Works by Manakova, Elena

Results: 29

Design of Rigid Compounds to Enhance Selectivity for Carbonic Anhydrase IX.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 18, p. 1, doi. 10.1002/chem.202404409

By:

Vaškevičius, Aivaras;
Trumpickaitė, Gabrielė;
Parafjanovič, Edvin;
Manakova, Elena;
Mickevičiūtė, Aurelija;
Gedgaudas, Marius;
Kojis, Tautvydas;
Paketurytė‐Latvė, Vaida;
Smirnov, Alexey;
Baranauskiene, Lina;
Gražulis, Saulius;
Zubrienė, Asta;
Dudutienė, Virginija;
Matulis, Daumantas

Publication type:

Article

Structural mechanisms for the 5′-CCWGG sequence recognition by the N- and C-terminal domains of EcoRII.

Published in:

Nucleic Acids Research, 2009, v. 37, n. 19, p. 6613, doi. 10.1093/nar/gkp699

By:

Golovenko, Dmitrij;
Manakova, Elena;
Tamulaitiene, Giedre;
Grazulis, Saulius;
Siksnys, Virginijus

Publication type:

Article

Crystallography Open Database -- an open-access collection of crystal structures.

Published in:

Journal of Applied Crystallography, 2009, v. 42, n. 4, p. 726

By:

Gražulis, Saulius;
Chateigner, Daniel;
Downs, Robert T.;
Yokochi, A. F. T.;
Quirós, Miguel;
Lutterotti, Luca;
Manakova, Elena;
Butkus, Justas;
Moeck, Peter;
Le Bail, Armel

Publication type:

Article

Nucleotide flips determine the specificity of the Ecl18kI restriction endonuclease.

Published in:

EMBO Journal, 2006, v. 25, n. 10, p. 2219, doi. 10.1038/sj.emboj.7601096

By:

Bochtler, Matthias;
Szczepanowski, Roman H.;
Tamulaitis, Gintautas;
Grazulis, Saulius;
Czapinska, Honorata;
Manakova, Elena;
Siksnys, Virginijus

Publication type:

Article

4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases.

Published in:

Molecules, 2014, v. 19, n. 11, p. 17356, doi. 10.3390/molecules191117356

By:

Rutkauskas, Kęstutis;
Zubrienė, Asta;
Tumosienė, Ingrida;
Kantminienė, Kristina;
Kažemėkaitė, Marytė;
Smirnov, Alexey;
Kazokaitė, Justina;
Morkūnaitė, Vaida;
Čapkauskaitė, Edita;
Manakova, Elena;
Gražulis, Saulius;
Beresnevičius, Zigmuntas J.;
Matulis, Daumantas

Publication type:

Article

Prokaryotic Argonaute from Archaeoglobus fulgidus interacts with DNA as a homodimer.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-83889-4

By:

Golovinas, Edvardas;
Rutkauskas, Danielis;
Manakova, Elena;
Jankunec, Marija;
Silanskas, Arunas;
Sasnauskas, Giedrius;
Zaremba, Mindaugas

Publication type:

Article

Structure and mechanism of secondary sulfonamide binding to carbonic anhydrases.

Published in:

European Biophysics Journal, 2021, v. 50, n. 7, p. 993, doi. 10.1007/s00249-021-01561-1

By:

Baronas, Denis;
Dudutienė, Virginija;
Paketurytė, Vaida;
Kairys, Visvaldas;
Smirnov, Alexey;
Juozapaitienė, Vaida;
Vaškevičius, Aivaras;
Manakova, Elena;
Gražulis, Saulius;
Zubrienė, Asta;
Matulis, Daumantas

Publication type:

Article

Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.

Published in:

European Biophysics Journal, 2018, v. 47, n. 3, p. 271, doi. 10.1007/s00249-017-1256-0

By:

Mickevičiūtė, Aurelija;
Timm, David D.;
Gedgaudas, Marius;
Linkuvienė, Vaida;
Chen, Zhiwei;
Waheed, Abdul;
Michailovienė, Vilma;
Zubrienė, Asta;
Smirnov, Alexey;
Čapkauskaitė, Edita;
Baranauskienė, Lina;
Jachno, Jelena;
Revuckienė, Jurgita;
Manakova, Elena;
Gražulis, Saulius;
Matulienė, Jurgita;
Di Cera, Enrico;
Sly, William S.;
Matulis, Daumantas

Publication type:

Article

DNA recognition by Arabidopsis transcription factors ABI3 and NGA1.

Published in:

FEBS Journal, 2018, v. 285, n. 21, p. 4041, doi. 10.1111/febs.14649

By:

Sasnauskas, Giedrius;
Manakova, Elena;
Lapėnas, Kęstutis;
Kauneckaitė, Kotryna;
Siksnys, Virginijus

Publication type:

Article

Switching the Inhibitor-Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII.

Published in:

ChemistryOpen, 2021, v. 10, n. 5, p. 567, doi. 10.1002/open.202100042

By:

Smirnovienė, Joana;
Smirnov, Alexey;
Zakšauskas, Audrius;
Zubrienė, Asta;
Petrauskas, Vytautas;
Mickevičiūtė, Aurelija;
Michailovienė, Vilma;
Čapkauskaitė, Edita;
Manakova, Elena;
Gražulis, Saulius;
Baranauskienė, Lina;
Chen, Wen-Yih;
Ladbury, John E.;
Matulis, Daumantas

Publication type:

Article

Intrinsic Thermodynamics and Structures of 2,4- and 3,4-Substituted Fluorinated Benzenesulfonamides Binding to Carbonic Anhydrases.

Published in:

ChemMedChem, 2017, v. 12, n. 2, p. 161, doi. 10.1002/cmdc.201600509

By:

Zubrienė, Asta;
Smirnov, Alexey;
Dudutienė, Virginija;
Timm, David D.;
Matulienė, Jurgita;
Michailovienė, Vilma;
Zakšauskas, Audrius;
Manakova, Elena;
Gražulis, Saulius;
Matulis, Daumantas

Publication type:

Article

Functionalization of Fluorinated Benzenesulfonamides and Their Inhibitory Properties toward Carbonic Anhydrases.

Published in:

ChemMedChem, 2015, v. 10, n. 4, p. 662, doi. 10.1002/cmdc.201402490

By:

Dudutienė, Virginija;
Zubrienė, Asta;
Smirnov, Alexey;
Timm, David D.;
Smirnovienė, Joana;
Kazokaitė, Justina;
Michailovienė, Vilma;
Zakšauskas, Audrius;
Manakova, Elena;
Gražulis, Saulius;
Matulis, Daumantas

Publication type:

Article

Thermodynamic, kinetic, and structural parameterization of human carbonic anhydrase interactions toward enhanced inhibitor design.

Published in:

Quarterly Reviews of Biophysics, 2018, v. 51, p. 1, doi. 10.1017/S0033583518000082

By:

Linkuvienė, Vaida;
Zubrienė, Asta;
Manakova, Elena;
Petrauskas, Vytautas;
Baranauskienė, Lina;
Zakšauskas, Audrius;
Smirnov, Alexey;
Gražulis, Saulius;
Ladbury, John E.;
Matulis, Daumantas

Publication type:

Article

Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 1, p. 130, doi. 10.3390/ijms23010130

By:

Zakšauskas, Audrius;
Čapkauskaitė, Edita;
Paketurytė-Latvė, Vaida;
Smirnov, Alexey;
Leitans, Janis;
Kazaks, Andris;
Dvinskis, Elviss;
Stančaitis, Laimonas;
Mickevičiūtė, Aurelija;
Jachno, Jelena;
Jezepčikas, Linas;
Linkuvienė, Vaida;
Sakalauskas, Andrius;
Manakova, Elena;
Gražulis, Saulius;
Matulienė, Jurgita;
Tars, Kaspars;
Matulis, Daumantas

Publication type:

Article

Unique mechanism of target recognition by PfoI restriction endonuclease of the CCGG-family.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 2, p. 997, doi. 10.1093/nar/gky1137

By:

Tamulaitiene, Giedre;
Manakova, Elena;
Jovaisaite, Virginija;
Tamulaitis, Gintautas;
Grazulis, Saulius;
Bochtler, Matthias;
Siksnys, Virginijus

Publication type:

Article

Activity and structure of EcoKMcrA.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 18, p. 9829, doi. 10.1093/nar/gky731

By:

Czapinska, Honorata;
Kowalska, Monika;
Zagorskaitė, Evelina;
Manakova, Elena;
Slyvka, Anton;
Xu, Shuang-yong;
Siksnys, Virginijus;
Sasnauskas, Giedrius;
Bochtler, Matthias

Publication type:

Article

The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1 helicase-like motor.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 5, p. 2560, doi. 10.1093/nar/gky107

By:

Toliusis, Paulius;
Tamulaitiene, Giedre;
Grigaitis, Rokas;
Tuminauskaite, Donata;
Silanskas, Arunas;
Manakova, Elena;
Venclovas, Česlovas;
Szczelkun, Mark D;
Siksnys, Virginijus;
Zaremba, Mindaugas

Publication type:

Article

Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA.

Published in:

Nucleic Acids Research, 2017, v. 45, n. 6, p. 3547, doi. 10.1093/nar/gkw1310

By:

Tamulaitiene, Giedre;
Jovaisaite, Virginija;
Tamulaitis, Gintautas;
Songailiene, Inga;
Manakova, Elena;
Zaremba, Mindaugas;
Grazulis, Saulius;
Shuang-yong Xu;
Siksnys, Virginijus

Publication type:

Article

DNA cleavage by CgII and NgoAVII requires interaction between N- and R-proteins and extensive nucleotide hydrolysis.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 22, p. 13887, doi. 10.1093/nar/gku1236

By:

Zaremba, Mindaugas;
Toliusis, Paulius;
Grigaitis, Rokas;
Manakova, Elena;
Silanskas, Arunas;
Tamulaitiene, Giedre;
Szczelkun, Mark D.;
Siksnys, Virginijus

Publication type:

Article

Structural insight into the specificity of the B3 DNA-binding domains provided by the co-crystal structure of the C-terminal fragment of BfiI restriction enzyme.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 6, p. 4113, doi. 10.1093/nar/gkt1368

By:

Golovenko, Dmitrij;
Manakova, Elena;
Zakrys, Linas;
Zaremba, Mindaugas;
Sasnauskas, Giedrius;
Gražulis, Saulius;
Siksnys, Virginijus

Publication type:

Article

Structural mechanisms of the degenerate sequence recognition by Bse634I restriction endonuclease.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 14, p. 6741, doi. 10.1093/nar/gks300

By:

Manakova, Elena;
Gražulis, Saulius;
Zaremba, Mindaugas;
Tamulaitiene, Giedre;
Golovenko, Dmitrij;
Siksnys, Virginijus

Publication type:

Article

Recognition of modified cytosine variants by the DNA‐binding domain of methyl‐directed endonuclease McrBC.

Published in:

FEBS Letters, 2018, v. 592, n. 19, p. 3335, doi. 10.1002/1873-3468.13244

By:

Zagorskaitė, Evelina;
Manakova, Elena;
Sasnauskas, Giedrius

Publication type:

Article

Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.101401

By:

Vaškevičius, Aivaras;
Baronas, Denis;
Leitans, Janis;
Kvietkauskaitė, Agnė;
Rukšėnaitė, Audronė;
Manakova, Elena;
Toleikis, Zigmantas;
Kaupinis, Algirdas;
Kazaks, Andris;
Gedgaudas, Marius;
Mickevičiūtė, Aurelija;
Juozapaitienė, Vaida;
Schiöth, Helgi B.;
Jaudzems, Kristaps;
Valius, Mindaugas;
Tars, Kaspars;
Gražulis, Saulius;
Meyer-Almes, Franz-Josef;
Matulienė, Jurgita;
Zubrienė, Asta

Publication type:

Article

Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 4, p. N.PAG, doi. 10.3390/ph15040477

By:

Balandis, Benas;
Šimkūnas, Tomas;
Paketurytė-Latvė, Vaida;
Michailovienė, Vilma;
Mickevičiūtė, Aurelija;
Manakova, Elena;
Gražulis, Saulius;
Belyakov, Sergey;
Kairys, Visvaldas;
Mickevičius, Vytautas;
Zubrienė, Asta;
Matulis, Daumantas

Publication type:

Article

Intrinsic Thermodynamics and Structure Correlation of Benzenesulfonamides with a Pyrimidine Moiety Binding to Carbonic Anhydrases I, II, VII, XII, and XIII.

Published in:

PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0114106

By:

Kišonaitė, Miglė;
Zubrienė, Asta;
Čapkauskaitė, Edita;
Smirnov, Alexey;
Smirnovienė, Joana;
Kairys, Visvaldas;
Michailovienė, Vilma;
Manakova, Elena;
Gražulis, Saulius;
Matulis, Daumantas

Publication type:

Article

Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding.

Published in:

PeerJ, 2018, p. 1, doi. 10.7717/peerj.4412

By:

Smirnov, Alexey;
Zubrienė, Asta;
Manakova, Elena;
Gražulis, Saulius;
Matulis, Daumantas

Publication type:

Article

Inhibition and binding studies of carbonic anhydrase isozymes I, II and IX with benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulphonamides.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2010, v. 25, n. 6, p. 863, doi. 10.3109/14756360903571685

By:

Baranauskienė, Lina;
Hilvo, Mika;
Matulienė, Jurgita;
Golovenko, Dmitrij;
Manakova, Elena;
Dudutienė, Virginija;
Michailovienė, Vilma;
Torresan, Jolanta;
Jachno, Jelena;
Parkkila, Seppo;
Maresca, Alfonso;
Supuran, Claudiu T.;
Gražulis, Saulius;
Matulis, Daumantas

Publication type:

Article

Structural basis for sequence-specific recognition of guide and target strands by the Archaeoglobus fulgidus Argonaute protein.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-32600-w

By:

Manakova, Elena;
Golovinas, Edvardas;
Pocevičiūtė, Reda;
Sasnauskas, Giedrius;
Grybauskas, Algirdas;
Gražulis, Saulius;
Zaremba, Mindaugas

Publication type:

Article

The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein.

Published in:

Nucleic Acids Research, 2024, v. 52, n. 5, p. 2530, doi. 10.1093/nar/gkad1241

By:

Manakova, Elena;
Golovinas, Edvardas;
Pocevičiūtė, Reda;
Sasnauskas, Giedrius;
Silanskas, Arunas;
Rutkauskas, Danielis;
Jankunec, Marija;
Zagorskaitė, Evelina;
Jurgelaitis, Edvinas;
Grybauskas, Algirdas;
Venclovas, Česlovas;
Zaremba, Mindaugas

Publication type:

Article