Works by Malcolm Tingle

Results: 29

CYP-catalysed cycling of clozapine and clozapine-N-oxide promotes the generation of reactive oxygen species in vitro.

Published in:

Xenobiotica, 2024, v. 54, n. 1, p. 26, doi. 10.1080/00498254.2023.2294473

By:

Kingston, Ellen;
Tingle, Malcolm;
Bellissima, Brandi L.;
Helsby, Nuala;
Burns, Kathryn

Publication type:

Article

Oral antibiotics used in the treatment of chronic rhinosinusitis have limited penetration into the sinonasal mucosa: a randomized trial.

Published in:

Xenobiotica, 2020, v. 50, n. 12, p. 1443, doi. 10.1080/00498254.2020.1814973

By:

Siu, Joey;
Klingler, Lilian;
Wang, Yi;
Hung, Cheung-Tak;
Jeong, Soo Hee;
Smith, Susan;
Tingle, Malcolm Drummond;
Wagner Mackenzie, Brett;
Biswas, Kristi;
Douglas, Richard George

Publication type:

Article

Ascending single dose pharmacokinetics of cytisine in healthy adult smokers.

Published in:

Xenobiotica, 2019, v. 49, n. 11, p. 1332, doi. 10.1080/00498254.2018.1557760

By:

Jeong, Soo Hee;
Sheridan, Janie;
Bullen, Chris;
Newcombe, David;
Walker, Natalie;
Tingle, Malcolm

Publication type:

Article

Plasma concentrations of cytisine, a commercially available plant-based alkaloid, in healthy adult smokers taking recommended doses for smoking cessation.

Published in:

Xenobiotica, 2018, v. 48, n. 12, p. 1245, doi. 10.1080/00498254.2017.1409916

By:

Soo Hee Jeong;
Sheridan, Janie;
Newcombe, David;
Tingle, Malcolm

Publication type:

Article

Indirect regulation of CYP2C19 gene expression via DNA methylation.

Published in:

Xenobiotica, 2018, v. 48, n. 8, p. 781, doi. 10.1080/00498254.2017.1372648

By:

Burns, Kathryn Elisa;
Shepherd, Phillip;
Finlay, Graeme;
Tingle, Malcolm Drummond;
Helsby, Nuala Ann

Publication type:

Article

A pharmacokinetic framework describing antibiotic adsorption to cardiopulmonary bypass devices.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 8, p. 1409, doi. 10.1002/psp4.13180

By:

O'Hanlon, Conor J.;
Holford, Nick;
Anderson, Brian J.;
Greaves, Mark;
Blackburn, Lee;
Tingle, Malcolm D.;
Hannam, Jacqueline A.

Publication type:

Article

Adenosine Amine Congener as a Cochlear Rescue Agent.

Published in:

BioMed Research International, 2014, v. 2014, p. 1, doi. 10.1155/2014/841489

By:

Vlajkovic, Srdjan M.;
Hao Chang;
Song Yee Paek;
Howard H.-T. Chi;
Sreebhavan, Sreevalsan;
Telang, Ravindra S.;
Tingle, Malcolm;
Housley, Gary D.;
Thorne, Peter R.

Publication type:

Article

Circulating microRNA as biomarkers of clozapine-induced cardiotoxicity.

Published in:

Biomarkers, 2020, v. 25, n. 1, p. 76, doi. 10.1080/1354750X.2019.1693631

By:

Burns, Kathryn E.;
Deane-Alder, Kieran D.;
Bellissima, Brandi L.;
Tingle, Malcolm D.

Publication type:

Article

Use of a metabolic inhibitor to reduce dapsone-dependent haematological toxicity.

Published in:

Drug Development Research, 1992, v. 25, n. 1, p. 1, doi. 10.1002/ddr.430250102

By:

Coleman, Michael Damian;
Tingle, Malcolm Drummond

Publication type:

Article

Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption.

Published in:

2002

By:

Collier, Abby C.;
Tingle, Malcolm D.;
Paxton, James W.;
Mitchell, Murray D.;
Keelan, Jeffrey A.

Publication type:

journal article

Varenicline improves motor and cognitive symptoms in early Huntington's disease.

Published in:

Neuropsychiatric Disease & Treatment, 2016, v. 12, p. 2381, doi. 10.2147/NDT.S111083

By:

McGregor, Ailsa L.;
Dysart, Jo;
Tingle, Malcolm D.;
Russell, Bruce R.;
Kydd, Rob R.;
Finucane, Gregory

Publication type:

Article

Satraplatin activation by haemoglobin, cytochrome C and liver microsomes in vitro.

Published in:

Cancer Chemotherapy & Pharmacology, 2006, v. 57, n. 4, p. 483, doi. 10.1007/s00280-005-0069-5

By:

Carr, Jocelyn L.;
Tingle, Malcolm D.;
McKeage, Mark J.

Publication type:

Article

Rapid biotransformation of satraplatin by human red blood cells in vitro.

Published in:

Cancer Chemotherapy & Pharmacology, 2002, v. 50, n. 1, p. 9, doi. 10.1007/s00280-002-0462-2

By:

Carr, Jocelyn L.;
Tingle, Malcolm D.;
McKeage, Mark J.

Publication type:

Article

Gender differences in the metabolism and pharmacokinetics of the experimental anticancer agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

Published in:

Cancer Chemotherapy & Pharmacology, 2002, v. 49, n. 2, p. 126, doi. 10.1007/s00280-001-0383-5

By:

Zhou, Shufeng;
Kestell, Philip;
Tingle, Malcolm D.;
Paxton, James W.

Publication type:

Article

Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration.

Published in:

BioMed Research International, 2017, v. 2017, p. 1, doi. 10.1155/2017/8091462

By:

Chang, Hao;
Telang, Ravindra S.;
Sreebhavan, Sreevalsan;
Tingle, Malcolm;
Thorne, Peter R.;
Vlajkovic, Srdjan M.

Publication type:

Article

Contrasting effects of acute and chronic dietary exposure to 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) on xenobiotic metabolising enzymes in the male Fischer 344 Rat: implications for chemoprevention studies.

Published in:

European Journal of Nutrition, 2001, v. 40, n. 1, p. 39, doi. 10.1007/PL00007384

By:

McPherson, Rachel A.C.;
Tingle, Malcolm D.;
Ferguson, Lynnette R.

Publication type:

Article

Sinonasal and gastrointestinal bacterial composition and abundance are stable after 1 week of once‐daily oral antibiotic treatment for chronic rhinosinusitis.

Published in:

International Forum of Allergy & Rhinology, 2021, v. 11, n. 9, p. 1355, doi. 10.1002/alr.22799

By:

Siu, Joey;
Mackenzie, Brett Wagner;
Klingler, Lilian;
Biswas, Kristi;
Wang, Yi;
Hung, Cheung‐Tak;
Jeong, Soo Hee;
Barnett, Daniel;
Tingle, Malcolm Drummond;
Douglas, Richard George

Publication type:

Article

COMPARATIVE PROTEIN BINDING, STABILITY AND DEGRADATION OF SATRAPLATIN, JM118 AND CISPLATIN IN HUMAN PLASMA IN VITRO.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2008, v. 35, n. 12, p. 1440, doi. 10.1111/j.1440-1681.2008.05017.x

By:

Bell, Deanna N;
Liu, Johnson J;
Tingle, Malcolm D;
Rattel, Benno;
Meyer, Thorsten Ulf;
McKeage, Mark J

Publication type:

Article

The combined impact of CYP2C19 and CYP2B6 pharmacogenetics on cyclophosphamide bioactivation N. A. Helsby et al. Cyclophosphamide activation by CYP2C19 and CYP2B6.

Published in:

British Journal of Clinical Pharmacology, 2010, v. 70, n. 6, p. 844, doi. 10.1111/j.1365-2125.2010.03789.x

By:

Helsby, Nuala A.;
Hui, Chung-Yee;
Goldthorpe, Michael A.;
Coller, Janet K.;
Soh, May Ching;
Gow, Peter J.;
De Zoysa, Janak Z.;
Tingle, Malcolm D.

Publication type:

Article

Effects of anticancer drugs on the metabolism of the anticancer drug 5,6-dimethylxanthenone-4-acetic (DMXAA) by human liver microsomes.

Published in:

British Journal of Clinical Pharmacology, 2001, v. 52, n. 2, p. 129, doi. 10.1046/j.0306-5251.2001.01438.x

By:

Zhou, Shufeng;
Chin, Rebecca;
Kestell, Philip;
Tingle, Malcolm D.;
Paxton, James W.

Publication type:

Article

Comparison of Sinus Deposition from an Aqueous Nasal Spray and Pressurised MDI in a Post-Endoscopic Sinus Surgery Nasal Replica.

Published in:

Pharmaceutical Research, 2022, v. 39, n. 2, p. 317, doi. 10.1007/s11095-021-03129-2

By:

Siu, Joey;
van Strien, James;
Campbell, Rosa;
Roberts, Paul;
Tingle, Malcolm Drummond;
Inthavong, Kiao;
Douglas, Richard George

Publication type:

Article

Reversible binding of the novel anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid to plasma proteins and its distribution into blood cells in various species.

Published in:

Journal of Pharmacy & Pharmacology, 2001, v. 53, n. 4, p. 463, doi. 10.1211/0022357011775758

By:

Zhou, Shufeng;
Paxton, James W.;
Kestell, Philip;
Tingle, Malcolm D.

Publication type:

Article

Metabolic interactions with piperazine-based 'party pill' drugs.

Published in:

Journal of Pharmacy & Pharmacology, 2009, v. 61, n. 7, p. 877, doi. 10.1211/jpp/61.07.0006

By:

Ushtana Antia;
Malcolm Tingle;
Bruce Russell

Publication type:

Article

Validation of an LC–MS Method for the Detection and Quantification of BZP and TFMPP and their Hydroxylated Metabolites in Human Plasma and its Application to the Pharmacokinetic Study of TFMPP in Humans.

Published in:

Journal of Forensic Sciences, 2010, v. 55, n. 5, p. 1311, doi. 10.1111/j.1556-4029.2010.01457.x

By:

Antia, Ushtana;
Tingle, Malcolm D.;
Russell, Bruce R.

Publication type:

Article

Ethnic disparity in clozapine dosing and cardiotoxicity in New Zealand.

Published in:

2022

By:

Burns, Kathryn E.;
Bellissima, Brandi L.;
Garavan, Fintan;
Helsby, Nuala A.;
Tingle, Malcolm D.

Publication type:

journal article

A difference between the rat and mouse in the pharmacokinetic interaction of 5,6-dimethylxanthenone-4-acetic acid with thalidomide.

Published in:

Cancer Chemotherapy & Pharmacology, 2001, v. 47, n. 6, p. 541, doi. 10.1007/s002800100285

By:

Shufeng Zhou;
Kestell, Philip;
Tingle, Malcolm D.;
Lai-Ming Ching;
Paxton, James W.

Publication type:

Article

In vitro and in vivo kinetic interactions of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid with thalidomide and diclofenac.

Published in:

Cancer Chemotherapy & Pharmacology, 2001, v. 47, n. 4, p. 319, doi. 10.1007/s002800000249

By:

Shufeng Zhou;
Paxton, James W.;
Kestell, Philip;
Tingle, Malcolm D.;
Lai-Ming Ching

Publication type:

Article

The importance of correct assignment of CYP2B6 genetic variants with respect to cyclophosphamide metabolizer status.

Published in:

American Journal of Hematology, 2011, v. 86, n. 4, p. 383, doi. 10.1002/ajh.21987

By:

Helsby, Nuala;
Tingle, Malcolm

Publication type:

Article

Pharmacokinetics of cytisine, an α<sub>4</sub>β<sub>2</sub> nicotinic receptor partial agonist, in healthy smokers following a single dose.

Published in:

Drug Testing & Analysis, 2015, v. 7, n. 6, p. 475, doi. 10.1002/dta.1707

By:

Jeong, Soo Hee;
Newcombe, David;
Sheridan, Janie;
Tingle, Malcolm

Publication type:

Article