Works by Lushchekina, Sofya V.

Results: 28
    1

    Conjugates of amiridine and salicylic derivatives as promising multifunctional CNS agents for potential treatment of Alzheimer's disease.

    Published in:
    Archiv der Pharmazie, 2025, v. 358, n. 1, p. 1, doi. 10.1002/ardp.202400819
    By:
    • Makhaeva, Galina F.;
    • Grishchenko, Maria V.;
    • Kovaleva, Nadezhda V.;
    • Boltneva, Natalia P.;
    • Rudakova, Elena V.;
    • Astakhova, Tatiana Y.;
    • Timokhina, Elena N.;
    • Pronkin, Pavel G.;
    • Lushchekina, Sofya V.;
    • Khudina, Olga G.;
    • Zhilina, Ekaterina F.;
    • Shchegolkov, Evgeny V.;
    • Lapshina, Maria A.;
    • Dubrovskaya, Elena S.;
    • Radchenko, Eugene V.;
    • Palyulin, Vladimir A.;
    • Burgart, Yanina V.;
    • Saloutin, Victor I.;
    • Charushin, Valery N.;
    • Richardson, Rudy J.
    Publication type:
    Article
    2

    Conjugates of amiridine and thiouracil derivatives as effective inhibitors of butyrylcholinesterase with the potential to block β‐amyloid aggregation.

    Published in:
    Archiv der Pharmazie, 2024, v. 357, n. 2, p. 1, doi. 10.1002/ardp.202300447
    By:
    • Khudina, Olga G.;
    • Grishchenko, Maria V.;
    • Makhaeva, Galina F.;
    • Kovaleva, Nadezhda V.;
    • Boltneva, Natalia P.;
    • Rudakova, Elena V.;
    • Lushchekina, Sofya V.;
    • Shchegolkov, Evgeny V.;
    • Borisevich, Sophia S.;
    • Burgart, Yanina V.;
    • Saloutin, Victor I.;
    • Charushin, Valery N.
    Publication type:
    Article
    3

    Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer's disease.

    Published in:
    Frontiers in Pharmacology, 2023, p. 01, doi. 10.3389/fphar.2023.1219980
    By:
    • Makhaeva, Galina F.;
    • Kovaleva, Nadezhda V.;
    • Rudakova, Elena V.;
    • Boltneva, Natalia P.;
    • Lushchekina, Sofya V.;
    • Astakhova, Tatiana Yu;
    • Timokhina, Elena N.;
    • Serebryakova, Olga G.;
    • Shchepochkin, Alexander V.;
    • Averkov, Maxim A.;
    • Utepova, Irina A.;
    • Demina, Nadezhda S.;
    • Radchenko, Eugene V.;
    • Palyulin, Vladimir A.;
    • Fisenko, Vladimir P.;
    • Bachurin, Sergey O.;
    • Chupakhin, Oleg N.;
    • Charushin, Valery N.;
    • Richardson, Rudy J.
    Publication type:
    Article
    4
    5

    Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N -Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile.

    Published in:
    Molecules, 2022, v. 27, n. 3, p. 1060, doi. 10.3390/molecules27031060
    By:
    • Makhaeva, Galina F.;
    • Kovaleva, Nadezhda V.;
    • Boltneva, Natalia P.;
    • Rudakova, Elena V.;
    • Lushchekina, Sofya V.;
    • Astakhova, Tatiana Yu.;
    • Serkov, Igor V.;
    • Proshin, Alexey N.;
    • Radchenko, Eugene V.;
    • Palyulin, Vladimir A.;
    • Korabecny, Jan;
    • Soukup, Ondrej;
    • Bachurin, Sergey O.;
    • Richardson, Rudy J.
    Publication type:
    Article
    6

    Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands.

    Published in:
    Molecules, 2021, v. 26, n. 18, p. 5527, doi. 10.3390/molecules26185527
    By:
    • Bachurin, Sergey O.;
    • Makhaeva, Galina F.;
    • Shevtsova, Elena F.;
    • Aksinenko, Alexey Yu.;
    • Grigoriev, Vladimir V.;
    • Shevtsov, Pavel N.;
    • Goreva, Tatiana V.;
    • Epishina, Tatiana A.;
    • Kovaleva, Nadezhda V.;
    • Pushkareva, Elena A.;
    • Boltneva, Natalia P.;
    • Lushchekina, Sofya V.;
    • Gabrelyan, Alexey V.;
    • Zamoyski, Vladimir L.;
    • Dubova, Lyudmila G.;
    • Rudakova, Elena V.;
    • Fisenko, Vladimir P.;
    • Bovina, Elena V.;
    • Richardson, Rudy J.
    Publication type:
    Article
    7

    New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer's Disease Treatment.

    Published in:
    Molecules, 2020, v. 25, n. 24, p. 5891, doi. 10.3390/molecules25245891
    By:
    • Makhaeva, Galina F.;
    • Kovaleva, Nadezhda V.;
    • Rudakova, Elena V.;
    • Boltneva, Natalia P.;
    • Lushchekina, Sofya V.;
    • Faingold, Irina I.;
    • Poletaeva, Darya A.;
    • Soldatova, Yuliya V.;
    • Kotelnikova, Raisa A.;
    • Serkov, Igor V.;
    • Ustinov, Anatoly K.;
    • Proshin, Alexey N.;
    • Radchenko, Eugene V.;
    • Palyulin, Vladimir A.;
    • Richardson, Rudy J.;
    • Plech, Tomasz
    Publication type:
    Article
    8
    9

    New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment.

    Published in:
    Molecules, 2020, v. 25, n. 17, p. 3915, doi. 10.3390/molecules25173915
    By:
    • Makhaeva, Galina F.;
    • Kovaleva, Nadezhda V.;
    • Boltneva, Natalia P.;
    • Lushchekina, Sofya V.;
    • Astakhova, Tatiana Yu.;
    • Rudakova, Elena V.;
    • Proshin, Alexey N.;
    • Serkov, Igor V.;
    • Radchenko, Eugene V.;
    • Palyulin, Vladimir A.;
    • Bachurin, Sergey O.;
    • Richardson, Rudy J.;
    • Kovarik, Zrinka
    Publication type:
    Article
    10
    11
    12
    13

    6-Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease.

    Published in:
    ChemMedChem, 2015, v. 10, n. 11, p. 1863, doi. 10.1002/cmdc.201500334
    By:
    • Semenov, Vyacheslav E.;
    • Zueva, Irina V.;
    • Mukhamedyarov, Marat A.;
    • Lushchekina, Sofya V.;
    • Kharlamova, Alexandra D.;
    • Petukhova, Elena O.;
    • Mikhailov, Anatoly S.;
    • Podyachev, Sergey N.;
    • Saifina, Lilya F.;
    • Petrov, Konstantin A.;
    • Minnekhanova, Oksana A.;
    • Zobov, Vladimir V.;
    • Nikolsky, Evgeny E.;
    • Masson, Patrick;
    • Reznik, Vladimir S.
    Publication type:
    Article
    14

    Bis-γ-carbolines as new potential multitarget agents for Alzheimer's disease.

    Published in:
    Pure & Applied Chemistry, 2020, v. 92, n. 7, p. 1057, doi. 10.1515/pac-2019-1206
    By:
    • Makhaeva, Galina F.;
    • Shevtsova, Elena F.;
    • Aksinenko, Alexey Y.;
    • Kovaleva, Nadezhda V.;
    • Boltneva, Natalia P.;
    • Lushchekina, Sofya V.;
    • Rudakova, Еlena V.;
    • Pushkareva, Elena A.;
    • Serkova, Tatyana P.;
    • Dubova, Lyudmila G.;
    • Shevtsov, Pavel N.;
    • Sokolov, Vladimir B.;
    • Radchenko, Eugene V.;
    • Palyulin, Vladimir A.;
    • Bachurin, Sergey O.;
    • Richardson, Rudy J.
    Publication type:
    Article
    15

    Focused design of polypharmacophoric neuroprotective compounds: Conjugates of γ-carbolines with carbazole derivatives and tetrahydrocarbazole.

    Published in:
    Pure & Applied Chemistry, 2017, v. 89, n. 8, p. 1167, doi. 10.1515/pac-2017-0308
    By:
    • Makhaeva, Galina F.;
    • Sokolov, Vladimir B.;
    • Shevtsova, Elena F.;
    • Kovaleva, Nadezhda V.;
    • Lushchekina, Sofya V.;
    • Boltneva, Natalia P.;
    • Rudakova, Elena V.;
    • Aksinenko, Alexey Yu.;
    • Shevtsov, Pavel N.;
    • Neganova, Margarita E.;
    • Dubova, Ludmila G.;
    • Bachurin, Sergey O.
    Publication type:
    Article
    16

    Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment.

    Published in:
    Biochemical Journal, 2016, v. 473, n. 9, p. 1225, doi. 10.1042/BCJ20160084
    By:
    • Kharlamova, Alexandra D.;
    • Lushchekina, Sofya V.;
    • Petrov, Konstantin A.;
    • Kots, Ekaterina D.;
    • Nachon, Florian;
    • Villard-Wandhammer, Marielle;
    • Zueva, Irina V.;
    • Krejci, Eric;
    • Reznik, Vladimir S.;
    • Zobov, Vladimir V.;
    • Nikolsky, Evgeny E.;
    • Masson, Patrick
    Publication type:
    Article
    17

    Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases.

    Published in:
    Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-41272-4
    By:
    • Bachurin, Sergey O.;
    • Makhaeva, Galina F.;
    • Shevtsova, Elena F.;
    • Boltneva, Natalia P.;
    • Kovaleva, Nadezhda V.;
    • Lushchekina, Sofya V.;
    • Rudakova, Elena V.;
    • Dubova, Ludmila G.;
    • Vinogradova, Daria V.;
    • Sokolov, Vladimir B.;
    • Aksinenko, Alexey Yu.;
    • Fisenko, Vladimir P.;
    • Richardson, Rudy J.;
    • Aliev, Gjumrakch
    Publication type:
    Article
    18

    Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System.

    Published in:
    Biomolecules (2218-273X), 2020, v. 10, n. 2, p. 283, doi. 10.3390/biom10020283
    By:
    • Akimov, Mikhail G.;
    • Kudryavtsev, Denis S.;
    • Kryukova, Elena V.;
    • Fomina-Ageeva, Elena V.;
    • Zakharov, Stanislav S.;
    • Gretskaya, Natalia M.;
    • Zinchenko, Galina N.;
    • Serkov, Igor V.;
    • Makhaeva, Galina F.;
    • Boltneva, Natalia P.;
    • Kovaleva, Nadezhda V.;
    • Serebryakova, Olga G.;
    • Lushchekina, Sofya V.;
    • Palikov, Victor A.;
    • Palikova, Yulia;
    • Dyachenko, Igor A.;
    • Kasheverov, Igor E.;
    • Tsetlin, Victor I.;
    • Bezuglov, Vladimir V.
    Publication type:
    Article
    19

    Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease.

    Published in:
    International Journal of Molecular Sciences, 2023, v. 24, n. 3, p. 2285, doi. 10.3390/ijms24032285
    By:
    • Makhaeva, Galina F.;
    • Kovaleva, Nadezhda V.;
    • Rudakova, Elena V.;
    • Boltneva, Natalia P.;
    • Grishchenko, Maria V.;
    • Lushchekina, Sofya V.;
    • Astakhova, Tatiana Y.;
    • Serebryakova, Olga G.;
    • Timokhina, Elena N.;
    • Zhilina, Ekaterina F.;
    • Shchegolkov, Evgeny V.;
    • Ulitko, Mariya V.;
    • Radchenko, Eugene V.;
    • Palyulin, Vladimir A.;
    • Burgart, Yanina V.;
    • Saloutin, Victor I.;
    • Bachurin, Sergey O.;
    • Richardson, Rudy J.
    Publication type:
    Article
    20

    Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease.

    Published in:
    International Journal of Molecular Sciences, 2022, v. 23, n. 22, p. 13925, doi. 10.3390/ijms232213925
    By:
    • Bachurin, Sergey O.;
    • Shevtsova, Elena F.;
    • Makhaeva, Galina F.;
    • Aksinenko, Alexey Yu.;
    • Grigoriev, Vladimir V.;
    • Goreva, Tatiana V.;
    • Epishina, Tatiana A.;
    • Kovaleva, Nadezhda V.;
    • Boltneva, Natalia P.;
    • Lushchekina, Sofya V.;
    • Rudakova, Elena V.;
    • Vinogradova, Darya V.;
    • Shevtsov, Pavel N.;
    • Pushkareva, Elena A.;
    • Dubova, Ludmila G.;
    • Serkova, Tatiana P.;
    • Veselov, Ivan M.;
    • Fisenko, Vladimir P.;
    • Richardson, Rudy J.
    Publication type:
    Article
    21

    Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment.

    Published in:
    Scientific Reports, 2017, p. 45627, doi. 10.1038/srep45627
    By:
    • Bachurin, Sergey O.;
    • Shevtsova, Elena F.;
    • Makhaeva, Galina F.;
    • Grigoriev, Vladimir V.;
    • Boltneva, Natalia P.;
    • Kovaleva, Nadezhda V.;
    • Lushchekina, Sofya V.;
    • Shevtsov, Pavel N.;
    • Neganova, Margarita E.;
    • Redkozubova, Olga M.;
    • Bovina, Elena V.;
    • Gabrelyan, Alexey V.;
    • Fisenko, Vladimir P.;
    • Sokolov, Vladimir B.;
    • Aksinenko, Alexey Yu;
    • Echeverria, Valentina;
    • Barreto, George E.;
    • Aliev, Gjumrakch
    Publication type:
    Article
    22
    23

    New Infestin-4 Mutants with Increased Selectivity against Factor XIIa.

    Published in:
    PLoS ONE, 2015, v. 10, n. 12, p. 1, doi. 10.1371/journal.pone.0144940
    By:
    • Kolyadko, Vladimir N.;
    • Lushchekina, Sofya V.;
    • Vuimo, Tatiana A.;
    • Surov, Stepan S.;
    • Ovsepyan, Ruzanna A.;
    • Korneeva, Vera A.;
    • Vorobiev, Ivan I.;
    • Orlova, Nadezhda A.;
    • Minakhin, Leonid;
    • Kuznedelov, Konstantin;
    • Severinov, Konstantin V.;
    • Ataullakhanov, Fazoil I.;
    • Panteleev, Mikhail A.
    Publication type:
    Article
    24

    Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease.

    Published in:
    Molecules, 2024, v. 29, n. 2, p. 321, doi. 10.3390/molecules29020321
    By:
    • Makhaeva, Galina F.;
    • Kovaleva, Nadezhda V.;
    • Rudakova, Elena V.;
    • Boltneva, Natalia P.;
    • Lushchekina, Sofya V.;
    • Astakhova, Tatiana Y.;
    • Timokhina, Elena N.;
    • Serkov, Igor V.;
    • Proshin, Alexey N.;
    • Soldatova, Yuliya V.;
    • Poletaeva, Darya A.;
    • Faingold, Irina I.;
    • Mumyatova, Viktoriya A.;
    • Terentiev, Alexey A.;
    • Radchenko, Eugene V.;
    • Palyulin, Vladimir A.;
    • Bachurin, Sergey O.;
    • Richardson, Rudy J.
    Publication type:
    Article
    25
    26

    New Multifunctional Agents for Potential Alzheimer's Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones.

    Published in:
    Biomolecules (2218-273X), 2022, v. 12, n. 11, p. 1551, doi. 10.3390/biom12111551
    By:
    • Elkina, Natalia A.;
    • Grishchenko, Maria V.;
    • Shchegolkov, Evgeny V.;
    • Makhaeva, Galina F.;
    • Kovaleva, Nadezhda V.;
    • Rudakova, Elena V.;
    • Boltneva, Natalia P.;
    • Lushchekina, Sofya V.;
    • Astakhova, Tatiana Y.;
    • Radchenko, Eugene V.;
    • Palyulin, Vladimir A.;
    • Zhilina, Ekaterina F.;
    • Perminova, Anastasiya N.;
    • Lapshin, Luka S.;
    • Burgart, Yanina V.;
    • Saloutin, Victor I.;
    • Richardson, Rudy J.
    Publication type:
    Article
    27
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