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Early investigation of a novel SI306 theranostic prodrug for glioblastoma treatment.
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- Drug Development Research, 2024, v. 85, n. 1, p. 1, doi. 10.1002/ddr.22158
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- Publication type:
- Article
Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe.
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- Cell Death & Disease, 2018, v. 9, n. 2, p. 1, doi. 10.1038/s41419-017-0142-0
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- Article
Synthesis of 5,6-dihydro-4 H-benzo[ d]isoxazol-7-one and 5,6-dihydro-4 H-isoxazolo[5,4- c]pyridin-7-one Derivatives as Potential Hsp90 Inhibitors.
- Published in:
- Chemical Biology & Drug Design, 2015, v. 86, n. 5, p. 1030, doi. 10.1111/cbdd.12570
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- Article
LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators.
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- Medicinal Research Reviews, 2012, v. 32, n. 5, p. 968, doi. 10.1002/med.20230
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- Article
Stereoselective Synthesis of Sofosbuvir through Nucleoside Phosphorylation Controlled by Kinetic Resolution.
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- European Journal of Organic Chemistry, 2018, v. 2018, n. 20/21, p. 2622, doi. 10.1002/ejoc.201800158
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- Article
The Veterinary Anti-Parasitic Selamectin Is a Novel Inhibitor of the Mycobacterium tuberculosis DprE1 Enzyme.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 2, p. 771, doi. 10.3390/ijms23020771
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- Article
The Antimalarial Mefloquine Shows Activity against Mycobacterium abscessus , Inhibiting Mycolic Acid Metabolism.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 16, p. 8533, doi. 10.3390/ijms22168533
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- Article
Next generation of antiretroviral agents targeting the RNA binding site of the HIV-1 cellular cofactor DDX3: an innovative therapeutic approach.
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- 2012
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- Publication type:
- Abstract
A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolyticlike activity with neuroprotective effect through the modulation of CB1 receptor.
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- Journal of Pharmacy & Pharmacology, 2021, v. 73, n. 9, p. 1161, doi. 10.1093/jpp/rgab067
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- Article
ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL.
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- Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-19575-2
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- Article
Improved BM212 MmpL3 Inhibitor Analogue Shows Efficacy in Acute Murine Model of Tuberculosis Infection.
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- PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0056980
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- Article
Structure Prediction and Validation of the ERK8 Kinase Domain.
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- PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0052011
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- Publication type:
- Article
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway.
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- Scientific Reports, 2016, p. 23479, doi. 10.1038/srep23479
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- Publication type:
- Article
Cannabidiol Isolated From Cannabis sativa L. Protects Intestinal Barrier From In Vitro Inflammation and Oxidative Stress.
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- Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.641210
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- Publication type:
- Article
Differentially activated Src kinase in chemo-naïve human primary osteosarcoma cells and effects of a Src kinase inhibitor.
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- Biofactors, 2017, v. 43, n. 6, p. 801, doi. 10.1002/biof.1382
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- Article
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria.
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- ChemMedChem, 2016, v. 11, n. 7, p. 674, doi. 10.1002/cmdc.201500578
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- Article
Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation.
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- ChemMedChem, 2011, v. 6, n. 8, p. 1371, doi. 10.1002/cmdc.201100166
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- Publication type:
- Article
Developing Pyrrole-Derived Antimycobacterial Agents: a Rational Lead Optimization Approach.
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- ChemMedChem, 2011, v. 6, n. 4, p. 593, doi. 10.1002/cmdc.201000526
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- Publication type:
- Article
3D QSAR Models Built on Structure-Based Alignments of Abl Tyrosine Kinase Inhibitors.
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- ChemMedChem, 2009, v. 4, n. 6, p. 976, doi. 10.1002/cmdc.200800441
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- Publication type:
- Article
C6-Unsubstituted Pyrazolo[3,4- d]pyrimidines Are Dual Src/Abl Inhibitors Effective against Imatinib Mesylate Resistant Chronic Myeloid Leukemia Cell Lines.
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- ChemMedChem, 2009, v. 4, n. 1, p. 118, doi. 10.1002/cmdc.200800320
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- Publication type:
- Article
Substituted Pyrazolo[3,4- b]pyridines as Potent A<sub>1</sub> Adenosine Antagonists: Synthesis, Biological Evaluation, and Development of an A<sub>1</sub> Bovine Receptor Model.
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- ChemMedChem, 2008, v. 3, n. 6, p. 898, doi. 10.1002/cmdc.200700355
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- Publication type:
- Article
Inhibition of Bcr-Abl Phosphorylation and Induction of Apoptosis by Pyrazolo[3,4- d]pyrimidines in Human Leukemia Cells.
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- ChemMedChem, 2007, v. 2, n. 3, p. 343, doi. 10.1002/cmdc.200600214
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- Publication type:
- Article
Ligand-Based Virtual Screening, Parallel Solution-Phase and Microwave-Assisted Synthesis as Tools to Identify and Synthesize New Inhibitors of Mycobacterium tuberculosis.
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- ChemMedChem, 2006, v. 1, n. 9, p. 973, doi. 10.1002/cmdc.200600026
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- Publication type:
- Article
Homogentisate 1,2 dioxygenase is expressed in brain: implications in alkaptonuria.
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- Journal of Inherited Metabolic Disease, 2015, v. 38, n. 5, p. 807, doi. 10.1007/s10545-015-9829-5
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- Publication type:
- Article
Small Molecule Inhibitors Targeting HIV-1 Reverse Transcriptase Dimerization.
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- ChemBioChem, 2008, v. 9, n. 6, p. 916, doi. 10.1002/cbic.200700669
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- Publication type:
- Article
Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol.
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- Phytotherapy Research, 2023, v. 37, n. 10, p. 4304, doi. 10.1002/ptr.7941
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- Publication type:
- Article
Cannabidiol‐rich non‐psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2‐mediated microglial neuroinflammation.
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- Phytotherapy Research, 2023, v. 37, n. 5, p. 1924, doi. 10.1002/ptr.7710
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- Publication type:
- Article
Non‐psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors‐, endocannabinoids‐, and NF‐κB‐mediated signaling.
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- Phytotherapy Research, 2022, v. 36, n. 5, p. 2246, doi. 10.1002/ptr.7458
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- Publication type:
- Article
Quercetin‐3‐Oleate Contributes to Skin Wound Healing Targeting FFA1/GPR40.
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- ChemistrySelect, 2019, v. 4, n. 29, p. 8429, doi. 10.1002/slct.201902572
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- Publication type:
- Article
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells.
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- FASEB Journal, 2008, v. 22, n. 5, p. 1560, doi. 10.1096/fj.07-9873com
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- Publication type:
- Article
Novel smoothened antagonists as anti‐neoplastic agents for the treatment of osteosarcoma.
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- Journal of Cellular Physiology, 2018, v. 233, n. 6, p. 4961, doi. 10.1002/jcp.26330
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- Publication type:
- Article
Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria.
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- Journal of Cellular Physiology, 2017, v. 232, n. 11, p. 3103, doi. 10.1002/jcp.25761
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- Publication type:
- Article
A molecular spectroscopy approach for the investigation of early phase ochronotic pigment development in Alkaptonuria.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-01670-z
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- Publication type:
- Article
Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate.
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- Angewandte Chemie International Edition, 2007, v. 46, n. 11, p. 1810, doi. 10.1002/anie.200604165
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- Publication type:
- Article
Effects of in vitro simulated digestion on the antioxidant activity of different Camellia sinensis (L.) Kuntze leaves extracts.
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- European Food Research & Technology, 2022, v. 248, n. 1, p. 119, doi. 10.1007/s00217-021-03864-1
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- Publication type:
- Article
Olive Oil Lipophenols Induce Insulin Secretion in 832/13 β-Cell Models.
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- Pharmaceutics, 2021, v. 13, n. 7, p. 1085, doi. 10.3390/pharmaceutics13071085
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- Publication type:
- Article
Deletion of 82–85 N-Terminal Residues in SARS-CoV-2 Nsp1 Restricts Virus Replication.
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- Viruses (1999-4915), 2024, v. 16, n. 5, p. 689, doi. 10.3390/v16050689
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- Publication type:
- Article
Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells.
- Published in:
- PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0149919
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- Publication type:
- Article