Works by MARUGAN, JUAN

Results: 67

Disease models for the development of therapies for lysosomal storage diseases.

Published in:

Annals of the New York Academy of Sciences, 2016, v. 1371, n. 1, p. 15, doi. 10.1111/nyas.13052

By:

Xu, Miao;
Motabar, Omid;
Ferrer, Marc;
Marugan, Juan J.;
Zheng, Wei;
Ottinger, Elizabeth A.

Publication type:

Article

c-Abl/TFEB Pathway Activation as a Common Pathogenic Mechanism in Lysosomal Storage Diseases: Therapeutic Potential of c-Abl Inhibitors.

Published in:

Antioxidants, 2025, v. 14, n. 5, p. 611, doi. 10.3390/antiox14050611

By:

Guerra, Miguel V.;
Castro, Juan;
Moreno, Antonio;
Balboa, Elisa;
Marugan, Juan J.;
Alvarez, Alejandra R.;
Zanlungo, Silvana

Publication type:

Article

c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration.

Published in:

Antioxidants, 2023, v. 12, n. 11, p. 2007, doi. 10.3390/antiox12112007

By:

Martinez, Alexis;
Lamaizon, Cristian M.;
Valls, Cristian;
Llambi, Fabien;
Leal, Nancy;
Fitzgerald, Patrick;
Guy, Cliff;
Kamiński, Marcin M.;
Inestrosa, Nibaldo C.;
van Zundert, Brigitte;
Cancino, Gonzalo I.;
Dulcey, Andrés E.;
Zanlungo, Silvana;
Marugan, Juan J.;
Hetz, Claudio;
Green, Douglas R.;
Alvarez, Alejandra R.

Publication type:

Article

Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A.

Published in:

Stem Cells Translational Medicine, 2016, v. 5, n. 12, p. 1644, doi. 10.5966/sctm.2015-0373

By:

Long, Yan;
Xu, Miao;
Li, Rong;
Dai, Sheng;
Beers, Jeanette;
Chen, Guokai;
Soheilian, Ferri;
Baxa, Ulrich;
Wang, Mengqiao;
Marugan, Juan J.;
Muro, Silvia;
Li, Zhiyuan;
Brady, Roscoe;
Zheng, Wei

Publication type:

Article

A Multiplex High-Throughput Gene Expression Assay to Simultaneously Detect Disease and Functional Markers in Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium.

Published in:

Stem Cells Translational Medicine, 2014, v. 3, n. 8, p. 911, doi. 10.5966/sctm.2013-0192

By:

FERRER, MARC;
CORNEO, BARBARA;
DAVIS, JANINE;
WAN, QIN;
MIYAGISHIMA, KIYOHARU JOSHUA;
KING, REBECCA;
MAMINISHKIS, ARVYDAS;
MARUGAN, JUAN;
SHARMA, RUCHI;
SHURE, MICHAEL;
TEMPLE, SALLY;
MILLER, SHELDON;
BHARTI, KAPIL

Publication type:

Article

c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer's disease.

Published in:

Frontiers in Aging Neuroscience, 2023, p. 1, doi. 10.3389/fnagi.2023.1180987

By:

León, Rilda;
Gutiérrez, Daniela A.;
Pinto, Claudio;
Morales, Cristian;
de la Fuente, Catalina;
Riquelme, Cristóbal;
Cortés, Bastián I.;
González-Martin, Adrián;
Chamorro, David;
Espinosa, Nelson;
Fuentealba, Pablo;
Cancino, Gonzalo I.;
Zanlungo, Silvana;
Dulcey, Andrés E.;
Marugan, Juan J.;
Álvarez Rojas, Alejandra

Publication type:

Article

In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.

Published in:

Viruses (1999-4915), 2023, v. 15, n. 7, p. 1503, doi. 10.3390/v15071503

By:

Hu, Xin;
Morazzani, Elaine;
Compton, Jaimee R.;
Harmon, Moeshia;
Soloveva, Veronica;
Glass, Pamela J.;
Garcia, Andres Dulcey;
Marugan, Juan J.;
Legler, Patricia M.

Publication type:

Article

Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 29, p. 7693, doi. 10.1523/JNEUROSCI.0628-16.2016

By:

Mazzulli, Joseph R.;
Zunke, Friederike;
Tsunemi, Taiji;
Toker, Nicholas J.;
Jeon, Sohee;
Burbulla, Lena F.;
Patnaik, Samarjit;
Sidransky, Ellen;
Marugan, Juan J.;
Sue, Carolyn M.;
Krainc, Dimitri

Publication type:

Article

A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism.

Published in:

Journal of Neuroscience, 2016, v. 38, n. 28, p. 7441, doi. 10.1523/JNEUROSCI.0636-16.2016

By:

Aflaki, Elma;
Borger, Daniel K.;
Moaven, Nima;
Stubblefield, Barbara K.;
Rogers, Steven A.;
Patnaik, Samarjit;
Schoenen, Frank J.;
Westbroek, Wendy;
Wei Zheng;
Sullivan, Patricia;
Fujiwara, Hideji;
Sidhu, Rohini;
Khaliq, Zayd M.;
Fopez, Grisel J.;
Goldstein, David S.;
Ory, Daniel S.;
Marugan, Juan;
Sidransky, Ellen

Publication type:

Article

Characterization and Chemical Optimization of the D2 Dopamine Receptor‐Selective Antagonist, ML321, Identifies Lead Compounds for the Clinical Treatment of Neuropsychiatric Disorders.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2720

By:

Nilson, Ashley N.;
Dulcey Garcia, Andres;
Free, R. B.;
Boldizsar, Noelia;
Pearlstein, Hannah;
Rocereta, Julia A.;
Rodriguiz, Ramona M.;
Lane, J. R.;
Lee, Kuo H.;
Shi, Lei;
Wetsel, William C.;
Marugan, Juan J.;
Sibley, David R.

Publication type:

Article

RXFP2 Small Molecule Agonists: Potential Therapeutics for Osteoporosis.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2398

By:

Esteban‐Lopez, Maria;
Wilson, Kenneth;
Myhr, Courtney;
Kaftanovskaya, Elena;
Henderson, Mark;
Southall, Noel;
Hu, Xin;
Barnaeva, Elena;
Ferrer, Marc;
Kim, David;
Ye, Wenjuan;
Morello, Roy;
Agoulnik, Irina;
Marugan, Juan;
Agoulnik, Alexander

Publication type:

Article

A Biased Relaxin Receptor Agonist, ML290, Attenuates Atherosclerotic Calcification in Apolipoprotein E‐deficient Mice.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02926

By:

Ng, Hooi Hooi;
Medina, Daniela;
Wilson, Kenneth;
Marugan, Juan;
Agoulnik, Alexander;
Hutcheson, Joshua

Publication type:

Article

Optimization of ML321: a D2 dopamine receptor‐selective antagonist for the treatment of neuropsychiatric disorders.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02466

By:

Rocereta, Julia;
Free, R.;
Dulcey Garcia, Andres;
Southall, Noel;
Shi, Lei;
Lane, J.;
Wetsel, William;
Marugan, Juan;
Sibley, David

Publication type:

Article

Plasma and Tissue Concentrations of α-Tocopherol and δ-Tocopherol Following High Dose Dietary Supplementation in Mice.

Published in:

2012

By:

Baxter, Laura L.;
Marugan, Juan J.;
Jingbo Xiao;
Incao, Art;
McKew, John C.;
Wei Zheng;
Pavan, William J.

Publication type:

Journal Article

Metabolism and pharmacokinetics characterization of metarrestin in multiple species.

Published in:

2020

By:

Padilha, Elias C.;
Shah, Pranav;
Wang, Amy Q.;
Singleton, Marc D.;
Hughes, Emma A.;
Li, Dandan;
Rice, Kelly A.;
Konrath, Kylie M.;
Patnaik, Samarjit;
Marugan, Juan;
Rudloff, Udo;
Xu, Xin

Publication type:

journal article

Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer.

Published in:

2018

By:

Vilimas, Tomas;
Wang, Amy Q.;
Patnaik, Samarjit;
Hughes, Emma A.;
Singleton, Marc D.;
Knotts, Zachary;
Li, Dandan;
Frankowski, Kevin;
Schlomer, Jerome J.;
Guerin, Theresa M.;
Springer, Stephanie;
Drennan, Catherine;
Dextras, Christopher;
Wang, Chen;
Gilbert, Debra;
Southall, Noel;
Ferrer, Marc;
Huang, Sui;
Kozlov, Serguei;
Marugan, Juan

Publication type:

journal article

Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding.

Published in:

Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-0831-6

By:

Huang, Bill X.;
Hu, Xin;
Kwon, Heung-Sun;
Fu, Cheng;
Lee, Ji-Won;
Southall, Noel;
Marugan, Juan;
Kim, Hee-Yong

Publication type:

Article

Discovery of small molecule inhibitors that effectively disrupt IQGAP1-Cdc42 interaction in breast cancer cells.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-21342-w

By:

Sayedyahossein, Samar;
Smith, Jessica;
Barnaeva, Elena;
Li, Zhigang;
Choe, Jun;
Ronzetti, Michael;
Dextras, Christopher;
Hu, Xin;
Marugan, Juan;
Southall, Noel;
Baljinnyam, Bolormaa;
Thines, Louise;
Tran, Andy D.;
Ferrer, Marc;
Sacks, David B.

Publication type:

Article

combinatorial approach increases SMN level in SMA model mice.

Published in:

Human Molecular Genetics, 2022, v. 31, n. 17, p. 2989, doi. 10.1093/hmg/ddac068

By:

Dumas, Samantha A;
Villalón, Eric;
Bergman, Elizabeth M;
Wilson, Kenneth J;
Marugan, Juan J;
Lorson, Christian L;
Burnett, Barrington G

Publication type:

Article

Activation of relaxin family receptor 1 from different mammalian species by relaxin peptide and small-molecule agonist ML290.

Published in:

Frontiers in Endocrinology, 2015, p. 1, doi. 10.3389/fendo.2015.00128

By:

Zaohua Huang;
Myhr, Courtney;
Ho, Brian A.;
Bueno, Amaya;
Agoulnik, Alexander I.;
Bathgate, Ross A. D.;
Xin Hu;
Jingbo Xiao;
Southall, Noel;
Barnaeva, Elena;
Marugan, Juan J.;
Ferrer, Marc;
Agoulnik, Irina U.

Publication type:

Article

Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5340, doi. 10.3390/ijms24065340

By:

Kwon, Heung-Sun;
Kevala, Karl;
Qian, Haohua;
Abu-Asab, Mones;
Patnaik, Samarjit;
Marugan, Juan;
Kim, Hee-Yong

Publication type:

Article

Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 7, p. 3386, doi. 10.3390/ijms22073386

By:

Kwon, Heungsun;
Kevala, Karl;
Xin, Hu;
Patnaik, Samarjit;
Marugan, Juan;
Kim, Hee-Yong;
Jendelova, Pavla

Publication type:

Article

Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1.

Published in:

2017

By:

Agoulnik, Alexander I;
Agoulnik, Irina U;
Hu, Xin;
Marugan, Juan

Publication type:

journal article

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.

Published in:

Science Translational Medicine, 2015, v. 7, n. 282, p. 1, doi. 10.1126/scitranslmed.3010286

By:

Shanshan He;
Billy Lin;
Chu, Virginia;
Zongyi Hu;
Xin Hu;
Jingbo Xiao;
Wang, Amy Q.;
Schweitzer, Cameron J.;
Qisheng Li;
Michio Imamura;
Nobuhiko Hiraga;
Southall, Noel;
Ferrer, Marc;
Wei Zheng;
Kazuaki Chayama;
Marugan, Juan J.;
Liang, T. Jake

Publication type:

Article

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

Published in:

Science Translational Medicine, 2014, v. 6, n. 268, p. 1, doi. 10.1126/scitranslmed.3010523

By:

Xiao-Hong Lu;
Mattis, Virginia B.;
Nan Wang;
Al-Ramahi, Ismael;
van den Berg, Nick;
Fratantoni, Silvina A.;
Waldvogel, Henry;
Greiner, Erin;
Osmand, Alex;
Elzein, Karla;
Jingbo Xiao;
Dijkstra, Sipke;
de Pril, Remko;
Vinters, Harry V.;
Faull, Richard;
Signer, Ethan;
Seung Kwak;
Marugan, Juan J.;
Botas, Juan;
Fischer, David F.

Publication type:

Article

Macrophage Models of Gaucher Disease for Evaluating Disease Pathogenesis and Candidate Drugs.

Published in:

Science Translational Medicine, 2014, v. 6, n. 240, p. 1, doi. 10.1126/scitranslmed.3008659

By:

Aflaki, Elma;
Stubblefield, Barbara K.;
Maniwang, Emerson;
Lopez, Grisel;
Moaven, Nima;
Goldin, Ehud;
Marugan, Juan;
Patnaik, Samarjit;
Dutra, Amalia;
Southall, Noel;
Wei Zheng;
Tayebi, Nahid;
Sidransky, Ellen

Publication type:

Article

Cell-based high-throughput screening identifies galactocerebrosidase enhancers as potential small-molecule therapies for Krabbe's disease.

Published in:

Journal of Neuroscience Research, 2016, v. 94, n. 11, p. 1231, doi. 10.1002/jnr.23875

By:

Jang, Dae Song;
Ye, Wenjuan;
Guimei, Tian;
Solomon, Melani;
Southall, Noel;
Hu, Xin;
Marugan, Juan;
Ferrer, Marc;
Maegawa, Gustavo H.B.

Publication type:

Article

A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis.

Published in:

Autophagy, 2019, v. 15, n. 10, p. 1694, doi. 10.1080/15548627.2019.1586257

By:

Sharma, Gaurav;
Guardia, Carlos M.;
Roy, Ajit;
Vassilev, Alex;
Saric, Amra;
Griner, Lori N.;
Marugan, Juan;
Ferrer, Marc;
Bonifacino, Juan S.;
DePamphilis, Melvin L.

Publication type:

Article

A Novel Brain Penetrant NPS Receptor Antagonist, NCGC00185684, Blocks Alcohol-Induced ERK-Phosphorylation in the Central Amygdala and Decreases Operant Alcohol Self-Administration in Rats.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 24, p. 10132, doi. 10.1523/JNEUROSCI.4742-12.2013

By:

Thorsell, Annika;
Tapocik, Jenica D.;
Ke Liu;
Zook, Michelle;
Bell, Lauren;
Flanigan, Meghan;
Patnaik, Samarjit;
Marugan, Juan;
Damadzic, Ruslan;
Dehdashti, Seameen J.;
Schwandt, Melanie L.;
Southall, Noel;
Austin, Christopher P.;
Eskay, Robert;
Ciccocioppo, Roberto;
Wei Zheng;
Heilig, Markus

Publication type:

Article

Consulta enfermera de Educación Terapéutica en asma grave.

Published in:

Metas de Enfermería, 2023, v. 26, n. 8, p. 23, doi. 10.35667/MetasEnf,2023,26.1003082159

By:

Martín-Gómez, Mónica;
Sierra-Maeso, Marta;
Soledad Hervás-Trujillo, María;
de Juan-Marugán, Amalia;
Gijón-Serrano, Helena Ángeles;
Álvarez-Arnela, Dionisia

Publication type:

Article

A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide.

Published in:

Analytical & Bioanalytical Chemistry, 2012, v. 402, n. 2, p. 731, doi. 10.1007/s00216-011-5496-z

By:

Motabar, Omid;
Goldin, Ehud;
Leister, William;
Liu, Ke;
Southall, Noel;
Huang, Wenwei;
Marugan, Juan;
Sidransky, Ellen;
Zheng, Wei

Publication type:

Article

Teaching principles of translational science to a broad scientific audience using a case study approach: A pilot course from the National Center for Advancing Translational Sciences.

Published in:

Journal of Clinical & Translational Science, 2022, v. 6, n. 1, p. 1, doi. 10.1017/cts.2022.374

By:

Faupel-Badger, Jessica M.;
Vogel, Amanda L.;
Hussain, Shadab F.;
Austin, Christopher P.;
Hall, Matthew D.;
Ness, Elizabeth;
Sanderson, Philip;
Terse, Pramod S.;
Xu, Xin;
Balakrishnan, Krishna;
Patnaik, Samarjit;
Marugan, Juan J.;
Rudloff, Udo;
Ferrer, Marc

Publication type:

Article

Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-60610-5

By:

Singh, Anju;
Dashnyam, Myagmarjav;
Chim, Bryan;
Escobar, Thelma M.;
Dulcey, Andrés E.;
Hu, Xin;
Wilson, Kelli M.;
Koganti, Prasanthi P.;
Spinner, Camille A.;
Xu, Xin;
Jadhav, Ajit;
Southall, Noel;
Marugan, Juan;
Selvaraj, Vimal;
Lazarevic, Vanja;
Muljo, Stefan A.;
Ferrer, Marc

Publication type:

Article

Progress and potential of non-inhibitory small molecule chaperones for the treatment of Gaucher disease and its implications for Parkinson disease.

Published in:

Expert Review of Proteomics, 2016, v. 13, n. 5, p. 471, doi. 10.1080/14789450.2016.1174583

By:

Jung, Olive;
Patnaik, Samarjit;
Marugan, Juan;
Sidransky, Ellen;
Westbroek, Wendy

Publication type:

Article

Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages.

Published in:

Aging Cell, 2016, v. 15, n. 1, p. 77, doi. 10.1111/acel.12409

By:

Aflaki, Elma;
Moaven, Nima;
Borger, Daniel K.;
Lopez, Grisel;
Westbroek, Wendy;
Chae, Jae Jin;
Marugan, Juan;
Patnaik, Samarjit;
Maniwang, Emerson;
Gonzalez, Ashley N.;
Sidransky, Ellen

Publication type:

Article

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-36144-2

By:

Rojas, Camilo;
Barnaeva, Elena;
Thomas, Ajit G.;
Hu, Xin;
Southall, Noel;
Marugan, Juan;
Chaudhuri, Amrita Datta;
Yoo, Seung-Wan;
Hin, Niyada;
Stepanek, Ondrej;
Wu, Ying;
Zimmermann, Sarah C.;
Gadiano, Alexandra G.;
Tsukamoto, Takashi;
Rais, Rana;
Haughey, Norman;
Ferrer, Marc;
Slusher, Barbara S.

Publication type:

Article

Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function.

Published in:

Nature Communications, 2016, v. 7, n. 10, p. 13123, doi. 10.1038/ncomms13123

By:

Lee, Ji-Won;
Huang, Bill X.;
Kwon, HeungSun;
Rashid, Md Abdur;
Kharebava, Giorgi;
Desai, Abhishek;
Patnaik, Samarjit;
Marugan, Juan;
Kim, Hee-Yong

Publication type:

Article

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.

Published in:

Nature Communications, 2016, v. 7, n. 6, p. 12109, doi. 10.1038/ncomms12109

By:

Zhang, Xiaoli;
Cheng, Xiping;
Yu, Lu;
Yang, Junsheng;
Calvo, Raul;
Patnaik, Samarjit;
Hu, Xin;
Gao, Qiong;
Yang, Meimei;
Lawas, Maria;
Delling, Markus;
Marugan, Juan;
Ferrer, Marc;
Xu, Haoxing

Publication type:

Article

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.

Published in:

Nature Communications, 2013, v. 4, n. 6, p. 1953, doi. 10.1038/ncomms2953

By:

Xiao, Jingbo;
Huang, Zaohua;
Chen, Catherine Z.;
Agoulnik, Irina U.;
Southall, Noel;
Hu, Xin;
Jones, Raisa E.;
Ferrer, Marc;
Zheng, Wei;
Agoulnik, Alexander I.;
Marugan, Juan J.

Publication type:

Article

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

Published in:

Nature Communications, 2013, v. 4, n. 6, p. 2044, doi. 10.1038/ncomms3044

By:

Childs-Disney, Jessica L.;
Stepniak-Konieczna, Ewa;
Tran, Tuan;
Yildirim, Ilyas;
Park, HaJeung;
Chen, Catherine Z.;
Hoskins, Jason;
Southall, Noel;
Marugan, Juan J.;
Patnaik, Samarjit;
Zheng, Wei;
Austin, Chris P.;
Schatz, George C.;
Sobczak, Krzysztof;
Thornton, Charles A.;
Disney, Matthew D.

Publication type:

Article

Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.

Published in:

Autophagy, 2017, v. 13, n. 8, p. 1435, doi. 10.1080/15548627.2017.1329081

By:

Dai, Sheng;
Dulcey, Andrés E.;
Hu, Xin;
Wassif, Christopher A.;
Porter, Forbes D.;
Austin, Christopher P.;
Ory, Daniel S.;
Marugan, Juan;
Zheng, Wei

Publication type:

Article

Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids.

Published in:

Autophagy, 2016, v. 12, n. 9, p. 1460, doi. 10.1080/15548627.2016.1187367

By:

Kuramoto, Kenta;
Wang, Nan;
Fan, Yuying;
Zhang, Weiran;
Schoenen, Frank J.;
Frankowski, Kevin J.;
Marugan, Juan;
Zhou, Yifa;
Huang, Sui;
He, Congcong

Publication type:

Article

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 10, p. 6591, doi. 10.1093/nar/gku275

By:

Hoskins, Jason W.;
Ofori, Leslie O.;
Chen, Catherine Z.;
Kumar, Amit;
Sobczak, Krzysztof;
Nakamori, Masayuki;
Southall, Noel;
Patnaik, Samarjit;
Marugan, Juan J.;
Zheng, Wei;
Austin, Christopher P.;
Disney, Matthew D.;
Miller, Benjamin L.;
Thornton, Charles A.

Publication type:

Article

Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

Published in:

2018

By:

Rolt, Adam;
Le, Derek;
Zongyi Hu;
Wang, Amy Q.;
Shah, Pranav;
Singleton, Marc;
Hughes, Emma;
Dulcey, Andrés E.;
He, Shanshan;
Michio Imamura;
Takuro Uchida;
Kazuaki Chayama;
Xin Xu;
Marugan, Juan J.;
Liang, T. Jake;
Hu, Zongyi;
Imamura, Michio;
Uchida, Takuro;
Chayama, Kazuaki;
Xu, Xin

Publication type:

journal article

Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis.

Published in:

FASEB Journal, 2019, v. 33, n. 11, p. 12435, doi. 10.1096/fj.201901046R

By:

Kaftanovskaya, Elena M.;
Hooi Hooi Ng;
Soula, Mariluz;
Rivas, Bryan;
Myhr, Courtney;
Ho, Brian A.;
Cervantes, Briana A.;
Shupe, Thomas D.;
Devarasetty, Mahesh;
Xin Hu;
Xin Xu;
Patnaik, Samarjit;
Wilson, Kenneth J.;
Barnaeva, Elena;
Ferrer, Marc;
Southall, Noel T.;
Marugan, Juan J.;
Bishop, Colin E.;
Agoulnik, Irina U.;
Agoulnik, Alexander I.

Publication type:

Article

Discovery and characterization of a G protein‐biased agonist of the D2 dopamine receptor (662.7).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.662.7

By:

Chun, Lani;
Free, R.;
Moritz, Amy;
Conroy, Jennie;
Meade, Julie;
Xiao, Jingbo;
Dulcey, Andrés;
Vekariya, Rakesh;
Ferrer, Marc;
Javitch, Jonathan;
Beuming, Thijs;
Shi, Lei;
Southall, Noel;
Marugan, Juan;
Aubé, Jeff;
Frankowski, Kevin;
Sibley, David

Publication type:

Article

Discovery, characterization, and optimization of highly selective D2 dopaminergic antagonists.

Published in:

FASEB Journal, 2013, v. 27, p. 655.7, doi. 10.1096/fasebj.27.1_supplement.655.7

By:

Free, R. Benjamin;
Xiao, Jingbo;
Doyle, Trevor;
Conroy, Jennie;
Titus, Steve;
Bryant‐Genevier, Melanie;
Southall, Noel;
Hu, Xin;
Ferrer, Marc;
Javitch, Jonathan A;
Marugan, Juan J;
Sibley, David R

Publication type:

Article

GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice.

Published in:

2021

By:

Chen, Huazhen;
Kevala, Karl;
Aflaki, Elma;
Marugan, Juan;
Kim, Hee-Yong

Publication type:

journal article

The function of phosphatidylinositol 5-phosphate 4-kinase ɣ (PI5P4Kɣ) explored using a specific inhibitor that targets the PI5P-binding site.

Published in:

Biochemical Journal, 2015, v. 466, n. 2, p. 359, doi. 10.1042/BJ20141333

By:

Clarke, Jonathan H.;
Giudici, Maria-Luisa;
Burke, John E.;
Williams, Roger L.;
Maloney, David J.;
Marugan, Juan;
Irvine, Robin F.

Publication type:

Article

Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-90944-7

By:

Singh, Anju;
Dashynam, Myagmarjav;
Chim, Bryan;
Escobar, Thelma M.;
Liu, Xiuhuai;
Hu, Xin;
Patnaik, Samarjit;
Xu, Xin;
Southall, Noel;
Marugan, Juan;
Jadhav, Ajit;
Lazarevic, Vanja;
Muljo, Stefan A.;
Ferrer, Marc

Publication type:

Article