Works by Lowell, Bradford B

Results: 55

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

Published in:

2007

By:

Parton, Laura E.;
Chian Ping Ye;
Coppari, Roberto;
Enriori, Pablo J.;
Choi, Brian;
Chen-Yu Zhang;
Chun Xu;
Vianna, Claudia R.;
Balthasar, Nina;
Lee, Charlotte E.;
Elmquist, Joel K.;
Cowley, Michael A.;
Lowell, Bradford B.

Publication type:

Letter

Quantitation of Brown Adipose Tissue Perfusion in Transgenic Mice Using Near-Infrared Fluorescence Imaging.

Published in:

Molecular Imaging, 2003, v. 2, n. 1, p. 37, doi. 10.1162/153535003765276273

By:

Nakayama, Akira;
Bianco, Antonio C.;
Zhang, Chen-Yu;
Lowell, Bradford B.;
Frangiom, John V.

Publication type:

Article

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25380-2

By:

Xiao, Xing;
Yeghiazaryan, Gagik;
Hess, Simon;
Klemm, Paul;
Sieben, Anna;
Kleinridders, André;
Morgan, Donald A.;
Wunderlich, F. Thomas;
Rahmouni, Kamal;
Kong, Dong;
Scammell, Thomas E.;
Lowell, Bradford B.;
Kloppenburg, Peter;
Brüning, Jens C.;
Hausen, A. Christine

Publication type:

Article

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.

Published in:

2011

By:

Krashes, Michael J.;
Shuichi Koda;
ChianPing Ye;
Rogan, Sarah C.;
Adams, Andrew C.;
Cusher, Daniel S.;
Maratos-Flier, Eleftheria;
Roth, Bryan L.;
Lowell, Bradford B.;
Koda, Shuichi;
Ye, ChianPing

Publication type:

journal article

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

Published in:

2008

By:

Hill, Jennifer W.;
Williams, Kevin W.;
Chianping Ye;
Ji Luo;
Balthasar, Nina;
Coppari, Roberto;
Cowley, Michael A.;
Cantley, Lewis C.;
Lowell, Bradford B.;
Elmquist, Joel K.;
Ye, Chianping;
Luo, Ji

Publication type:

journal article

Mice lacking ghrelin receptors resist the development of diet-induced obesity.

Published in:

2005

By:

Zigman, Jeffrey M.;
Nakano, Yoshihide;
Coppari, Roberto;
Balthasar, Nina;
Marcus, Jacob N.;
Lee, Charlotte E.;
Jones, Juli E.;
Deysher, Amy E.;
Waxman, Amanda R.;
White, Ryan D.;
Williams, Todd D.;
Lachey, Jennifer L.;
Seeley, Randy J.;
Lowell, Bradford B.;
Elmquist, Joel K.

Publication type:

journal article

The mitochondrial uncoupling-protein homologues.

Published in:

Nature Reviews Molecular Cell Biology, 2005, v. 6, n. 3, p. 248, doi. 10.1038/nrm1592

By:

Krauss, Stefan;
Chen-Yu Zang;
Lowell, Bradford B.

Publication type:

Article

Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.66609

By:

Kim, Angela;
Madara, Joseph C.;
Chen Wu;
Andermann, Mark L.;
Lowell, Bradford B.

Publication type:

Article

Association between uncoupling protein polymorphisms ( UCP2-UCP3) and energy metabolism/obesity in Pima Indians.

Published in:

Human Molecular Genetics, 1998, v. 7, n. 9, p. 1431, doi. 10.1093/hmg/7.9.1431

By:

Walder, Ken;
Norman, Rod A.;
Hanson, Robert L.;
Schrauwen, Patrick;
Neverova, Maria;
Jenkinson, Chris P.;
Easlick, Juliet;
Warden, Craig H.;
Pecqueur, Claire;
Raimbault, Serge;
Ricquier, Daniel;
Silver, Michael Harper4, Kristi;
Shuldiner, Alan R.;
Solanes, Gemma;
Lowell, Bradford B.;
Chung, Wendy K.;
Leibel, Rudolph L.;
Pratley, Richard;
Ravussin, Eric

Publication type:

Article

Orexin neurons inhibit sleep to promote arousal.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31591-y

By:

De Luca, Roberto;
Nardone, Stefano;
Grace, Kevin P.;
Venner, Anne;
Cristofolini, Michela;
Bandaru, Sathyajit S.;
Sohn, Lauren T.;
Kong, Dong;
Mochizuki, Takatoshi;
Viberti, Bianca;
Zhu, Lin;
Zito, Antonino;
Scammell, Thomas E.;
Saper, Clifford B.;
Lowell, Bradford B.;
Fuller, Patrick M.;
Arrigoni, Elda

Publication type:

Article

Leptin-Responsive GABAergic Neurons Regulate Fertility through Pathways That Result in Reduced Kisspeptinergic Tone.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 17, p. 6047, doi. 10.1523/JNEUROSCI.3003-13.2014

By:

Martin, Cecilia;
Navarro, Víctor M.;
Simavli, Serap;
Linh Vong;
Carroll, Rona S.;
Lowell, Bradford B.;
Kaiser, Ursula B.

Publication type:

Article

Runxl Controls Terminal Morphology and Mechanosensitivity of VGLUT3-expressing C-Mechanoreceptors.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 3, p. 870, doi. 10.1523/JNEUROSCI.3942-12.2013

By:

Shan Lou;
Bo Duan;
Linh Vong;
Lowell, Bradford B.;
Qiufu Ma

Publication type:

Article

A Serotonin and Melanocortin Circuit Mediates D-Fenfluramine Anorexia.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 44, p. 14630, doi. 10.1523/JNEUROSCI.5412-09.2010

By:

Yong Xu;
Jones, Juli E.;
Lauzon, Danielle A.;
Anderson, Jason G.;
Balthasar, Nina;
Heisler, Lora K.;
Zinn, Andrew R.;
Lowell, Bradford B.;
Elmquist, Joel K.

Publication type:

Article

Neuromedin B and Gastrin-Releasing Peptide Excite Arcuate Nucleus Neuropeptide Y Neurons in a Novel Transgenic Mouse Expressing Strong Renilla Green Fluorescent Protein in NPY Neurons.

Published in:

Journal of Neuroscience, 2009, v. 29, n. 14, p. 4622, doi. 10.1523/JNEUROSCI.3249-08.2009

By:

van den Pol, Anthony N.;
Yang Yao;
Li-Ying Fu;
Kylie Foo;
Hao Huang;
Coppari, Roberto;
Lowell, Bradford B.;
Broberger, Christian

Publication type:

Article

Monitoring FoxO1 Localization in Chemically Identified Neurons.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 50, p. 13640, doi. 10.1523/JNEUROSCI.4023-08.2008

By:

Fukuda, Makoto;
Jones, Juli E.;
Olson, David;
Hill, Jennifer;
Lee, Charlotte E.;
Gautron, Laurent;
Choi, Michelle;
Zigman, Jeffrey M.;
Lowell, Bradford B.;
Elmquist, Joel K.

Publication type:

Article

A neural basis for melanocortin-4 receptor-regulated appetite.

Published in:

Nature Neuroscience, 2015, v. 18, n. 6, p. 863, doi. 10.1038/nn.4011

By:

Garfield, Alastair S;
Li, Chia;
Madara, Joseph C;
Shah, Bhavik P;
Webber, Emily;
Steger, Jennifer S;
Campbell, John N;
Gavrilova, Oksana;
Lee, Charlotte E;
Olson, David P;
Elmquist, Joel K;
Tannous, Bakhos A;
Krashes, Michael J;
Lowell, Bradford B

Publication type:

Article

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.

Published in:

Nature Neuroscience, 2015, v. 18, n. 4, p. 545, doi. 10.1038/nn.3972

By:

Pleil, Kristen E;
Rinker, Jennifer A;
Lowery-Gionta, Emily G;
Mazzone, Christopher M;
McCall, Nora M;
Kendra, Alexis M;
Olson, David P;
Lowell, Bradford B;
Grant, Kathleen A;
Thiele, Todd E;
Kash, Thomas L

Publication type:

Article

Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia.

Published in:

Nature Neuroscience, 2014, v. 17, n. 7, p. 911, doi. 10.1038/nn.3737

By:

Berglund, Eric D;
Liu, Tiemin;
Kong, Xingxing;
Sohn, Jong-Woo;
Vong, Linh;
Deng, Zhuo;
Lee, Charlotte E;
Lee, Syann;
Williams, Kevin W;
Olson, David P;
Scherer, Philipp E;
Lowell, Bradford B;
Elmquist, Joel K

Publication type:

Article

Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling.

Published in:

Nature Neuroscience, 2012, v. 15, n. 10, p. 1391, doi. 10.1038/nn.3207

By:

Huang, Hu;
Kong, Dong;
Byun, Kyung Hee;
Ye, Chianping;
Koda, Shuichi;
Lee, Dae Ho;
Oh, Byung-Chul;
Lee, Sam W;
Lee, Bonghee;
Zabolotny, Janice M;
Kim, Min Seon;
Bjørbæk, Christian;
Lowell, Bradford B;
Kim, Young-Bum

Publication type:

Article

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons.

Published in:

Nature Neuroscience, 2011, v. 14, n. 7, p. 911, doi. 10.1038/nn.2847

By:

Klöckener, Tim;
Hess, Simon;
Belgardt, Bengt F.;
Paeger, Lars;
Verhagen, Linda A. W.;
Husch, Andreas;
Sohn, Jong-Woo;
Hampel, Brigitte;
Dhillon, Harveen;
Zigman, Jeffrey M.;
Lowell, Bradford B.;
Williams, Kevin W.;
Elmquist, Joel K.;
Horvath, Tamas L.;
Kloppenburg, Peter;
Brüning, Jens C.

Publication type:

Article

5-HT<sub>2C</sub>Rs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.

Published in:

Nature Neuroscience, 2010, v. 13, n. 12, p. 1457, doi. 10.1038/nn.2664

By:

Yong Xu;
Berglund, Eric D.;
Jong-Woo Sohn;
Holland, William L.;
Jen-Chieh Chuang;
Fukuda, Makoto;
Rossi, Jari;
Williams, Kevin W.;
Jones, Juli E.;
Zigman, Jeffrey M.;
Lowell, Bradford B.;
Scherer, Philipp E.;
Elmquist, Joel K.

Publication type:

Article

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance.

Published in:

Nature Neuroscience, 2008, v. 11, n. 9, p. 998, doi. 10.1038/nn.2167

By:

Qingchun Tong;
Chian-Ping Ye;
Jones, Juli E.;
Elmquist, Joel K.;
Lowell, Bradford B.

Publication type:

Article

Descending projections from the basal forebrain to the orexin neurons in mice.

Published in:

Journal of Comparative Neurology, 2017, v. 525, n. 7, p. 1668, doi. 10.1002/cne.24158

By:

Agostinelli, Lindsay J.;
Ferrari, Loris L.;
Mahoney, Carrie E.;
Mochizuki, Takatoshi;
Lowell, Bradford B.;
Arrigoni, Elda;
Scammell, Thomas E.

Publication type:

Article

Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus.

Published in:

Journal of Comparative Neurology, 2012, v. 520, n. 16, p. 3617, doi. 10.1002/cne.23116

By:

Lee, Syann;
Bookout, Angie L.;
Lee, Charlotte E.;
Gautron, Laurent;
Harper, Matthew J.;
Elias, Carol F.;
Lowell, Bradford B.;
Elmquist, Joel K.

Publication type:

Article

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

Published in:

Nature Medicine, 2000, v. 6, n. 8, p. 924, doi. 10.1038/78693

By:

Zisman, Ariel;
Peroni, Odile D.;
Abel, E. Dale;
Michael, M. Dodson;
Mauvais-Jarvis, Franck;
Lowell, Bradford B.;
Wojtaszewski, Jorgen F.P.;
Hirshman, Michael F.;
Virkamaki, Antti;
Goodyear, Laurie J.;
Kahn, C. Ronald;
Kahn, Barbara B.

Publication type:

Article

Slimming with a leaner enzyme.

Published in:

Nature, 1996, v. 382, n. 6592, p. 585, doi. 10.1038/382585a0

By:

Lowell, Bradford B.

Publication type:

Article

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue.

Published in:

Nature, 1993, v. 366, n. 6457, p. 740, doi. 10.1038/366740a0

By:

Lowell, Bradford B.;
S-Susulic, Vedrana

Publication type:

Article

Corrigendum: Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.

Published in:

Nature Communications, 2016, v. 7, n. 3, p. 11019, doi. 10.1038/ncomms11019

By:

Nakajima, Ken-ichiro;
Cui, Zhenzhong;
Li, Chia;
Meister, Jaroslawna;
Cui, Yinghong;
Fu, Ou;
Smith, Adam S.;
Jain, Shalini;
Lowell, Bradford B.;
Krashes, Michael J.;
Wess, Jürgen

Publication type:

Article

Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.

Published in:

Nature Communications, 2016, v. 7, n. 1, p. 10268, doi. 10.1038/ncomms10268

By:

Nakajima, Ken-ichiro;
Cui, Zhenzhong;
Li, Chia;
Meister, Jaroslawna;
Cui, Yinghong;
Fu, Ou;
Smith, Adam S.;
Jain, Shalini;
Lowell, Bradford B.;
Krashes, Michael J.;
Wess, Jürgen

Publication type:

Article

UCP2 Regulates the Glucagon Response to Fasting and Starvation.

Published in:

Diabetes, 2013, v. 62, n. 5, p. 1623, doi. 10.2337/db12-0981

By:

Allister, Emma M.;
Robson-Doucette, Christine A.;
Prentice, Kacey J.;
Hardy, Alexandre B.;
Sultan, Sobia;
Gaisano, Herbert Y.;
Dong Kong;
Gilon, Patrick;
Herrera, Pedro L.;
Lowell, Bradford B.;
Wheeler, Michael B.

Publication type:

Article

Role of VMH Glutamate in Counterregulatory Response to Hypoglycemia.

Published in:

Diabetes, 2007, v. 56, p. A99

By:

McCrimmon, Rory;
Tong, Qingchun;
Wang, Ajin;
Zhou, Ligang;
Lowell, Bradford B.;
Sherwin, Robert

Publication type:

Article

Glucose-Sensing by POMC Neurons Is Impaired in Obesity and Is Regulated by UCP2.

Published in:

Diabetes, 2007, v. 56, p. A7

By:

Parton, Laura E.;
Ye, Chianping;
Coppari, Roberto;
Enriori, Pablo J.;
Choi, Brian;
Chen-Yu Zhang;
Chun Xu;
Vianna, Claudia R.;
Lee, Charlotte E.;
Elmquist, Joel K.;
Cowley, Michaela;
Lowell, Bradford B.

Publication type:

Article

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet.

Published in:

2002

By:

Joseph, Jamie W.;
Koshkin, Vasilij;
Zhang, Chen-Yu;
Wang, Jing;
Lowell, Bradford B.;
Chan, Catherine B.;
Wheeler, Michael B.

Publication type:

journal article

Perspectives in Diabetes.

Published in:

Diabetes, 2000, v. 49, n. 2, p. 143

By:

Boss, Olivier;
Hagen, Thilo;
Lowell, Bradford B.

Publication type:

Article

Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements.

Published in:

1998

By:

Ito, Moriko;
Grujic, Danica;
Abel, E. Dale;
Vidal-Puig, Antonio;
Susulic, Vedrana S.;
Lawitts, Joel;
Harper, Mary-Ellen;
Himms-Hagen, Jean;
Strosberg, A. Donny;
Lowell, Bradford B.;
Ito, M;
Grujic, D;
Abel, E D;
Vidal-Puig, A;
Susulic, V S;
Lawitts, J;
Harper, M E;
Himms-Hagen, J;
Strosberg, A D;
Lowell, B B

Publication type:

journal article

Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations.

Published in:

1998

By:

Mantzoros, Christos S.;
Frederich, Robert C.;
Qu, Daqing;
Lowell, Bradford B.;
Maratos-Flier, Eleftheria;
Flier, Jeffrey S.;
Mantzoros, C S;
Frederich, R C;
Qu, D;
Lowell, B B;
Maratos-Flier, E;
Flier, J S

Publication type:

journal article

Activation of β<sub>3</sub> Adrenergic Receptors Suppresses Leptin Expression and Mediates a Leptin-Independent Inhibition of Food Intake in Mice.

Published in:

Diabetes, 1996, v. 45, n. 7, p. 909, doi. 10.2337/diab.45.7.909

By:

Mantzoros, Christos S.;
Qu, Daqing;
Frederich, Robert C.;
Susulic, Vedrana S.;
Lowell, Bradford B.;
Maratos-Flier, Eleftheria;
Flier, Jeffrey S.

Publication type:

Article

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.

Published in:

Nature, 2003, v. 424, n. 6951, p. 952, doi. 10.1038/nature01825

By:

Danial, Nika N.;
Gamm, Colette F.;
Scorrano, Luca;
Chen-Yu Zhang;
Krauss, Stefan;
Ranger, Ann M.;
Datta, Sandeep Robert;
Greenberg, Michael E.;
Licklider, Lawrence J.;
Lowell, Bradford B.;
Gygi, Steven P.;
Korsmeyer, Stanley J.

Publication type:

Article

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres.

Published in:

Nature, 2002, v. 418, n. 6899, p. 797, doi. 10.1038/nature00904

By:

Lin, Jiandie;
Hai Wu;
Tarr, Paul T.;
Chen-Yu Zhang;
Zhidan Wu;
Boss, Olivier;
Michael, Laura F.;
Puigserver, Pere;
Isotani, Eiji;
Olson, Eric N.;
Lowell, Bradford B.;
Bassel-Duby, Rhonda;
Spiegelman, Bruce M.

Publication type:

Article

Towards a molecular understanding of adaptive thermogenesis.

Published in:

Nature, 2000, v. 404, n. 6778, p. 652, doi. 10.1038/35007527

By:

Lowell, Bradford B.;
Spiegelman, Bruce M.

Publication type:

Article

Mice lacking melanin-concentrating hormone are hypophagic and lean.

Published in:

Nature, 1998, v. 396, n. 6712, p. 670, doi. 10.1038/25341

By:

Shimada, Masako;
Tritos, Nicholas A.;
Lowell, Bradford B.;
Flier, Jeffrey S.;
Maratos-Flier, Eleftheria

Publication type:

Article

EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses.

Published in:

Nature Neuroscience, 2007, v. 10, n. 9, p. 1131, doi. 10.1038/nn1949

By:

Lazarus, Michael;
Yoshida, Kyoko;
Coppari, Roberto;
Bass, Caroline E.;
Mochizuki, Takatoshi;
Lowell, Bradford B.;
Saper, Clifford B.

Publication type:

Article

An Obligate Role of Oxytocin Neurons in Diet Induced Energy Expenditure.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0045167

By:

Zhaofei Wu;
Yuanzhong Xu;
Yaming Zhu;
Sutton, Amy K.;
Rongjie Zhao;
Lowell, Bradford B.;
Olson, David P.;
Qingchun Tong;
Xin-Yun Lu

Publication type:

Article

Brainstem and Spinal Cord Circuitry Regulating REM Sleep and Muscle Atonia.

Published in:

PLoS ONE, 2011, v. 6, n. 10, p. 1, doi. 10.1371/journal.pone.0024998

By:

Krenzer, Martina;
Anaclet, Christelle;
Vetrivelan, Ramalingam;
Nishang Wang;
Linh Vong;
Lowell, Bradford B.;
Fuller, Patrick M.;
Jun Lu

Publication type:

Article

Cholinergic Interneurons Mediate Fast VGluT3-Dependent Glutamatergic Transmission in the Striatum.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0019155

By:

Higley, Michael J.;
Gittis, Aryn H.;
Oldenburg, Ian A.;
Balthasar, Nina;
Seal, Rebecca P.;
Edwards, Robert H.;
Lowell, Bradford B.;
Kreitzer, Anatol C.;
Sabatini, Bernardo L.

Publication type:

Article

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.

Published in:

Nature, 2014, v. 507, n. 7491, p. 238, doi. 10.1038/nature12956

By:

Krashes, Michael J.;
Shah, Bhavik P.;
Madara, Joseph C.;
Olson, David P.;
Strochlic, David E.;
Garfield, Alastair S.;
Vong, Linh;
Pei, Hongjuan;
Watabe-Uchida, Mitsuko;
Uchida, Naoshige;
Liberles, Stephen D.;
Lowell, Bradford B.

Publication type:

Article

Corrigendum: Recurrent network activity drives striatal synaptogenesis.

Published in:

2012

By:

Kozorovitskiy, Yevgenia;
Saunders, Arpiar;
Johnson, Caroline A.;
Lowell, Bradford B.;
Sabatini, Bernardo L.

Publication type:

Erratum

Recurrent network activity drives striatal synaptogenesis.

Published in:

Nature, 2012, v. 485, n. 7400, p. 646, doi. 10.1038/nature11052

By:

Kozorovitskiy, Yevgenia;
Saunders, Arpiar;
Johnson, Caroline A.;
Lowell, Bradford B.;
Sabatini, Bernardo L.

Publication type:

Article

Neuron-type-specific signals for reward and punishment in the ventral tegmental area.

Published in:

Nature, 2012, v. 482, n. 7383, p. 85, doi. 10.1038/nature10754

By:

Cohen, Jeremiah Y.;
Haesler, Sebastian;
Vong, Linh;
Lowell, Bradford B.;
Uchida, Naoshige

Publication type:

Article

A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.15392

By:

Keenan, William Thomas;
Rupp, Alan C.;
Ross, Rachel A.;
Somasundaram, Preethi;
Hiriyanna, Suja;
Zhijian Wu;
Badea, Tudor C.;
Robinson, Phyllis R.;
Lowell, Bradford B.;
Hattar, Samer S.

Publication type:

Article