Works by Mager, Donald E.

Results: 71

In Memoriam: Darrell R. Abernethy 1949–2017.

Published in:

2018

By:

Greenblatt, David J.;
Mager, Donald E.;
Meibohm, Bernd;
Burckart, Gilbert J.

Publication type:

Obituary

Merging Systems Biology with Pharmacodynamics.

Published in:

Science Translational Medicine, 2012, v. 4, n. 126, p. 1, doi. 10.1126/scitranslmed.3003563

By:

Iyengar, Ravi;
Zhao, Shan;
Chung, Seung-Wook;
Mager, Donald E.;
Gallo, James M.

Publication type:

Article

Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer.

Published in:

2020

By:

Greene, Michelle K.;
Chen, Ting;
Robinson, Eifion;
Straubinger, Ninfa L.;
Minx, Charlene;
Chan, Darren K. W.;
Wang, Jun;
Burrows, James F.;
Van Schaeybroeck, Sandra;
Baker, James R.;
Caddick, Stephen;
Longley, Daniel B.;
Mager, Donald E.;
Straubinger, Robert M.;
Chudasama, Vijay;
Scott, Christopher J.

Publication type:

journal article

Pharmacometrics and Systems Pharmacology 2030.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 1, p. 76, doi. 10.1002/cpt.1683

By:

Mentré, France;
Friberg, Lena E.;
Duffull, Stephen;
French, Jonathan;
Lauffenburger, Douglas A.;
Li, Lang;
Mager, Donald E.;
Sinha, Vikram;
Sobie, Eric;
Zhao, Ping

Publication type:

Article

Application of Pharmacokinetic and Pharmacodynamic Analysis to the Development of Liposomal Formulations for Oncology.

Published in:

Pharmaceutics, 2014, v. 6, n. 1, p. 137, doi. 10.3390/pharmaceutics6010137

By:

Ait-Oudhia, Sihem;
Mager, Donald E.;
Straubinger, Robert M.

Publication type:

Article

Rituximab dosing in hematological malignancies: an old question, revisited.

Published in:

2019

By:

Morcos, Peter N.;
Boehnke, Axel;
Valente, Nancy;
Mager, Donald E.

Publication type:

journal article

Quantitative structure–property relationships of camptothecins in humans.

Published in:

2010

By:

Xu C;
Barchet TM;
Mager DE;
Xu, Chao;
Barchet, Thomas M;
Mager, Donald E

Publication type:

journal article

Quantitative structure–property relationships of camptothecins in humans.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 65, n. 2, p. 325, doi. 10.1007/s00280-009-1037-2

By:

Chao Xu;
Barchet, Thomas M.;
Mager, Donald E.

Publication type:

Article

Population Pharmacokinetic Model of N-acetylmannosamine (ManNAc) and N-acetylneuraminic acid (Neu5Ac) in Subjects with GNE Myopathy.

Published in:

Drugs in R&D, 2021, v. 21, n. 2, p. 189, doi. 10.1007/s40268-021-00343-6

By:

Van Wart, Scott;
Mager, Donald E.;
Bednasz, Cindy J.;
Huizing, Marjan;
Carrillo, Nuria

Publication type:

Article

Population Pharmacokinetics and Pharmacodynamics of Carfilzomib in Combination with Rituximab, Ifosfamide, Carboplatin, and Etoposide in Adult Patients with Relapsed/Refractory Diffuse Large B Cell Lymphoma.

Published in:

Targeted Oncology, 2023, v. 18, n. 5, p. 685, doi. 10.1007/s11523-023-00992-4

By:

Lin, Lan-Hsi;
Ghasemi, Mohammad;
Burke, Sarah M.;
Mavis, Cory K.;
Nichols, Jenna R.;
Torka, Pallawi;
Mager, Donald E.;
Hernandez-Ilizaliturri, Francisco J.;
Goey, Andrew K. L.

Publication type:

Article

Testosterone Concentrations in Diabetic and Nondiabetic Obese Men.

Published in:

Diabetes Care, 2010, v. 33, n. 6, p. 1186, doi. 10.2337/dc09-1649

By:

Dhindsa, Sandeep;
Miller, Michael G.;
McWhirter, Cecilia L.;
Mager, Donald E.;
Ghanim, Husam;
Chaudhuri, Ajay;
Dandona, Paresh

Publication type:

Article

Comparison of sequential and joint nonlinear mixed effects modeling of tumor kinetics and survival following Durvalumab treatment in patients with metastatic urothelial carcinoma.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2023, v. 50, n. 4, p. 251, doi. 10.1007/s10928-023-09848-w

By:

Chen, Ting;
Zheng, Yanan;
Roskos, Lorin;
Mager, Donald E.

Publication type:

Article

Accelerating robust plausible virtual patient cohort generation by substituting ODE simulations with parameter space mapping.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2022, v. 49, n. 6, p. 625, doi. 10.1007/s10928-022-09826-8

By:

Derippe, Thibaud;
Fouliard, Sylvain;
Declèves, Xavier;
Mager, Donald E.

Publication type:

Article

Population-based meta-analysis of bortezomib exposure–response relationships in multiple myeloma patients.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2020, v. 47, n. 1, p. 77, doi. 10.1007/s10928-019-09670-3

By:

Zhang, Li;
Mager, Donald E.

Publication type:

Article

Boolean network modeling in systems pharmacology.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 1, p. 159, doi. 10.1007/s10928-017-9567-4

By:

Bloomingdale, Peter;
Nguyen, Van Anh;
Niu, Jin;
Mager, Donald E.

Publication type:

Article

Impact of dose selection on parameter estimation using a rapid binding approximation model of target-mediated drug disposition.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2011, v. 38, n. 2, p. 223, doi. 10.1007/s10928-010-9190-0

By:

Marathe, Anshu;
Van Wart, Scott;
Mager, Donald E.

Publication type:

Article

The impact of tacrolimus exposure on extrarenal adverse effects in adult renal transplant recipients.

Published in:

British Journal of Clinical Pharmacology, 2019, v. 85, n. 3, p. 516, doi. 10.1111/bcp.13811

By:

Campagne, Olivia;
Mager, Donald E.;
Brazeau, Daniel;
Venuto, Rocco C.;
Tornatore, Kathleen M.

Publication type:

Article

Population pharmacokinetics of exenatide.

Published in:

British Journal of Clinical Pharmacology, 2017, v. 83, n. 3, p. 517, doi. 10.1111/bcp.13135

By:

Cirincione, Brenda;
Mager, Donald E.

Publication type:

Article

Systems model identifies baseline cytokine concentrations as potential predictors of rheumatoid arthritis inflammatory response to biologics.

Published in:

British Journal of Pharmacology, 2022, v. 179, n. 16, p. 4063, doi. 10.1111/bph.15845

By:

Nakada, Tomohisa;
Mager, Donald E.

Publication type:

Article

PKPD modelling to predict altered disposition of 1α,25-dihydroxyvitamin D3 in mice due to dose-dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation.

Published in:

2015

By:

Quach, Holly P;
Yang, Qi J;
Chow, Edwin C;
Mager, Donald E;
Hoi, Stacie Y;
Pang, K Sandy

Publication type:

journal article

PKPD modelling to predict altered disposition of 1α,25-dihydroxyvitamin D<sub>3</sub> in mice due to dose-dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation.

Published in:

British Journal of Pharmacology, 2015, v. 172, n. 14, p. 3611, doi. 10.1111/bph.13153

By:

Quach, Holly P;
Yang, Qi J;
Chow, Edwin C;
Mager, Donald E;
Hoi, Stacie Y;
Pang, K Sandy

Publication type:

Article

Pharmaceutical Sciences: Insights and Observations from Academic Chairs and Vice Chairs.

Published in:

AAPS Journal, 2025, v. 27, n. 1, p. 1, doi. 10.1208/s12248-025-01026-9

By:

Ainslie, Kristy M.;
Bowers, Albert A;
Chichewicz, Robert H.;
Collier, Lara S.;
Doorn, Jonathan A.;
Frei, Christopher R.;
Ghandehari, Hamidreza;
Gibbs, Robert B.;
Lawrence, David S.;
Lee, Craig R.;
Mager, Donald E.;
Marker, Paul;
Schwendeman, Anna;
Suryanarayanan, Raj;
Williams III, Robert O.;
Xi, Yaguang;
Xie, Wen;
Xie, Xiang-Qun;
Zhu, Guizhi;
Nguyen, Juliane

Publication type:

Article

FOLFIRINOX Pharmacodynamic Interactions in 2D and 3D Pancreatic Cancer Cell Cultures.

Published in:

AAPS Journal, 2022, v. 24, n. 6, p. 1, doi. 10.1208/s12248-022-00752-8

By:

Allen-Coyle, Taylor J.;
Niu, Jin;
Welsch, Eva;
Conlon, Neil T.;
Garner, Weylon;
Clynes, Martin;
O'Sullivan, Finbarr;
Straubinger, Robert M.;
Mager, Donald E.;
Roche, Sandra

Publication type:

Article

Cluster Gauss–Newton and CellNOpt Parameter Estimation in a Small Protein Signaling Network of Vorinostat and Bortezomib Pharmacodynamics.

Published in:

AAPS Journal, 2021, v. 23, n. 6, p. 1, doi. 10.1208/s12248-021-00640-7

By:

Niu, Jin;
Nguyen, Van Anh;
Ghasemi, Mohammad;
Chen, Ting;
Mager, Donald E.

Publication type:

Article

Network-Based Systems Analysis Explains Sequence-Dependent Synergism of Bortezomib and Vorinostat in Multiple Myeloma.

Published in:

AAPS Journal, 2021, v. 23, n. 5, p. 1, doi. 10.1208/s12248-021-00622-9

By:

Nanavati, Charvi;
Mager, Donald E.

Publication type:

Article

Race-specific coregulatory and transcriptomic profiles associated with DNA methylation and androgen receptor in prostate cancer.

Published in:

Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01323-6

By:

Ramakrishnan, Swathi;
Cortes-Gomez, Eduardo;
Athans, Sarah R.;
Attwood, Kristopher M.;
Rosario, Spencer R.;
Kim, Se Jin;
Mager, Donald E.;
Isenhart, Emily G.;
Hu, Qiang;
Wang, Jianmin;
Woloszynska, Anna

Publication type:

Article

Machine Learning Models for the Prediction of Chemotherapy-Induced Peripheral Neuropathy.

Published in:

Pharmaceutical Research, 2019, v. 36, n. 2, p. 1, doi. 10.1007/s11095-018-2562-7

By:

Bloomingdale, Peter;
Mager, Donald E.

Publication type:

Article

Interspecies Scaling of Receptor-Mediated Pharmacokinetics and Pharmacodynamics of Type I Interferons.

Published in:

Pharmaceutical Research, 2010, v. 27, n. 5, p. 920, doi. 10.1007/s11095-010-0098-6

By:

Kagan, Leonid;
Abraham, Anson K.;
Harrold, John M.;
Mager, Donald E.

Publication type:

Article

Immunosuppressant adherence in adult outpatient hematopoietic cell transplant recipients.

Published in:

Journal of Oncology Pharmacy Practice, 2024, v. 30, n. 2, p. 322, doi. 10.1177/10781552231171607

By:

McCune, Jeannine S;
Armenian, Saro H;
Nakamura, Ryotaro;
Shan, Haoyue;
Kanakry, Christopher G;
Mielcarek, Marco;
Gao, Wei;
Mager, Donald E

Publication type:

Article

Factor VIII associated with lipidic nanoparticles retains efficacy in the presence of anti-factor VIII antibodies in hemophilia A mice.

Published in:

Biopharmaceutics & Drug Disposition, 2016, v. 37, n. 7, p. 409, doi. 10.1002/bdd.2023

By:

Shetty, Krithika A.;
Kosloski, Matthew P.;
Mager, Donald E.;
Balu‐Iyer, Sathy V.

Publication type:

Article

Effects of hypertonic buffer composition on lymph node uptake and bioavailability of rituximab, after subcutaneous administration.

Published in:

Biopharmaceutics & Drug Disposition, 2015, v. 36, n. 2, p. 115, doi. 10.1002/bdd.1925

By:

Fathallah, Anas M.;
Turner, Michael R.;
Mager, Donald E.;
Balu‐Iyer, Sathy V.

Publication type:

Article

Nonlinear pharmacokinetics of factor VIII and its phosphatidylinositol lipidic complex in hemophilia A mice.

Published in:

Biopharmaceutics & Drug Disposition, 2014, v. 35, n. 3, p. 154, doi. 10.1002/bdd.1880

By:

Kosloski, Matthew P.;
Pisal, Dipak S.;
Mager, Donald E.;
Balu‐Iyer, Sathy V.

Publication type:

Article

Population-based meta-analysis of furosemide pharmacokinetics.

Published in:

Biopharmaceutics & Drug Disposition, 2014, v. 35, n. 2, p. 119, doi. 10.1002/bdd.1874

By:

Van Wart, Scott A.;
Shoaf, Susan E.;
Mallikaarjun, Suresh;
Mager, Donald E.

Publication type:

Article

Population-based meta-analysis of hydrochlorothiazide pharmacokinetics.

Published in:

Biopharmaceutics & Drug Disposition, 2013, v. 34, n. 9, p. 527, doi. 10.1002/bdd.1863

By:

Van Wart, Scott A.;
Shoaf, Susan E.;
Mallikaarjun, Suresh;
Mager, Donald E.

Publication type:

Article

Population pharmacokinetics of tolvaptan in healthy subjects and patients with hyponatremia secondary to congestive heart failure or hepatic cirrhosis.

Published in:

Biopharmaceutics & Drug Disposition, 2013, v. 34, n. 6, p. 336, doi. 10.1002/bdd.1849

By:

Van Wart, Scott A.;
Shoaf, Susan E.;
Mallikaarjun, Suresh;
Mager, Donald E.

Publication type:

Article

Integrated model for denosumab and ibandronate pharmacodynamics in postmenopausal women.

Published in:

Biopharmaceutics & Drug Disposition, 2011, v. 32, n. 8, p. 471, doi. 10.1002/bdd.770

By:

Marathe, Dhananjay D.;
Marathe, Anshu;
Mager, Donald E.

Publication type:

Article

Systems Pharmacology Modeling Identifies a Novel Treatment Strategy for Bortezomib-Induced Neuropathic Pain.

Published in:

Frontiers in Pharmacology, 2022, v. 12, p. 1, doi. 10.3389/fphar.2021.817236

By:

Bloomingdale, Peter;
Meregalli, Cristina;
Pollard, Kevin;
Canta, Annalisa;
Chiorazzi, Alessia;
Fumagalli, Giulia;
Monza, Laura;
Pozzi, Eleonora;
Alberti, Paola;
Ballarini, Elisa;
Oggioni, Norberto;
Carlson, Louise;
Liu, Wensheng;
Ghandili, Mehrnoosh;
Ignatowski, Tracey A.;
Lee, Kelvin P.;
Moore, Michael J.;
Cavaletti, Guido;
Mager, Donald E.

Publication type:

Article

Population Pharmacodynamic Modelling of Aspirin- and Ibuprofen-Induced Inhibition of Platelet Aggregation in Healthy Subjects.

Published in:

Clinical Pharmacokinetics, 2008, v. 47, n. 2, p. 129, doi. 10.2165/00003088-200847020-00006

By:

Ying Hong;
Gengo, Fran M.;
Rainka, Michelle M.;
Bates, Vernice E.;
Mager, Donald E.

Publication type:

Article

Enantioselective pharmacokinetics of ( R)- and ( S)-ketamine after a 5-day infusion in patients with complex regional pain syndrome.

Published in:

Chirality, 2011, v. 23, n. 2, p. 138, doi. 10.1002/chir.20890

By:

Goldberg, Michael E.;
Torjman, Marc C.;
Schwartzman, Robert J.;
Mager, Donald E.;
Wainer, Irving W.

Publication type:

Article

Pharmacokinetics and Toxicodynamics of Pralidoxime Effects on Paraoxon-Induced Respiratory Toxicity.

Published in:

Toxicological Sciences, 2010, v. 116, n. 2, p. 660, doi. 10.1093/toxsci/kfq152

By:

Houzé, Pascal;
Mager, Donald E.;
Risède, Patricia;
Baud, Frédéric J.

Publication type:

Article

Immune regulatory adjuvant approach to mitigate subcutaneous immunogenicity of monoclonal antibodies.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1496169

By:

Jarvi, Nicole L.;
Patel, Manali;
Shetty, Krithika A.;
Nguyen, Nhan H.;
Grasperge, Brooke F.;
Mager, Donald E.;
Straubinger, Robert M.;
Balu-Iyer, Sathy V.

Publication type:

Article

Challenges with sirolimus experimental data to inform QSP model of post‐transplantation cyclophosphamide regimens.

Published in:

CTS: Clinical & Translational Science, 2024, v. 17, n. 8, p. 1, doi. 10.1111/cts.70014

By:

Mohanan, Ezhilpavai;
Shen, Guofang;
Ren, Suping;
Fan, Hsuan‐Hao;
Moua, Kao Tang Ying;
Karolak, Aleksandra;
Rockne, Russell C.;
Nakamura, Ryotaro;
Horne, David A.;
Kanakry, Christopher G.;
Mager, Donald E.;
McCune, Jeannine S.

Publication type:

Article

Safety and pharmacokinetics of docetaxel in combination with pegvorhyaluronidase alfa in patients with non‐small cell lung cancer.

Published in:

CTS: Clinical & Translational Science, 2021, v. 14, n. 5, p. 1875, doi. 10.1111/cts.13041

By:

Heineman, Thomas;
Baumgart, Megan;
Nanavati, Charvi;
Gabrail, Nash;
Van Wart, Scott A.;
Mager, Donald E.;
Maneval, Daniel C.;
Fathallah, Anas M.;
Sekulovich, Rose E.

Publication type:

Article

Evaluation of the performance of a prior tacrolimus population pharmacokinetic kidney transplant model among adult allogeneic hematopoietic stem cell transplant patients.

Published in:

CTS: Clinical & Translational Science, 2021, v. 14, n. 3, p. 908, doi. 10.1111/cts.12956

By:

Zhu, Jing;
Campagne, Olivia;
Torrice, Chad D.;
Flynn, Gabrielle;
Miller, Jordan A.;
Patel, Tejendra;
Suzuki, Oscar;
Ptachcinski, Jonathan R.;
Armistead, Paul M.;
Wiltshire, Tim;
Mager, Donald E.;
Weiner, Daniel L.;
Crona, Daniel J.

Publication type:

Article

Pharmacodynamic modeling of synergistic birinapant/paclitaxel interactions in pancreatic cancer cells.

Published in:

2020

By:

Niu, Jin;
Wang, Xue;
Qu, Jun;
Mager, Donald E.;
Straubinger, Robert M.

Publication type:

journal article

Inter-Antibody Variability in the Clinical Pharmacokinetics of Monoclonal Antibodies Characterized Using Population Physiologically Based Pharmacokinetic Modeling.

Published in:

Antibodies (2073-4468), 2024, v. 13, n. 3, p. 54, doi. 10.3390/antib13030054

By:

Kumar, Mokshada;
Lanke, Sravani;
Yadav, Alka;
Ette, Mfonabasi;
Mager, Donald E.;
Shah, Dhaval K.

Publication type:

Article

Editorial: Model-informed decision making in the preclinical stages of pharmaceutical research and development.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2023.1184914

By:

Rui Li;
Craig, Morgan;
D’Argenio, David Z.;
Betts, Alison;
Mager, Donald E.;
Maurer, Tristan S.

Publication type:

Article

Dynamic Model of Platelet Lifespan in Adult and Newborn Mice.

Published in:

FASEB Journal, 2013, v. 27, p. lb535, doi. 10.1096/fasebj.27.1_supplement.lb535

By:

Ait‐Oudhia, Sihem;
Mager, Donald E.;
Liu, Zhi‐Jian;
Veng‐Pedersen, Peter;
Sola‐Visner, Martha

Publication type:

Article

Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats.

Published in:

FASEB Journal, 2006, v. 20, n. 6, p. 631, doi. 10.1096/fj.05-5263com

By:

Mager, Donald E.;
Ruiqian Wan;
Brown, Martin;
Aiwu Cheng;
Wareski, Przemyslaw;
Abernethy, Darrell R.;
Mattson, Mark P.

Publication type:

Article

Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression.

Published in:

British Journal of Clinical Pharmacology, 2012, v. 74, n. 2, p. 304, doi. 10.1111/j.1365-2125.2012.04198.x

By:

Zhao, Xiaochen;
Venkata, Swarajya Lakshmi Vattem;
Moaddel, Ruin;
Luckenbaugh, Dave A.;
Brutsche, Nancy E.;
Ibrahim, Lobna;
Zarate Jr, Carlos A.;
Mager, Donald E.;
Wainer, Irving W.

Publication type:

Article