Works by Machius, Mischa

Results: 19

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer.

Published in:

PLoS Biology, 2008, v. 6, n. 3, p. e50, doi. 10.1371/journal.pbio.0060050

By:

Maojun Yang;
Bing Li;
Chyong-Jy Liu;
Tomchick, Diana R;
Machius, Mischa;
Rizo, Josep;
Hongtao Yu;
Xuelian Luo

Publication type:

Article

Structural Basis for a Munc13-1 Homodimer to Munc13-1/RIM Heterodimer Switch.

Published in:

PLoS Biology, 2006, v. 4, n. 7, p. e192, doi. 10.1371/journal.pbio.0040192

By:

Lu, Jun;
Machius, Mischa;
Dulubova, Irina;
Han Dai;
Südhof, Thomas C.;
Tomchick, Diana R.;
Rizo, Josep

Publication type:

Article

Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain.

Published in:

Nature, 2005, v. 433, n. 7025, p. 488, doi. 10.1038/nature03251

By:

Otomo, Takanori;
Tomchick, Diana R.;
Otomo, Chinatsu;
Panchal, Sanjay C.;
Machius, Mischa;
Rosen, Michael K.

Publication type:

Article

Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.

Published in:

Molecular Human Reproduction, 2016, v. 22, n. 6, p. 410, doi. 10.1093/molehr/gaw016

By:

Danshina, Polina V.;
Weidong Qu;
Temple, Brenda R.;
Rojas, Rafael J.;
Miley, Michael J.;
Machius, Mischa;
Betts, Laurie;
O'Brien, Deborah A.

Publication type:

Article

Computational de novo design of a four-helix bundle protein- DND_4 HB.

Published in:

Protein Science: A Publication of the Protein Society, 2015, v. 24, n. 4, p. 434, doi. 10.1002/pro.2577

By:

Murphy, Grant S.;
Sathyamoorthy, Bharatwaj;
Der, Bryan S.;
Machius, Mischa C.;
Pulavarti, Surya V.;
Szyperski, Thomas;
Kuhlman, Brian

Publication type:

Article

Monovalent cation dependence and preference of GHKL ATPases and kinases1<FN ID="FN1"><NO>1</NO>Coordinates: atomic coordinates and structure factors of the LN40–ADPnP(Rb), LN40–ADPnP(K) and LN40(A100P)–ADPnP complex have been deposited with the Protein Data Bank (accession codes 1NHH, 1NHI and 1NHJ).</FN>

Published in:

FEBS Letters, 2003, v. 544, n. 1-3, p. 268, doi. 10.1016/S0014-5793(03)00519-2

By:

Hu, Xiaojian;
Machius, Mischa;
Yang, Wei

Publication type:

Article

Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica.

Published in:

PLoS Pathogens, 2012, v. 8, n. 11, p. 1, doi. 10.1371/journal.ppat.1003040

By:

Bosch, Dustin E.;
Kimple, Adam J.;
Muller, Robin E.;
Giguère, Patrick M.;
Machius, Mischa;
Willard, Francis S.;
Temple, Brenda R. S.;
Siderovski, David P.

Publication type:

Article

Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator from Bacillus subtilis reveal ligand-induced structural changes upon binding of several glycolytic intermediates.

Published in:

Molecular Microbiology, 2008, v. 69, n. 4, p. 895, doi. 10.1111/j.1365-2958.2008.06318.x

By:

Řezáčová, Pavlína;
Kožíšek, Milan;
Moy, Shiu F.;
Sieglová, Irena;
Joachimiak, Andrzej;
Machius, Mischa;
Otwinowski, Zbyszek

Publication type:

Article

The Crystal Structure of a Self-Activating G Protein a Subunit Reveals Its Distinct Mechanism of Signal Initiation.

Published in:

Science Signaling, 2011, v. 4, n. 159, p. 1, doi. 10.1126/scisignal.2001446

By:

Jones, Janice C.;
Duffy, Jeffrey W.;
Machius, Mischa;
Temple, Brenda R. S.;
Dohlman, Henrik G.;
Jones, Alan M.

Publication type:

Article

Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.

Published in:

ChemMedChem, 2017, v. 12, n. 3, p. 207, doi. 10.1002/cmdc.201600589

By:

McIver, Andrew L.;
Zhang, Weihe;
Liu, Qingyang;
Jiang, Xinpeng;
Stashko, Michael A.;
Nichols, James;
Miley, Michael J.;
Norris‐Drouin, Jacqueline;
Machius, Mischa;
DeRyckere, Deborah;
Wood, Edgar;
Graham, Douglas K.;
Earp, H. Shelton;
Kireev, Dmitri;
Frye, Stephen V.;
Wang, Xiaodong

Publication type:

Article

Activator Protein-1: redox switch controlling structure and DNA-binding.

Published in:

Nucleic Acids Research, 2017, v. 45, n. 19, p. 11425, doi. 10.1093/nar/gkx795

By:

Zhou Yin;
Machius, Mischa;
Nestler, Eric J.;
Rudenko, Gabby

Publication type:

Article

Crystal structure of a 12 ANK repeat stack from human ankyrinR.

Published in:

EMBO Journal, 2002, v. 21, n. 23, p. 6387, doi. 10.1093/emboj/cdf651

By:

Michaely, Peter;
Tomchick, Diana R.;
Machius, Mischa;
Anderson, Richard G. W.

Publication type:

Article

Structural Determinants of RGS‐RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis.

Published in:

FASEB Journal, 2013, v. 27, p. 656.2, doi. 10.1096/fasebj.27.1_supplement.656.2

By:

Bosch, Dustin E;
Kimple, Adam J;
Manning, Alyssa J;
Muller, Robin E;
Willard, Francis S;
Machius, Mischa;
Rogers, Stephen L;
Siderovski, David P

Publication type:

Article

Structural and Biochemical Studies on PACSIN.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A994

By:

Panchal, Sanjay C.;
Tomchick, Diana R.;
Machius, Mischa;
Rosen, Michael K.

Publication type:

Article

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 3, p. 280, doi. 10.1038/nsmb.1758

By:

Ok-Ho Shin;
Jun Lu;
Jeong-Seop Rhee;
Tomchick, Diana R.;
Pang, Zhiping P.;
Wojcik, Sonja M.;
Camacho-Perez, Marcial;
Brose, Nils;
Machius, Mischa;
Rizo, Josep;
Rosenmund, Christian;
Südhof, Thomas C.

Publication type:

Article

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 6, p. 535, doi. 10.1038/nsmb1255

By:

Maojun Yang;
Culhane, Jeffrey C.;
Szewczuk, Lawrence M.;
Gocke, Christian B.;
Brautigam, Chad A.;
Tomchick, Diana R.;
Machius, Mischa;
Cole, Philip A.;
Hongtao Yu

Publication type:

Article

Side chain and backbone contributions of Phe508 to CFTR folding.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 1, p. 10, doi. 10.1038/nsmb881

By:

Thibodeau, Patrick H.;
Brautigam, Chad A.;
Machius, Mischa;
Thomas, Philip J.

Publication type:

Article

Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 9, p. 844, doi. 10.1038/nsmb817

By:

Han Dai;
Ok-Ho Shin;
Machius, Mischa;
Tomchick, Diana R.;
Südhof, Thomas C .;
Rizo, Josep

Publication type:

Article

Crystal Structure of the Formin mDia1 in Autoinhibited Conformation.

Published in:

PLoS ONE, 2010, v. 5, n. 9, p. 1, doi. 10.1371/journal.pone.0012896

By:

Otomo, Takanori;
Tomchick, Diana R.;
Otomo, Chinatsu;
Machius, Mischa;
Rosen, Michael K.

Publication type:

Article

Works by Machius, Mischa

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer.

Structural Basis for a Munc13-1 Homodimer to Munc13-1/RIM Heterodimer Switch.

Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain.

Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.

Computational de novo design of a four-helix bundle protein- DND_4 HB.

Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica.

Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator from Bacillus subtilis reveal ligand-induced structural changes upon binding of several glycolytic intermediates.

The Crystal Structure of a Self-Activating G Protein a Subunit Reveals Its Distinct Mechanism of Signal Initiation.

Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.

Activator Protein-1: redox switch controlling structure and DNA-binding.

Crystal structure of a 12 ANK repeat stack from human ankyrinR.

Structural Determinants of RGS‐RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis.

Structural and Biochemical Studies on PACSIN.

Munc13 C<sub>2</sub>B domain is an activity-dependent Ca<sup>2+</sup> regulator of synaptic exocytosis.

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation.

Side chain and backbone contributions of Phe508 to CFTR folding.

Structural basis for the evolutionary inactivation of Ca<sup>2+</sup> binding to synaptotagmin 4.

Crystal Structure of the Formin mDia1 in Autoinhibited Conformation.