Works by MacLeod, Kenneth T.

Results: 28

Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia.
Published in:
Journal of Physiology, 2016, v. 594, n. 21, p. 6431, doi. 10.1113/JP272497
By:
- Williams, Alan J.;
- Bannister, Mark L.;
- Thomas, N. Lowri;
- Sikkel, Markus B.;
- Mukherjee, Saptarshi;
- Maxwell, Chloe;
- MacLeod, Kenneth T.;
- George, Christopher H.
Publication type:
Article
Novel stimulatory actions of the phytoestrogen genistein: effects on the gain of cardiac excitation‐contraction coupling.
Published in:
FASEB Journal, 2003, v. 17, n. 10, p. 1307, doi. 10.1096/fj.02-0760fje
By:
- Liew, Reginald;
- MacLeod, Kenneth T.;
- Collins, Peter
Publication type:
Article
Hierarchical statistical techniques are necessary to draw reliable conclusions fromanalysis of isolated cardiomyocyte studies.
Published in:
Cardiovascular Research, 2017, v. 113, n. 14, p. 1743, doi. 10.1093/cvr/cvx151
By:
- Sikkel, Markus B.;
- Francis, Darrel P.;
- Howard, James;
- Gordon, Fabiana;
- Rowlands, Christina;
- Peters, Nicholas S.;
- Lyon, Alexander R.;
- Harding, Sian E.;
- MacLeod, Kenneth T.
Publication type:
Article
Restitution slope is principally determined by steady-state action potential duration.
Published in:
Cardiovascular Research, 2017, v. 113, n. 7, p. 817, doi. 10.1093/cvr/cvx063
By:
- Shattock, Michael J.;
- Kyung Chan Park;
- Yang, Hsiang-Yu;
- Lee, Angela W. C.;
- Niederer, Steven;
- MacLeod, Kenneth T.;
- Winter, James
Publication type:
Article
Cardiac remodelling during pregnancy: whither the guinea pig?
Published in:
Cardiovascular Research, 2014, v. 104, n. 1, p. 226, doi. 10.1093/cvr/cvu198
By:
- Taggart, Michael J.;
- Hume, Richard;
- Lartey, Jon;
- Johnson, Mark;
- Tong, Wing-Chiu;
- Macleod, Kenneth T.
Publication type:
Article
Changes in cellular Ca2+ and Na+ regulation during the progression towards heart failure.
Published in:
Journal of Physiology, 2023, v. 601, n. 5, p. 905, doi. 10.1113/JP283082
By:
- MacLeod, Kenneth T.
Publication type:
Article
Moving in the right direction: elucidating the mechanisms of interaction between flecainide and the cardiac ryanodine receptor.
Published in:
British Journal of Pharmacology, 2022, v. 179, n. 11, p. 2558, doi. 10.1111/bph.15718
By:
- Bannister, Mark L.;
- MacLeod, Kenneth T.;
- George, Christopher H.
Publication type:
Article
OCT2013, an ischaemia‐activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine.
Published in:
British Journal of Pharmacology, 2022, v. 179, n. 9, p. 2037, doi. 10.1111/bph.15764
By:
- Hesketh, Louise M.;
- Sikkel, Markus B.;
- Mahoney‐Sanchez, Laura;
- Mazzacuva, Francesca;
- Chowdhury, Rasheda A.;
- Tzortzis, Konstantinos N.;
- Firth, Jahn;
- Winter, James;
- MacLeod, Kenneth T.;
- Ogrodzinski, Stefan;
- Wilder, Catherine D. E.;
- Patterson, Laurence H.;
- Peters, Nicholas S.;
- Curtis, Michael J.
Publication type:
Article
Approaches to High-Throughput Analysis of Cardiomyocyte Contractility.
Published in:
Frontiers in Physiology, 2020, v. 11, p. 1, doi. 10.3389/fphys.2020.00612
By:
- Wright, Peter T.;
- Tsui, Sharmane F.;
- Francis, Alice J.;
- MacLeod, Kenneth T.;
- Marston, Steven B.
Publication type:
Article
Erratum: High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes.
Published in:
Journal of Biophotonics, 2017, v. 10, n. 5, p. 744, doi. 10.1002/jbio.201700062
By:
- Sikkel, Markus B.;
- Kumar, Sunil;
- Maioli, Vincent;
- Rowlands, Christina;
- Gordon, Fabiana;
- Harding, Sian E.;
- Lyon, Alexander R.;
- MacLeod, Kenneth T.;
- Dunsby, Chris
Publication type:
Article
High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes.
Published in:
Journal of Biophotonics, 2016, v. 9, n. 3, p. 311, doi. 10.1002/jbio.201500193
By:
- Sikkel, Markus B.;
- Kumar, Sunil;
- Maioli, Vincent;
- Rowlands, Christina;
- Gordon, Fabiana;
- Harding, Sian E.;
- Lyon, Alexander R.;
- MacLeod, Kenneth T.;
- Dunsby, Chris
Publication type:
Article
Pumps and leaks in the heart.
Published in:
Journal of Physiology, 2002, v. 539, n. 1, p. 1, doi. 10.1113/jphysiol.2002.015586
By:
- MacLeod, Kenneth T.
Publication type:
Article
Na+−Ca2+ exchange and sarcoplasmic reticular Ca2+ regulation in ventricular myocytes from transgenic mice overexpressing the Na+−Ca2+ exchanger.
Published in:
Journal of Physiology, 1998, v. 512, n. 3, p. 651, doi. 10.1111/j.1469-7793.1998.651bd.x
By:
- Terracciano, Cesare M. N.;
- Souza, Ayesha I.;
- Philipson, Kenneth D.;
- MacLeod, Kenneth T.
Publication type:
Article
Integrins Increase Sarcoplasmic Reticulum Activity for Excitation—Contraction Coupling in Human Stem Cell-Derived Cardiomyocytes.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 18, p. N.PAG, doi. 10.3390/ijms231810940
By:
- Wang, Brian X.;
- Kane, Christopher;
- Nicastro, Laura;
- King, Oisín;
- Kit-Anan, Worrapong;
- Downing, Barrett;
- Deidda, Graziano;
- Couch, Liam S.;
- Pinali, Christian;
- Mitraki, Anna;
- MacLeod, Kenneth T.;
- Terracciano, Cesare M.
Publication type:
Article
SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway.
Published in:
European Heart Journal, 2012, v. 33, n. 9, p. 1067, doi. 10.1093/eurheartj/ehs043
By:
- Kumarswamy, Regalla;
- Lyon, Alexander R.;
- Volkmann, Ingo;
- Mills, Adam M.;
- Bretthauer, Julia;
- Pahuja, Aanchal;
- Geers-Knörr, Cornelia;
- Kraft, Theresia;
- Hajjar, Roger J.;
- Macleod, Kenneth T.;
- Harding, Sian E.;
- Thum, Thomas
Publication type:
Article
Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor.
Published in:
2016
By:
- Bannister, Mark L;
- Alvarez ‐ Laviada, Anita;
- Thomas, N Lowri;
- Mason, Sammy A;
- Coleman, Sharon;
- Plessis, Christo L;
- Moran, Abbygail T;
- Neill ‐ Hall, David;
- Osman, Hasnah;
- Bagley, Mark C;
- MacLeod, Kenneth T;
- George, Christopher H;
- Williams, Alan J;
- Alvarez-Laviada, Anita;
- du Plessis, Christo L;
- Neill-Hall, David
Publication type:
journal article
SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope.
Published in:
British Journal of Pharmacology, 2014, v. 171, n. 1, p. 38, doi. 10.1111/bph.12472
By:
- Sikkel, Markus B;
- Hayward, Carl;
- MacLeod, Kenneth T;
- Harding, Sian E;
- Lyon, Alexander R
Publication type:
Article
Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro.
Published in:
BMC Cardiovascular Disorders, 2006, v. 6, p. 1, doi. 10.1186/1471-2261-6-25
By:
- Tolmachov, Oleg;
- Yu-Ling Ma;
- Themis, Michael;
- Patel, Pravina;
- Spohr, Hilmar;
- MacLeod, Kenneth T;
- Ullrich, Nina D;
- Kienast, Yvonne;
- Coutelle, Charles;
- Peters, Nicholas S
Publication type:
Article
Raloxifene acutely suppresses ventricular myocyte contractility through inhibition of the L-type calcium current.
Published in:
British Journal of Pharmacology, 2004, v. 142, n. 1, p. 89, doi. 10.1038/sj.bjp.0705736
By:
- Liew, Reginald;
- Stagg, Mark A.;
- MacLeod, Kenneth T.;
- Collins, Peter
Publication type:
Article
Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current.
Published in:
Cardiovascular Research, 2013, v. 98, n. 2, p. 286, doi. 10.1093/cvr/cvt012
By:
- Sikkel, Markus B.;
- Collins, Thomas P.;
- Rowlands, Christina;
- Shah, Mit;
- O'Gara, Peter;
- Williams, Alan J.;
- Harding, Sian E.;
- Lyon, Alexander R.;
- MacLeod, Kenneth T.
Publication type:
Article
Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply.
Published in:
Cardiovascular Research, 2013, v. 98, n. 2, p. 327, doi. 10.1093/cvr/cvt068
By:
- Sikkel, Markus B.;
- Collins, Thomas P.;
- Rowlands, Christina;
- Shah, Mit;
- O'Gara, Peter;
- Williams, Alan J.;
- Harding, Sian E.;
- Lyon, Alexander R.;
- MacLeod, Kenneth T.
Publication type:
Article
Gender determines the acute actions of genistein on intracellular calcium regulation in the guinea-pig heart
Published in:
Cardiovascular Research, 2004, v. 61, n. 1, p. 66, doi. 10.1016/j.cardiores.2003.10.006
By:
- Liew, Reginald;
- Stagg, Mark A.;
- Chan, Joachim;
- Collins, Peter;
- MacLeod, Kenneth T.
Publication type:
Article
Overexpression of the Na/Ca exchanger and reduced SERCa function.
Published in:
Cardiovascular Research, 2001, v. 50, n. 1, p. 167, doi. 10.1016/S0008-6363(01)00235-8
By:
- Terracciano, Cesare M.N;
- MacLeod, Kenneth T
Publication type:
Article
Overexpression of the Na+/Ca2+ exchanger and inhibition of the sarcoplasmic reticulum Ca2+-ATPase in ventricular myocytes from transgenic mice.
Published in:
Cardiovascular Research, 2001, v. 49, n. 1, p. 38, doi. 10.1016/S0008-6363(00)00205-4
By:
- Terracciano, Cesare M.N.;
- Philipson, Kenneth D.;
- MacLeod, Kenneth T.
Publication type:
Article
The role of L-type calcium current in the generation of repolarization-induced contraction in cardiac myocytes.
Published in:
Cardiovascular Research, 2000, v. 48, n. 1, p. 59, doi. 10.1016/S0008-6363(00)00148-6
By:
- Egdell, Robin M;
- Milnes, James T;
- MacLeod, Kenneth T
Publication type:
Article
Relative importance of SR load and cytoplasmic calcium concentration in the genesis of aftercontractions in cardiac myocytes.
Published in:
Cardiovascular Research, 2000, v. 47, n. 4, p. 769, doi. 10.1016/S0008-6363(00)00147-4
By:
- Egdell, Robin M.;
- De Souza, Ayesha I.;
- Macleod, Kenneth T.
Publication type:
Article
GPER limits adverse changes to Ca2+ signalling and arrhythmogenic activity in ovariectomised guinea pig cardiomyocytes.
Published in:
Frontiers in Physiology, 2022, v. 13, p. 01, doi. 10.3389/fphys.2022.1023755
By:
- Francis, Alice J.;
- Firth, Jahn M.;
- Sanchez-Alonso, Jose L.;
- Gorelik, Julia;
- MacLeod, Kenneth T.
Publication type:
Article
Characterisation of Connexin Expression and Electrophysiological Properties in Stable Clones of the HL-1 Myocyte Cell Line.
Published in:
PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0090266
By:
- Dias, Priyanthi;
- Desplantez, Thomas;
- El-Harasis, Majd A.;
- Chowdhury, Rasheda A.;
- Ullrich, Nina D.;
- Cabestrero de Diego, Alberto;
- Peters, Nicholas S.;
- Severs, Nicholas J.;
- MacLeod, Kenneth T.;
- Dupont, Emmanuel
Publication type:
Article

Works by MacLeod, Kenneth T.

Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia.

Novel stimulatory actions of the phytoestrogen genistein: effects on the gain of cardiac excitation‐contraction coupling.

Hierarchical statistical techniques are necessary to draw reliable conclusions fromanalysis of isolated cardiomyocyte studies.

Restitution slope is principally determined by steady-state action potential duration.

Cardiac remodelling during pregnancy: whither the guinea pig?

Changes in cellular Ca<sup>2+</sup> and Na<sup>+</sup> regulation during the progression towards heart failure.

Moving in the right direction: elucidating the mechanisms of interaction between flecainide and the cardiac ryanodine receptor.

OCT2013, an ischaemia‐activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine.

Approaches to High-Throughput Analysis of Cardiomyocyte Contractility.

Erratum: High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes.

High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes.

Pumps and leaks in the heart.

Na<sup>+</sup>−Ca<sup>2+</sup> exchange and sarcoplasmic reticular Ca<sup>2+</sup> regulation in ventricular myocytes from transgenic mice overexpressing the Na<sup>+</sup>−Ca<sup>2+</sup> exchanger.

Integrins Increase Sarcoplasmic Reticulum Activity for Excitation—Contraction Coupling in Human Stem Cell-Derived Cardiomyocytes.

SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway.

Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor.

SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope.

Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro.

Raloxifene acutely suppresses ventricular myocyte contractility through inhibition of the L-type calcium current.

Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current.

Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply.

Gender determines the acute actions of genistein on intracellular calcium regulation in the guinea-pig heart

Overexpression of the Na/Ca exchanger and reduced SERCa function.

Overexpression of the Na+/Ca2+ exchanger and inhibition of the sarcoplasmic reticulum Ca2+-ATPase in ventricular myocytes from transgenic mice.

The role of L-type calcium current in the generation of repolarization-induced contraction in cardiac myocytes.

Relative importance of SR load and cytoplasmic calcium concentration in the genesis of aftercontractions in cardiac myocytes.

GPER limits adverse changes to Ca<sup>2+</sup> signalling and arrhythmogenic activity in ovariectomised guinea pig cardiomyocytes.

Characterisation of Connexin Expression and Electrophysiological Properties in Stable Clones of the HL-1 Myocyte Cell Line.