Works matching AU MacLeod, Kenneth T.

Results: 28

SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway.

Published in:

European Heart Journal, 2012, v. 33, n. 9, p. 1067, doi. 10.1093/eurheartj/ehs043

By:

Kumarswamy, Regalla;
Lyon, Alexander R.;
Volkmann, Ingo;
Mills, Adam M.;
Bretthauer, Julia;
Pahuja, Aanchal;
Geers-Knörr, Cornelia;
Kraft, Theresia;
Hajjar, Roger J.;
Macleod, Kenneth T.;
Harding, Sian E.;
Thum, Thomas

Publication type:

Article

Novel stimulatory actions of the phytoestrogen genistein: effects on the gain of cardiac excitation‐contraction coupling.

Published in:

FASEB Journal, 2003, v. 17, n. 10, p. 1307, doi. 10.1096/fj.02-0760fje

By:

Liew, Reginald;
MacLeod, Kenneth T.;
Collins, Peter

Publication type:

Article

Erratum: High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes.

Published in:

Journal of Biophotonics, 2017, v. 10, n. 5, p. 744, doi. 10.1002/jbio.201700062

By:

Sikkel, Markus B.;
Kumar, Sunil;
Maioli, Vincent;
Rowlands, Christina;
Gordon, Fabiana;
Harding, Sian E.;
Lyon, Alexander R.;
MacLeod, Kenneth T.;
Dunsby, Chris

Publication type:

Article

High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes.

Published in:

Journal of Biophotonics, 2016, v. 9, n. 3, p. 311, doi. 10.1002/jbio.201500193

By:

Sikkel, Markus B.;
Kumar, Sunil;
Maioli, Vincent;
Rowlands, Christina;
Gordon, Fabiana;
Harding, Sian E.;
Lyon, Alexander R.;
MacLeod, Kenneth T.;
Dunsby, Chris

Publication type:

Article

Raloxifene acutely suppresses ventricular myocyte contractility through inhibition of the L-type calcium current.

Published in:

British Journal of Pharmacology, 2004, v. 142, n. 1, p. 89, doi. 10.1038/sj.bjp.0705736

By:

Liew, Reginald;
Stagg, Mark A.;
MacLeod, Kenneth T.;
Collins, Peter

Publication type:

Article

Hierarchical statistical techniques are necessary to draw reliable conclusions fromanalysis of isolated cardiomyocyte studies.

Published in:

Cardiovascular Research, 2017, v. 113, n. 14, p. 1743, doi. 10.1093/cvr/cvx151

By:

Sikkel, Markus B.;
Francis, Darrel P.;
Howard, James;
Gordon, Fabiana;
Rowlands, Christina;
Peters, Nicholas S.;
Lyon, Alexander R.;
Harding, Sian E.;
MacLeod, Kenneth T.

Publication type:

Article

Restitution slope is principally determined by steady-state action potential duration.

Published in:

Cardiovascular Research, 2017, v. 113, n. 7, p. 817, doi. 10.1093/cvr/cvx063

By:

Shattock, Michael J.;
Kyung Chan Park;
Yang, Hsiang-Yu;
Lee, Angela W. C.;
Niederer, Steven;
MacLeod, Kenneth T.;
Winter, James

Publication type:

Article

Cardiac remodelling during pregnancy: whither the guinea pig?

Published in:

Cardiovascular Research, 2014, v. 104, n. 1, p. 226, doi. 10.1093/cvr/cvu198

By:

Taggart, Michael J.;
Hume, Richard;
Lartey, Jon;
Johnson, Mark;
Tong, Wing-Chiu;
Macleod, Kenneth T.

Publication type:

Article

Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current.

Published in:

Cardiovascular Research, 2013, v. 98, n. 2, p. 286, doi. 10.1093/cvr/cvt012

By:

Sikkel, Markus B.;
Collins, Thomas P.;
Rowlands, Christina;
Shah, Mit;
O'Gara, Peter;
Williams, Alan J.;
Harding, Sian E.;
Lyon, Alexander R.;
MacLeod, Kenneth T.

Publication type:

Article

Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply.

Published in:

Cardiovascular Research, 2013, v. 98, n. 2, p. 327, doi. 10.1093/cvr/cvt068

By:

Sikkel, Markus B.;
Collins, Thomas P.;
Rowlands, Christina;
Shah, Mit;
O'Gara, Peter;
Williams, Alan J.;
Harding, Sian E.;
Lyon, Alexander R.;
MacLeod, Kenneth T.

Publication type:

Article

Gender determines the acute actions of genistein on intracellular calcium regulation in the guinea-pig heart

Published in:

Cardiovascular Research, 2004, v. 61, n. 1, p. 66, doi. 10.1016/j.cardiores.2003.10.006

By:

Liew, Reginald;
Stagg, Mark A.;
Chan, Joachim;
Collins, Peter;
MacLeod, Kenneth T.

Publication type:

Article

Overexpression of the Na/Ca exchanger and reduced SERCa function.

Published in:

Cardiovascular Research, 2001, v. 50, n. 1, p. 167, doi. 10.1016/S0008-6363(01)00235-8

By:

Terracciano, Cesare M.N;
MacLeod, Kenneth T

Publication type:

Article

Overexpression of the Na+/Ca2+ exchanger and inhibition of the sarcoplasmic reticulum Ca2+-ATPase in ventricular myocytes from transgenic mice.

Published in:

Cardiovascular Research, 2001, v. 49, n. 1, p. 38, doi. 10.1016/S0008-6363(00)00205-4

By:

Terracciano, Cesare M.N.;
Philipson, Kenneth D.;
MacLeod, Kenneth T.

Publication type:

Article

The role of L-type calcium current in the generation of repolarization-induced contraction in cardiac myocytes.

Published in:

Cardiovascular Research, 2000, v. 48, n. 1, p. 59, doi. 10.1016/S0008-6363(00)00148-6

By:

Egdell, Robin M;
Milnes, James T;
MacLeod, Kenneth T

Publication type:

Article

Relative importance of SR load and cytoplasmic calcium concentration in the genesis of aftercontractions in cardiac myocytes.

Published in:

Cardiovascular Research, 2000, v. 47, n. 4, p. 769, doi. 10.1016/S0008-6363(00)00147-4

By:

Egdell, Robin M.;
De Souza, Ayesha I.;
Macleod, Kenneth T.

Publication type:

Article

Pumps and leaks in the heart.

Published in:

Journal of Physiology, 2002, v. 539, n. 1, p. 1, doi. 10.1113/jphysiol.2002.015586

By:

MacLeod, Kenneth T.

Publication type:

Article

Integrins Increase Sarcoplasmic Reticulum Activity for Excitation—Contraction Coupling in Human Stem Cell-Derived Cardiomyocytes.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 18, p. N.PAG, doi. 10.3390/ijms231810940

By:

Wang, Brian X.;
Kane, Christopher;
Nicastro, Laura;
King, Oisín;
Kit-Anan, Worrapong;
Downing, Barrett;
Deidda, Graziano;
Couch, Liam S.;
Pinali, Christian;
Mitraki, Anna;
MacLeod, Kenneth T.;
Terracciano, Cesare M.

Publication type:

Article

Na+−Ca2+ exchange and sarcoplasmic reticular Ca2+ regulation in ventricular myocytes from transgenic mice overexpressing the Na+−Ca2+ exchanger.

Published in:

Journal of Physiology, 1998, v. 512, n. 3, p. 651, doi. 10.1111/j.1469-7793.1998.651bd.x

By:

Terracciano, Cesare M. N.;
Souza, Ayesha I.;
Philipson, Kenneth D.;
MacLeod, Kenneth T.

Publication type:

Article

Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor.

Published in:

2016

By:

Bannister, Mark L;
Alvarez ‐ Laviada, Anita;
Thomas, N Lowri;
Mason, Sammy A;
Coleman, Sharon;
Plessis, Christo L;
Moran, Abbygail T;
Neill ‐ Hall, David;
Osman, Hasnah;
Bagley, Mark C;
MacLeod, Kenneth T;
George, Christopher H;
Williams, Alan J;
Alvarez-Laviada, Anita;
du Plessis, Christo L;
Neill-Hall, David

Publication type:

journal article

SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope.

Published in:

British Journal of Pharmacology, 2014, v. 171, n. 1, p. 38, doi. 10.1111/bph.12472

By:

Sikkel, Markus B;
Hayward, Carl;
MacLeod, Kenneth T;
Harding, Sian E;
Lyon, Alexander R

Publication type:

Article

GPER limits adverse changes to Ca2+ signalling and arrhythmogenic activity in ovariectomised guinea pig cardiomyocytes.

Published in:

Frontiers in Physiology, 2022, v. 13, p. 01, doi. 10.3389/fphys.2022.1023755

By:

Francis, Alice J.;
Firth, Jahn M.;
Sanchez-Alonso, Jose L.;
Gorelik, Julia;
MacLeod, Kenneth T.

Publication type:

Article

Approaches to High-Throughput Analysis of Cardiomyocyte Contractility.

Published in:

Frontiers in Physiology, 2020, v. 11, p. 1, doi. 10.3389/fphys.2020.00612

By:

Wright, Peter T.;
Tsui, Sharmane F.;
Francis, Alice J.;
MacLeod, Kenneth T.;
Marston, Steven B.

Publication type:

Article

Characterisation of Connexin Expression and Electrophysiological Properties in Stable Clones of the HL-1 Myocyte Cell Line.

Published in:

PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0090266

By:

Dias, Priyanthi;
Desplantez, Thomas;
El-Harasis, Majd A.;
Chowdhury, Rasheda A.;
Ullrich, Nina D.;
Cabestrero de Diego, Alberto;
Peters, Nicholas S.;
Severs, Nicholas J.;
MacLeod, Kenneth T.;
Dupont, Emmanuel

Publication type:

Article

Changes in cellular Ca2+ and Na+ regulation during the progression towards heart failure.

Published in:

Journal of Physiology, 2023, v. 601, n. 5, p. 905, doi. 10.1113/JP283082

By:

MacLeod, Kenneth T.

Publication type:

Article

Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia.

Published in:

Journal of Physiology, 2016, v. 594, n. 21, p. 6431, doi. 10.1113/JP272497

By:

Williams, Alan J.;
Bannister, Mark L.;
Thomas, N. Lowri;
Sikkel, Markus B.;
Mukherjee, Saptarshi;
Maxwell, Chloe;
MacLeod, Kenneth T.;
George, Christopher H.

Publication type:

Article

Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro.

Published in:

BMC Cardiovascular Disorders, 2006, v. 6, p. 1, doi. 10.1186/1471-2261-6-25

By:

Tolmachov, Oleg;
Yu-Ling Ma;
Themis, Michael;
Patel, Pravina;
Spohr, Hilmar;
MacLeod, Kenneth T;
Ullrich, Nina D;
Kienast, Yvonne;
Coutelle, Charles;
Peters, Nicholas S

Publication type:

Article

Moving in the right direction: elucidating the mechanisms of interaction between flecainide and the cardiac ryanodine receptor.

Published in:

British Journal of Pharmacology, 2022, v. 179, n. 11, p. 2558, doi. 10.1111/bph.15718

By:

Bannister, Mark L.;
MacLeod, Kenneth T.;
George, Christopher H.

Publication type:

Article

OCT2013, an ischaemia‐activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine.

Published in:

British Journal of Pharmacology, 2022, v. 179, n. 9, p. 2037, doi. 10.1111/bph.15764

By:

Hesketh, Louise M.;
Sikkel, Markus B.;
Mahoney‐Sanchez, Laura;
Mazzacuva, Francesca;
Chowdhury, Rasheda A.;
Tzortzis, Konstantinos N.;
Firth, Jahn;
Winter, James;
MacLeod, Kenneth T.;
Ogrodzinski, Stefan;
Wilder, Catherine D. E.;
Patterson, Laurence H.;
Peters, Nicholas S.;
Curtis, Michael J.

Publication type:

Article

Works matching AU MacLeod, Kenneth T.

SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway.

Novel stimulatory actions of the phytoestrogen genistein: effects on the gain of cardiac excitation‐contraction coupling.

Erratum: High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes.

High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes.

Raloxifene acutely suppresses ventricular myocyte contractility through inhibition of the L-type calcium current.

Hierarchical statistical techniques are necessary to draw reliable conclusions fromanalysis of isolated cardiomyocyte studies.

Restitution slope is principally determined by steady-state action potential duration.

Cardiac remodelling during pregnancy: whither the guinea pig?

Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current.

Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply.

Gender determines the acute actions of genistein on intracellular calcium regulation in the guinea-pig heart

Overexpression of the Na/Ca exchanger and reduced SERCa function.

Overexpression of the Na+/Ca2+ exchanger and inhibition of the sarcoplasmic reticulum Ca2+-ATPase in ventricular myocytes from transgenic mice.

The role of L-type calcium current in the generation of repolarization-induced contraction in cardiac myocytes.

Relative importance of SR load and cytoplasmic calcium concentration in the genesis of aftercontractions in cardiac myocytes.

Pumps and leaks in the heart.

Integrins Increase Sarcoplasmic Reticulum Activity for Excitation—Contraction Coupling in Human Stem Cell-Derived Cardiomyocytes.

Na<sup>+</sup>−Ca<sup>2+</sup> exchange and sarcoplasmic reticular Ca<sup>2+</sup> regulation in ventricular myocytes from transgenic mice overexpressing the Na<sup>+</sup>−Ca<sup>2+</sup> exchanger.

Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor.

SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope.

GPER limits adverse changes to Ca<sup>2+</sup> signalling and arrhythmogenic activity in ovariectomised guinea pig cardiomyocytes.

Approaches to High-Throughput Analysis of Cardiomyocyte Contractility.

Characterisation of Connexin Expression and Electrophysiological Properties in Stable Clones of the HL-1 Myocyte Cell Line.

Changes in cellular Ca<sup>2+</sup> and Na<sup>+</sup> regulation during the progression towards heart failure.

Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia.

Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro.

Moving in the right direction: elucidating the mechanisms of interaction between flecainide and the cardiac ryanodine receptor.

OCT2013, an ischaemia‐activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine.