Works by Lyssiotis, Costas A

Results: 49

Itaconate potentiates hepatic gluconeogenesis through NRF2 induction.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0322946

By:

El-Derany, Marwa O.;
Ramakrishnan, Sadeesh K.;
Li, Yingjie;
Buscher, Kathryn;
Jarad, Christina A.;
Schaller, Megan L.;
Cantwell, Marc;
Vigil, Thomas M.;
Frieler, Ryan A.;
Sajjakulnukit, Peter;
Lyssiotis, Costas A.;
Mortensen, Richard M.;
Shah, Yatrik M.

Publication type:

Article

Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells.

Published in:

Angewandte Chemie, 2011, v. 123, n. 25, p. 5852, doi. 10.1002/ange.201101042

By:

Staerk, Judith;
Lyssiotis, Costas A.;
Medeiro, Lea A.;
Bollong, Michael;
Foreman, Ruth K.;
Zhu, Shoutian;
Garcia, Michael;
Gao, Qing;
Bouchez, Laure C.;
Lairson, Luke L.;
Charette, Bradley D.;
Supekova, Lubica;
Janes, Jeffrey;
Brinker, Achim;
Cho, Charles Y.;
Jaenisch, Rudolf;
Schultz, Peter G.

Publication type:

Article

Chemische Kontrolle des Schicksals und Entwicklungspotenzials von Stammzellen.

Published in:

Angewandte Chemie, 2011, v. 123, n. 1, p. 210, doi. 10.1002/ange.201004284

By:

Lyssiotis, Costas A.;
Lairson, Luke L.;
Boitano, Anthony E.;
Wurdak, Heiko;
Zhu, Shoutian;
Schultz, Peter G.

Publication type:

Article

Transferrin Receptor‐Mediated Iron Uptake Promotes Colon Tumorigenesis.

Published in:

Advanced Science, 2023, v. 10, n. 10, p. 1, doi. 10.1002/advs.202207693

By:

Kim, Hyeoncheol;
Villareal, Luke B;
Liu, Zhaoli;
Haneef, Mohammad;
Falcon, Daniel M;
Martin, David R;
Lee, Ho‐Joon;
Dame, Michael K;
Attili, Durga;
Chen, Ying;
Varani, James;
Spence, Jason R.;
Kovbasnjuk, Olga;
Colacino, Justin A;
Lyssiotis, Costas A.;
Lin, Henry C;
Shah, Yatrik M;
Xue, Xiang

Publication type:

Article

Quiescence enables unrestricted cell fate in naive embryonic stem cells.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46121-1

By:

Khoa, Le Tran Phuc;
Yang, Wentao;
Shan, Mengrou;
Zhang, Li;
Mao, Fengbiao;
Zhou, Bo;
Li, Qiang;
Malcore, Rebecca;
Harris, Clair;
Zhao, Lili;
Rao, Rajesh;
Iwase, Shigeki;
Kalantry, Sundeep;
Bielas, Stephanie L.;
Lyssiotis, Costas A.;
Dou, Yali

Publication type:

Article

Quiescence enables unrestricted cell fate in naive embryonic stem cells.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46121-1

By:

Khoa, Le Tran Phuc;
Yang, Wentao;
Shan, Mengrou;
Zhang, Li;
Mao, Fengbiao;
Zhou, Bo;
Li, Qiang;
Malcore, Rebecca;
Harris, Clair;
Zhao, Lili;
Rao, Rajesh;
Iwase, Shigeki;
Kalantry, Sundeep;
Bielas, Stephanie L.;
Lyssiotis, Costas A.;
Dou, Yali

Publication type:

Article

Metabolic Reprogramming and Vulnerabilities in Cancer.

Published in:

2020

By:

Lyssiotis, Costas A.;
Nagrath, Deepak

Publication type:

Editorial

Metabolic Regulation of Redox Balance in Cancer.

Published in:

Cancers, 2019, v. 11, n. 7, p. 955, doi. 10.3390/cancers11070955

By:

Purohit, Vinee;
Simeone, Diane M.;
Lyssiotis, Costas A.

Publication type:

Article

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS/MS.

Published in:

Nature Protocols, 2019, v. 14, n. 2, p. 313, doi. 10.1038/s41596-018-0102-x

By:

Yuan, Min;
Kremer, Daniel M.;
Huang, He;
Breitkopf, Susanne B.;
Ben-Sahra, Issam;
Manning, Brendan D.;
Lyssiotis, Costas A.;
Asara, John M.

Publication type:

Article

Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions.

Published in:

PLoS ONE, 2024, v. 19, n. 6, p. 1, doi. 10.1371/journal.pone.0303577

By:

Alektiar, Jonathan M.;
Shan, Mengrou;
Radyk, Megan D.;
Zhang, Li;
Halbrook, Christopher J.;
Lin, Lin;
Espinoza, Carlos;
Mier, Ivan F.;
Lavoie, Brooke L.;
Salvatore, Lucie;
Pasca di Magliano, Marina;
Cantley, Lewis C.;
Mueller, Jacob L.;
Lyssiotis, Costas A.

Publication type:

Article

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.

Published in:

EMBO Journal, 2013, v. 32, n. 19, p. 2589, doi. 10.1038/emboj.2013.186

By:

Yeo, Hyeonju;
Lyssiotis, Costas A;
Zhang, Yuqing;
Ying, Haoqiang;
Asara, John M;
Cantley, Lewis C;
Paik, Ji‐Hye

Publication type:

Article

Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.73796

By:

Boyer, Seth;
Ho-Joon Lee;
Steele, Nina;
Li Zhang;
Sajjakulnukit, Peter;
Andren, Anthony;
Ward, Matthew H.;
Singh, Rima;
Basrur, Venkatesha;
Yaqing Zhang;
Nesvizhskii, Alexey I.;
di Magliano, Marina Pasca;
Halbrook, Christopher J.;
Lyssiotis, Costas A.

Publication type:

Article

Hyaluronic acid fuels pancreatic cancer cell growth.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.62645

By:

Kim, Peter K.;
Halbrook, Christopher J.;
Kerk, Samuel A.;
Radyk, Megan;
Wisner, Stephanie;
Kremer, Daniel M.;
Sajjakulnukit, Peter;
Andren, Anthony;
Hou, Sean W.;
Trivedi, Ayush;
Thurston, Galloway;
Anand, Abhinav;
Liang Yan;
Salamanca-Cardona, Lucia;
Welling, Samuel D.;
Li Zhang;
Pratt, Matthew R.;
Keshari, Kayvan R.;
Haoqiang Ying;
Lyssiotis, Costas A.

Publication type:

Article

Common biochemical properties of metabolic genes recurrently dysregulated in tumors.

Published in:

Cancer & Metabolism, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40170-020-0211-1

By:

Oruganty, Krishnadev;
Campit, Scott Edward;
Mamde, Sainath;
Lyssiotis, Costas A.;
Chandrasekaran, Sriram

Publication type:

Article

Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by β-lapachone.

Published in:

Cancer & Metabolism, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40170-015-0137-1

By:

Chakrabarti, Gaurab;
Moore, Zachary R.;
Xiuquan Luo;
Ilcheva, Mariya;
Ali, Aktar;
Padanad, Mahesh;
Yunyun Zhou;
Yang Xie;
Burma, Sandeep;
Scaglioni, Pier P.;
Cantley, Lewis C.;
DeBerardinis, Ralph J.;
Kimmelman, Alec C.;
Lyssiotis, Costas A.;
Boothman, David A.

Publication type:

Article

Amino acid metabolism in primary bone sarcomas.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.1001318

By:

Jiménez, Jennifer A.;
Lawlor, Elizabeth R.;
Lyssiotis, Costas A.

Publication type:

Article

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

Published in:

Nature Cell Biology, 2013, v. 15, n. 1, p. 124, doi. 10.1038/ncb2677

By:

Yang, Weiwei;
Zheng, Yanhua;
Xia, Yan;
Ji, Haitao;
Chen, Xiaomin;
Guo, Fang;
Lyssiotis, Costas A.;
Aldape, Kenneth;
Cantley, Lewis C.;
Lu, Zhimin

Publication type:

Article

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

Published in:

Nature Cell Biology, 2012, v. 14, n. 12, p. 1295, doi. 10.1038/ncb2629

By:

Yang, Weiwei;
Zheng, Yanhua;
Xia, Yan;
Ji, Haitao;
Chen, Xiaomin;
Guo, Fang;
Lyssiotis, Costas A.;
Aldape, Kenneth;
Cantley, Lewis C.;
Lu, Zhimin

Publication type:

Article

Menin regulates the serine biosynthetic pathway in Ewing sarcoma.

Published in:

Journal of Pathology, 2018, v. 245, n. 3, p. 324, doi. 10.1002/path.5085

By:

Svoboda, Laurie K.;
Teh, Selina Shiqing K.;
Sud, Sudha;
Kerk, Samuel;
Zebolsky, Aaron;
Treichel, Sydney;
Thomas, Dafydd;
Halbrook, Christopher J.;
Lee, Ho‐Joon;
Kremer, Daniel;
Zhang, Li;
Klossowski, Szymon;
Bankhead, Armand R.;
Magnuson, Brian;
Ljungman, Mats;
Cierpicki, Tomasz;
Grembecka, Jolanta;
Lyssiotis, Costas A.;
Lawlor, Elizabeth R.

Publication type:

Article

A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling.

Published in:

EMBO Journal, 2023, v. 42, n. 7, p. 1, doi. 10.15252/embj.2022111148

By:

Zhu, Lingxin;
Tang, Yi;
Li, Xiao‐Yan;
Kerk, Samuel A;
Lyssiotis, Costas A;
Feng, Wenqing;
Sun, Xiaoyue;
Hespe, Geoffrey E;
Wang, Zijun;
Stemmler, Marc P;
Brabletz, Simone;
Brabletz, Thomas;
Keller, Evan T;
Ma, Jun;
Cho, Jung‐Sun;
Yang, Jingwen;
Weiss, Stephen J

Publication type:

Article

A regenerative approach to the treatment of multiple sclerosis.

Published in:

Nature, 2013, v. 502, n. 7471, p. 327, doi. 10.1038/nature12647

By:

Deshmukh, Vishal A.;
Tardif, Virginie;
Lyssiotis, Costas A.;
Green, Chelsea C.;
Kerman, Bilal;
Kim, Hyung Joon;
Padmanabhan, Krishnan;
Swoboda, Jonathan G.;
Ahmad, Insha;
Kondo, Toru;
Gage, Fred H.;
Theofilopoulos, Argyrios N.;
Lawson, Brian R.;
Schultz, Peter G.;
Lairson, Luke L.

Publication type:

Article

Metabolic syndrome: F stands for fructose and fat.

Published in:

Nature, 2013, v. 502, n. 7470, p. 181, doi. 10.1038/502181a

By:

Lyssiotis, Costas A.;
Cantley, Lewis C.

Publication type:

Article

Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Published in:

Nature, 2013, v. 499, n. 7459, p. 504, doi. 10.1038/nature12317

By:

Son, Jaekyoung;
Lyssiotis, Costas A.;
Ying, Haoqiang;
Wang, Xiaoxu;
Hua, Sujun;
Ligorio, Matteo;
Perera, Rushika M.;
Ferrone, Cristina R.;
Mullarky, Edouard;
Shyh-Chang, Ng;
Kang, Ya'an;
Fleming, Jason B.;
Bardeesy, Nabeel;
Asara, John M.;
Haigis, Marcia C.;
DePinho, Ronald A.;
Cantley, Lewis C.;
Kimmelman, Alec C.

Publication type:

Article

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Published in:

Nature, 2013, v. 496, n. 7443, p. 101, doi. 10.1038/nature12040

By:

Son, Jaekyoung;
Lyssiotis, Costas A.;
Ying, Haoqiang;
Wang, Xiaoxu;
Hua, Sujun;
Ligorio, Matteo;
Perera, Rushika M.;
Ferrone, Cristina R.;
Mullarky, Edouard;
Shyh-Chang, Ng;
Kang, Ya'an;
Fleming, Jason B.;
Bardeesy, Nabeel;
Asara, John M.;
Haigis, Marcia C.;
DePinho, Ronald A.;
Cantley, Lewis C.;
Kimmelman, Alec C.

Publication type:

Article

478 Bacterial dysbiosis and its association with pancreatic cancer progression and poor survival.

Published in:

2025

By:

Attebury, Holly;
Arbor, Ann;
Awad, Dominik;
Donahue, Katelyn;
Elhossiny, Ahmed;
Frankel, Tim;
Schmidt, Tom;
Lyssiotis, Costas;
di Magliano, Marina Pasca;
Daley, Donnele

Publication type:

Abstract

3373 Modulation of Hedgehog Signaling Alters Immune Infiltration in Pancreatic Cancer.

Published in:

2019

By:

Steele, Nina;
Irizarry-Negron, Valerie;
Sirihorachai, Veerin;
Kemp, Samantha;
Carpenter, Eileen;
Halbrook, Christopher;
Lyssiotis, Costas;
Bednar, Filip;
Frankel, Timothy;
Allen, Benjamin;
Pasca di Magliano, Marina

Publication type:

Abstract

GENE-35. IDH1-R132H INDUCES AN EPIGENETIC REPROGRAMMING IN GLIOMA IMPACTING MEDIAN SURVIVAL, DNA-DAMAGE RESPONSE AND RADIO-SENSITIVITY.

Published in:

Neuro-Oncology, 2018, v. 20, p. vi111, doi. 10.1093/neuonc/noy148.461

By:

Nunez, Felipe;
Mendez, Flor;
Kadiyala, Padma;
Alghamri, Mahmoud;
Carney, Stephen;
Ljungman, Mats;
Qin, Tingting;
Sartor, Maureen;
Venneti, Sriram;
Lyssiotis, Costas

Publication type:

Article

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07472-8

By:

Santana-Codina, Naiara;
Roeth, Anjali A.;
Zhang, Yi;
Yang, Annan;
Mashadova, Oksana;
Asara, John M.;
Wang, Xiaoxu;
Bronson, Roderick T.;
Lyssiotis, Costas A.;
Ying, Haoqiang;
Kimmelman, Alec C.

Publication type:

Article

A colorectal cancer classification system that associates cellular phenotype and responses to therapy.

Published in:

Nature Medicine, 2013, v. 19, n. 5, p. 619, doi. 10.1038/nm.3175

By:

Sadanandam, Anguraj;
Lyssiotis, Costas A;
Homicsko, Krisztian;
Collisson, Eric A;
Gibb, William J;
Wullschleger, Stephan;
Ostos, Liliane C Gonzalez;
Lannon, William A;
Grotzinger, Carsten;
Del Rio, Maguy;
Lhermitte, Benoit;
Olshen, Adam B;
Wiedenmann, Bertram;
Cantley, Lewis C;
Gray, Joe W;
Hanahan, Douglas

Publication type:

Article

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.

Published in:

Nature, 2014, v. 514, n. 7524, p. 628, doi. 10.1038/nature13611

By:

Viale, Andrea;
Pettazzoni, Piergiorgio;
Kimmelman, Alec C.;
Wang, Huamin;
DePinho, Ronald A.;
Lyssiotis, Costas A.;
Cantley, Lewis C.;
Ying, Haoqiang;
Muller, Florian;
Colla, Simona;
Genovese, Giannicola;
Deem, Angela K.;
Kapoor, Avnish;
Wang, Y. Alan;
Sánchez, Nora;
Marchesini, Matteo;
Green, Tessa;
Nezi, Luigi;
Yao, Wantong;
Draetta, Giulio F.

Publication type:

Article

Auditory metabolomics, an approach to identify acute molecular effects of noise trauma.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-45385-8

By:

Ji, Lingchao;
Lee, Ho-Joon;
Wan, Guoqiang;
Wang, Guo-Peng;
Zhang, Li;
Sajjakulnukit, Peter;
Schacht, Jochen;
Lyssiotis, Costas A.;
Corfas, Gabriel

Publication type:

Article

Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infection.

Published in:

Gut Microbes, 2022, v. 14, n. 1, p. 1, doi. 10.1080/19490976.2022.2105609

By:

Brown, Julia A.;
Sanidad, Katherine Z.;
Lucotti, Serena;
Lieber, Carolin M.;
Cox, Robert M.;
Ananthanarayanan, Aparna;
Basu, Srijani;
Chen, Justin;
Shan, Mengrou;
Amir, Mohammed;
Schmidt, Fabian;
Weisblum, Yiska;
Cioffi, Michele;
Tingting Li;
Rowdo, Florencia Madorsky;
Martin, M. Laura;
Chun-Jun Guo;
Lyssiotis, Costas A.;
Layden, Brian T.;
Dannenberg, Andrew J.

Publication type:

Article

Spotlight on GOT2 in Cancer Metabolism.

Published in:

OncoTargets & Therapy, 2023, v. 16, p. 695, doi. 10.2147/OTT.S382161

By:

Kerk, Samuel A;
Garcia-Bermudez, Javier;
Birsoy, Kivanc;
Sherman, Mara H;
Shah, Yatrik M;
Lyssiotis, Costas A

Publication type:

Article

Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 25, p. 5734, doi. 10.1002/anie.201101042

By:

Staerk, Judith;
Lyssiotis, Costas A.;
Medeiro, Lea A.;
Bollong, Michael;
Foreman, Ruth K.;
Zhu, Shoutian;
Garcia, Michael;
Gao, Qing;
Bouchez, Laure C.;
Lairson, Luke L.;
Charette, Bradley D.;
Supekova, Lubica;
Janes, Jeffrey;
Brinker, Achim;
Cho, Charles Y.;
Jaenisch, Rudolf;
Schultz, Peter G.

Publication type:

Article

Chemical Control of Stem Cell Fate and Developmental Potential.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 1, p. 200, doi. 10.1002/anie.201004284

By:

Lyssiotis, Costas A.;
Lairson, Luke L.;
Boitano, Anthony E.;
Wurdak, Heiko;
Zhu, Shoutian;
Schultz, Peter G.

Publication type:

Article

Rod photoreceptor-specific deletion of cytosolic aspartate aminotransferase, GOT1, causes retinal degeneration.

Published in:

Frontiers in Ophthalmology, 2023, p. 1, doi. 10.3389/fopht.2023.1306019

By:

Subramanya, Shubha;
Goswami, Moloy T.;
Miller, Nicholas;
Weh, Eric;
Chaudhury, Sraboni;
Li Zhang;
Andren, Anthony;
Hager, Heather;
Weh, Katherine M.;
Lyssiotis, Costas A.;
Besirli, Cagri G.;
Wubben, Thomas J.

Publication type:

Article

Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages.

Published in:

Life Science Alliance, 2021, v. 4, n. 6, p. 1, doi. 10.26508/lsa.202000935

By:

Kemp, Samantha B.;
Steele, Nina G.;
Carpenter, Eileen S.;
Donahue, Katelyn L.;
Bushnell, Grace G.;
Morris, Aaron H.;
The, Stephanie;
Orbach, Sophia M.;
Sirihorachai, Veerin R.;
Nwosu, Zeribe C.;
Espinoza, Carlos;
Lima, Fatima;
Brown, Kristee;
Girgis, Alexander A.;
Gunchick, Valerie;
Yaqing Zhang;
Lyssiotis, Costas A.;
Franke, Timothy L.;
Bednar, Filip;
Rao, Arvind

Publication type:

Article

Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.81289

By:

Saab, Juan J. Apiz;
Dzierozynski, Lindsey N.;
Jonker, Patrick B.;
Tabrizi, Roya Amini;
Shah, Hardik;
Menjivar, Rosa Elena;
Scott, Andrew J.;
Nwosu, Zeribe C.;
Zhou Zhu;
Chen, Riona N.;
Oh, Moses;
Sheehan, Colin;
Wahl, Daniel R.;
di Magliano, Marina Pasca;
Lyssiotis, Costas A.;
Macleod, Kay F.;
Weber, Christopher R.;
Muir, Alexander

Publication type:

Article

Arginase 1 is a key driver of immune suppression in pancreatic cancer.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.80721

By:

Menjivar, Rosa E.;
Nwosu, Zeribe C.;
Wenting Du;
Donahue, Katelyn L.;
Hong, Hanna S.;
Espinoza, Carlos;
Brown, Kristee;
Velez-Delgado, Ashley;
Wei Yan;
Lima, Fatima;
Bischoff, Allison;
Kadiyala, Padma;
Salas-Escabillas, Daniel;
Crawford, Howard C.;
Bednar, Filip;
Carpenter, Eileen;
Yaqing Zhang;
Halbrook, Christopher J.;
Lyssiotis, Costas A.;
di Magliano, Marina Pasca

Publication type:

Article

Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-16506-7

By:

Guo, Angela H.;
Baliira, Rachael;
Skinner, Mary E.;
Kumar, Surinder;
Andren, Anthony;
Zhang, Li;
Goldsmith, Robert S.;
Michan, Shaday;
Davis, Norma J.;
Maccani, Merissa W.;
Day, Sharlene M.;
Sinclair, David A.;
Brody, Matthew J.;
Lyssiotis, Costas A.;
Stein, Adam B.;
Lombard, David B.

Publication type:

Article

The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-96995-0

By:

Carruthers, Nicholas J.;
Strieder-Barboza, Clarissa;
Caruso, Joseph A.;
Flesher, Carmen G.;
Baker, Nicki A.;
Kerk, Samuel A.;
Ky, Alexander;
Ehlers, Anne P.;
Varban, Oliver A.;
Lyssiotis, Costas A.;
Lumeng, Carey N.;
Stemmer, Paul M.;
O'Rourke, Robert W.

Publication type:

Article

Functional and biological heterogeneity of KRAS<sup>Q61</sup> mutations.

Published in:

Science Signaling, 2022, v. 15, n. 746, p. 1, doi. 10.1126/scisignal.abn2694

By:

Huynh, Minh V.;
Hobbs, G. Aaron;
Schaefer, Antje;
Pierobon, Mariaelena;
Carey, Leiah M.;
Diehl, J. Nathaniel;
DeLiberty, Jonathan M.;
Thurman, Ryan D.;
Cooke, Adelaide R.;
Goodwin, Craig M.;
Cook, Joshua H.;
Lin, Lin;
Waters, Andrew M.;
Rashid, Naim U.;
Petricoin III, Emanuel F.;
Campbell, Sharon L.;
Haigis, Kevin M.;
Simeone, Diane M.;
Lyssiotis, Costas A.;
Cox, Adrienne D.

Publication type:

Article

Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.

Published in:

Journal of Cell Biology, 2023, v. 222, n. 4, p. 1, doi. 10.1083/jcb.202206121

By:

Lingxin Zhu;
Yi Tang;
Xiao-Yan Li;
Kerk, Samuel A.;
Lyssiotis, Costas A.;
Xiaoyue Sun;
Zijun Wang;
Jung-Sun Cho;
Jun Ma;
Weiss, Stephen J.

Publication type:

Article

HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron.

Published in:

2021

By:

Singhal, Rashi;
Mitta, Sreedhar R.;
Das, Nupur K.;
Kerk, Samuel A.;
Sajjakulnukit, Peter;
Solanki, Sumeet;
Andren, Anthony;
Kumar, Roshan;
Olive, Kenneth P.;
Banerjee, Ruma;
Lyssiotis, Costas A.;
Shah, Yatrik M.

Publication type:

journal article

High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions.

Published in:

Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-0988-z

By:

Little, Andrew Charles;
Kovalenko, Ilya;
Goo, Laura Elaine;
Hong, Hanna Sungok;
Kerk, Samuel Andrew;
Yates, Joel Anthony;
Purohit, Vinee;
Lombard, David Benner;
Merajver, Sofia Diana;
Lyssiotis, Costas Andreas

Publication type:

Article

A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics.

Published in:

Metabolomics, 2019, v. 15, n. 7, p. N.PAG, doi. 10.1007/s11306-019-1564-8

By:

Lee, Ho-Joon;
Kremer, Daniel M.;
Sajjakulnukit, Peter;
Zhang, Li;
Lyssiotis, Costas A.

Publication type:

Article

Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma.

Published in:

Cancer & Metabolism, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40170-024-00341-7

By:

Peterson, Erik R.;
Sajjakulnukit, Peter;
Scott, Andrew J.;
Heaslip, Caleb;
Andren, Anthony;
Wilder-Romans, Kari;
Zhou, Weihua;
Palavalasa, Sravya;
Korimerla, Navyateja;
Lin, Angelica;
O'Brien, Alexandra;
Kothari, Ayesha;
Zhao, Zitong;
Zhang, Li;
Morgan, Meredith A.;
Venneti, Sriram;
Koschmann, Carl;
Jabado, Nada;
Lyssiotis, Costas A.;
Castro, Maria G.

Publication type:

Article

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

Published in:

Nature Genetics, 2011, v. 43, n. 9, p. 869, doi. 10.1038/ng.890

By:

Locasale, Jason W.;
Grassian, Alexandra R.;
Melman, Tamar;
Lyssiotis, Costas A.;
Mattaini, Katherine R.;
Bass, Adam J.;
Heffron, Gregory;
Metallo, Christian M.;
Muranen, Taru;
Sharfi, Hadar;
Sasaki, Atsuo T.;
Anastasiou, Dimitrios;
Mullarky, Edouard;
Vokes, Natalie I.;
Sasaki, Mika;
Beroukhim, Rameen;
Stephanopoulos, Gregory;
Ligon, Azra H.;
Meyerson, Matthew;
Richardson, Andrea L.

Publication type:

Article

Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance.

Published in:

Cell Cycle, 2013, v. 12, n. 13, p. 1987, doi. 10.4161/cc.25307

By:

Lyssiotis, Costas A.;
Jaekyoung Son;
Cantley, Lewis C.;
Kimmelman, Alec C.

Publication type:

Article