Works matching AU Lucet, Isabelle S.

Results: 26

Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02631-y

By:

Patel, Onisha;
Roy, Michael J.;
Kropp, Ashleigh;
Hardy, Joshua M.;
Dai, Weiwen;
Lucet, Isabelle S.

Publication type:

Article

Crystal structure of the putative cell‐wall lipoglycan biosynthesis protein LmcA from Mycobacterium smegmatis.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2022, v. 78, n. 4, p. 494, doi. 10.1107/S2059798322001772

By:

Patel, Onisha;
Brammananth, Rajini;
Dai, Weiwen;
Panjikar, Santosh;
Coppel, Ross L.;
Lucet, Isabelle S.;
Crellin, Paul K.

Publication type:

Article

Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis.

Published in:

Biomedicines, 2023, v. 11, n. 3, p. 990, doi. 10.3390/biomedicines11030990

By:

Carli, Annalisa L. E.;
Hardy, Joshua M.;
Hoblos, Hanadi;
Ernst, Matthias;
Lucet, Isabelle S.;
Buchert, Michael

Publication type:

Article

Two distinct regions of the large serine recombinase TnpX are required for DNA binding and biological function.

Published in:

Molecular Microbiology, 2006, v. 60, n. 3, p. 591, doi. 10.1111/j.1365-2958.2006.05120.x

By:

Adams, Vicki;
Lucet, Isabelle S.;
Tynan, Fleur E.;
Chiarezza, Martina;
Howarth, Pauline M.;
Kim, Jonathan;
Rossjohn, Jamie;
Lyras, Dena;
Rood, Julian I.

Publication type:

Article

DNA binding properties of TnpX indicate that different synapses are formed in the excision and integration of the Tn 4451 family.

Published in:

Molecular Microbiology, 2004, v. 53, n. 4, p. 1195, doi. 10.1111/j.1365-2958.2004.04198.x

By:

Adams, Vicki;
Lucet, Isabelle S.;
Lyras, Dena;
Rood, Julian I.

Publication type:

Article

Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23474-5

By:

Garcia, Laura Ramos;
Tenev, Tencho;
Newman, Richard;
Haich, Rachel O.;
Liccardi, Gianmaria;
John, Sidonie Wicky;
Annibaldi, Alessandro;
Yu, Lu;
Pardo, Mercedes;
Young, Samuel N.;
Fitzgibbon, Cheree;
Fernando, Winnie;
Guppy, Naomi;
Kim, Hyojin;
Liang, Lung-Yu;
Lucet, Isabelle S.;
Kueh, Andrew;
Roxanis, Ioannis;
Gazinska, Patrycja;
Sims, Martin

Publication type:

Article

Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite Plasmodium falciparum.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-53325-9

By:

Bui, Hai T. N.;
Niederwieser, Igor;
Bird, Megan J.;
Dai, Weiwen;
Brancucci, Nicolas M. B.;
Moes, Suzette;
Jenoe, Paul;
Lucet, Isabelle S.;
Doerig, Christian;
Voss, Till S.

Publication type:

Article

Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38869-9

By:

Roy, Michael J.;
Surudoi, Minglyanna G.;
Kropp, Ashleigh;
Hou, Jianmei;
Dai, Weiwen;
Hardy, Joshua M.;
Liang, Lung-Yu;
Cotton, Thomas R.;
Lechtenberg, Bernhard C.;
Dite, Toby A.;
Ma, Xiuquan;
Daly, Roger J.;
Patel, Onisha;
Lucet, Isabelle S.

Publication type:

Article

DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression.

Published in:

Science Signaling, 2024, v. 17, n. 854, p. 1, doi. 10.1126/scisignal.abq4888

By:

Afshar-Sterle, Shoukat;
Carli, Annalisa L.E.;
O'Keefe, Ryan;
Tse, Janson;
Fischer, Stefanie;
Azimpour, Alexander I.;
Baloyan, David;
Elias, Lena;
Thilakasiri, Pathum;
Patel, Onisha;
Ferguson, Fleur M.;
Eissmann, Moritz F.;
Chand, Ashwini L.;
Gray, Nathanael S.;
Busuttil, Rita;
Boussioutas, Alex;
Lucet, Isabelle S.;
Ernst, Matthias;
Buchert, Michael

Publication type:

Article

Molecular dissection of the pseudokinase ZED1 expands effector recognition to the tomato immune receptor ZAR1.

Published in:

Plant Physiology, 2024, v. 196, n. 1, p. 651, doi. 10.1093/plphys/kiae268

By:

Diplock, Nathan;
Baudin, Maël;
Xiang, Xincheng;
Liang, Lung-Yu;
Dai, Weiwen;
Murphy, James M;
Lucet, Isabelle S;
Hassan, Jana A;
Lewis, Jennifer D

Publication type:

Article

Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06118-4

By:

Liang, Lung-Yu;
Geoghegan, Niall D.;
Mlodzianoski, Michael;
Leis, Andrew;
Whitehead, Lachlan W.;
Surudoi, Minglyanna G.;
Young, Samuel N.;
Janes, Peter;
Shepherd, Doulin;
Ghosal, Debnath;
Rogers, Kelly L.;
Murphy, James M.;
Lucet, Isabelle S.

Publication type:

Article

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04714-7

By:

Petrie, Emma J.;
Sandow, Jarrod J.;
Jacobsen, Annette V.;
Smith, Brian J.;
Griffin, Michael D. W.;
Lucet, Isabelle S.;
Weiwen Dai;
Young, Samuel N.;
Tanzer, Maria C.;
Wardak, Ahmad;
Lung-Yu Liang;
Cowan, Angus D.;
Hildebrand, Joanne M.;
Kersten, Wilhelmus J. A.;
Lessene, Guillaume;
Silke, John;
Czabotar, Peter E.;
Webb, Andrew I.;
Murphy, James M.

Publication type:

Article

The molecular basis of JAK/STAT inhibition by SOCS1.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04013-1

By:

Liau, Nicholas P. D.;
Laktyushin, Artem;
Lucet, Isabelle S.;
Murphy, James M.;
Shenggen Yao;
Whitlock, Eden;
Callaghan, Kimberley;
Nicola, Nicos A.;
Kershaw, Nadia J.;
Babon, Jeffrey J.

Publication type:

Article

Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01279-9

By:

Patel, Onisha;
Griffin, Michael D. W.;
Panjikar, Santosh;
Weiwen Dai;
Xiuquan Ma;
Chan, Howard;
Celine Zheng;
Kropp, Ashleigh;
Murphy, James M.;
Daly, Roger J.;
Lucet, Isabelle S.

Publication type:

Article

SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 4, p. 469, doi. 10.1038/nsmb.2519

By:

Kershaw, Nadia J;
Murphy, James M;
Liau, Nicholas P D;
Varghese, Leila N;
Laktyushin, Artem;
Whitlock, Eden L;
Lucet, Isabelle S;
Nicola, Nicos A;
Babon, Jeffrey J

Publication type:

Article

The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain.

Published in:

Biochemical Journal, 2016, v. 473, n. 12, p. 1733, doi. 10.1042/BCJ20160189

By:

Kelan Chen;
Dobson, Renwick C. J.;
Lucet, Isabelle S.;
Young, Samuel N.;
Pearce, F. Grant;
Blewitt, Marnie E.;
Murphy, James M.

Publication type:

Article

The molecular regulation of Janus kinase (JAK) activation.

Published in:

Biochemical Journal, 2014, v. 462, n. 1, p. 1, doi. 10.1042/BJ20140712

By:

BABON, Jeffrey J.;
LUCET, Isabelle S.;
MURPHY, James M.;
NICOLA, Nicos A.;
VARGHESE, Leila N.

Publication type:

Article

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.

Published in:

Biochemical Journal, 2014, v. 458, n. 2, p. 395, doi. 10.1042/BJ20131516

By:

VARGHESE, Leila N.;
UNGUREANU, Daniela;
LIAU, Nicholas P. D.;
YOUNG, Samuel N.;
LAKTYUSHIN, Artem;
HAMMAREN, Henrik;
LUCET, Isabelle S.;
NICOLA, Nicos A.;
SILVENNOINEN, Olli;
BABON, Jeffrey J.;
MURPHY, James M.

Publication type:

Article

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.

Published in:

Biochemical Journal, 2014, v. 457, n. 3, p. 369, doi. 10.1042/BJ20131270

By:

MURPHY, James M.;
LUCET, Isabelle S.;
HILDEBRAND, Joanne M.;
TANZER, Maria C.;
YOUNG, Samuel N.;
SHARMA, Pooja;
LESSENE, Guillaume;
ALEXANDER, Warren S.;
BABON, Jeffrey J.;
SILKE, John;
CZABOTAR, Peter E.

Publication type:

Article

Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-21191-7

By:

Oliver, Michael R.;
Horne, Christopher R.;
Shrestha, Safal;
Keown, Jeremy R.;
Liang, Lung-Yu;
Young, Samuel N.;
Sandow, Jarrod J.;
Webb, Andrew I.;
Goldstone, David C.;
Lucet, Isabelle S.;
Kannan, Natarajan;
Metcalf, Peter;
Murphy, James M.

Publication type:

Article

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16823-3

By:

Davies, Katherine A.;
Fitzgibbon, Cheree;
Young, Samuel N.;
Garnish, Sarah E.;
Yeung, Wayland;
Coursier, Diane;
Birkinshaw, Richard W.;
Sandow, Jarrod J.;
Lehmann, Wil I. L.;
Liang, Lung-Yu;
Lucet, Isabelle S.;
Chalmers, James D.;
Patrick, Wayne M.;
Kannan, Natarajan;
Petrie, Emma J.;
Czabotar, Peter E.;
Murphy, James M.

Publication type:

Article

Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family.

Published in:

Science Signaling, 2022, v. 15, n. 722, p. 1, doi. 10.1126/scisignal.abj3554

By:

Hou, Jianmei;
Nguyen, Elizabeth V.;
Surudoi, Minglyanna;
Roy, Michael J.;
Patel, Onisha;
Lucet, Isabelle S.;
Ma, Xiuquan;
Daly, Roger J.

Publication type:

Article

A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity.

Published in:

EMBO Reports, 2020, v. 21, n. 11, p. 1, doi. 10.15252/embr.202050400

By:

Heim, Valentin J;
Dagley, Laura F;
Stafford, Che A;
Hansen, Fynn M;
Clayer, Elise;
Bankovacki, Aleksandra;
Webb, Andrew I;
Lucet, Isabelle S;
Silke, John;
Nachbur, Ueli

Publication type:

Article

Regulation of Janus kinases by SOCS proteins.

Published in:

Biochemical Society Transactions, 2013, v. 41, n. 4, p. 1042, doi. 10.1042/BST20130077

By:

Kershaw, Nadia J.;
Murphy, James M.;
Lucet, Isabelle S.;
Nicola, Nicos A.;
Babon, Jeffrey J.

Publication type:

Article

Techniques to examine nucleotide binding by pseudokinases.

Published in:

Biochemical Society Transactions, 2013, v. 41, n. 4, p. 975, doi. 10.1042/BST20130075

By:

Lucet, Isabelle S.;
Babon, Jeffrey J.;
Murphy, James M.

Publication type:

Article

The PEAK family of pseudokinases, their role in cell signalling and cancer.

Published in:

FEBS Journal, 2020, v. 287, n. 19, p. 4183, doi. 10.1111/febs.15087

By:

Patel, Onisha;
Roy, Michael J.;
Murphy, James M.;
Lucet, Isabelle S.

Publication type:

Article