Works by Maechler, Pierre

Results: 55

Correction to: Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase.

Published in:

2021

By:

Luczkowska, Karolina;
Stekelenburg, Caroline;
Sloan-Béna, Frédérique;
Ranza, Emmanuelle;
Gastaldi, Giacomo;
Schwitzgebel, Valérie;
Maechler, Pierre

Publication type:

Correction Notice

Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase.

Published in:

Human Genomics, 2020, v. 14, n. 1, p. 1, doi. 10.1186/s40246-020-00262-8

By:

Luczkowska, Karolina;
Stekelenburg, Caroline;
Sloan-Béna, Frédérique;
Ranza, Emmanuelle;
Gastaldi, Giacomo;
Schwitzgebel, Valérie;
Maechler, Pierre

Publication type:

Article

Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.

Published in:

Frontiers in Neuroscience, 2021, p. 1, doi. 10.3389/fnins.2021.646291

By:

Voss, Caroline M.;
Arildsen, Lene;
Nissen, Jakob D.;
Waagepetersen, Helle S.;
Schousboe, Arne;
Maechler, Pierre;
Ott, Peter;
Vilstrup, Hendrik;
Walls, Anne B.

Publication type:

Article

Molecular targets of a human HNF1a mutation responsible for pancreatic ß-cell dysfunction.

Published in:

EMBO Journal, 2000, v. 19, n. 16, p. 4257, doi. 10.1093/emboj/19.16.4257

By:

Haiyan Wang;
Antinozzi, Peter A.;
Hagenfeldt, Kerstin A.;
Maechler, Pierre;
Wollheim, Claes B.

Publication type:

Article

Dominant-negative suppression of HNF-1a function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic ß-cell line.

Published in:

EMBO Journal, 1998, v. 17, n. 22, p. 6701, doi. 10.1093/emboj/17.22.6701

By:

Haiyan Wang;
Maechler, Pierre;
Hagenfeldt, Kerstin A.;
Wollheim, Claes B.

Publication type:

Article

Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic ß-cells.

Published in:

EMBO Journal, 1997, v. 16, n. 13, p. 3833, doi. 10.1093/emboj/16.13.3833

By:

Maechler, Pierre;
Kennedy, Eleanor D.;
Pozzan, Tullio;
Wollheim, Claes B.

Publication type:

Article

In Situ Assessment of Hepatic Glutamate Dehydrogenase Activity Provides Novel Insights into Amino Acid Metabolism.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02338

By:

Zhou, Yan;
Luczkowska, Karolina;
Maechler, Pierre

Publication type:

Article

Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27133-7

By:

Stojanović, Ozren;
Altirriba, Jordi;
Rigo, Dorothée;
Spiljar, Martina;
Evrard, Emilien;
Roska, Benedek;
Fabbiano, Salvatore;
Zamboni, Nicola;
Maechler, Pierre;
Rohner-Jeanrenaud, Françoise;
Trajkovski, Mirko

Publication type:

Article

Role of mitochondria in metabolism-secretion coupling of insulin release in the pancreatic Beta-cell.

Published in:

Biofactors, 1998, v. 8, n. 3/4, p. 255, doi. 10.1002/biof.5520080313

By:

Maechler, Pierre;
Wollheim, Claes B.

Publication type:

Article

Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2018, v. 38, n. 10, p. 1754, doi. 10.1177/0271678X17714680

By:

Hohnholt, Michaela C.;
Andersen, Vibe H.;
Andersen, Jens V.;
Christensen, Sofie K.;
Karaca, Melis;
Maechler, Pierre;
Waagepetersen, Helle S.

Publication type:

Article

Hepatic glucose sensing is required to preserve β cell glucose competence.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 4, p. 1662, doi. 10.1172/JCI65538

By:

Seyer, Pascal;
Vallois, David;
Poitry-Yamate, Carole;
Schütz, Frédéric;
Metref, Salima;
Tarussio, David;
Maechler, Pierre;
Staels, Bart;
Lanz, Bernard;
Grueter, Rolf;
Decaris, Julie;
Turner, Scott;
da Costa, Anabela;
Preitner, Frédéric;
Minehira, Kaori;
Foretz, Marc;
Thorens, Bernard

Publication type:

Article

Loss of Nexmif results in the expression of phenotypic variability and loss of genomic integrity.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-17845-1

By:

Stekelenburg, Caroline;
Blouin, Jean-Louis;
Santoni, Federico;
Zaghloul, Norann;
O'Hare, Elisabeth A.;
Dusaulcy, Rodolphe;
Maechler, Pierre;
Schwitzgebel, Valerie M.

Publication type:

Article

Glutamate Dehydrogenase–Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction.

Published in:

Schizophrenia Bulletin, 2019, v. 45, n. 1, p. 127, doi. 10.1093/schbul/sby011

By:

Lander, Sharon S;
Khan, Usman;
Lewandowski, Nicole;
Chakraborty, Darpan;
Provenzano, Frank A;
Mingote, Susana;
Chornyy, Sergiy;
Frigerio, Francesca;
Maechler, Pierre;
Kaphzan, Hanoch;
Small, Scott A;
Rayport, Stephen;
Gaisler-Salomon, Inna

Publication type:

Article

Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 1, p. 324, doi. 10.3390/ijms23010324

By:

Oberhauser, Lucie;
Maechler, Pierre

Publication type:

Article

AMPK Profiling in Rodent and Human Pancreatic Beta-Cells under Nutrient-Rich Metabolic Stress.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 11, p. 3982, doi. 10.3390/ijms21113982

By:

Brun, Thierry;
Jiménez-Sánchez, Cecilia;
Madsen, Jesper Grud Skat;
Hadadi, Noushin;
Duhamel, Dominique;
Bartley, Clarissa;
Oberhauser, Lucie;
Trajkovski, Mirko;
Mandrup, Susanne;
Maechler, Pierre

Publication type:

Article

Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell.

Published in:

Journal of Physiology, 2000, v. 529, n. 1, p. 49, doi. 10.1111/j.1469-7793.2000.00049.x

By:

Maechler, Pierre;
Wollheim, Claes B.

Publication type:

Article

Development of Mice with Brain-Specific Deletion of Floxed Glud1 (Glutamate Dehydrogenase 1) Using Cre Recombinase Driven by the Nestin Promoter.

Published in:

Neurochemical Research, 2014, v. 39, n. 3, p. 456, doi. 10.1007/s11064-013-1041-0

By:

Karaca, Melis;
Maechler, Pierre

Publication type:

Article

Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.

Published in:

Acta Diabetologica, 2013, v. 50, n. 1, p. 61, doi. 10.1007/s00592-012-0381-6

By:

Russo, Lucia;
Marsella, Claudia;
Nardo, Giovanni;
Massignan, Tania;
Alessio, Massimo;
Piermarini, Emanuela;
La Rosa, Stefano;
Finzi, Giovanna;
Bonetto, Valentina;
Bertuzzi, Federico;
Maechler, Pierre;
Massa, Ornella

Publication type:

Article

Mitochondrial activation and the pyruvate paradox in a human cell line

Published in:

FEBS Letters, 2004, v. 578, n. 3, p. 224, doi. 10.1016/j.febslet.2004.10.088

By:

de Andrade, Paula B.M.;
Casimir, Marina;
Maechler, Pierre

Publication type:

Article

Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion

Published in:

FEBS Letters, 2003, v. 545, n. 2/3, p. 167, doi. 10.1016/S0014-5793(03)00526-X

By:

Broca, Christophe;
Brennan, Lorraine;
Petit, Pierre;
Newsholme, Philip;
Maechler, Pierre

Publication type:

Article

Brain endothelial cells metabolize glutamate via glutamate dehydrogenase to replenish TCA‐intermediates and produce ATP under hypoglycemic conditions.

Published in:

Journal of Neurochemistry, 2021, v. 157, n. 6, p. 1861, doi. 10.1111/jnc.15207

By:

Hinca, Sven B.;
Salcedo, Claudia;
Wagner, Antonie;
Goldeman, Charlotte;
Sadat, Edris;
Aibar, Marco M.D.;
Maechler, Pierre;
Brodin, Birger;
Aldana, Blanca I.;
Helms, Hans C.C.

Publication type:

Article

Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion.

Published in:

Pflügers Archiv: European Journal of Physiology, 2019, v. 471, n. 2, p. 337, doi. 10.1007/s00424-018-2215-z

By:

Casimir, Marina;
Chaffard, Gaelle;
Maechler, Pierre

Publication type:

Article

Mitochondrial Carriers Regulating Insulin Secretion Profiled in Human Islets upon Metabolic Stress.

Published in:

Biomolecules (2218-273X), 2020, v. 10, n. 11, p. 1543, doi. 10.3390/biom10111543

By:

Jimenez-Sánchez, Cecilia;
Brun, Thierry;
Maechler, Pierre

Publication type:

Article

AMP‐activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics.

Published in:

Glia (0894-1491), 2020, v. 68, n. 9, p. 1824, doi. 10.1002/glia.23808

By:

Voss, Caroline M.;
Andersen, Jens V.;
Jakobsen, Emil;
Siamka, Olga;
Karaca, Melis;
Maechler, Pierre;
Waagepetersen, Helle S.

Publication type:

Article

Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?

Published in:

Nature Medicine, 2015, v. 21, n. 4, p. 310, doi. 10.1038/nm.3835

By:

Wollheim, Claes B;
Maechler, Pierre

Publication type:

Article

Energy balance impairment in mice with Central Nervous System specific glutamate dehydrogenase knockout.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1042, doi. 10.1096/fasebj.21.6.a1042

By:

Frigerio, Francesca;
Carobbio, Stefania;
Gruetter, Rolf;
Maechler, Pierre

Publication type:

Article

Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression.

Published in:

2017

By:

Brun, Julia;
Berthou, Flavien;
Trajkovski, Mirko;
Maechler, Pierre;
Foti, Michanlegelo;
Bonnet, Nicolas

Publication type:

journal article

Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes Development.

Published in:

Diabetes, 2013, v. 62, n. 10, p. 3488, doi. 10.2337/db13-0152

By:

Supale, Sachin;
Thorel, Fabrizio;
Merkwirth, Carsten;
Gjinovci, Asllan;
Herrera, Pedro L.;
Scorrano, Luca;
Meda, Paolo;
Langer, Thomas;
Maechler, Pierre

Publication type:

Article

NADPH Oxidase NOX2 Defines a New Antagonistic Role for Reactive Oxygen Species and cAMP/PKA in the Regulation of Insulin Secretion.

Published in:

Diabetes, 2012, v. 61, n. 11, p. 2842, doi. 10.2337/db12-0009

By:

Ning Li;
Bin Li;
Brun, Thierry;
Deffert-Delbouille, Christine;
Mahiout, Zahia;
Daali, Youssef;
Xiao-Juan Ma;
Krause, Karl-Heinz;
Maechler, Pierre

Publication type:

Article

Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.

Published in:

2005

By:

Herrero, Laura;
Rubí, Blanca;
Sebastián, David;
Serra, Dolors;
Asins, Guillermina;
Maechler, Pierre;
Prentki, Marc;
Hegardt, Fausto G.;
Rubí, Blanca;
Sebastián, David

Publication type:

journal article

Inhibition of Mitochondrial Na[sup+] -Ca[sup2+] Exchanger Increases Mitochondrial Metabolism and Potentiates Glucose-Stimulated Insulin Secretion in Rat Pancreatic Islets.

Published in:

Diabetes, 2003, v. 52, n. 4, p. 965, doi. 10.2337/diabetes.52.4.965

By:

Lee, Bumsup;
Miles, Philip D.;
Vargas, Leonardo;
Luan, Peng;
Glasco, Susan;
Kushnareva, Yulia;
Kornbrust, Elisabeth S.;
Grako, Kathryn A.;
Wollheim, Claes B.;
Maechler, Pierre;
Olefsky, Jerrold M.;
Anderson, Christen M.

Publication type:

Article

Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites.

Published in:

2002

By:

Wollheim, Claes B;
Maechler, Pierre

Publication type:

journal article

Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas.

Published in:

2002

By:

Maechler, Pierre;
Gjinovci, Asllan;
Wollheim, Claes B.

Publication type:

journal article

β-Cell Mitochondria and Insulin Secretion.

Published in:

Diabetes, 2002, v. 51, p. S37, doi. 10.2337/diabetes.51.2007.S37

By:

Wollheim, Claes B.;
Maechler, Pierre

Publication type:

Article

Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells.

Published in:

1998

By:

Kennedy, Eleanor D.;
Maechler, Pierre;
Wollheim, Claes B.;
Kennedy, E D;
Maechler, P;
Wollheim, C B

Publication type:

journal article

Deletion of glutamate dehydrogenase 1 ( Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.

Published in:

Journal of Neurochemistry, 2012, v. 123, n. 3, p. 342, doi. 10.1111/j.1471-4159.2012.07933.x

By:

Frigerio, Francesca;
Karaca, Melis;
Roo, Mathias;
Mlynárik, Vladimír;
Skytt, Dorte M.;
Carobbio, Stefania;
Pajęcka, Kamilla;
Waagepetersen, Helle S.;
Gruetter, Rolf;
Muller, Dominique;
Maechler, Pierre

Publication type:

Article

Vesicular storage and secretion ofl-glutamate from glucagon-like peptide 1-secreting clonal intestinal L cells.

Published in:

Journal of Neurochemistry, 2006, v. 96, n. 2, p. 550, doi. 10.1111/j.1471-4159.2005.03575.x

By:

Uehara, Shunsuke;
Jung, Sun-Kyung;
Morimoto, Riyo;
Arioka, Shigeo;
Miyaji, Takaaki;
Juge, Narinobu;
Hiasa, Miki;
Shimizu, Kahori;
Ishimura, Akinori;
Otsuka, Masato;
Yamamoto, Akitsugu;
Maechler, Pierre;
Moriyama, Yoshinori

Publication type:

Article

Mitochondrial function in normal and diabetic Beta-cells.

Published in:

Nature, 2001, v. 414, n. 6865, p. 807, doi. 10.1038/414807a

By:

Maechler, Pierre;
Wollheim, B.

Publication type:

Article

Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.

Published in:

Nature, 1999, v. 402, n. 6762, p. 685, doi. 10.1038/45280

By:

Maechler, Pierre;
Wollheim, Claes B.

Publication type:

Article

Islet B-cell secretion determines glucagon release from neighbouring a-cells.

Published in:

Nature Cell Biology, 2003, v. 5, n. 4, p. 330, doi. 10.1038/ncb951

By:

Ishihara, Hisamitsu;
Maechler, Pierre;
Gjinovci, Asllan;
Herrera, Pedro-Luis;
Wollheim, Claes B.

Publication type:

Article

Modulation of Glutamate Generation in Mitochondria Affects Hormone Secretion in INS-1E Beta Cells.

Published in:

IUBMB Life, 2000, v. 50, n. 1, p. 27, doi. 10.1080/15216540050176557

By:

Maechler, Pierre;
Antinozzi, Peter A.;
Wollheim, Claes B.

Publication type:

Article

Changes in Mitochondrial Carriers Exhibit Stress-Specific Signatures in INS-1Eβ-Cells Exposed to Glucose Versus Fatty Acids.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0082364

By:

Brun, Thierry;
Scarcia, Pasquale;
Li, Ning;
Gaudet, Pascale;
Duhamel, Dominique;
Palmieri, Ferdinando;
Maechler, Pierre

Publication type:

Article

Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA.

Published in:

PLoS ONE, 2008, v. 3, n. 9, p. 1, doi. 10.1371/journal.pone.0003257

By:

Parone, Philippe A.;
da Cruz, Sandrine;
Tondera, Daniel;
Mattenberger, Yves;
James, Dominic I.;
Maechler, Pierre;
Barja, François;
Martinou, Jean-Claude

Publication type:

Article

The Effect of a Lipid Surface Coating on the Permeation of Upconverting Nanoparticles through a 3D Human Lung Epithelial Model.

Published in:

Advanced Functional Materials, 2024, v. 34, n. 11, p. 1, doi. 10.1002/adfm.202310078

By:

Kim, Doyoung;
Mandl, Gabrielle A.;
Balkota, Marta;
Vernaz, Jimmy;
Huang, Song;
Constant, Samuel;
Maechler, Pierre;
DeWolf, Christine;
Capobianco, John A.;
Bonacina, Luigi

Publication type:

Article

Increase in cellular glutamate levels stimulates exocytosis in pancreatic β-cells

Published in:

FEBS Letters, 2002, v. 531, n. 2, p. 199, doi. 10.1016/S0014-5793(02)03500-7

By:

Høy, Marianne;
Maechler, Pierre;
Efanov, Alexander M.;
Wollheim, Claes B.;
Berggren, Per-Olof;
Gromada, Jesper

Publication type:

Article

Lysophosphatidylinositols Are Upregulated After Human β-Cell Loss and Potentiate Insulin Release.

Published in:

Diabetes, 2024, v. 73, n. 1, p. 93, doi. 10.2337/db23-0205

By:

Jiménez-Sánchez, Cecilia;
Sinturel, Flore;
Mezza, Teresa;
Loizides-Mangold, Ursula;
Montoya, Jonathan Paz;
Li, Lingzi;
Di Giuseppe, Gianfranco;
Quero, Giuseppe;
Guessous, Idris;
Jornayvaz, François;
Schrauwen, Patrick;
Stenvers, Dirk Jan;
Alfieri, Sergio;
Giaccari, Andrea;
Berishvili, Ekaterine;
Compagnon, Philippe;
Bosco, Domenico;
Riezman, Howard;
Dibner, Charna;
Maechler, Pierre

Publication type:

Article

Metabolomics Identifies a Biomarker Revealing In Vivo Loss of Functional β-Cell Mass Before Diabetes Onset.

Published in:

2019

By:

Li, Lingzi;
Krznar, Petra;
Erban, Alexander;
Agazzi, Andrea;
Martin-Levilain, Juliette;
Supale, Sachin;
Kopka, Joachim;
Zamboni, Nicola;
Maechler, Pierre

Publication type:

journal article

Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis.

Published in:

2018

By:

Dizin, Eva;
Karaca, Melis;
Martin-Levilain, Juliette;
Grimaldi, Mariagrazia;
Li, Lingzi;
Maechler, Pierre;
Emre, Yalin

Publication type:

journal article

A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes.

Published in:

2011

By:

Casimir, Marina;
de Andrade, Paula B.;
Gjinovci, Asllan;
Montani, Jean-Pierre;
Maechler, Pierre;
Dulloo, Abdul G.

Publication type:

Journal Article

A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes.

Published in:

Nutrition & Metabolism, 2011, v. 8, n. 1, p. 1, doi. 10.1186/1743-7075-8-2

By:

Casimir, Marina;
de Andrade, Paula B.;
Gjinovci, Asllan;
Montani, Jean-Pierre;
Maechler, Pierre;
Dulloo, Abdul G.

Publication type:

Article