Works by MacLaren, Robert

Results: 226

Two Novel CAPN5 Variants Associated with Mild and Severe Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy Phenotypes.

Published in:

2019

By:

Randazzo, Nadia M.;
Shanks, Morag E.;
Clouston, Penny;
MacLaren, Robert E.;
Randazzo, Nadia M MBBCh, BSc(Hons);
Shanks, Morag E PhD;
Clouston, Penny PhD, FRCPath;
MacLaren, Robert E MB ChB, DPhil, FRCOphth

Publication type:

journal article

A Review of Stress Ulcer Prophylaxis.

Published in:

Journal of Pharmacy Practice, 2002, v. 15, n. 2, p. 147, doi. 10.1106/EAD9-P8RX-D7J7

By:

MacLaren, Robert

Publication type:

Article

Gene therapy for choroideremia using an adeno-associated viral vector encoding Rab escort protein 1: the REGENERATE open-label trial.

Published in:

Efficacy & Mechanism Evaluation (EME), 2024, v. 11, n. 9, p. 1, doi. 10.3310/WARA5730

By:

Cehajic-Kapetanovic, Jasmina;
Bellini, Marco P.;
Taylor, Laura J.;
Yusuf, Imran H.;
Soomro, Taha;
da Cruz, Lyndon;
MacLaren, Robert E.

Publication type:

Article

Comparison of CRISPR-Cas13b RNA base editing approaches for USH2A-associated inherited retinal degeneration.

Published in:

Communications Biology, 2025, p. 1, doi. 10.1038/s42003-025-07557-3

By:

Fry, Lewis E.;
Major, Lauren;
Salman, Ahmed;
McDermott, Lucy A.;
Yang, Jun;
King, Andrew J.;
McClements, Michelle E.;
MacLaren, Robert E.

Publication type:

Article

Longitudinal Study to Assess the Quantitative Use of Fundus Autofluorescence for Monitoring Disease Progression in Choroideremia.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 2, p. 232, doi. 10.3390/jcm10020232

By:

Dubis, Adam M;
Lim, Wei S;
Jolly, Jasleen K;
Toms, Maria;
MacLaren, Robert E;
Webster, Andrew R;
Moosajee, Mariya

Publication type:

Article

Comparison of Fixed-Dose Inhaled Epoprostenol and Inhaled Nitric Oxide for Acute Respiratory Distress Syndrome in Critically Ill Adults.

Published in:

Journal of Intensive Care Medicine, 2021, v. 36, n. 4, p. 466, doi. 10.1177/0885066620906800

By:

Buckley, Mitchell S.;
Agarwal, Sumit K.;
Garcia-Orr, Roxanne;
Saggar, Rajeev;
MacLaren, Robert

Publication type:

Article

Adverse Hemodynamic Events Associated With Concomitant Dexmedetomidine and Propofol for Sedation in Mechanically Ventilated ICU Patients.

Published in:

Journal of Intensive Care Medicine, 2020, v. 35, n. 12, p. 1536, doi. 10.1177/0885066619884548

By:

Buckley, Mitchell S.;
Agarwal, Sumit K.;
MacLaren, Robert;
Kane-Gill, Sandra L.

Publication type:

Article

Thiocyanate Accumulation in Critically Ill Patients Receiving Nitroprusside Infusions.

Published in:

Journal of Intensive Care Medicine, 2017, v. 32, n. 9, p. 547, doi. 10.1177/0885066616657004

By:

Morris, Amanda A.;
Page, Robert L.;
Baumgartner, Laura J.;
Mueller, Scott W.;
MacLaren, Robert;
Fish, Douglas N.;
Kiser, Tyree H.

Publication type:

Article

Authors’ Response.

Published in:

2016

By:

Vander Weide, Luke A.;
MacLaren, Robert;
Mueller, Scott W.

Publication type:

Letter to the Editor

Evaluation of Early Dexmedetomidine Addition to the Standard of Care for Severe Alcohol Withdrawal in the ICU.

Published in:

Journal of Intensive Care Medicine, 2016, v. 31, n. 3, p. 198, doi. 10.1177/0885066614554908

By:

VanderWeide, Luke A.;
Foster, Charles J.;
MacLaren, Robert;
Kiser, Tyree H.;
Fish, Douglas N.;
Mueller, Scott W.

Publication type:

Article

A Randomized, Double-Blind Pilot Study of Dexmedetomidine Versus Midazolam for Intensive Care Unit Sedation: Patient Recall of Their Experiences and Short-Term Psychological Outcomes.

Published in:

Journal of Intensive Care Medicine, 2015, v. 30, n. 3, p. 167, doi. 10.1177/0885066613510874

By:

MacLaren, Robert;
Preslaski, Candice R.;
Mueller, Scott W.;
Kiser, Tyree H.;
Fish, Douglas N.;
Lavelle, James C.;
Malkoski, Stephen P.

Publication type:

Article

Optogenetic Gene Therapy for the Degenerate Retina: Recent Advances.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. N.PAG, doi. 10.3389/fnins.2020.570909

By:

McClements, Michelle E.;
Staurenghi, Federica;
MacLaren, Robert E.;
Cehajic-Kapetanovic, Jasmina

Publication type:

Article

Absence of Neuroplastin-65 Affects Synaptogenesis in Mouse Inner Hair Cells and Causes Profound Hearing Loss.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 1, p. 222, doi. 10.1523/JNEUROSCI.1808-15.2016

By:

Carrott, Leanne;
Bowl, Michael R.;
Aguilar, Carlos;
Johnson, Stuart L.;
Chessum, Lauren;
West, Melissa;
Morse, Susan;
Dorning, Joanne;
Smart, Elizabeth;
Hardisty-Hughes, Rachel;
Ball, Greg;
Parker, Andrew;
Barnard, Alun R.;
MacLaren, Robert E.;
Wells, Sara;
Marcotti, Walter;
Brown, Steve D. M.

Publication type:

Article

An Economic Evaluation of Voretigene Neparvovec for the Treatment of Biallelic RPE65-Mediated Inherited Retinal Dystrophies in the UK.

Published in:

2020

By:

Viriato, Daniel;
Bennett, Natalie;
Sidhu, Raisa;
Hancock, Elizabeth;
Lomax, Hannah;
Trueman, David;
MacLaren, Robert E.

Publication type:

journal article

The EXTRIP (EXtracorporeal TReatments In Poisoning) workgroup: Guideline methodology.

Published in:

Clinical Toxicology (15563650), 2012, v. 50, n. 5, p. 403, doi. 10.3109/15563650.2012.683436

By:

Lavergne, Valéry;
Nolin, Thomas D.;
Hoffman, Robert S.;
Roberts, Darren;
Gosselin, Sophie;
Goldfarb, David S.;
Kielstein, Jan T.;
Mactier, Robert;
Maclaren, Robert;
Mowry, James B.;
Bunchman, Timothy E.;
Juurlink, David;
Megarbane, Bruno;
Anseeuw, Kurt;
Winchester, James F.;
Dargan, Paul I.;
Liu, Kathleen D.;
Hoegberg, Lotte C.;
Li, Yi;
Calello, Diane P.

Publication type:

Article

An analysis of the Kozak consensus in retinal genes and its relevance to gene therapy.

Published in:

Molecular Vision, 2021, v. 27, p. 233

By:

McClements, Michelle E.;
Butt, Anum;
Piotter, Elena;
Peddle, Caroline F.;
MacLaren, Robert E.

Publication type:

Article

Correlation between heparin anti‐Xa activity and thromboelastography in adult critically ill COVID‐19 patients.

Published in:

Pharmacotherapy, 2023, v. 43, n. 8, p. 795, doi. 10.1002/phar.2829

By:

Buckley, Mitchell S.;
Benanti, Grace E.;
Gilbert, Brian;
Meckel, Jordan;
Dzierba, Amy L.;
MacLaren, Robert

Publication type:

Article

Management of noncytotoxic extravasation injuries: A focused update on medications, treatment strategies, and peripheral administration of vasopressors and hypertonic saline.

Published in:

Pharmacotherapy, 2023, v. 43, n. 4, p. 321, doi. 10.1002/phar.2794

By:

Stefanos, Sylvia S.;
Kiser, Tyree H.;
MacLaren, Robert;
Mueller, Scott W.;
Reynolds, Paul M.

Publication type:

Article

Correlation between partial thromboplastin time and thromboelastography in adult critically ill patients requiring bivalirudin for extracorporeal membrane oxygenation.

Published in:

Pharmacotherapy, 2023, v. 43, n. 3, p. 196, doi. 10.1002/phar.2776

By:

Buckley, Mitchell S.;
Benanti, Grace E.;
Meckel, Jordan;
Tekle, Luwam A.;
Gilbert, Brian;
Puebla Neira, Daniel;
McNierney, Dakota A.;
Korkames, Grace;
Yerondopoulos, Melanie;
Park, Andrew;
O'Hea, Jennifer A.;
MacLaren, Robert

Publication type:

Article

Restrictive resuscitation in patients with sepsis and mortality: A systematic review and meta‐analysis with trial sequential analysis.

Published in:

Pharmacotherapy, 2023, v. 43, n. 2, p. 104, doi. 10.1002/phar.2764

By:

Reynolds, Paul M.;
Stefanos, Sylvia;
MacLaren, Robert

Publication type:

Article

A pragmatic assessment of proton pump inhibitors vs. histamine type 2 receptor antagonists on clinically important gastrointestinal bleeding and mortality when used for stress ulcer prophylaxis in the ICU.

Published in:

Pharmacotherapy, 2021, v. 41, n. 10, p. 820, doi. 10.1002/phar.2621

By:

Boyd, Carly;
Hassig, Tanna;
MacLaren, Robert

Publication type:

Article

Establishing the Therapeutic Index of Fluid Resuscitation in the Septic Patient: A Narrative Review and Meta‐Analysis.

Published in:

Pharmacotherapy, 2020, v. 40, n. 3, p. 256, doi. 10.1002/phar.2371

By:

Reynolds, Paul M.;
Wells, Lauren;
MacLaren, Robert;
Scoular, Sarah K.

Publication type:

Article

Vasopressin, not octreotide, may be beneficial in the treatment of hepatorenal syndrome: a retrospective study.

Published in:

Nephrology Dialysis Transplantation, 2005, v. 20, n. 9, p. 1813, doi. 10.1093/ndt/gfh930

By:

Tyree H. Kiser;
Douglas N. Fish;
Marilee D. Obritsch;
Rose Jung;
Robert MacLaren;
Chirag R. Parikh

Publication type:

Article

Retrospective Comparison of Andexanet Alfa and 4-Factor Prothrombin Complex for Reversal of Factor Xa-Inhibitor Related Bleeding.

Published in:

Clinical & Applied Thrombosis/Hemostasis, 2021, v. 27, p. 1, doi. 10.1177/10760296211039020

By:

Stevens, Victoria M.;
Trujillo, Toby C.;
Kiser, Tyree H.;
MacLaren, Robert;
Reynolds, Paul M.;
Mueller, Scott W.

Publication type:

Article

Coagulation Factor Xa (Recombinant), Inactivated-Zhzo (Andexanet Alfa) Hemostatic Outcomes and Thrombotic Event Incidence at an Academic Medical Center.

Published in:

Clinical & Applied Thrombosis/Hemostasis, 2019, v. 25, p. 1, doi. 10.1177/1076029619896619

By:

Stevens, Victoria M.;
Trujillo, Toby;
Mueller, Scott W.;
MacLaren, Robert;
Reynolds, Paul M.;
Kiser, Tyree H.

Publication type:

Article

Antithrombin Administration During Intravenous Heparin Anticoagulation in the Intensive Care Unit: A Single-Center Matched Retrospective Cohort Study.

Published in:

Clinical & Applied Thrombosis/Hemostasis, 2018, v. 24, n. 1, p. 145, doi. 10.1177/1076029616668407

By:

Beyer, Jacob T.;
Schoeppler, Kelly E.;
Zanotti, Giorgio;
Weiss, Gregory M.;
Mueller, Scott W.;
MacLaren, Robert;
Fish, Douglas N.;
Kiser, Tyree H.

Publication type:

Article

Optical Coherence Tomography Feature of Retinoschisis in CRB1-Associated Maculopathy.

Published in:

JAMA Ophthalmology, 2024, v. 142, n. 2, p. 158, doi. 10.1001/jamaophthalmol.2023.5886

By:

Bellingrath, Julia-Sophia;
Birtel, Johannes;
Yusuf, Imran H.;
MacLaren, Robert E.;
Charbel Issa, Peter

Publication type:

Article

Changes in Retinal Sensitivity Associated With Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa With RPGR Gene Variations.

Published in:

JAMA Ophthalmology, 2023, v. 141, n. 3, p. 275, doi. 10.1001/jamaophthalmol.2022.6254

By:

von Krusenstiern, Lenore;
Liu, Jiajun;
Liao, Eileen;
Gow, James A.;
Chen, Guo;
Ong, Tuyen;
Lotery, Andrew J.;
Jalil, Assad;
Lam, Byron L.;
MacLaren, Robert E.

Publication type:

Article

Analysis of Pathogenic Variants Correctable With CRISPR Base Editing Among Patients With Recessive Inherited Retinal Degeneration.

Published in:

2021

By:

Fry, Lewis E.;
McClements, Michelle E.;
MacLaren, Robert E.

Publication type:

journal article

Association of a Novel Intronic Variant in RPGR With Hypomorphic Phenotype of X-Linked Retinitis Pigmentosa.

Published in:

2020

By:

Cehajic-Kapetanovic, Jasmina;
McClements, Michelle E.;
Whitfield, Jennifer;
Shanks, Morag;
Clouston, Penny;
MacLaren, Robert E.

Publication type:

journal article

Association of Clinical and Genetic Heterogeneity With BEST1 Sequence Variations.

Published in:

2020

By:

Shah, Mital;
Broadgate, Suzanne;
Shanks, Morag;
Clouston, Penny;
Yu, Jing;
MacLaren, Robert E.;
Németh, Andrea H.;
Halford, Stephanie;
Downes, Susan M.

Publication type:

journal article

Association of Messenger RNA Level With Phenotype in Patients With Choroideremia: Potential Implications for Gene Therapy Dose.

Published in:

2020

By:

Fry, Lewis E.;
Patrício, Maria I.;
Williams, Jonathan;
Aylward, James W.;
Hewitt, Harriet;
Clouston, Penny;
Xue, Kanmin;
Barnard, Alun R.;
MacLaren, Robert E.

Publication type:

journal article

Efficacy and Safety of Retinal Gene Therapy Using Adeno-Associated Virus Vector for Patients With Choroideremia: A Randomized Clinical Trial.

Published in:

2019

By:

Fischer, M. Dominik;
Ochakovski, G. Alex;
Beier, Benjamin;
Seitz, Immanuel P.;
Vaheb, Yousof;
Kortuem, Constanze;
Reichel, Felix F. L.;
Kuehlewein, Laura;
Kahle, Nadine A.;
Peters, Tobias;
Girach, Aniz;
Zrenner, Eberhart;
Ueffing, Marius;
MacLaren, Robert E.;
Bartz-Schmidt, Karl Ulrich;
Wilhelm, Barbara

Publication type:

journal article

Clinical Characterization of Retinitis Pigmentosa Associated With Variants in SNRNP200.

Published in:

2019

By:

Yusuf, Imran H.;
Birtel, Johannes;
Shanks, Morag E.;
Clouston, Penny;
Downes, Susan M.;
Charbel Issa, Peter;
MacLaren, Robert E.

Publication type:

journal article

Olfactory Dysfunction in Patients With CNGB1-Associated Retinitis Pigmentosa.

Published in:

2018

By:

Charbel Issa, Peter;
Reuter, Peggy;
Kühlewein, Laura;
Birtel, Johannes;
Gliem, Martin;
Tropitzsch, Anke;
Whitcroft, Katherine L.;
Bolz, Hanno J.;
Ishihara, Kenji;
MacLaren, Robert E.;
Downes, Susan M.;
Oishi, Akio;
Zrenner, Eberhart;
Kohl, Susanne;
Hummel, Thomas;
Kühlewein, Laura

Publication type:

journal article

Using Rho Kinase Inhibitors for Retinal Detachment-Reply.

Published in:

2017

By:

Simunovic, Matthew P.;
Kanmin Xue;
MacLaren, Robert E.;
Xue, Kanmin

Publication type:

journal article

Detailed Clinical Phenotype and Molecular Genetic Findings in CLN3-Associated Isolated Retinal Degeneration.

Published in:

2017

By:

Ku, Cristy A.;
Hull, Sarah;
Arno, Gavin;
Vincent, Ajoy;
Carss, Keren;
Kayton, Robert;
Weeks, Douglas;
Anderson, Glenn W.;
Geraets, Ryan;
Parker, Camille;
Pearce, David A.;
Michaelides, Michel;
MacLaren, Robert E.;
Robson, Anthony G.;
Holder, Graham E.;
Heon, Elise;
Raymond, F. Lucy;
Moore, Anthony T.;
Webster, Andrew R.;
Pennesi, Mark E.

Publication type:

journal article

Structural and Functional Recovery Following Limited Iatrogenic Macular Detachment for Retinal Gene Therapy.

Published in:

2017

By:

Simunovic, Matthew P.;
Xue, Kanmin;
Jolly, Jasleen K.;
MacLaren, Robert E.

Publication type:

journal article

The Role of Inflammation in Age-Related Macular Degeneration—Therapeutic Landscapes in Geographic Atrophy.

Published in:

Cells (2073-4409), 2023, v. 12, n. 16, p. 2092, doi. 10.3390/cells12162092

By:

Borchert, Grace A.;
Shamsnajafabadi, Hoda;
Hu, Monica L.;
De Silva, Samantha R.;
Downes, Susan M.;
MacLaren, Robert E.;
Xue, Kanmin;
Cehajic-Kapetanovic, Jasmina

Publication type:

Article

Current and Future Landscape in Genetic Therapies for Leber Hereditary Optic Neuropathy.

Published in:

Cells (2073-4409), 2023, v. 12, n. 15, p. 2013, doi. 10.3390/cells12152013

By:

Shamsnajafabadi, Hoda;
MacLaren, Robert E.;
Cehajic-Kapetanovic, Jasmina

Publication type:

Article

Future Perspectives of Prime Editing for the Treatment of Inherited Retinal Diseases.

Published in:

Cells (2073-4409), 2023, v. 12, n. 3, p. 440, doi. 10.3390/cells12030440

By:

Hansen, Silja;
McClements, Michelle E.;
Corydon, Thomas J.;
MacLaren, Robert E.

Publication type:

Article

Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina.

Published in:

Cells (2073-4409), 2021, v. 10, n. 8, p. 1957, doi. 10.3390/cells10081957

By:

Salman, Ahmed;
McClements, Michelle E.;
MacLaren, Robert E.

Publication type:

Article

Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25204-3

By:

Orlans, Harry O.;
McClements, Michelle E.;
Barnard, Alun R.;
Martinez-Fernandez de la Camara, Cristina;
MacLaren, Robert E.

Publication type:

Article

Levetiracetam Pharmacokinetics in a Patient with Intracranial Hemorrhage Undergoing Continuous Veno-Venous Hemofiltration.

Published in:

American Journal of Case Reports, 2017, v. 18, p. 458, doi. 10.12659/AJCR.902709

By:

Van Matre, Edward T.;
Mueller, Scott W.;
Fish, Douglas N.;
MacLaren, Robert;
Cava, Luis F.;
Neumann, Robert T.;
Kiser, Tyree H.

Publication type:

Article

Non-Viral Delivery of CRISPR/Cas Cargo to the Retina Using Nanoparticles: Current Possibilities, Challenges, and Limitations.

Published in:

Pharmaceutics, 2022, v. 14, n. 9, p. N.PAG, doi. 10.3390/pharmaceutics14091842

By:

Salman, Ahmed;
Kantor, Ariel;
McClements, Michelle E.;
Marfany, Gemma;
Trigueros, Sonia;
MacLaren, Robert E.

Publication type:

Article

Clinical Research on the Leading Causes of Severe Sight Impairment in the UK General and Working Populations.

Published in:

Clinical Ophthalmology, 2023, v. 17, p. 2729, doi. 10.2147/OPTH.S417773

By:

Liu, Wei Jia;
Taylor, Laura J;
MacLaren, Robert E;
Jolly, Jasleen K

Publication type:

Article

Rapid Quantification of the Binocular Visual Field for Clinical Trials: Performance of a Modified Esterman Supra-Threshold Test Implemented with the Open Perimetry Interface.

Published in:

Clinical Ophthalmology, 2022, v. 16, p. 1513, doi. 10.2147/OPTH.S352004

By:

Andrews, Colm D;
Sheldon, Aislin A;
Bridge, Holly;
Downes, Susan M;
MacLaren, Robert E;
Jolly, Jasleen K

Publication type:

Article

Binocular Visual Function in a Pre-Presbyopic Patient with Uniocular Cataract Undergoing Cataract Surgery with a Multifocal Intraocular Lens.

Published in:

Clinical Ophthalmology, 2020, v. 14, p. 2001, doi. 10.2147/OPTH.S254532

By:

Wood, Laura J;
Jolly, Jasleen K;
Groppe, Markus;
Benjamin, Larry;
Kirwan, James F;
Patel, Nishal;
Elgohary, Mostafa A;
MacLaren, Robert E

Publication type:

Article

Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life.

Published in:

Clinical Ophthalmology, 2017, v. 11, p. 39, doi. 10.2147/OPTH.S115685

By:

Breukink, Myrte B.;
Dingemans, Alexander J. M.;
den Hollander, Anneke I.;
Keunen, Jan E. E.;
MacLaren, Robert E.;
Fauser, Sascha;
Querques, Giuseppe;
Hoyng, Carel B.;
Downes, Susan M.;
Boon, Camiel J. F.

Publication type:

Article

Recent advances and future prospects in choroideremia.

Published in:

Clinical Ophthalmology, 2015, v. 9, p. 2195, doi. 10.2147/OPTH.S65732

By:

Zinkernagel, Martin S.;
MacLaren, Robert E.

Publication type:

Article