Works by Manfredi, Paolo L.

Results: 21

Subanalysis of Subjective Cognitive Measures From a Phase 2, Double-Blind, Randomized Trial of REL-1017 in Patients With Major Depressive Disorder.

Published in:

Primary Care Companion for CNS Disorders (2155-7772), 2023, v. 25, n. 1, p. e1, doi. 10.4088/PCC.22m03267

By:

Guidetti, Clotilde;
Serra, Giulia;
Pani, Luca;
Pappagallo, Marco;
Maglio, Gino;
De Martin, Sara;
Mattarei, Andrea;
Folli, Franco;
Manfredi, Paolo L.;
Fava, Maurizio

Publication type:

Article

The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users.

Published in:

Translational Psychiatry, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41398-023-02473-8

By:

Shram, Megan J.;
Henningfield, Jack E.;
Apseloff, Glen;
Gorodetzky, Charles W.;
De Martin, Sara;
Vocci, Frank L.;
Sapienza, Frank L.;
Kosten, Thomas R.;
Huston, Jeff;
Buchhalter, August;
Ashworth, Judy;
Lanier, Ryan;
Folli, Franco;
Mattarei, Andrea;
Guidetti, Clotilde;
Comai, Stefano;
O'Gorman, Cedric;
Traversa, Sergio;
Inturrisi, Charles E.;
Manfredi, Paolo L.

Publication type:

Article

N-methyl-D-aspartate Receptors and Depression: Linking Psychopharmacology, Pathology and Physiology in a Unifying Hypothesis for the Epigenetic Code of Neural Plasticity.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 12, p. 1618, doi. 10.3390/ph17121618

By:

Comai, Stefano;
De Martin, Sara;
Mattarei, Andrea;
Guidetti, Clotilde;
Pappagallo, Marco;
Folli, Franco;
Alimonti, Andrea;
Manfredi, Paolo L.

Publication type:

Article

Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 8, p. 997, doi. 10.3390/ph15080997

By:

Bettini, Ezio;
Stahl, Stephen M.;
De Martin, Sara;
Mattarei, Andrea;
Sgrignani, Jacopo;
Carignani, Corrado;
Nola, Selena;
Locatelli, Patrizia;
Pappagallo, Marco;
Inturrisi, Charles E.;
Bifari, Francesco;
Cavalli, Andrea;
Alimonti, Andrea;
Pani, Luca;
Fava, Maurizio;
Traversa, Sergio;
Folli, Franco;
Manfredi, Paolo L.

Publication type:

Article

The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 7, p. N.PAG, doi. 10.3390/ph15070882

By:

Bettini, Ezio;
De Martin, Sara;
Mattarei, Andrea;
Pappagallo, Marco;
Stahl, Stephen M.;
Bifari, Francesco;
Inturrisi, Charles E.;
Folli, Franco;
Traversa, Sergio;
Manfredi, Paolo L.

Publication type:

Article

Pharmacokinetics, Tolerability, and Safety of Esmethadone in Subjects with Chronic Kidney Disease or Hepatic Impairment.

Published in:

Drugs in R&D, 2024, v. 24, n. 2, p. 341, doi. 10.1007/s40268-024-00477-3

By:

Ferri, Nicola;
De Martin, Sara;
Stuart, James;
Traversa, Sergio;
Mattarei, Andrea;
Comai, Stefano;
Folli, Franco;
Pappagallo, Marco;
Guidetti, Clotilde;
Inturrisi, Charles E.;
Manfredi, Paolo L.

Publication type:

Article

Drug–Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism.

Published in:

Drugs in R&D, 2024, v. 24, n. 1, p. 51, doi. 10.1007/s40268-023-00450-6

By:

Ferri, Nicola;
De Martin, Sara;
Stuart, James;
Traversa, Sergio;
Folli, Franco;
Pappagallo, Marco;
O'Gorman, Cedric;
Guidetti, Clotilde;
Mattarei, Andrea;
Inturrisi, Charles E.;
Manfredi, Paolo L.

Publication type:

Article

Opioid treatment for agitation in patients with advanced dementia.

Published in:

International Journal of Geriatric Psychiatry, 2003, v. 18, n. 8, p. 700, doi. 10.1002/gps.906

By:

Manfredi, Paolo L.;
Breuer, Brenda;
Wallenstein, Sylvan;
Stegmann, Marian;
Bottomley, Gail;
Libow, Leslie

Publication type:

Article

Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 20, p. 12196, doi. 10.3390/ijms232012196

By:

Stahl, Stephen M.;
De Martin, Sara;
Mattarei, Andrea;
Bettini, Ezio;
Pani, Luca;
Guidetti, Clotilde;
Folli, Franco;
de Somer, Marc;
Traversa, Sergio;
Inturrisi, Charles E.;
Pappagallo, Marco;
Gentilucci, Marco;
Alimonti, Andrea;
Fava, Maurizio;
Manfredi, Paolo L.

Publication type:

Article

Sex-dependent effects of the uncompetitive N-methyl-D-aspartate receptor antagonist REL-1017 in G93A-SOD1 amyotrophic lateral sclerosis mice.

Published in:

Frontiers in Neurology, 2024, p. 1, doi. 10.3389/fneur.2024.1384829

By:

Colognesi, Martina;
Shkodra, Atea;
Gabbia, Daniela;
Kawamata, Hibiki;
Manfredi, Paolo L.;
Manfredi, Giovanni;
De Martin, Sara

Publication type:

Article

REL-1017 (Esmethadone), A Novel NMDAR Blocker for the Treatment of MDD is Not Neurotoxic in Sprague-Dawley Rats.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.863959

By:

Bifari, Francesco;
Pappagallo, Marco;
Bleavins, Michael;
Traversa, Sergio;
Folli, Franco;
Manfredi, Paolo L.

Publication type:

Article

REL-1017 (Esmethadone), A Novel NMDAR Blocker for the Treatment of MDD is Not Neurotoxic in Sprague-Dawley Rats.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.863959

By:

Bifari, Francesco;
Pappagallo, Marco;
Bleavins, Michael;
Traversa, Sergio;
Folli, Franco;
Manfredi, Paolo L.

Publication type:

Article

REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study.

Published in:

Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.671859

By:

De Martin, Sara;
Gabbia, Daniela;
Folli, Franco;
Bifari, Francesco;
Fiorina, Paolo;
Ferri, Nicola;
Stahl, Stephen;
Inturrisi, Charles E.;
Pappagallo, Marco;
Traversa, Sergio;
Manfredi, Paolo L.

Publication type:

Article

Sumatriptan for Headache Caused by Head and Neck Cancer.

Published in:

Headache: The Journal of Head & Face Pain, 2000, v. 40, n. 9, p. 758, doi. 10.1046/j.1526-4610.2000.00134.x

By:

Manfredi, Paolo L.;
Shenoy, Sachin;
Payne, Richard

Publication type:

Article

ANXIOLYTIC- AND PROCOGNITIVELIKE EFFECTS OF A 30-DAY CHRONIC TREATMENT WITH A LOW NONPSYCHEDELIC DOSE OF PSILOCYBIN IN C57BL/6J MICE.

Published in:

International Journal of Neuropsychopharmacology, 2025, v. 28, p. i108, doi. 10.1093/ijnp/pyae059.186

By:

Nasini, Sofia;
Tidei, Sara;
Barzon, Benedetta;
De Martin, Sara;
Banzato, Marco;
Mattarei, Andrea;
Folli, Franco;
Pappagallo, Marco;
Manfredi, Paolo L.;
Comai, Stefano

Publication type:

Article

Comment on "Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status".

Published in:

2022

By:

Pappagallo, Marco;
Inturrisi, Charles E.;
Manfredi, Paolo L.

Publication type:

Letter

Outcome of cancer pain consultations.

Published in:

2000

By:

Manfredi, Paolo L.;
Chandler, Sonja;
Pigazzi, Alessio;
Payne, Richard;
Manfredi, P L;
Chandler, S;
Pigazzi, A;
Payne, R

Publication type:

journal article

REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-15055-3

By:

Henningfield, Jack;
Gauvin, David;
Bifari, Francesco;
Fant, Reginald;
Shram, Megan;
Buchhalter, August;
Ashworth, Judy;
Lanier, Ryan;
Pappagallo, Marco;
Inturrisi, Charles;
Folli, Franco;
Traversa, Sergio;
Manfredi, Paolo L.

Publication type:

Article

Esmethadone-HCl (REL-1017): a promising rapid antidepressant.

Published in:

European Archives of Psychiatry & Clinical Neuroscience, 2023, v. 273, n. 7, p. 1463, doi. 10.1007/s00406-023-01571-4

By:

Fava, Maurizio;
Stahl, Stephen M.;
De Martin, Sara;
Mattarei, Andrea;
Bettini, Ezio;
Comai, Stefano;
Alimonti, Andrea;
Bifari, Francesco;
Pani, Luca;
Folli, Franco;
Guidetti, Clotilde;
Furlan, Alberto;
Sgrignani, Jacopo;
Locatelli, Patrizia;
Cavalli, Andrea;
O'Gorman, Cedric;
Traversa, Sergio;
Inturrisi, Charles E.;
Pappagallo, Marco;
Manfredi, Paolo L.

Publication type:

Article

A safe and effective method for converting patients from transdermal to intravenous fentanyl for the treatment of acute cancer-related pain.

Published in:

Cancer (0008543X), 2003, v. 97, n. 12, p. 3121

By:

Craig A. Kornick;
Juan Santiago-Palma;
Glenn Schulman;
Peter C. O'Brien;
Stephen Weigand;
Richard Payne;
Paolo L. Manfredi

Publication type:

Article

A safe and effective method for converting cancer patients from intravenous to transdermal fentanyl.

Published in:

2001

By:

Kornick, Craig A.;
Santiago-Palma, Juan;
Khojainova, Natalia;
Primavera, Louis H.;
Payne, Richard;
Manfredi, Paolo L.;
Kornick, C A;
Santiago-Palma, J;
Khojainova, N;
Primavera, L H;
Payne, R;
Manfredi, P L

Publication type:

journal article