Works by Mandelkow, Eckhard

Results: 100

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution.

Published in:

PLoS Biology, 2009, v. 7, n. 2, p. e1000034, doi. 10.1371/journal.pbio.1000034

By:

Mukrasch, Marco D.;
Bibow, Stefan;
Korukottu, Jegannath;
Jeganathan, Sadasivam;
Biernat, Jacek;
Griesinger, Christian;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Potent Tau Aggregation Inhibitor D‐Peptides Selected against Tau‐Repeat 2 Using Mirror Image Phage Display.

Published in:

ChemBioChem, 2021, v. 22, n. 21, p. 3049, doi. 10.1002/cbic.202100287

By:

Malhis, Marwa;
Kaniyappan, Senthilvelrajan;
Aillaud, Isabelle;
Chandupatla, Ram Reddy;
Ramirez, Lisa Marie;
Zweckstetter, Markus;
Horn, Anselm H. C.;
Mandelkow, Eckhard;
Sticht, Heinrich;
Funke, Susanne Aileen

Publication type:

Article

Die dynamische Struktur von Tau-Filamenten.

Published in:

Angewandte Chemie, 2011, v. 123, n. 48, p. 11723, doi. 10.1002/ange.201105493

By:

Bibow, Stefan;
Mukrasch, Marco D.;
Chinnathambi, Subashchandrabose;
Biernat, Jacek;
Griesinger, Christian;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Role of fimbrin and villin in determining the interfilament distances of actin bundles.

Published in:

Nature, 1983, v. 301, n. 5897, p. 209, doi. 10.1038/301209a0

By:

Matsudaira, Paul;
Mandelkow, Eckhard;
Renner, Winfried;
Hesterberg, Lyndal K.;
Weber, Klaus

Publication type:

Article

Fast Motions Dominate Dynamics of Intrinsically Disordered Tau Protein at High Temperatures.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 17, p. 1, doi. 10.1002/chem.202203493

By:

Abyzov, Anton;
Mandelkow, Eckhard;
Zweckstetter, Markus;
Rezaei‐Ghaleh, Nasrollah

Publication type:

Article

Die krankheitsassoziierte Tau‐Phosphorylierung behindert die Tubulinpolymerisation in Tau‐Kondensaten.

Published in:

Angewandte Chemie, 2021, v. 133, n. 2, p. 737, doi. 10.1002/ange.202011157

By:

Savastano, Adriana;
Flores, David;
Kadavath, Harindranath;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

The Potential for ß-Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 3, p. 737, doi. 10.1523/JNEUROSCI.2824-07.2008

By:

Mocanu, Maria-Magdalena;
Nissen, Astrid;
Eckermann, Katrin;
Khlistunova, Inna;
Biernat, Jacek;
Drexler, Dagmar;
Petrova, Olga;
Schönig, Kai;
Bujard, Hermann;
Mandelkow, Eckhard;
Lepu Zhou;
Rune, Gabriele;
Mandelkow, Eva-Maria

Publication type:

Article

Swimming against the Tide: Mobility of the Microtubule-Associated Protein Tau in Neurons.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 37, p. 9916, doi. 10.1523/JNEUROSCI.0927-07.2007

By:

Konzack, Sven;
Thies, Edda;
Marx, Alexander;
Mandelkow, Eva-Maria;
Mandelkow, Eckhard

Publication type:

Article

Gaining Insights into Specific Drug Formulation Additives for Solubilizing a Potential Anti-Alzheimer Disease Drug B4A1.

Published in:

Macromolecular Bioscience, 2017, v. 17, n. 10, p. n/a, doi. 10.1002/mabi.201700109

By:

Lawatscheck, Carmen;
Pickhardt, Marcus;
Grafl, Anna;
Linkert, Katharina;
Polster, Frank;
Mandelkow, Eckhard;
Börner, Hans G.

Publication type:

Article

Low-Power Solid-State NMR Experiments for Resonance Assignment under Fast Magic-Angle Spinning.

Published in:

ChemPhysChem, 2009, v. 10, n. 13, p. 2205, doi. 10.1002/cphc.200900439

By:

Vijayan, Vinesh;
Demers, Jean-Philippe;
Biernat, Jacek;
Mandelkow, Eckhard;
Becker, Stefan;
Lange, Adam

Publication type:

Article

Tubulin hoops.

Published in:

Nature, 1977, v. 265, n. 5595, p. 655, doi. 10.1038/265655a0

By:

MANDELKOW, EVA-MARIA;
MANDELKOW, ECKHARD;
UNWIN, NIGEL;
COHEN, CAROLYN

Publication type:

Article

Initiation and modulation of Tau protein phase separation by the drug suramin.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-29846-9

By:

Prince, Prabhu Rajaiah;
Hochmair, Janine;
Brognaro, Hévila;
Gevorgyan, Susanna;
Franck, Maximilian;
Schubert, Robin;
Lorenzen, Kristina;
Yazici, Selin;
Mandelkow, Eckhard;
Wegmann, Susanne;
Betzel, Christian

Publication type:

Article

Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0167432

By:

Dammers, Christina;
Yolcu, Deniz;
Kukuk, Laura;
Willbold, Dieter;
Pickhardt, Marcus;
Mandelkow, Eckhard;
Horn, Anselm H. C.;
Sticht, Heinrich;
Malhis, Marwa Nidal;
Will, Nadja;
Schuster, Judith;
Funke, Susanne Aileen

Publication type:

Article

The Dynamic Structure of Filamentous Tau.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 48, p. 11520, doi. 10.1002/anie.201105493

By:

Bibow, Stefan;
Mukrasch, Marco D.;
Chinnathambi, Subashchandrabose;
Biernat, Jacek;
Griesinger, Christian;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Development of Tau Aggregation Inhibitors for Alzheimer's Disease.

Published in:

Angewandte Chemie International Edition, 2009, v. 48, n. 10, p. 1740, doi. 10.1002/anie.200802621

By:

Bulic, Bruno;
Pickhardt, Marcus;
Schmidt, Boris;
Mandelkow, Eva-Maria;
Waldmann, Herbert;
Mandelkow, Eckhard

Publication type:

Article

Rhodanine-Based Tau Aggregation Inhibitors in Cell Models of Tauopathy.

Published in:

Angewandte Chemie International Edition, 2007, v. 46, n. 48, p. 9215, doi. 10.1002/anie.200704051

By:

Bulic, Bruno;
Pickhardt, Marcus;
Khlistunova, Inna;
Biernat, Jacek;
Mandelkow, Eva-Maria;
Mandelkow, Eckhard;
Waldmann, Herbert

Publication type:

Article

Anti-aggregant tau mutant promotes neurogenesis.

Published in:

Molecular Neurodegeneration, 2017, v. 12, p. 1, doi. 10.1186/s13024-017-0230-8

By:

Joseph, Maria;
Anglada-Huguet, Marta;
Paesler, Katharina;
Mandelkow, Eckhard;
Eva-Maria, Mandelkow

Publication type:

Article

The release and trans-synaptic transmission of Tau via exosomes.

Published in:

Molecular Neurodegeneration, 2017, v. 12, p. 1, doi. 10.1186/s13024-016-0143-y

By:

Yipeng Wang;
Balaji, Varun;
Kaniyappan, Senthilvelrajan;
Krüger, Lars;
Irsen, Stephan;
Tepper, Katharina;
Chandupatla, RamReddy;
Maetzler, Walter;
Schneider, Anja;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria

Publication type:

Article

Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model.

Published in:

Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0096-1

By:

Pir, Ghulam Jeelani;
Choudhary, Bikash;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria

Publication type:

Article

Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9260, doi. 10.3390/ijms24119260

By:

Anglada-Huguet, Marta;
Endepols, Heike;
Sydow, Astrid;
Hilgers, Ronja;
Neumaier, Bernd;
Drzezga, Alexander;
Kaniyappan, Senthilvelrajan;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria

Publication type:

Article

Quick-Frozen Microtubules Studied by Cryoelectron Microscopy and Image Processing.

Published in:

Annals of the New York Academy of Sciences, 1986, v. 483, n. 1, p. 13, doi. 10.1111/j.1749-6632.1986.tb34489.x

By:

MANDELKOW, ECKHARD;
MANDELKOW, EVA-MARIA

Publication type:

Article

What is the evidence that tau pathology spreads through prion-like propagation?

Published in:

Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0488-7

By:

Mudher, Amrit;
Colin, Morvane;
Dujardin, Simon;
Medina, Miguel;
Dewachter, Ilse;
Alavi Naini, Seyedeh Maryam;
Eva-Maria, Mandelkow;
Mandelkow, Eckhard;
Buée, Luc;
Goedert, Michel;
Jean-Pierre Brion

Publication type:

Article

Atypical, non-standard functions of the microtubule associated Tau protein.

Published in:

Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0489-6

By:

Sotiropoulos, Ioannis;
Galas, Marie-Christine;
Silva, Joana M.;
Skoulakis, Efthimios;
Wegmann, Susanne;
Maina, Mahmoud Bukar;
Blum, David;
Sayas, Carmen Laura;
Mandelkow, Eva-Maria;
Mandelkow, Eckhard;
Spillantini, Maria Grazia;
Sousa, Nuno;
Avila, Jesus;
Medina, Miguel;
Mudher, Amrit;
Buee, Luc

Publication type:

Article

Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.

Published in:

Acta Neuropathologica Communications, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40478-015-0204-4

By:

Hochgräfe, Katja;
Sydow, Astrid;
Cadinu, Daniela;
Könen, Stefanie;
Petrova, Olga;
Pickhardt, Marcus;
Goll, Petra;
Morellini, Fabio;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria

Publication type:

Article

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation.

Published in:

Acta Neuropathologica Communications, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40478-015-0193-3

By:

Decker, Jochen Martin;
Krüger, Lars;
Sydow, Astrid;
Zhao, Shanting;
Frotscher, Michael;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria

Publication type:

Article

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation.

Published in:

Acta Neuropathologica Communications, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40478-015-0193-3

By:

Decker, Jochen Martin;
Krüger, Lars;
Sydow, Astrid;
Shanting Zhao;
Frotscher, Michael;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria

Publication type:

Article

Inhibition of APP Trafficking by Tau Protein Does Not Increase the Generation of Amyloid-β Peptides.

Published in:

Traffic, 2006, v. 7, n. 7, p. 873, doi. 10.1111/j.1600-0854.2006.00434.x

By:

Goldsbury, Claire;
Mocanu, Maria-Magdalena;
Thies, Edda;
Kaether, Christoph;
Haass, Christian;
Keller, Patrick;
Biernat, Jacek;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria

Publication type:

Article

Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 2, p. 726, doi. 10.1002/anie.202011157

By:

Savastano, Adriana;
Flores, David;
Kadavath, Harindranath;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer.

Published in:

Protein Science: A Publication of the Protein Society, 2016, v. 25, n. 5, p. 1010, doi. 10.1002/pro.2911

By:

Akoury, Elias;
Mukrasch, Marco D.;
Biernat, Jacek;
Tepper, Katharina;
Ozenne, Valery;
Mandelkow, Eckhard;
Blackledge, Martin;
Zweckstetter, Markus

Publication type:

Article

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 7, p. 2511, doi. 10.1523/JNEUROSCI.5245-10.2011

By:

Sydow, Astrid;
van der Jeugd, Ann;
Fang Zheng;
Ahmed, Tariq;
Balschun, Detlef;
Petrova, Olga;
Drexler, Dagmar;
Zhou, Lepu;
Rune, Gabriele;
Mandelkow, Eckhard;
D'Hooge, Rudi;
Alzheimer, Christian;
Mandelkow, Eva-Maria

Publication type:

Article

Aβ Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 36, p. 11938, doi. 10.1523/JNEUROSCI.2357-10.2010

By:

Zempel, Hans;
Thies, Edda;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria

Publication type:

Article

Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates.

Published in:

EMBO Journal, 2022, v. 41, n. 11, p. 1, doi. 10.15252/embj.2021108882

By:

Hochmair, Janine;
Exner, Christian;
Franck, Maximilian;
Dominguez‐Baquero, Alvaro;
Diez, Lisa;
Brognaro, Hévila;
Kraushar, Matthew L;
Mielke, Thorsten;
Radbruch, Helena;
Kaniyappan, Senthilvelrajan;
Falke, Sven;
Mandelkow, Eckhard;
Betzel, Christian;
Wegmann, Susanne

Publication type:

Article

Tau protein liquid–liquid phase separation can initiate tau aggregation.

Published in:

EMBO Journal, 2018, v. 37, n. 7, p. 1, doi. 10.15252/embj.201798049

By:

Wegmann, Susanne;
Eftekharzadeh, Bahareh;
Tepper, Katharina;
Zoltowska, Katarzyna M.;
Bennett, Rachel E.;
Dujardin, Simon;
Laskowski, Pawel R.;
MacKenzie, Danny;
Kamath, Tarun;
Commins, Caitlin;
Vanderburg, Charles;
Roe, Allyson D.;
Fan, Zhanyun;
Molliex, Amandine M.;
Hernandez‐Vega, Amayra;
Muller, Daniel;
Hyman, Anthony A.;
Mandelkow, Eckhard;
Taylor, J. Paul;
Hyman, Bradley T.

Publication type:

Article

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin.

Published in:

EMBO Journal, 2013, v. 32, n. 22, p. 2920, doi. 10.1038/emboj.2013.207

By:

Zempel, Hans;
Luedtke, Julia;
Kumar, Yatender;
Biernat, Jacek;
Dawson, Hana;
Mandelkow, Eckhard;
Mandelkow, Eva‐Maria

Publication type:

Article

Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering.

Published in:

Proteins, 2011, v. 79, n. 7, p. 2122, doi. 10.1002/prot.23033

By:

Shkumatov, Alexander V.;
Chinnathambi, Subashchandrabose;
Mandelkow, Eckhard;
Svergun, Dmitri I.

Publication type:

Article

Interplay of pathogenic forms of human tau with different autophagic pathways.

Published in:

Aging Cell, 2018, v. 17, n. 1, p. 1, doi. 10.1111/acel.12692

By:

Caballero, Benjamin;
Wang, Yipeng;
Diaz, Antonio;
Tasset, Inmaculada;
Juste, Yves Robert;
Stiller, Barbara;
Mandelkow, Eva‐Maria;
Mandelkow, Eckhard;
Cuervo, Ana Maria

Publication type:

Article

Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00480-0

By:

Ambadipudi, Susmitha;
Biernat, Jacek;
Riedel, Dietmar;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.

Published in:

Nature Communications, 2015, v. 6, n. 4, p. 7025, doi. 10.1038/ncomms8025

By:

Shammas, Sarah L.;
Garcia, Gonzalo A.;
Kumar, Satish;
Kjaergaard, Magnus;
Horrocks, Mathew H.;
Shivji, Nadia;
Mandelkow, Eva;
Knowles, Tuomas P.J.;
Mandelkow, Eckhard;
Klenerman, David

Publication type:

Article

Microtubule structure studied by quick freezing: Cryo-electron microscopy and freeze fracture.

Published in:

Journal of Microscopy, 1986, v. 141, n. 3, p. 361, doi. 10.1111/j.1365-2818.1986.tb02729.x

By:

Mandelkow, Eva-Maria;
Rapp, Roberto;
Mandelkow, Eckhard

Publication type:

Article

Curcumin-Derived Pyrazoles and Isoxazoles: Swiss Army Knives or Blunt Tools for Alzheimer's Disease?

Published in:

ChemMedChem, 2008, v. 3, n. 1, p. 165, doi. 10.1002/cmdc.200700218

By:

Narlawar, Rajeshwar;
Pickhardt, Marcus;
Leuchtenberger, Stefanie;
Baumann, Karlheinz;
Krause, Sabine;
Dyrks, Thomas;
Weggen, Sascha;
Mandelkow, Eckhard;
Schmidt, Boris

Publication type:

Article

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems.

Published in:

Autophagy, 2018, v. 14, n. 12, p. 2139, doi. 10.1080/15548627.2018.1509607

By:

Balaji, Varun;
Kaniyappan, Senthilvelrajan;
Mandelkow, Eckhard;
Wang, Yipeng;
Mandelkow, Eva-Maria

Publication type:

Article

Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation.

Published in:

Autophagy, 2010, v. 6, n. 1, p. 182, doi. 10.4161/auto.6.1.10815

By:

Yipeng Wang;
Martinez-Vicente, Marta;
Krüger, Ulrike;
Kaushik, Susmita;
Wong, Esther;
Mandelkow, Eva-Maria;
Cuervo, Ana Maria;
Mandelkow, Eckhard

Publication type:

Article

Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein.

Published in:

2008

By:

Timm T;
Marx A;
Panneerselvam S;
Mandelkow E;
Mandelkow EM;
Timm, Thomas;
Marx, Alexander;
Panneerselvam, Saravanan;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria

Publication type:

journal article

Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein.

Published in:

BMC Neuroscience, 2008, v. 9, p. 1, doi. 10.1186/1471-2202-9-S2-S9

By:

Timm, Thomas;
Marx, Alexander;
Panneerselvam, Saravanan;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria

Publication type:

Article

Der Bindungsmodus eines Tau‐Peptids mit Tubulin.

Published in:

Angewandte Chemie, 2018, v. 130, n. 12, p. 3301, doi. 10.1002/ange.201712089

By:

Kadavath, Harindranath;
Cabrales Fontela, Yunior;
Jaremko, Mariusz;
Jaremko, Łukasz;
Overkamp, Kerstin;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Erweiterung des Konzeptes spezifischer Wirkstoff-Formulierungsadditive auf nichtfluoreszierende Wirkstoffe: eine Studie zur Solubilisierung potenzieller Anti-Alzheimer-Wirkstoffe.

Published in:

Angewandte Chemie, 2016, v. 128, n. 30, p. 8894, doi. 10.1002/ange.201601147

By:

Lawatscheck, Carmen;
Pickhardt, Marcus;
Wieczorek, Sebastian;
Grafmüller, Andrea;
Mandelkow, Eckhard;
Börner, Hans G.

Publication type:

Article

Faltungszustand des Proteins Tau bei Bindung an Mikrotubuli.

Published in:

Angewandte Chemie, 2015, v. 127, n. 35, p. 10488, doi. 10.1002/ange.201501714

By:

Kadavath, Harindranath;
Jaremko, Mariusz;
Jaremko, Łukasz;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Mechanismus der Phenothiazin-induzierten Hemmung der Tau-Aggregation.

Published in:

Angewandte Chemie, 2013, v. 125, n. 12, p. 3596, doi. 10.1002/ange.201208290

By:

Akoury, Elias;
Pickhardt, Marcus;
Gajda, Michal;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

N′-Benzylidene-Benzohydrazides as Novel and Selective Tau-PHF Ligands.

Published in:

Journal of Alzheimer's Disease, 2011, v. 27, n. 4, p. 835, doi. 10.3233/JAD-2011-111238

By:

Taghavi, Ali;
Nasir, Samir;
Pickhardt, Marcus;
Hauβen, Roland Heyny-von;
Mall, Gerhard;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria;
Schmidt, Boris

Publication type:

Article

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06880-0

By:

Oroz, Javier;
Chang, Bliss J.;
Wysoczanski, Piotr;
Lee, Chung-Tien;
Pérez-Lara, Ángel;
Chakraborty, Pijush;
Hofele, Romina V.;
Baker, Jeremy D.;
Blair, Laura J.;
Biernat, Jacek;
Urlaub, Henning;
Mandelkow, Eckhard;
Dickey, Chad A.;
Zweckstetter, Markus

Publication type:

Article