Works by Manczak, Maria

Results: 39

Mitochondria-Targeted Antioxidant SS31 Prevents Amyloid Beta-Induced Mitochondrial Abnormalities and Synaptic Degeneration in Alzheimer's Disease.

Published in:

Pharmaceuticals (14248247), 2012, v. 5, n. 10, p. 1103, doi. 10.3390/ph5101103

By:

Calkins, Marcus J.;
Manczak, Maria;
Hemachandr, P.

Publication type:

Article

partial reduction of Drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic Tau mouse model of Alzheimer disease.

Published in:

Human Molecular Genetics, 2022, v. 31, n. 11, p. 1788, doi. 10.1093/hmg/ddab360

By:

Kandimalla, Ramesh;
Manczak, Maria;
Pradeepkiran, Jangampalli Adi;
Morton, Hallie;
Reddy, P Hemachandra

Publication type:

Article

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression.

Published in:

Human Molecular Genetics, 2006, v. 15, n. 9, p. 1437, doi. 10.1093/hmg/ddl066

By:

Manczak, Maria;
Anekonda, Thimmappa S.;
Henson, Edward;
Park, Byung S.;
Quinn, Joseph;
Reddy, P. Hemachandra

Publication type:

Article

Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease.

Published in:

Human Molecular Genetics, 2004, v. 13, n. 12, p. 1225, doi. 10.1093/hmg/ddh140

By:

Reddy, P. Hemachandra;
McWeeney, Shannon;
Park, Byung S.;
Manczak, Maria;
Gutala, Ramana V.;
Partovi, Dara;
Jung, Youngsin;
Yau, Vincent;
Searles, Robert;
Mori, Motomi;
Quinn, Joseph

Publication type:

Article

Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin.

Published in:

NeuroMolecular Medicine, 2005, v. 7, n. 4, p. 297, doi. 10.1385/NMM:7:4:297

By:

Sayer, Jonathan;
Manczak, Maria;
Akileswaran, Lakshmi;
Reddy, P.;
Coghlan, Vincent

Publication type:

Article

Differential expression of oxidative phosphorylation genes in patients with Alzheimer’s disease.

Published in:

NeuroMolecular Medicine, 2004, v. 5, n. 2, p. 147, doi. 10.1385/NMM:5:2:147

By:

Manczak, Maria;
Park, Byung;
Jung, Youngsin;
Reddy, P.

Publication type:

Article

Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline.

Published in:

Journal of Alzheimer's Disease, 2010, v. 20, p. 499, doi. 10.3233/JAD-2010-100504

By:

Reddy, P. Hemachandra;
Manczak, Maria;
Peizhong Mao;
Calkins, Marcus J.;
Reddy, Arubala P.;
Shirendeb, Ulziibat

Publication type:

Article

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons.

Published in:

Journal of Alzheimer's Disease, 2010, v. 20, p. 609, doi. 10.3233/JAD-2010-100564

By:

Manczak, Maria;
Peizhong Mao;
Calkins, Marcus J.;
Cornea, Anda;
Reddy, Arubala P.;
Murphy, Michael P.;
Szeto, Hazel H.;
Park, Byung;
Reddy, P. Hemachandra

Publication type:

Article

Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.

Published in:

2010

By:

Manczak M;
Mao P;
Calkins MJ;
Cornea A;
Reddy AP;
Murphy MP;
Szeto HH;
Park B;
Reddy PH;
Manczak, Maria;
Mao, Peizhong;
Calkins, Marcus J;
Cornea, Anda;
Reddy, Arubala P;
Murphy, Michael P;
Szeto, Hazel H;
Park, Byung;
Reddy, P Hemachandra

Publication type:

journal article

Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline.

Published in:

2010

By:

Reddy PH;
Manczak M;
Mao P;
Calkins MJ;
Reddy AP;
Shirendeb U;
Reddy, P Hemachandra;
Manczak, Maria;
Mao, Peizhong;
Calkins, Marcus J;
Reddy, Arubala P;
Shirendeb, Ulziibat

Publication type:

journal article

Differential loss of synaptic proteins in Alzheimer's disease: Implications for synaptic dysfunction.

Published in:

Journal of Alzheimer's Disease, 2005, v. 7, n. 2, p. 103, doi. 10.3233/JAD-2005-7203

By:

Reddy, P. Hemachandra;
Mani, Geethalakshmi;
Park, Byung S.;
Jacques, Joline;
Murdoch, Geoffrey;
Whetsell Jr., William;
Kaye, Jeffrey;
Manczak, Maria

Publication type:

Article

Granulocyte-macrophage colony-stimulating factor antibody suppresses microglial activity: implications for anti-inflammatory effects in Alzheimer’s Disease and multiple sclerosis.

Published in:

Journal of Neurochemistry, 2009, v. 111, n. 6, p. 1514, doi. 10.1111/j.1471-4159.2009.06432.x

By:

Reddy, P. Hemachandra;
Manczak, Maria;
Wei Zhao;
Nakamura, Kazuhiro;
Bebbington, Christopher;
Yarranton, Geoffrey;
Mao, Peizhong

Publication type:

Article

Time-course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochromecin aging.

Published in:

Journal of Neurochemistry, 2005, v. 92, n. 3, p. 494, doi. 10.1111/j.1471-4159.2004.02884.x

By:

Manczak, Maria;
Jung, Youngsin;
Park, Byung S.;
Partovi, Dara;
Reddy, P. Hemachandra

Publication type:

Article

Mitochondria-Targeted Small Peptide, SS31 Ameliorates Diabetes Induced Mitochondrial Dynamics in Male TallyHO/JngJ Mice.

Published in:

Molecular Neurobiology, 2021, v. 58, n. 2, p. 795, doi. 10.1007/s12035-020-02142-7

By:

Bhatti, Jasvinder Singh;
Thamarai, Kavya;
Kandimalla, Ramesh;
Manczak, Maria;
Yin, Xiangling;
Kumar, Subodh;
Vijayan, Murali;
Reddy, P. Hemachandra

Publication type:

Article

PROTECTIVE EFFECTS OF SELECTIVE SEROTONIN REUPTAKE INHIBITOR AND NEUROSTEROIDS AGAINST ALZHEIMER'S DISEASE NEURONS.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P651, doi. 10.1016/j.jalz.2016.06.1307

By:

Reddy, Arubala P.;
Manczak, Maria;
Yin, XiangLing;
Reddy, Hemachandra

Publication type:

Article

Abnormal mitochondrial structural and functional changes caused by amyloid beta in Alzheimer's disease

Published in:

2009

By:

Mao, Peizhong;
Manczak, Maria;
Shree, Divya;
Reddy, P. Hemachandra

Publication type:

Abstract

P4-169: Mitochondrially targeted antioxidant therapeutics in Alzheimer's disease

Published in:

2008

By:

Reddy, P. Hemachandra;
Manczak, Maria;
Zhao, Wei

Publication type:

Abstract

Protective effects of BACE1 inhibitory ligand molecules against amyloid beta-induced synaptic and mitochondrial toxicities in Alzheimer's disease.

Published in:

Human Molecular Genetics, 2020, v. 29, n. 1, p. 49, doi. 10.1093/hmg/ddz227

By:

Pradeepkiran, Jangampalli Adi;
Reddy, Arubala P;
Yin, Xiangling;
Manczak, Maria;
Reddy, P Hemachandra

Publication type:

Article

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.

Published in:

Human Molecular Genetics, 2019, v. 28, n. 5, p. 875, doi. 10.1093/hmg/ddy399

By:

Manczak, Maria;
Kandimalla, Ramesh;
Yin, Xiangling;
Reddy, P Hemachandra

Publication type:

Article

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.

Published in:

Human Molecular Genetics, 2019, v. 28, n. 2, p. 177, doi. 10.1093/hmg/ddy335

By:

Manczak, Maria;
Kandimalla, Ramesh;
Yin, Xiangling;
Reddy, P Hemachandra

Publication type:

Article

Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.

Published in:

Human Molecular Genetics, 2018, v. 27, n. 14, p. 2502, doi. 10.1093/hmg/ddy154

By:

Reddy, P. Hemachandra;
XiangLing Yin;
Manczak, Maria;
Kumar, Subodh;
Pradeepkiran, Jangampalli Adi;
Vijayan, Murali;
Reddy, Arubala P.

Publication type:

Article

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease.

Published in:

Human Molecular Genetics, 2018, v. 27, n. 8, p. 1332, doi. 10.1093/hmg/ddy042

By:

Manczak, Maria;
Kandimalla, Ramesh;
Xiangling Yin;
Hemachandra Reddy, P.

Publication type:

Article

Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.

Published in:

Human Molecular Genetics, 2018, v. 27, n. 1, p. 30, doi. 10.1093/hmg/ddx381

By:

Kandimalla, Ramesh;
Manczak, Maria;
Xiangling Yin;
Rui Wang;
Reddy, P. Hemachandra

Publication type:

Article

Aqua-soluble DDQ reduces the levels of Drp1 and Aβ and inhibits abnormal interactions between Ab and Drp1 and protects Alzheimer's disease neurons from Aβ- and Drp1-induced mitochondrial and synaptic toxicities.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 17, p. 3375, doi. 10.1093/hmg/ddx226

By:

Kuruva, Chandra Sekhar;
Manczak, Maria;
Xiangling Yin;
Ogunmokun, Gilbert;
Reddy, Arubala P.;
Reddy, P. Hemachandra

Publication type:

Article

Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 8, p. 1483, doi. 10.1093/hmg/ddx052

By:

Reddy, P. Hemachandra;
Manczak, Maria;
Kandimalla, Ramesh

Publication type:

Article

Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.

Published in:

Human Molecular Genetics, 2016, v. 25, n. 23, p. 5148, doi. 10.1093/hmg/ddw330

By:

Manczak, Maria;
Kandimalla, Ramesh;
Fry, David;
Sesaki, Hiromi;
Hemachandra Reddy, P.

Publication type:

Article

Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.

Published in:

Human Molecular Genetics, 2016, v. 25, n. 22, p. 4881, doi. 10.1093/hmg/ddw312

By:

Kandimalla, Ramesh;
Manczak, Maria;
Fry, David;
Suneetha, Yeguvapalli;
Hiromi Sesaki;
Reddy, P. Hemachandra

Publication type:

Article

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.

Published in:

Human Molecular Genetics, 2016, v. 25, n. 9, p. 1739, doi. 10.1093/hmg/ddw045

By:

Xiangling Yin;
Manczak, Maria;
Reddy, P. Hemachandra

Publication type:

Article

Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.

Published in:

Human Molecular Genetics, 2015, v. 24, n. 25, p. 7308, doi. 10.1093/hmg/ddv429

By:

Manczak, Maria;
Reddy, P. Hemachandra

Publication type:

Article

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 23, p. 5131, doi. 10.1093/hmg/dds360

By:

Manczak, Maria;
Reddy, P. Hemachandra

Publication type:

Article

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 13, p. 2973, doi. 10.1093/hmg/dds128

By:

Mao, Peizhong;
Manczak, Maria;
Calkins, Marcus J.;
Truong, Quang;
Reddy, Tejaswini P.;
Reddy, Arubala P.;
Shirendeb, Ulziibat;
Lo, Herng-Hsiang;
Rabinovitch, Peter S.;
Reddy, P. Hemachandra

Publication type:

Article

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 11, p. 2538, doi. 10.1093/hmg/dds072

By:

Manczak, Maria;
Reddy, P. Hemachandra

Publication type:

Article

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 2, p. 406, doi. 10.1093/hmg/ddr475

By:

Shirendeb, Ulziibat P.;
Calkins, Marcus J.;
Manczak, Maria;
Anekonda, Vishwanath;
Dufour, Brett;
McBride, Jodi L.;
Mao, Peizhong;
Reddy, P. Hemachandra

Publication type:

Article

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.

Published in:

Human Molecular Genetics, 2011, v. 20, n. 23, p. 4515, doi. 10.1093/hmg/ddr381

By:

Calkins, Marcus J.;
Manczak, Maria;
Mao, Peizhong;
Shirendeb, Ulziibat;
Reddy, P. Hemachandra

Publication type:

Article

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.

Published in:

Human Molecular Genetics, 2011, v. 20, n. 13, p. 2495, doi. 10.1093/hmg/ddr139

By:

Manczak, Maria;
Calkins, Marcus J.;
Reddy, P. Hemachandra

Publication type:

Article

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.

Published in:

Human Molecular Genetics, 2011, v. 20, n. 7, p. 1438, doi. 10.1093/hmg/ddr024

By:

Shirendeb, Ulziibat;
Reddy, Arubala P.;
Manczak, Maria;
Calkins, Marcus J.;
Mao, Peizhong;
Tagle, Danilo A.;
Hemachandra Reddy, P.

Publication type:

Article

Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease.

Published in:

Human Molecular Genetics, 2009, v. 18, n. 20, p. 3876, doi. 10.1093/hmg/ddp331

By:

Manczak, Maria;
Mao, Peizhong;
Nakamura, Kazuhiro;
Bebbington, Christopher;
Park, Byung;
Reddy, P. Hemachandra

Publication type:

Article

Distribution of CTLA-4 Polymorphisms in Allergic Asthma.

Published in:

International Archives of Allergy & Immunology, 2006, v. 141, n. 3, p. 223, doi. 10.1159/000095292

By:

Jasek, Monika;
Łuszczek, Wioleta;
Obojski, Andrzej;
Winiarska, Beata;
Hałubek, Katarzyna;
Nowak, Izabela;
Mańczak, Maria;
Wiśniewski, Andrzej;
Pawlik, Andrzej;
Jonkisz, Anna;
Lebioda, Arleta;
Majorczyk, Edyta;
Dobosz, Tadeusz;
Kuśnierczyk, Piotr

Publication type:

Article

Are Single Nucleotide Polymorphisms of the Immunoglobulin A Fc Receptor Gene Associated with Allergic Asthma?

Published in:

International Archives of Allergy & Immunology, 2004, v. 135, n. 4, p. 325, doi. 10.1159/000082327

By:

Jasek, Monika;
Obojski, Andrzej;
Mańczak, Maria;
Wiśniewski, Andrzej;
Winiarska, Beata;
Małolepszy, Józef;
Jutel, Marek;
Łuszczek, Wioleta;
Kuśnierczyk, Piotr

Publication type:

Article