Works by MARUGAN, JUAN
Results: 64
Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction.
- Published in:
- Frontiers in Physiology, 2021, v. 12, p. 1, doi. 10.3389/fphys.2021.650769
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- Publication type:
- Article
Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
- Published in:
- Journal of Neuroscience, 2016, v. 36, n. 29, p. 7693, doi. 10.1523/JNEUROSCI.0628-16.2016
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- Publication type:
- Article
A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism.
- Published in:
- Journal of Neuroscience, 2016, v. 38, n. 28, p. 7441, doi. 10.1523/JNEUROSCI.0636-16.2016
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- Publication type:
- Article
A Novel Brain Penetrant NPS Receptor Antagonist, NCGC00185684, Blocks Alcohol-Induced ERK-Phosphorylation in the Central Amygdala and Decreases Operant Alcohol Self-Administration in Rats.
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- Journal of Neuroscience, 2013, v. 33, n. 24, p. 10132, doi. 10.1523/JNEUROSCI.4742-12.2013
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- Publication type:
- Article
Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding.
- Published in:
- Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-0831-6
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- Publication type:
- Article
Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-60610-5
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- Publication type:
- Article
Analytical Characterization of Methyl-β-Cyclodextrin for Pharmacological Activity to Reduce Lysosomal Cholesterol Accumulation in Niemann-Pick Disease Type C1 Cells.
- Published in:
- Assay & Drug Development Technologies, 2017, v. 15, n. 4, p. 154, doi. 10.1089/adt.2017.774
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- Publication type:
- Article
Analytical Characterization of Methyl-β-Cyclodextrin for Pharmacological Activity to Reduce Lysosomal Cholesterol Accumulation in Niemann-Pick Disease Type C1 Cells.
- Published in:
- Assay & Drug Development Technologies, 2017, v. 15, n. 4, p. 154, doi. 10.1089/adt.2017.774
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- Publication type:
- Article
Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2.
- Published in:
- Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-04143-9
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- Publication type:
- Article
In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.
- Published in:
- Viruses (1999-4915), 2023, v. 15, n. 7, p. 1503, doi. 10.3390/v15071503
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- Publication type:
- Article
Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.
- Published in:
- 2018
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- Publication type:
- journal article
The function of phosphatidylinositol 5-phosphate 4-kinase ɣ (PI5P4Kɣ) explored using a specific inhibitor that targets the PI5P-binding site.
- Published in:
- Biochemical Journal, 2015, v. 466, n. 2, p. 359, doi. 10.1042/BJ20141333
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- Publication type:
- Article
Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function.
- Published in:
- Nature Communications, 2016, v. 7, n. 10, p. 13123, doi. 10.1038/ncomms13123
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- Publication type:
- Article
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.
- Published in:
- Nature Communications, 2016, v. 7, n. 6, p. 12109, doi. 10.1038/ncomms12109
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- Publication type:
- Article
Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.
- Published in:
- Nature Communications, 2013, v. 4, n. 6, p. 1953, doi. 10.1038/ncomms2953
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- Publication type:
- Article
Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.
- Published in:
- Nature Communications, 2013, v. 4, n. 6, p. 2044, doi. 10.1038/ncomms3044
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- Publication type:
- Article
Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus.
- Published in:
- PLoS Pathogens, 2016, v. 12, n. 6, p. 1, doi. 10.1371/journal.ppat.1005717
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- Publication type:
- Article
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.
- Published in:
- Science Translational Medicine, 2015, v. 7, n. 282, p. 1, doi. 10.1126/scitranslmed.3010286
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- Publication type:
- Article
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.
- Published in:
- Science Translational Medicine, 2014, v. 6, n. 268, p. 1, doi. 10.1126/scitranslmed.3010523
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- Publication type:
- Article
Macrophage Models of Gaucher Disease for Evaluating Disease Pathogenesis and Candidate Drugs.
- Published in:
- Science Translational Medicine, 2014, v. 6, n. 240, p. 1, doi. 10.1126/scitranslmed.3008659
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- Publication type:
- Article
Characterization and Chemical Optimization of the D2 Dopamine Receptor‐Selective Antagonist, ML321, Identifies Lead Compounds for the Clinical Treatment of Neuropsychiatric Disorders.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2720
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- Publication type:
- Article
RXFP2 Small Molecule Agonists: Potential Therapeutics for Osteoporosis.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2398
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- Publication type:
- Article
A Biased Relaxin Receptor Agonist, ML290, Attenuates Atherosclerotic Calcification in Apolipoprotein E‐deficient Mice.
- Published in:
- FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02926
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- Publication type:
- Article
Optimization of ML321: a D<sub>2</sub> dopamine receptor‐selective antagonist for the treatment of neuropsychiatric disorders.
- Published in:
- FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02466
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- Publication type:
- Article
Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis.
- Published in:
- FASEB Journal, 2019, v. 33, n. 11, p. 12435, doi. 10.1096/fj.201901046R
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- Publication type:
- Article
Discovery and characterization of a G protein‐biased agonist of the D<sub>2</sub> dopamine receptor (662.7).
- Published in:
- FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.662.7
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- Publication type:
- Article
Implementation of Safety Aspects in IFMIF-DONES Design.
- Published in:
- Journal of Nuclear Engineering (JNE), 2022, v. 3, n. 4, p. 373, doi. 10.3390/jne3040024
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- Publication type:
- Article
Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages.
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- Aging Cell, 2016, v. 15, n. 1, p. 77, doi. 10.1111/acel.12409
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- Publication type:
- Article
Cell-based high-throughput screening identifies galactocerebrosidase enhancers as potential small-molecule therapies for Krabbe's disease.
- Published in:
- Journal of Neuroscience Research, 2016, v. 94, n. 11, p. 1231, doi. 10.1002/jnr.23875
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- Publication type:
- Article
Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5340, doi. 10.3390/ijms24065340
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- Publication type:
- Article
Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 7, p. 3386, doi. 10.3390/ijms22073386
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- Publication type:
- Article
c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration.
- Published in:
- Antioxidants, 2023, v. 12, n. 11, p. 2007, doi. 10.3390/antiox12112007
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- Publication type:
- Article
DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.
- Published in:
- Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-36144-2
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- Publication type:
- Article
Plasma and Tissue Concentrations of α-Tocopherol and δ-Tocopherol Following High Dose Dietary Supplementation in Mice.
- Published in:
- 2012
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- Publication type:
- Journal Article
Consulta enfermera de Educación Terapéutica en asma grave.
- Published in:
- Metas de Enfermería, 2023, v. 26, n. 8, p. 23, doi. 10.35667/MetasEnf,2023,26.1003082159
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- Publication type:
- Article
Disease models for the development of therapies for lysosomal storage diseases.
- Published in:
- Annals of the New York Academy of Sciences, 2016, v. 1371, n. 1, p. 15, doi. 10.1111/nyas.13052
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- Publication type:
- Article
A high-throughput sphingomyelinase assay using natural substrate.
- Published in:
- Analytical & Bioanalytical Chemistry, 2012, v. 404, n. 2, p. 407, doi. 10.1007/s00216-012-6174-5
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- Publication type:
- Article
Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.
- Published in:
- Analytical & Bioanalytical Chemistry, 2012, v. 402, n. 5, p. 1889, doi. 10.1007/s00216-011-5604-0
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- Publication type:
- Article
A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide.
- Published in:
- Analytical & Bioanalytical Chemistry, 2012, v. 402, n. 2, p. 731, doi. 10.1007/s00216-011-5496-z
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- Publication type:
- Article
Metabolism and pharmacokinetics characterization of metarrestin in multiple species.
- Published in:
- 2020
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- Publication type:
- journal article
Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-Kras<sup>G12D/+</sup>;Tp53<sup>R172H/+</sup> (KPC) mice, a genetically engineered model of pancreatic cancer.
- Published in:
- 2018
- By:
- Publication type:
- journal article
Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1.
- Published in:
- 2017
- By:
- Publication type:
- journal article
combinatorial approach increases SMN level in SMA model mice.
- Published in:
- Human Molecular Genetics, 2022, v. 31, n. 17, p. 2989, doi. 10.1093/hmg/ddac068
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- Publication type:
- Article
Sunitinib promotes myogenic regeneration and mitigates disease progression in the mdx mouse model of Duchenne muscular dystrophy.
- Published in:
- Human Molecular Genetics, 2019, v. 28, n. 13, p. 2120, doi. 10.1093/hmg/ddz044
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- Publication type:
- Article
Activation of relaxin family receptor 1 from different mammalian species by relaxin peptide and small-molecule agonist ML290.
- Published in:
- Frontiers in Endocrinology, 2015, p. 1, doi. 10.3389/fendo.2015.00128
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- Publication type:
- Article
An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers.
- Published in:
- Journal of Clinical Endocrinology & Metabolism, 2024, v. 109, n. 9, p. 2306, doi. 10.1210/clinem/dgae114
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- Publication type:
- Article
Teaching principles of translational science to a broad scientific audience using a case study approach: A pilot course from the National Center for Advancing Translational Sciences.
- Published in:
- Journal of Clinical & Translational Science, 2022, v. 6, n. 1, p. 1, doi. 10.1017/cts.2022.374
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- Publication type:
- Article
Inhibition of PIP4Kg ameliorates the pathological effects of mutant huntingtin protein.
- Published in:
- eLife, 2017, p. 1, doi. 10.7554/eLife.29123.001
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- Publication type:
- Article
Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A.
- Published in:
- Stem Cells Translational Medicine, 2016, v. 5, n. 12, p. 1644, doi. 10.5966/sctm.2015-0373
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- Publication type:
- Article
A Multiplex High-Throughput Gene Expression Assay to Simultaneously Detect Disease and Functional Markers in Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium.
- Published in:
- Stem Cells Translational Medicine, 2014, v. 3, n. 8, p. 911, doi. 10.5966/sctm.2013-0192
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- Publication type:
- Article