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Discovery of a Potent and Orally Active Dual GPBAR1/CysLT<sub>1</sub>R Modulator for the Treatment of Metabolic Fatty Liver Disease.
- Published in:
- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.858137
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- Publication type:
- Article
A field-based disparity analysis of new 1,2,5-oxadiazole derivatives endowed with antiproliferative activity.
- Published in:
- Chemical Biology & Drug Design, 2017, v. 90, n. 5, p. 820, doi. 10.1111/cbdd.13003
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- Publication type:
- Article
PCSK9 Induces Rat Smooth Muscle Cell Proliferation and Counteracts the Pleiotropic Effects of Simvastatin.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 8, p. 4114, doi. 10.3390/ijms22084114
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- Publication type:
- Article
The crosstalk between gut barrier impairment, mitochondrial dysfunction, and microbiota alterations in people living with HIV.
- Published in:
- Journal of Medical Virology, 2023, v. 95, n. 1, p. 1, doi. 10.1002/jmv.28402
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- Publication type:
- Article
Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH.
- Published in:
- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-28647-4
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- Publication type:
- Article
Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists.
- Published in:
- Scientific Reports, 2017, p. 43290, doi. 10.1038/srep43290
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- Publication type:
- Article
BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis.
- Published in:
- Scientific Reports, 2017, p. 42801, doi. 10.1038/srep42801
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- Publication type:
- Article
Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands.
- Published in:
- Scientific Reports, 2016, p. 29320, doi. 10.1038/srep29320
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- Publication type:
- Article
The MyoGravity project to study real microgravity effects on human muscle precursor cells and tissue.
- Published in:
- NPJ Microgravity, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41526-024-00432-1
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- Publication type:
- Article
Development of poly(lactide-co-glycolide) nanoparticles functionalized with a mitochondria penetrating peptide.
- Published in:
- Journal of Peptide Science, 2017, v. 23, n. 2, p. 182, doi. 10.1002/psc.2952
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- Publication type:
- Article
Learn from Your Elders: Developmental Biology Lessons to Guide Maturation of Stem Cell-Derived Cardiomyocytes.
- Published in:
- Pediatric Cardiology, 2019, v. 40, n. 7, p. 1367, doi. 10.1007/s00246-019-02165-5
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- Publication type:
- Article
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists.
- Published in:
- Molecules, 2023, v. 28, n. 6, p. 2840, doi. 10.3390/molecules28062840
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- Publication type:
- Article
Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential.
- Published in:
- Frontiers in Oncology, 2021, v. 11, p. N.PAG, doi. 10.3389/fonc.2021.663771
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- Publication type:
- Article
Atorvastatin protects against liver and vascular damage in a model of diet induced steatohepatitis by resetting FXR and GPBAR1 signaling.
- Published in:
- FASEB Journal, 2022, v. 36, n. 1, p. 1, doi. 10.1096/fj.202101397R
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- Publication type:
- Article
The bile acid activated receptors GPBAR1 and FXR exert antagonistic effects on autophagy.
- Published in:
- FASEB Journal, 2021, v. 35, n. 1, p. 1, doi. 10.1096/fj.202001386R
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- Publication type:
- Article
Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis.
- Published in:
- FASEB Journal, 2019, v. 33, n. 2, p. 2809, doi. 10.1096/fj.201801373RR
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- Publication type:
- Article
Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G-Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease.
- Published in:
- Journal of the American Heart Association, 2023, v. 12, n. 23, p. 1, doi. 10.1161/JAHA.123.031241
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- Publication type:
- Article
TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β‐catenin signalling.
- Published in:
- British Journal of Pharmacology, 2023, v. 180, n. 2, p. 235, doi. 10.1111/bph.15960
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- Publication type:
- Article
Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma.
- Published in:
- Cells (2073-4409), 2022, v. 11, n. 21, p. 3482, doi. 10.3390/cells11213482
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- Publication type:
- Article
Bile Acids Activated Receptors in Inflammatory Bowel Disease.
- Published in:
- Cells (2073-4409), 2021, v. 10, n. 6, p. 1281, doi. 10.3390/cells10061281
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- Publication type:
- Article
Metabolic Variability of a Multispecies Probiotic Preparation Impacts on the Anti-inflammatory Activity.
- Published in:
- Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00505
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- Publication type:
- Article
Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases.
- Published in:
- Frontiers in Pharmacology, 2017, v. 8, p. 1, doi. 10.3389/fphar.2017.00162
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- Publication type:
- Article
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties.
- Published in:
- Molecules, 2019, v. 24, n. 6, p. 1043, doi. 10.3390/molecules24061043
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- Publication type:
- Article
Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-38840-z
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- Publication type:
- Article
Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma.
- Published in:
- Frontiers in Oncology, 2023, v. 13, p. 1, doi. 10.3389/fonc.2023.1140730
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- Publication type:
- Article
Next-Generation Sequencing Analysis of Gastric Cancer Identifies the Leukemia Inhibitory Factor Receptor as a Driving Factor in Gastric Cancer Progression and as a Predictor of Poor Prognosis.
- Published in:
- Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.939969
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- Publication type:
- Article
The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer.
- Published in:
- Cellular Oncology (2211-3428), 2024, v. 47, n. 2, p. 695, doi. 10.1007/s13402-023-00893-8
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- Publication type:
- Article
Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation.
- Published in:
- Nutrients, 2020, v. 12, n. 7, p. 1945, doi. 10.3390/nu12071945
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- Publication type:
- Article
The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions.
- Published in:
- Nutrients, 2019, v. 11, n. 8, p. 1820, doi. 10.3390/nu11081820
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- Publication type:
- Article
Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation.
- Published in:
- Nutrients, 2019, v. 11, n. 5, p. 1, doi. 10.3390/nu11051132
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- Publication type:
- Article
Divergent Effectiveness of Multispecies Probiotic Preparations on Intestinal Microbiota Structure Depends on Metabolic Properties.
- Published in:
- Nutrients, 2019, v. 11, n. 2, p. 325, doi. 10.3390/nu11020325
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- Publication type:
- Article
Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9.
- Published in:
- 2017
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- Publication type:
- journal article