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Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation.
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- Biochemical Journal, 2024, v. 481, n. 17, p. 1125, doi. 10.1042/BCJ20240255
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- Article
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.
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- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42255-w
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- Article
Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling.
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- Cell Death & Disease, 2022, v. 13, n. 6, p. 1, doi. 10.1038/s41419-022-05009-y
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- Article
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.
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- Cell Death & Disease, 2022, v. 13, n. 4, p. 1, doi. 10.1038/s41419-022-04740-w
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- Article
A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes.
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- Cell Death & Disease, 2021, v. 12, n. 4, p. 1, doi. 10.1038/s41419-021-03636-5
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- Article
The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis.
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- Cell Death & Disease, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41419-021-03418-z
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- Article
Pulmonary Endothelial Tau Aggregation After Infection.
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- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R4516
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- Article
PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.
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- FASEB Journal, 2020, v. 34, n. 9, p. 12533, doi. 10.1096/fj.202001016RR
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- Article
Quantification of modelling uncertainties in a large ensemble of climate change simulations.
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- Nature, 2004, v. 430, n. 7001, p. 768, doi. 10.1038/nature02771
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- Article
Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion.
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- Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06118-4
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- Article
Genetic variation and population structure among larval Lethenteron spp. within the Yukon River drainage, Alaska.
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- Journal of Fish Biology, 2018, v. 93, n. 6, p. 1130, doi. 10.1111/jfb.13833
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- Article
Regional Heterogeneity for the Intracranial Self-Administration of Ethanol and Acetaldehyde within the Ventral Tegmental Area of Alcohol-Preferring (P) Rats: Involvement of Dopamine and Serotonin.
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- Neuropsychopharmacology, 2005, v. 30, n. 2, p. 330, doi. 10.1038/sj.npp.1300561
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- Article
Effects of Repeated Alcohol Deprivations on Operant Ethanol Self-Administration by Alcohol-Preferring (P) Rats.
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- Neuropsychopharmacology, 2003, v. 28, n. 9, p. 1614, doi. 10.1038/sj.npp.1300214
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- Article
Alcohol Stimulates the Release of Dopamine in the Ventral Pallidum but not in the Globus Pallidus: A Dual-Probe Microdialysis Study.
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- Neuropsychopharmacology, 2003, v. 28, n. 5, p. 939, doi. 10.1038/sj.npp.1300081
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- Article
FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-44098-2
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- Article
Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association.
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- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01279-9
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- Article
Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis.
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- Nature Communications, 2017, v. 8, n. 3, p. 14729, doi. 10.1038/ncomms14729
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- Article
An objective ocean temperature and salinity analysis using covariances from a global climate model.
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- Journal of Geophysical Research. Oceans, 2007, v. 112, n. C2, p. n/a, doi. 10.1029/2005JC003172
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- Article
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling.
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- Science Signaling, 2021, v. 14, n. 668, p. 1, doi. 10.1126/scisignal.abc6178
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- Article
Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid–binding residues.
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- Science Signaling, 2020, v. 13, n. 636, p. 1, doi. 10.1126/scisignal.aaz5599
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Structure-based mechanism of preferential complex formation by apoptosis signal–regulating kinases.
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- Science Signaling, 2020, v. 13, n. 622, p. 1, doi. 10.1126/scisignal.aay6318
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- Article
Emerging concepts in pseudoenzyme classification, evolution, and signaling.
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- Science Signaling, 2019, v. 12, n. 594, p. 1, doi. 10.1126/scisignal.aat9797
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- Article
Focal Adhesion Kinase Activity and Localization is Critical for TNF-α-Induced Nuclear Factor-κB Activation.
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- Inflammation, 2021, v. 44, n. 3, p. 1130, doi. 10.1007/s10753-020-01408-5
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- Article
Utilizing DNA metabarcoding to characterize the diet of marine-phase Arctic lamprey (Lethenteron camtschaticum) in the eastern Bering Sea.
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- Canadian Journal of Fisheries & Aquatic Sciences, 2019, v. 76, n. 11, p. 1993, doi. 10.1139/cjfas-2018-0299
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- Article
Biochemical Society Transactions: celebrating 50 years.
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- Biochemical Society Transactions, 2023, v. 51, n. 4, p. 1417, doi. 10.1042/BST20230828
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- Article
Relating SMCHD1 structure to its function in epigenetic silencing.
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- Biochemical Society Transactions, 2020, v. 48, n. 4, p. 1751, doi. 10.1042/BST20200242
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- Article
The secret life of kinases: insights into noncatalytic signalling functions from pseudokinases.
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- Biochemical Society Transactions, 2017, v. 45, n. 3, p. 665, doi. 10.1042/BST20160331
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- Article
Bio-Zombie: the rise of pseudoenzymes in biology.
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- Biochemical Society Transactions, 2017, v. 45, n. 2, p. 537, doi. 10.1042/BST20160400
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- Article
Regulation of Janus kinases by SOCS proteins.
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- Biochemical Society Transactions, 2013, v. 41, n. 4, p. 1042, doi. 10.1042/BST20130077
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- Article
Dawn of the dead: protein pseudokinases signal new adventures in cell biology.
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- Biochemical Society Transactions, 2013, v. 41, n. 4, p. 969, doi. 10.1042/BST20130115
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- Article
Techniques to examine nucleotide binding by pseudokinases.
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- Biochemical Society Transactions, 2013, v. 41, n. 4, p. 975, doi. 10.1042/BST20130075
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- Article
FAK Family Kinases in Vascular Diseases.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 10, p. 3630, doi. 10.3390/ijms21103630
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- Article
A Quantitative Method to Measure Low Levels of ROS in Nonphagocytic Cells by Using a Chemiluminescent Imaging System.
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- Oxidative Medicine & Cellular Longevity, 2019, p. 1, doi. 10.1155/2019/1754593
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- Article
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
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- Nature Structural & Molecular Biology, 2013, v. 20, n. 4, p. 469, doi. 10.1038/nsmb.2519
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- Article
Serotonin mechanisms in alcohol drinking behavior.
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- Drug Development Research, 1993, v. 30, n. 3, p. 170, doi. 10.1002/ddr.430300309
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- Article
A theoretical guarantee for data completion via geometric separation.
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- PAMM: Proceedings in Applied Mathematics & Mechanics, 2017, v. 17, n. 1, p. 833, doi. 10.1002/pamm.201710384
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- Article
SMCHD1’s ubiquitin-like domain is required for N-terminal dimerization and chromatin localization.
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- Biochemical Journal, 2021, v. 478, n. 13, p. 2555, doi. 10.1042/BCJ20210278
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- Article
Identification of a second binding site on the TRIM25 B30.2 domain.
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- Biochemical Journal, 2018, v. 475, n. 2, p. 429, doi. 10.1042/BCJ20170427
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- Article
The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain.
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- Biochemical Journal, 2016, v. 473, n. 12, p. 1733, doi. 10.1042/BCJ20160189
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- Article
The hinge domain of the epigenetic repressor Smchd1 adopts an unconventional homodimeric configuration.
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- Biochemical Journal, 2016, v. 473, n. 6, p. 733, doi. 10.1042/BJ20151049
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- Article
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.
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- Biochemical Journal, 2015, v. 471, n. 2, p. 255, doi. 10.1042/BJ20150678
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- Article
Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation.
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- Biochemical Journal, 2014, v. 463, n. 3, p. 393, doi. 10.1042/BJ20140863
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- Article
The molecular regulation of Janus kinase (JAK) activation.
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- Biochemical Journal, 2014, v. 462, n. 1, p. 1, doi. 10.1042/BJ20140712
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- Article
Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.
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- Biochemical Journal, 2014, v. 458, n. 2, p. 395, doi. 10.1042/BJ20131516
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- Article
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.
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- Biochemical Journal, 2014, v. 457, n. 3, p. 369, doi. 10.1042/BJ20131270
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- Article
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
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- Biochemical Journal, 2014, v. 457, n. 2, p. 323, doi. 10.1042/BJ20131174
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- Article
Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats.
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- Psychopharmacology, 2003, v. 165, n. 3, p. 252, doi. 10.1007/s00213-002-1300-2
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- Article
Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of female Wistar rats.
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- Psychopharmacology, 2000, v. 149, n. 3, p. 217, doi. 10.1007/s002139900347
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- Article
A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06186-1
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- Article
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04714-7
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- Article