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A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 21, p. 11380, doi. 10.3390/ijms222111380
By:
- Thistlethwaite, Sian;
- Jeffreys, Laura N.;
- Girvan, Hazel M.;
- McLean, Kirsty J.;
- Munro, Andrew W.
Publication type:
Article
Resonance Raman studies of Bacillus megaterium cytochrome P450 BM3 and biotechnologically important mutants.
Published in:
Journal of Raman Spectroscopy, 2018, v. 49, n. 2, p. 287, doi. 10.1002/jrs.5278
By:
- Liu, Yilin;
- McLean, Kirsty J.;
- Munro, Andrew W.;
- Kincaid, James R.
Publication type:
Article
Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3.
Published in:
Biochemical Journal, 2014, v. 460, n. 2, p. 247, doi. 10.1042/BJ20140030
By:
- BUTLER, Christopher F.;
- PEET, Caroline;
- MCLEAN, Kirsty J.;
- BAYNHAM, Michael T.;
- BLANKLEY, Richard T.;
- FISHER, Karl;
- RIGBY, Stephen E. J.;
- LEYS, David;
- VOICE, Michael W.;
- MUNRO, Andrew W.
Publication type:
Article
Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase.
Published in:
FEBS Journal, 2005, v. 272, n. 18, p. 4660, doi. 10.1111/j.1742-4658.2005.04875.x
By:
- Khan, Huma;
- Barna, Terez;
- Bruce, Neil C.;
- Munro, Andrew W.;
- Leys, David;
- Scrutton, Nigel S.
Publication type:
Article
Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121.
Published in:
Angewandte Chemie, 2012, v. 124, n. 37, p. 9445, doi. 10.1002/ange.201202544
By:
- Hudson, Sean A.;
- McLean, Kirsty J.;
- Surade, Sachin;
- Yang, Yong-Qing;
- Leys, David;
- Ciulli, Alessio;
- Munro, Andrew W.;
- Abell, Chris
Publication type:
Article
Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis.
Published in:
Scientific Reports, 2016, p. 26628, doi. 10.1038/srep26628
By:
- Chenge, Jude;
- Kavanagh, Madeline E.;
- Driscoll, Max D.;
- McLean, Kirsty J.;
- Young, Douglas B.;
- Cortes, Teresa;
- Matak-Vinkovic, Dijana;
- Levy, Colin W.;
- Rigby, Stephen E. J.;
- Leys, David;
- Abell, Chris;
- Munro, Andrew W.
Publication type:
Article
Bacillus megaterium Has Both a Functional BluB Protein Required for DMB Synthesis and a Related Flavoprotein That Forms a Stable Radical Species.
Published in:
PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055708
By:
- Collins, Hannah F.;
- Biedendieck, Rebekka;
- Leech, Helen K.;
- Gray, Michael;
- Escalante-Semerena, Jorge C.;
- McLean, Kirsty J.;
- Munro, Andrew W.;
- Rigby, Stephen E. J.;
- Warren, Martin J.;
- Lawrence, Andrew D.
Publication type:
Article
Characterisation of PduS, the pdu Metabolosome Corrin Reductase, and Evidence of Substructural Organisation within the Bacterial Microcompartment.
Published in:
PLoS ONE, 2010, v. 5, n. 11, p. 1, doi. 10.1371/journal.pone.0014009
By:
- Parsons, Joshua B.;
- Lawrence, Andrew D.;
- McLean, Kirsty J.;
- Munro, Andrew W.;
- Rigby, Stephen E. J.;
- Warren, Martin J.
Publication type:
Article
Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors.
Published in:
ChemistryOpen, 2019, v. 8, n. 7, p. 995, doi. 10.1002/open.201900227
By:
- Kishk, Safaa M.;
- McLean, Kirsty J.;
- Sood, Sakshi;
- Smith, Darren;
- Evans, Jack W.D.;
- Helal, Mohamed A.;
- Gomaa, Mohamed S.;
- Salama, Ismail;
- Mostafa, Samia M.;
- de Carvalho, Luiz Pedro S.;
- Levy, Colin W.;
- Munro, Andrew W.;
- Simons, Claire
Publication type:
Article
The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway.
Published in:
Molecular Microbiology, 2014, v. 93, n. 2, p. 247, doi. 10.1111/mmi.12656
By:
- Palmer, David J.;
- Schroeder, Susanne;
- Lawrence, Andrew D.;
- Deery, Evelyne;
- Lobo, Susana A.;
- Saraiva, Ligia M.;
- McLean, Kirsty J.;
- Munro, Andrew W.;
- Ferguson, Stuart J.;
- Pickersgill, Richard W.;
- Brown, David G.;
- Warren, Martin J.
Publication type:
Article
Biofragments: An Approach towards Predicting Protein Function Using Biologically Related Fragments and its Application to Mycobacterium tuberculosis CYP126.
Published in:
ChemBioChem, 2014, v. 15, n. 4, p. 549, doi. 10.1002/cbic.201300697
By:
- Hudson, Sean A.;
- Mashalidis, Ellene H.;
- Bender, Andreas;
- McLean, Kirsty J.;
- Munro, Andrew W.;
- Abell, Chris
Publication type:
Article
Tyrosyl Radical Formation and Propagation in Flavin Dependent Monoamine Oxidases.
Published in:
ChemBioChem, 2010, v. 11, n. 9, p. 1228, doi. 10.1002/cbic.201000184
By:
- Dunn, Rachel V.;
- Munro, Andrew W.;
- Turner, Nicholas J.;
- Rigby, Stephen E. J.;
- Scrutton, Nigel S.
Publication type:
Article
Bacterial cytochromes P-450.
Published in:
Molecular Microbiology, 1996, v. 20, n. 6, p. 1115, doi. 10.1111/j.1365-2958.1996.tb02632.x
By:
- Munro, Andrew W.;
- Lindsay, J. Gordon
Publication type:
Article
Activation of potassium channels during metabolite detoxification in Escherichia coli.
Published in:
Molecular Microbiology, 1993, v. 9, n. 6, p. 1297, doi. 10.1111/j.1365-2958.1993.tb01259.x
By:
- Ferguson, Gail P.;
- Munro, Andrew W.;
- Douglas, Roseileen M.;
- McLaggan, Debra;
- Booth, Ian R.
Publication type:
Article
The genome sequence of Mycobacterium tuberculosis reveals cytochromes P450 as novel anti-TB drug targets.
Published in:
Journal of Chemical Technology & Biotechnology, 2000, v. 75, n. 10, p. 933, doi. 10.1002/1097-4660(200010)75:10<933::AID-JCTB301>3.0.CO;2-C
By:
- Souter, Alison;
- McLean, Kirsty J;
- Smith, W Ewen;
- Munro, Andrew W
Publication type:
Article
Special Issue: Cytochrome P450 structure and function.
Published in:
FEBS Journal, 2012, v. 279, n. 9, p. 1515, doi. 10.1111/j.1742-4658.2012.08578.x
By:
- Munro, Andrew W.;
- Leys, David
Publication type:
Article
Characterization of Cupriavidus metallidurans CYP116B1 - A thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein.
Published in:
FEBS Journal, 2012, v. 279, n. 9, p. 1675, doi. 10.1111/j.1742-4658.2012.08543.x
By:
- Warman, Ashley J.;
- Robinson, Jacob W.;
- Luciakova, Dominika;
- Lawrence, Andrew D.;
- Marshall, Ker R.;
- Warren, Martin J.;
- Cheesman, Myles R.;
- Rigby, Stephen E. J.;
- Munro, Andrew W.;
- McLean, Kirsty J.
Publication type:
Article
The crystal structure of the FAD/NADPH-binding domain of flavocytochrome P450 BM3.
Published in:
FEBS Journal, 2012, v. 279, n. 9, p. 1694, doi. 10.1111/j.1742-4658.2012.08544.x
By:
- Joyce, Michael G;
- Ekanem, Idorenyin S.;
- Roitel, Olivier;
- Dunford, Adrian J.;
- Neeli, Rajasekhar;
- Girvan, Hazel M.;
- Baker, George J.;
- Curtis, Robin A.;
- Munro, Andrew W.;
- Leys, David
Publication type:
Article
Inter-flavin electron transfer in cytochrome P450 reductase – effects of solvent and pH identify hidden complexity in mechanism.
Published in:
FEBS Journal, 2008, v. 275, n. 18, p. 4540, doi. 10.1111/j.1742-4658.2008.06597.x
By:
- Brenner, Sibylle;
- Hay, Sam;
- Munro, Andrew W.;
- Scrutton, Nigel S.
Publication type:
Article
The pH dependence of kinetic isotope effects in monoamine oxidase A indicates stabilization of the neutral amine in the enzyme–substrate complex.
Published in:
FEBS Journal, 2008, v. 275, n. 15, p. 3850, doi. 10.1111/j.1742-4658.2008.06532.x
By:
- Dunn, Rachel V.;
- Marshall, Ker R.;
- Munro, Andrew W.;
- Scrutton, Nigel S.
Publication type:
Article
Structure and function of the cytochrome P450 peroxygenase enzymes.
Published in:
Biochemical Society Transactions, 2018, v. 46, n. 1, p. 183, doi. 10.1042/BST20170218
By:
- Munro, Andrew W.;
- McLean, Kirsty J.;
- Grant, Job L.;
- Makris, Thomas M.
Publication type:
Article
Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets.
Published in:
Biochemical Society Transactions, 2012, v. 40, n. 3, p. 573, doi. 10.1042/BST20120062
By:
- Hudson, Sean A.;
- McLean, Kirsty J.;
- Munro, Andrew W.;
- Abell, Chris
Publication type:
Article
Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes.
Published in:
Biochemical Society Transactions, 2012, v. 40, n. 3, p. 587, doi. 10.1042/BST20120077
By:
- McLean, Kirsty J.;
- Hans, Marcus;
- Munro, Andrew W.
Publication type:
Article
Production of alkenes and novel secondary products by P450 Ole TJE using novel H2O2-generating fusion protein systems.
Published in:
FEBS Letters, 2017, v. 591, n. 5, p. 737, doi. 10.1002/1873-3468.12581
By:
- Matthews, Sarah;
- Tee, Kang Lan;
- Rattray, Nicholas J.;
- McLean, Kirsty J.;
- Leys, David;
- Parker, David A.;
- Blankley, Richard T.;
- Munro, Andrew W.
Publication type:
Article
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Published in:
Chemistry - A European Journal, 2023, v. 29, n. 29, p. 1, doi. 10.1002/chem.202203868
By:
- Katariya, Mona M.;
- Snee, Matthew;
- Tunnicliffe, Richard B.;
- Kavanagh, Madeline E.;
- Boshoff, Helena I. M.;
- Amadi, Cecilia N.;
- Levy, Colin W.;
- Munro, Andrew W.;
- Abell, Chris;
- Leys, David;
- Coyne, Anthony G.;
- McLean, Kirsty J.
Publication type:
Article
Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-37330-y
By:
- Jeffreys, Laura N.;
- Poddar, Harshwardhan;
- Golovanova, Marina;
- Levy, Colin W.;
- Girvan, Hazel M.;
- McLean, Kirsty J.;
- Voice, Michael W.;
- Leys, David;
- Munro, Andrew W.
Publication type:
Article
Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.
Published in:
ChemMedChem, 2017, v. 12, n. 2, p. 194, doi. 10.1002/cmdc.201600619
By:
- Kavanagh, Madeline E.;
- Gray, Janine L.;
- Gilbert, Sophie H.;
- Coyne, Anthony G.;
- McLean, Kirsty J.;
- Davis, Holly J.;
- Munro, Andrew W.;
- Abell, Chris
Publication type:
Article
Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.
Published in:
ChemMedChem, 2016, v. 11, n. 17, p. 1924, doi. 10.1002/cmdc.201600248
By:
- Kavanagh, Madeline E.;
- Gray, Janine L.;
- Gilbert, Sophie H.;
- Coyne, Anthony G.;
- McLean, Kirsty J.;
- Davis, Holly J.;
- Munro, Andrew W.;
- Abell, Chris
Publication type:
Article
Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121.
Published in:
ChemMedChem, 2013, v. 8, n. 9, p. 1451, doi. 10.1002/cmdc.201300219
By:
- Hudson, Sean A.;
- Surade, Sachin;
- Coyne, Anthony G.;
- McLean, Kirsty J.;
- Leys, David;
- Munro, Andrew W.;
- Abell, Chris
Publication type:
Article
The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase
Published in:
FEBS Letters, 2005, v. 579, n. 25, p. 5582, doi. 10.1016/j.febslet.2005.09.023
By:
- Neeli, Rajasekhar;
- Girvan, Hazel M.;
- Lawrence, Andrew;
- Warren, Martin J.;
- Leys, David;
- Scrutton, Nigel S.;
- Munro, Andrew W.
Publication type:
Article
Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121.
Published in:
Angewandte Chemie International Edition, 2012, v. 51, n. 37, p. 9311, doi. 10.1002/anie.201202544
By:
- Hudson, Sean A.;
- McLean, Kirsty J.;
- Surade, Sachin;
- Yang, Yong-Qing;
- Leys, David;
- Ciulli, Alessio;
- Munro, Andrew W.;
- Abell, Chris
Publication type:
Article

Found: 31

A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism.

Resonance Raman studies of Bacillus megaterium cytochrome P450 BM3 and biotechnologically important mutants.

Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3.

Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase.

Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121.

Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis.

<i>Bacillus megaterium</i> Has Both a Functional BluB Protein Required for DMB Synthesis and a Related Flavoprotein That Forms a Stable Radical Species.

Characterisation of PduS, the pdu Metabolosome Corrin Reductase, and Evidence of Substructural Organisation within the Bacterial Microcompartment.

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors.

The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway.

Biofragments: An Approach towards Predicting Protein Function Using Biologically Related Fragments and its Application to Mycobacterium tuberculosis CYP126.

Tyrosyl Radical Formation and Propagation in Flavin Dependent Monoamine Oxidases.

Bacterial cytochromes P-450.

Activation of potassium channels during metabolite detoxification in Escherichia coli.

The genome sequence of Mycobacterium tuberculosis reveals cytochromes P450 as novel anti-TB drug targets.

Special Issue: Cytochrome P450 structure and function.

Characterization of Cupriavidus metallidurans CYP116B1 - A thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein.

The crystal structure of the FAD/NADPH-binding domain of flavocytochrome P450 BM3.

Inter-flavin electron transfer in cytochrome P450 reductase – effects of solvent and pH identify hidden complexity in mechanism.

The pH dependence of kinetic isotope effects in monoamine oxidase A indicates stabilization of the neutral amine in the enzyme–substrate complex.

Structure and function of the cytochrome P450 peroxygenase enzymes.

Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets.

Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes.

Production of alkenes and novel secondary products by P450 Ole T<sub>JE</sub> using novel H<sub>2</sub>O<sub>2</sub>-generating fusion protein systems.

Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs.

Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.

Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.

Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121.

The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase

Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121.