Found: 4

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  • Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.

    Published in:
    Nature, 2011, v. 477, n. 7363, p. 225, doi. 10.1038/nature10363
    By:
    • Frezza, Christian;
    • Zheng, Liang;
    • Folger, Ori;
    • Rajagopalan, Kartik N.;
    • MacKenzie, Elaine D.;
    • Jerby, Livnat;
    • Micaroni, Massimo;
    • Chaneton, Barbara;
    • Adam, Julie;
    • Hedley, Ann;
    • Kalna, Gabriela;
    • Tomlinson, Ian P. M.;
    • Pollard, Patrick J.;
    • Watson, Dave G.;
    • Deberardinis, Ralph J.;
    • Shlomi, Tomer;
    • Ruppin, Eytan;
    • Gottlieb, Eyal
    Publication type:
    Article

  • Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.

    Published in:
    Nature Cell Biology, 2015, v. 17, n. 10, p. 1317, doi. 10.1038/ncb3233
    By:
    • Tumanov, Sergey;
    • Bulusu, Vinay;
    • Kamphorst, Jurre J.;
    • Cardaci, Simone;
    • Zheng, Liang;
    • MacKay, Gillian;
    • van den Broek, Niels J. F.;
    • MacKenzie, Elaine D.;
    • Nixon, Colin;
    • Stevenson, David;
    • Vazquez, Alexei;
    • Kalna, Gabriela;
    • Blyth, Karen;
    • Strathdee, Douglas;
    • Gottlieb, Eyal;
    • Fleming, Stewart;
    • Schiavi, Francesca
    Publication type:
    Article

  • Fumarate induces redox-dependent senescence by modifying glutathione metabolism.

    Published in:
    Nature Communications, 2015, v. 6, n. 1, p. 6001, doi. 10.1038/ncomms7001
    By:
    • Zheng, Liang;
    • Cardaci, Simone;
    • Jerby, Livnat;
    • MacKenzie, Elaine D.;
    • Sciacovelli, Marco;
    • Johnson, T. Isaac;
    • Gaude, Edoardo;
    • King, Ayala;
    • Leach, Joshua D. G.;
    • Edrada-Ebel, RuAngelie;
    • Hedley, Ann;
    • Morrice, Nicholas A.;
    • Kalna, Gabriela;
    • Blyth, Karen;
    • Ruppin, Eytan;
    • Frezza, Christian;
    • Gottlieb, Eyal
    Publication type:
    Article

  • Cardiolipin provides an essential activating platform for caspase-8 on mitochondria.

    Published in:
    Journal of Cell Biology, 2008, v. 183, n. 4, p. 681, doi. 10.1083/jcb.200803129
    By:
    • Gonzalvez, Francois;
    • Schug, Zachary T.;
    • Houtkooper, Riekelt H.;
    • MacKenzie, Elaine D.;
    • Brooks, David G.;
    • Wanders, Ronald J. A.;
    • Petit, Patrice X.;
    • Vaz, Frédéric M.;
    • Gottlieb, Eyal
    Publication type:
    Article