Works by Mahrhold, Stefan

Results: 15

Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1‐SV2 plasma membrane nanocluster for synaptic vesicle entry.

Published in:

EMBO Journal, 2023, v. 42, n. 13, p. 1, doi. 10.15252/embj.2022112095

By:

Joensuu, Merja;
Syed, Parnayan;
Saber, Saber H;
Lanoue, Vanessa;
Wallis, Tristan P;
Rae, James;
Blum, Ailisa;
Gormal, Rachel S;
Small, Christopher;
Sanders, Shanley;
Jiang, Anmin;
Mahrhold, Stefan;
Krez, Nadja;
Cousin, Michael A;
Cooper‐White, Ruby;
Cooper‐White, Justin J;
Collins, Brett M;
Parton, Robert G;
Balistreri, Giuseppe;
Rummel, Andreas

Publication type:

Article

The H<sub>CC</sub>-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction.

Published in:

Molecular Microbiology, 2004, v. 51, n. 3, p. 631, doi. 10.1046/j.1365-2958.2003.03872.x

By:

Rummel, Andreas;
Mahrhold, Stefan;
Bigalke, Hans;
Binz, Thomas

Publication type:

Article

Innovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies.

Published in:

Toxins, 2021, v. 13, n. 4, p. 266, doi. 10.3390/toxins13040266

By:

Neumann, Thea;
Krüger, Maren;
Weisemann, Jasmin;
Mahrhold, Stefan;
Stern, Daniel;
Dorner, Martin B.;
Feraudet-Tarisse, Cécile;
Pöhlmann, Christopher;
Schulz, Katharina;
Messelhäußer, Ute;
Rimek, Dagmar;
Gessler, Frank;
Elßner, Thomas;
Simon, Stéphanie;
Rummel, Andreas;
Dorner, Brigitte G.

Publication type:

Article

The 25 kDa H CN Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity.

Published in:

Toxins, 2020, v. 12, n. 12, p. 743, doi. 10.3390/toxins12120743

By:

Deppe, Julian;
Weisemann, Jasmin;
Mahrhold, Stefan;
Rummel, Andreas

Publication type:

Article

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin.

Published in:

Toxins, 2016, v. 8, n. 5, p. 154, doi. 10.3390/toxins8050154

By:

Weisemann, Jasmin;
Stern, Daniel;
Mahrhold, Stefan;
Dorner, Brigitte G.;
Rummel, Andreas

Publication type:

Article

The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.

Published in:

Molecular Microbiology, 2011, v. 81, n. 1, p. 143, doi. 10.1111/j.1365-2958.2011.07682.x

By:

Strotmeier, Jasmin;
Gu, Shenyan;
Jutzi, Stephan;
Mahrhold, Stefan;
Zhou, Jie;
Pich, Andreas;
Eichner, Timo;
Bigalke, Hans;
Rummel, Andreas;
Jin, Rongsheng;
Binz, Thomas

Publication type:

Article

Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1.

Published in:

Biochemical Journal, 2016, v. 473, n. 17, p. 2645, doi. 10.1042/BCJ20160439

By:

Mahrhold, Stefan;
Bergström, Tomas;
Stern, Daniel;
Dorner, Brigitte Gertrud;
Åstot, Crister;
Rummel, Andreas

Publication type:

Article

Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.

Published in:

Biochemical Journal, 2013, v. 453, n. 1, p. 37, doi. 10.1042/BJ20130391

By:

MAHRHOLD, Stefan;
STROTMEIER, Jasmin;
GARCIA-RODRIGUEZ, Consuelo;
Jianlong LOU;
MARKS, James D.;
RUMMEL, Andreas;
BINZ, Thomas

Publication type:

Article

Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-41722-z

By:

von Berg, Laura;
Stern, Daniel;
Pauly, Diana;
Mahrhold, Stefan;
Weisemann, Jasmin;
Jentsch, Lisa;
Hansbauer, Eva-Maria;
Müller, Christian;
Avondet, Marc A.;
Rummel, Andreas;
Dorner, Martin B.;
Dorner, Brigitte G.

Publication type:

Article

Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A.

Published in:

FEBS Letters, 2014, v. 588, n. 7, p. 1087, doi. 10.1016/j.febslet.2014.02.034

By:

Strotmeier, Jasmin;
Mahrhold, Stefan;
Krez, Nadja;
Janzen, Constantin;
Lou, Jianlong;
Marks, James D.;
Binz, Thomas;
Rummel, Andreas

Publication type:

Article

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

Published in:

FEBS Letters, 2013, v. 587, n. 23, p. 3831, doi. 10.1016/j.febslet.2013.10.010

By:

Pirazzini, Marco;
Henke, Tina;
Rossetto, Ornella;
Mahrhold, Stefan;
Krez, Nadja;
Rummel, Andreas;
Montecucco, Cesare;
Binz, Thomas

Publication type:

Article

Exchange of the H<sub>CC</sub> domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin.

Published in:

FEBS Journal, 2011, v. 278, n. 23, p. 4506, doi. 10.1111/j.1742-4658.2011.08196.x

By:

Rummel, Andreas;
Mahrhold, Stefan;
Bigalke, Hans;
Binz, Thomas

Publication type:

Article

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves

Published in:

FEBS Letters, 2006, v. 580, n. 8, p. 2011, doi. 10.1016/j.febslet.2006.02.074

By:

Mahrhold, Stefan;
Rummel, Andreas;
Bigalke, Hans;
Davletov, Bazbek;
Binz, Thomas

Publication type:

Article

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.

Published in:

PLoS Pathogens, 2018, v. 14, n. 5, p. 1, doi. 10.1371/journal.ppat.1007048

By:

Stern, Daniel;
Weisemann, Jasmin;
Le Blanc, Alexander;
von Berg, Laura;
Mahrhold, Stefan;
Piesker, Janett;
Laue, Michael;
Luppa, Peter B.;
Dorner, Martin Bernhard;
Dorner, Brigitte Gertrud;
Rummel, Andreas

Publication type:

Article

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor.

Published in:

Journal of Neurochemistry, 2009, v. 110, n. 6, p. 1942, doi. 10.1111/j.1471-4159.2009.06298.x

By:

Rummel, Andreas;
H#x00E4;fner, Kirstin;
Mahrhold, Stefan;
Darashchonak, Natallia;
Holt, Matthew;
Jahn, Reinhard;
Beermann, Silke;
Karnath, Tino;
Bigalke, Hans;
Binz, Thomas

Publication type:

Article