Works matching AU Mangelsdorf, David J.

Results: 39

Nuclear Receptor Expression Defines a Set of Prognostic Biomarkers for Lung Cancer.

Published in:

PLoS Medicine, 2010, v. 7, n. 12, p. 1, doi. 10.1371/journal.pmed.1000378

By:

Yangsik Jeong;
Yang Xie;
Guanghua Xiao;
Behrens, Carmen;
Girard, Luc;
Wistuba, Ignacio I.;
Minna, John D.;
Mangelsdorf, David J.

Publication type:

Article

Bile Acids as Hormones: The FXR-FGF15/19 Pathway.

Published in:

Digestive Diseases, 2015, v. 33, n. 3, p. 327, doi. 10.1159/000371670

By:

Kliewer, Steven a.;
Mangelsdorf, David J.

Publication type:

Article

FGF21 contributes to neuroendocrine control of female reproduction.

Published in:

Nature Medicine, 2013, v. 19, n. 9, p. 1153, doi. 10.1038/nm.3250

By:

Owen, Bryn M;
Bookout, Angie L;
Ding, Xunshan;
Lin, Vicky Y;
Atkin, Stan D;
Gautron, Laurent;
Kliewer, Steven A;
Mangelsdorf, David J

Publication type:

Article

FGF21 regulates metabolism and circadian behavior by acting on the nervous system.

Published in:

Nature Medicine, 2013, v. 19, n. 9, p. 1147, doi. 10.1038/nm.3249

By:

Bookout, Angie L;
de Groot, Marleen H M;
Owen, Bryn M;
Lee, Syann;
Gautron, Laurent;
Lawrence, Heather L;
Ding, Xunshan;
Elmquist, Joel K;
Takahashi, Joseph S;
Mangelsdorf, David J;
Kliewer, Steven A

Publication type:

Article

27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.

Published in:

Nature Medicine, 2007, v. 13, n. 10, p. 1185, doi. 10.1038/nm1641

By:

Umetani, Michihisa;
Domoto, Hideharu;
Gormley, Andrew K.;
Yuhanna, Ivan S.;
Cummins, Carolyn L.;
Javitt, Norman B.;
Korach, Kenneth S.;
Shaul, Philip W.;
Mangelsdorf, David J.

Publication type:

Article

Identification of a hormonal basis for gallbladder filling.

Published in:

Nature Medicine, 2006, v. 12, n. 11, p. 1253, doi. 10.1038/nm1501

By:

Choi, Mihwa;
Moschetta, Antonio;
Bookout, Angie L.;
Peng, Li;
Umetani, Michihisa;
Holmstrom, Sam R.;
Suino-Powell, Kelly;
Xu, H. Eric;
Richardson, James A.;
Gerard, Robert D.;
Mangelsdorf, David J.;
Kliewer, Steven A.

Publication type:

Article

Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.

Published in:

Nature Medicine, 2004, v. 10, n. 12, p. 1352, doi. 10.1038/nm1138

By:

Moschetta, Antonio;
Bookout, Angie L;
Mangelsdorf, David J

Publication type:

Article

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.

Published in:

Nature Medicine, 2003, v. 9, n. 2, p. 213, doi. 10.1038/nm820

By:

Joseph, Sean B.;
Castrillo, Antonio;
Laffitte, Bryan A.;
Mangelsdorf, David J.;
Tontonoz, Peter

Publication type:

Article

The liver X receptor gene team: Potential new players in atherosclerosis.

Published in:

Nature Medicine, 2002, v. 8, n. 11, p. 1243, doi. 10.1038/nm1102-1243

By:

Repa, Joyce J.;
Mangelsdorf, David J.

Publication type:

Article

Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid.

Published in:

PLoS Pathogens, 2016, v. 12, n. 1, p. 1, doi. 10.1371/journal.ppat.1005358

By:

Albarqi, Mennatallah M. Y.;
Stoltzfus, Jonathan D.;
Pilgrim, Adeiye A.;
Nolan, Thomas J.;
Wang, Zhu;
Kliewer, Steven A.;
Mangelsdorf, David J.;
Lok, James B.

Publication type:

Article

Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.73535

By:

Zhu Wang;
Mi Cheong Cheong;
Jet Tsien;
Heping Deng;
Tian Qin;
Stoltzfus, Jonathan D. C.;
Jaleta, Tegegn G.;
Xinshe Li;
Lok, James B.;
Kliewer, Steven A.;
Mangelsdorf, David J.

Publication type:

Article

Cardiac peroxisome proliferator-activated receptor γ is essential in protecting cardiomyocytes from oxidative damage

Published in:

Cardiovascular Research, 2007, v. 76, n. 2, p. 269, doi. 10.1016/j.cardiores.2007.06.027

By:

Ding, Guoliang;
Fu, Mingui;
Qin, Qianhong;
Lewis, William;
Kim, Ha Won;
Fukai, Tohru;
Bacanamwo, Methode;
Chen, Yuqing Eugene;
Schneider, Michael D.;
Mangelsdorf, David J.;
Evans, Ronald M.;
Yang, Qinglin

Publication type:

Article

Establishment of a monoclonal antibody for human LXRα: Detection of LXRα protein expression in human macrophages.

Published in:

Nuclear Receptor, 2003, v. 1, p. 1, doi. 10.1186/1478-1336-1-1

By:

Watanabe, Yuichiro;
Tanaka, Toshiya;
Uchiyama, Yasutoshi;
Takeno, Tetsu;
Izumi, Akashi;
Yamashita, Hisahiko;
Kumakura, Junko;
Iwanari, Hiroko;
Jiang Shu-Ying;
Naito, Makoto;
Mangelsdorf, David J.;
Hamakubo, Takao;
Kodama, Tatsuhiko

Publication type:

Article

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy.

Published in:

Science Translational Medicine, 2020, v. 12, n. 525, p. 1, doi. 10.1126/scitranslmed.aay5186

By:

Hernandez, Genaro;
Luo, Ting;
Javed, Tanveer A.;
Wen, Li;
Kalwat, Michael A.;
Vale, Kevin;
Ammouri, Farah;
Husain, Sohail Z.;
Kliewer, Steven A.;
Mangelsdorf, David J.

Publication type:

Article

Placental expression of the nuclear receptors for oxysterols LXRα and LXRβ during mouse and human development.

Published in:

Anatomical Record: Advances in Integrative Anatomy & Evolutionary Biology, 2005, v. 283A, n. 1, p. 175, doi. 10.1002/ar.a.20157

By:

Marceau, Geoffroy;
Volle, David H.;
Gallot, Denis;
Mangelsdorf, David J.;
Sapin, Vincent;
Lobaccaro, Jean-Marc A.

Publication type:

Article

Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation.

Published in:

Parasites & Vectors, 2020, v. 13, n. 1, p. 1, doi. 10.1186/s13071-020-04035-z

By:

Ayoade, Katherine Omueti;
Carranza, Faith R.;
Cho, Woong Hee;
Wang, Zhu;
Kliewer, Steven A.;
Mangelsdorf, David J.;
Stoltzfus, Jonathan D. C.

Publication type:

Article

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice.

Published in:

2012

By:

Zhang Y;
Breevoort SR;
Angdisen J;
Fu M;
Schmidt DR;
Holmstrom SR;
Kliewer SA;
Mangelsdorf DJ;
Schulman IG;
Zhang, Yuan;
Breevoort, Sarah R;
Angdisen, Jerry;
Fu, Mingui;
Schmidt, Daniel R;
Holmstrom, Sam R;
Kliewer, Steven A;
Mangelsdorf, David J;
Schulman, Ira G

Publication type:

journal article

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 5, p. 1688, doi. 10.1172/JCI59817

By:

Zhang, Yuan;
Breevoort, Sarah R.;
Angdisen, Jerry;
Fu, Mingui;
Schmidt, Daniel R.;
Holmstrom, Sam R.;
Kliewer, Steven A.;
Mangelsdorf, David J.;
Schulman, Ira G.

Publication type:

Article

LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.

Published in:

2011

By:

Patel, Rucha;
Patel, Monika;
Tsai, Ricky;
Lin, Vicky;
Bookout, Angie L.;
Yuan Zhang;
Magomedova, Lilia;
Tingting Li;
Chan, Jessica F.;
Budd, Conrad;
Mangelsdorf, David J.;
Cummins, Carolyn L.;
Zhang, Yuan;
Li, Tingting

Publication type:

journal article

Liver X receptors regulate adrenal cholesterol balance.

Published in:

Journal of Clinical Investigation, 2006, v. 116, n. 7, p. 1902, doi. 10.1172/JCI28400

By:

Cummins, Carolyn L.;
Volle, David H.;
Yuan Zhang;
McDonald, Jeffrey G.;
Sion, Benoît;
Lefrançois-Martinez, Anne-Marie;
Caira, Françoise;
Veyssière, Georges;
Mangelsdorf, David J.;
Lobaccaro, Jean-Marc A.

Publication type:

Article

Bile acids lower triglyceride levels via a pathway involving FXR,SHP,and SREBP-1c.

Published in:

Journal of Clinical Investigation, 2004, v. 113, n. 10, p. 1408, doi. 10.1172/JCI200421025

By:

Watanabe, Mitsuhiro;
Houten, Sander M.;
Li Wang;
Moschetta, Antonio;
Mangelsdorf, David J.;
Heyman, Richard A.;
Moore, David D.;
Auwerx, Johan

Publication type:

Article

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.

Published in:

2004

By:

Watanabe, Mitsuhiro;
Houten, Sander M;
Wang, Li;
Moschetta, Antonio;
Mangelsdorf, David J;
Heyman, Richard A;
Moore, David D;
Auwerx, Johan

Publication type:

journal article

Oxysterol Stimulation of Epidermal Differentiation is Mediated by Liver X Receptor-β in Murine Epidermis.

Published in:

Journal of Investigative Dermatology, 2002, v. 118, n. 1, p. 25, doi. 10.1046/j.0022-202x.2001.01628.x

By:

Kömüves, László G;
Schmuth, Matthias;
Fowler, Ashley J;
Elias, Peter M;
Hanley, Karen;
Man, Mao-Qiang;
Moser, Arthur H;
Lobaccaro, Jean-Marc A;
Williams, Mary L;
Mangelsdorf, David J;
Feingold, Kenneth R

Publication type:

Article

Oxysterols Induce Differentiation in Human Keratinocytes and Increase Ap-1-Dependent Involucrin Transcription.

Published in:

Journal of Investigative Dermatology, 2000, v. 114, n. 3, p. 545, doi. 10.1046/j.1523-1747.2000.00895.x

By:

Hanley, Karen;
Ng, Dean C.;
He, Shan Shan;
Lau, Peggy;
Min, Katherine;
Elias, Peter M.;
Bikle, Daniel D.;
Mangelsdorf, David J.;
Williams, Mary L.;
Feingold, Kenneth R.

Publication type:

Article

Liver X Receptor α Is a Transcriptional Repressor of the Uncoupling Protein 1 Gene and the Brown Fat Phenotype.

Published in:

Molecular & Cellular Biology, 2008, v. 28, n. 7, p. 7, doi. 10.1128/MCB.01479-07

By:

Haibo Wang;
Yuan Zhang;
Yehuda-Shnaidman, Einav;
Medvedev, Alexander V.;
Kumar, Naresh;
Daniel, Kiefer W.;
Robidoux, Jacques;
Czech, Michael P.;
Mangelsdorf, David J.;
Collins, Sheila

Publication type:

Article

Nuclear receptors: emerging drug targets for parasitic diseases.

Published in:

2017

By:

Zhu Wang;
Schaffer, Nathaniel E.;
Kliewer, Steven A.;
Mangelsdorf, David J.;
Wang, Zhu

Publication type:

journal article

Liver X Receptor Activators Display Anti-Inflammatory Activity in Irritant and Allergic Contact Dermatitis Models: Liver-X-Receptor-Specific Inhibition of Inflammation and Primary Cytokine Production.

Published in:

Journal of Investigative Dermatology, 2003, v. 120, n. 2, p. 246, doi. 10.1046/j.1523-1747.2003.12033.x

By:

Fowler, Ashley J.;
Sheu, Mary Y.;
Schmuth, Matthias;
Kao, Jack;
Fluhr, Joachim W.;
Rhein, Linda;
Collins, Jon L.;
Willson, Timothy M.;
Mangelsdorf, David J.;
Elias, Peter M.;
Feingold, Kenneth R.

Publication type:

Article

Vitamin A Receptors.

Published in:

Nutrition Reviews, 1994, v. 52, n. 2, p. S32

By:

Mangelsdorf, David J.

Publication type:

Article

Regulation of nutrient metabolism by nuclear receptor/FGF signaling pathways.

Published in:

2012

By:

Kliewer, Steven A.;
Mangelsdorf, David J.

Publication type:

Abstract

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding.

Published in:

Diabetes, 2014, v. 63, n. 12, p. 4057, doi. 10.2337/db14-0595

By:

Markan, Kathleen R.;
Naber, Meghan C.;
Ameka, Magdalene K.;
Anderegg, Maxwell D.;
Mangelsdorf, David J.;
Kliewer, Steven A.;
Mohammadi, Moosa;
Potthoff, Matthew J.

Publication type:

Article

Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.

Published in:

2008

By:

Satapati S;
He T;
Inagaki T;
Potthoff M;
Merritt ME;
Esser V;
Mangelsdorf DJ;
Kliewer SA;
Browning JD;
Burgess SC;
Satapati, Santhosh;
He, Tianteng;
Inagaki, Takeshi;
Potthoff, Matthew;
Merritt, Matthew E;
Esser, Victoria;
Mangelsdorf, David J;
Kliewer, Steven A;
Browning, Jeffrey D;
Burgess, Shawn C

Publication type:

journal article

Partial Resistance to Peroxisome Proliferator-Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism.

Published in:

Diabetes, 2008, v. 57, n. 8, p. 2012, doi. 10.2337/db08-0226

By:

Satapati, Santhosh;
He, TianTeng;
Inagaki, Takeshi;
Potthoff, Matthew;
Merritt, Matthew E.;
Esser, Victoria;
Mangelsdorf, David J.;
Kliewer, Steven A.;
Browning, Jeffrey D.;
Burgess, Shawn C.

Publication type:

Article

Pro-differentiating effects of oxysterols in keratinocytes.

Published in:

Experimental Dermatology, 2005, v. 14, n. 2, p. 154, doi. 10.1111/j.0906-6705.2005.0266g.x

By:

Schmuth, Matthias;
Bikle, Dan D.;
Willson, Tim M.;
Mangelsdorf, David J.;
Elias, Peter M.;
Feingold, Kenneth R.

Publication type:

Article

The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3.

Published in:

PLoS Pathogens, 2021, v. 17, n. 12, p. 1, doi. 10.1371/journal.ppat.1010140

By:

Romero, Aracely A.;
Cobb, Sarah A.;
Collins, Julie N. R.;
Kliewer, Steven A.;
Mangelsdorf, David J.;
Collins III, James J.

Publication type:

Article

Nuclear receptors of the enteric tract: guarding the frontier.

Published in:

Nutrition Reviews, 2008, v. 66, p. S88, doi. 10.1111/j.1753-4887.2008.00092.x

By:

Schmidt, Daniel R.;
Mangelsdorf, David J.

Publication type:

Article

The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.

Published in:

Aging Cell, 2011, v. 10, n. 5, p. 879, doi. 10.1111/j.1474-9726.2011.00733.x

By:

Wollam, Joshua;
Magomedova, Lilia;
Magner, Daniel B.;
Shen, Yidong;
Rottiers, Veerle;
Motola, Daniel L.;
Mangelsdorf, David J.;
Cummins, Carolyn L.;
Antebi, Adam

Publication type:

Article

Retinoic acid receptor expression abnormalities in lung cancer: Important clues or major obstacles?

Published in:

1997

By:

Minna, John D.;
Mangelsdorf, David J.

Publication type:

Editorial

Loss of the liver X receptor LXRa/β in peripheral sensory neurons modifies energy expenditure.

Published in:

eLife, 2015, p. 1, doi. 10.7554/eLife.06667

By:

Mansuy-Aubert, Virginie;
Gautron, Laurent;
Syann Lee;
Bookout, Angie L.;
Kusminski, Christine M.;
Kai Sun;
Yuan Zhang;
Scherer, Philipp E.;
Mangelsdorf, David J.;
Elmquist, Joel K.

Publication type:

Article

The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes.

Published in:

PLoS Genetics, 2015, v. 11, n. 3, p. 1, doi. 10.1371/journal.pgen.1005027

By:

Wang, Zhu;
Stoltzfus, Jonathan;
You, Young-jai;
Ranjit, Najju;
Tang, Hao;
Xie, Yang;
Lok, James B.;
Mangelsdorf, David J.;
Kliewer, Steven A.

Publication type:

Article