

Gene Therapy, 2000, v. 7, n. 6, p. 511, doi. 10.1038/sj.gt.3301116

By:

Marples, B;
Scott, S D;
Hendry, J H;
Embleton, M J;
Lashford, L S;
Margison, G P

Publication type:

Article

A novel dual function retrovirus expressing multidrug resistance 1 and O6-alkylguanine-DNA-alkyltransferase for engineering resistance of haemopoietic progenitor cells to multiple chemotherapeutic agents.

Published in:

Gene Therapy, 1999, v. 6, n. 8, p. 1489, doi. 10.1038/sj.gt.3300962

By:

Jelinek, J;
Rafferty, J A;
Cmejla, R;
Hildinger, M;
Chinnasamy, D;
Lashford, L S;
Ostertag, W;
Margison, G P;
Dexter, T M;
Fairbairn, L J;
Baum, C

Publication type:

Article

Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro.

Published in:

Gene Therapy, 1998, v. 5, n. 6, p. 835, doi. 10.1038/sj.gt.3300698

By:

Hickson, I;
Fairbairn, L J;
Chinnasamy, N;
Lashford, L S;
Thatcher, N;
Margison, G P;
Dexter, T M;
Rafferty, J A

Publication type:

Article

Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.

Published in:

Gene Therapy, 1998, v. 5, n. 6, p. 842, doi. 10.1038/sj.gt.3300699

By:

Chinnasamy, N;
Rafferty, J A;
Hickson, I;
Lashford, L S;
Longhurst, S J;
Thatcher, N;
Margison, G P;
Dexter, T M;
Fairbairn, L J

Publication type:

Article

Dietary variables associated with DNA N7-methylguanine levels and O6-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa.

Published in:

Carcinogenesis, 2009, v. 30, n. 4, p. 615, doi. 10.1093/carcin/bgp020

By:

H. A. Billson;
K. L. Harrison;
N. P. Lees;
C. N. Hall;
G. P. Margison;
A. C. Povey

Publication type:

Article

Works matching AU Margison, G. P.

Exploring molecular mechanisms in chemically induced cancer: Complementation of mammalian DNA repair defects by a prokaryotic gene.

A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours.

PON1 increases cellular DNA damage by lactone substrates.

Development of a novel rapid assay to assess the fidelity of DNA double-strand-break repair in human tumour cells.

Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells.

A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.

A phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma.

A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.

Phase II study of SPI-77 (sterically stabilised liposomal cisplatin) in advanced non-small-cell lung cancer.

O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts.

Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies.

Differential radiosensitisation by ZD1839 (Iressa), a highly selective epidermal growth factor receptor tyrosine kinase inhibitor in two related bladder cancer cell lines.

Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum.

Heterogeneity of O6-alkylguanine DNA-alkyltransferase expression in human breast tumours.

Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer.

Expression of Ku70 correlates with survival in carcinoma of the cervix.

Fern spore extracts can damage DNA.

A phase I trial of lomeguatrib and irinotecan in metastatic colorectal cancer.

Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts.

Effect of expression of the Escherichia coli nth gene in Saccharomyces cerevisiae on the toxicity of ionizing radiation and hydrogen peroxide.

Relationships between the Cytotoxic Effects of Restriction Endonucleases and Radiation on Mammalian Cells.

Bacterial and mammalian DNA alkyltransferases sensitize Escherichia coli to the lethal and mutagenic effects of dibromoalkanes.

Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene.

Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy.

Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus.

A radiation-controlled molecular switch for use in gene therapy of cancer.

Development of synthetic promoters for radiation-mediated gene therapy.

A novel dual function retrovirus expressing multidrug resistance 1 and O<sup>6</sup>-alkylguanine-DNA-alkyltransferase for engineering resistance of haemopoietic progenitor cells to multiple chemotherapeutic agents.

Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O<sup>6</sup>-benzylguanine-resistant O<sup>6</sup>-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O<sup>6</sup>-alkylating agents in vitro.

Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O<sup>6</sup>-alkylguanine-DNA alkyltransferase.

Dietary variables associated with DNA N7-methylguanine levels and O<sup>6</sup>-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa.