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Hidden Aggregation Hot-Spots on Human Apolipoprotein E: A Structural Study.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 9, p. 2274, doi. 10.3390/ijms20092274
By:
- Tsiolaki, Paraskevi L.;
- Katsafana, Aikaterini D.;
- Baltoumas, Fotis A.;
- Louros, Nikolaos N.;
- Iconomidou, Vassiliki A.
Publication type:
Article
Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28955-9
By:
- Louros, Nikolaos;
- Ramakers, Meine;
- Michiels, Emiel;
- Konstantoulea, Katerina;
- Morelli, Chiara;
- Garcia, Teresa;
- Moonen, Nele;
- D'Haeyer, Sam;
- Goossens, Vera;
- Thal, Dietmar Rudolf;
- Audenaert, Dominique;
- Rousseau, Frederic;
- Schymkowitz, Joost
Publication type:
Article
Enhanced therapeutic window for antimicrobial Pept-ins by investigating their structure-activity relationship.
Published in:
PLoS ONE, 2023, v. 17, n. 3, p. 1, doi. 10.1371/journal.pone.0283674
By:
- Wu, Guiqin;
- Khodaparast, Laleh;
- Khodaparast, Ladan;
- De Vleeschouwer, Matthias;
- Louros, Nikolaos;
- Gallardo, Rodrigo;
- Yi, Pengpeng;
- Rousseau, Frederic;
- Schymkowitz, Joost
Publication type:
Article
Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure.
Published in:
EMBO Journal, 2022, v. 41, n. 2, p. 1, doi. 10.15252/embj.2021108591
By:
- Konstantoulea, Katerina;
- Guerreiro, Patricia;
- Ramakers, Meine;
- Louros, Nikolaos;
- Aubrey, Liam D;
- Houben, Bert;
- Michiels, Emiel;
- De Vleeschouwer, Matthias;
- Lampi, Yulia;
- Ribeiro, Luís F;
- de Wit, Joris;
- Xue, Wei‐Feng;
- Schymkowitz, Joost;
- Rousseau, Frederic
Publication type:
Article
Autonomous aggregation suppression by acidic residues explains why chaperones favour basic residues.
Published in:
EMBO Journal, 2020, v. 39, n. 11, p. 1, doi. 10.15252/embj.2019102864
By:
- Houben, Bert;
- Michiels, Emiel;
- Ramakers, Meine;
- Konstantoulea, Katerina;
- Louros, Nikolaos;
- Verniers, Joffré;
- der Kant, Rob;
- De Vleeschouwer, Matthias;
- Chicória, Nuno;
- Vanpoucke, Thomas;
- Gallardo, Rodrigo;
- Schymkowitz, Joost;
- Rousseau, Frederic
Publication type:
Article
CORDAX web server: an online platform for the prediction and 3D visualization of aggregation motifs in protein sequences.
Published in:
Bioinformatics, 2024, v. 40, n. 5, p. 1, doi. 10.1093/bioinformatics/btae279
By:
- Louros, Nikolaos;
- Rousseau, Frederic;
- Schymkowitz, Joost
Publication type:
Article
StAmP-DB: a platform for structures of polymorphic amyloid fibril cores.
Published in:
Bioinformatics, 2022, v. 38, n. 9, p. 2636, doi. 10.1093/bioinformatics/btac126
By:
- Louros, Nikolaos;
- van der Kant, Rob;
- Schymkowitz, Joost;
- Rousseau, Frederic
Publication type:
Article
Local structural preferences in shaping tau amyloid polymorphism.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45429-2
By:
- Louros, Nikolaos;
- Wilkinson, Martin;
- Tsaka, Grigoria;
- Ramakers, Meine;
- Morelli, Chiara;
- Garcia, Teresa;
- Gallardo, Rodrigo;
- D'Haeyer, Sam;
- Goossens, Vera;
- Audenaert, Dominique;
- Thal, Dietmar Rudolf;
- Mackenzie, Ian R.;
- Rademakers, Rosa;
- Ranson, Neil A.;
- Radford, Sheena E.;
- Rousseau, Frederic;
- Schymkowitz, Joost
Publication type:
Article
Author Correction: Reverse engineering synthetic antiviral amyloids.
Published in:
2023
By:
- Michiels, Emiel;
- Roose, Kenny;
- Gallardo, Rodrigo;
- Khodaparast, Ladan;
- Khodaparast, Laleh;
- van der Kant, Rob;
- Siemons, Maxime;
- Houben, Bert;
- Ramakers, Meine;
- Wilkinson, Hannah;
- Guerreiro, Patricia;
- Louros, Nikolaos;
- Kaptein, Suzanne J. F.;
- Ibañez, Lorena Itatí;
- Smet, Anouk;
- Baatsen, Pieter;
- Liu, Shu;
- Vorberg, Ina;
- Bormans, Guy;
- Neyts, Johan
Publication type:
Correction Notice
Structural Analysis of Peptide-Analogues of Human Zona Pellucida ZP1 Protein with Amyloidogenic Properties: Insights into Mammalian Zona Pellucida Formation.
Published in:
PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0073258
By:
- Louros, Nikolaos N.;
- Iconomidou, Vassiliki A.;
- Giannelou, Polina;
- Hamodrakas, Stavros J.
Publication type:
Article
Heterotypic interactions in amyloid function and disease.
Published in:
FEBS Journal, 2022, v. 289, n. 8, p. 2025, doi. 10.1111/febs.15719
By:
- Konstantoulea, Katerina;
- Louros, Nikolaos;
- Rousseau, Frederic;
- Schymkowitz, Joost
Publication type:
Article
A β-solenoid model of the Pmel17 repeat domain: insights to the formation of functional amyloid fibrils.
Published in:
Journal of Computer-Aided Molecular Design, 2016, v. 30, n. 2, p. 153, doi. 10.1007/s10822-015-9892-x
By:
- Louros, Nikolaos;
- Baltoumas, Fotis;
- Hamodrakas, Stavros;
- Iconomidou, Vassiliki
Publication type:
Article
Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.
Published in:
PEDS: Protein Engineering, Design & Selection, 2019, v. 32, n. 10, p. 443, doi. 10.1093/protein/gzaa008
By:
- Claes, Filip;
- Rudyak, Stanislav;
- Laird, Angela S;
- Louros, Nikolaos;
- Beerten, Jacinte;
- Debulpaep, Maja;
- Michiels, Emiel;
- van der Kant, Rob;
- Durme, Joost Van;
- Baets, Greet De;
- Houben, Bert;
- Ramakers, Meine;
- Yuan, Kristy;
- Gwee, Serene S L;
- Hernandez, Sara;
- Broersen, Kerensa;
- Oliveberg, Mikael;
- Moahamed, Barbara;
- Kirstein, Janine;
- Robberecht, Wim
Publication type:
Article
WALTZ-DB 2.0: an updated database containing structural information of experimentally determined amyloid-forming peptides.
Published in:
Nucleic Acids Research, 2020, v. 48, n. D1, p. D389, doi. 10.1093/nar/gkz758
By:
- Louros, Nikolaos;
- Konstantoulea, Katerina;
- De Vleeschouwer, Matthias;
- Ramakers, Meine;
- Schymkowitz, Joost;
- Rousseau, Frederic
Publication type:
Article
Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03131-0
By:
- Khodaparast, Ladan;
- Khodaparast, Laleh;
- Gallardo, Rodrigo;
- Louros, Nikolaos N.;
- Michiels, Emiel;
- Ramakrishnan, Reshmi;
- Ramakers, Meine;
- Claes, Filip;
- Young, Lydia;
- Shahrooei, Mohammad;
- Wilkinson, Hannah;
- Desager, Matyas;
- Tadesse, Wubishet Mengistu;
- Nilsson, K. Peter R.;
- Hammarström, Per;
- Aertsen, Abram;
- Carpentier, Sebastien;
- Van Eldere, Johan;
- Rousseau, Frederic;
- Schymkowitz, Joost
Publication type:
Article
A common 'aggregation-prone' interface possibly participates in the self-assembly of human zona pellucida proteins.
Published in:
FEBS Letters, 2016, v. 590, n. 5, p. 619, doi. 10.1002/1873-3468.12099
By:
- Louros, Nikolaos N.;
- Chrysina, Evangelia D.;
- Baltatzis, Georgios E.;
- Patsouris, Efstratios S.;
- Hamodrakas, Stavros J.;
- Iconomidou, Vassiliki A.
Publication type:
Article
An N-terminal pro-atrial natriuretic peptide (NT-proANP) ‘aggregation-prone’ segment involved in isolated atrial amyloidosis.
Published in:
FEBS Letters, 2014, v. 588, n. 1, p. 52, doi. 10.1016/j.febslet.2013.10.049
By:
- Louros, Nikolaos N.;
- Iconomidou, Vassiliki A.;
- Tsiolaki, Paraskevi L.;
- Chrysina, Evangelia D.;
- Baltatzis, Georgios E.;
- Patsouris, Efstratios S.;
- Hamodrakas, Stavros J.
Publication type:
Article
Arabidopsis thaliana Plant Natriuretic Peptide Active Domain Forms Amyloid-like Fibrils in a pH-Dependent Manner.
Published in:
Plants (2223-7747), 2022, v. 11, n. 1, p. 9, doi. 10.3390/plants11010009
By:
- Nasi, Georgia I.;
- Aktypi, Foteini D.;
- Spatharas, Panagiotis M.;
- Louros, Nikolaos N.;
- Tsiolaki, Paraskevi L.;
- Magafa, Vassiliki;
- Trougakos, Ioannis P.;
- Iconomidou, Vassiliki A.
Publication type:
Article
Unraveling the Aggregation Propensity of Human Insulin C-Peptide.
Published in:
Biopolymers, 2017, v. 108, n. 2, p. 1, doi. 10.1002/bip.22882
By:
- Tsiolaki, Paraskevi L.;
- Louros, Nikolaos N.;
- Zompra, Aikaterini A.;
- Hamodrakas, Stavros J.;
- Iconomidou, Vassiliki A.
Publication type:
Article
Identification of an amyloid fibril forming segment of human Pmel17 repeat domain ( RPT domain).
Published in:
Biopolymers, 2016, v. 106, n. 1, p. 133, doi. 10.1002/bip.22746
By:
- Louros, Nikolaos N.;
- Iconomidou, Vassiliki A.
Publication type:
Article
Structural studies and cytotoxicity assays of 'aggregation-prone' IAPP8-16 and its non-amyloidogenic variants suggest its important role in fibrillogenesis and cytotoxicity of human amylin.
Published in:
Biopolymers, 2015, v. 104, n. 3, p. 196, doi. 10.1002/bip.22650
By:
- Louros, Nikolaos N.;
- Tsiolaki, Paraskevi L.;
- Zompra, Aikaterini A.;
- Pappa, Eleni V.;
- Magafa, Vassiliki;
- Pairas, George;
- Cordopatis, Paul;
- Cheimonidou, Christina;
- Trougakos, Ioannis P.;
- Iconomidou, Vassiliki A.;
- Hamodrakas, Stavros J.
Publication type:
Article
Structural studies of 'aggregation-prone' peptide-analogues of teleostean egg chorion ZPB proteins.
Published in:
Biopolymers, 2014, v. 102, n. 6, p. 427, doi. 10.1002/bip.22563
By:
- Louros, Nikolaos N.;
- Petronikolou, Nektaria;
- Karamanos, Theodoros;
- Cordopatis, Paul;
- Iconomidou, Vassiliki A.;
- Hamodrakas, Stavros J.
Publication type:
Article
Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17207-3
By:
- Louros, Nikolaos;
- Orlando, Gabriele;
- De Vleeschouwer, Matthias;
- Rousseau, Frederic;
- Schymkowitz, Joost
Publication type:
Article
Reverse engineering synthetic antiviral amyloids.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16721-8
By:
- Michiels, Emiel;
- Roose, Kenny;
- Gallardo, Rodrigo;
- Khodaparast, Ladan;
- Khodaparast, Laleh;
- van der Kant, Rob;
- Siemons, Maxime;
- Houben, Bert;
- Ramakers, Meine;
- Wilkinson, Hannah;
- Guerreiro, Patricia;
- Louros, Nikolaos;
- Kaptein, Suzanne J. F.;
- Ibañez, Lorena Itatí;
- Smet, Anouk;
- Baatsen, Pieter;
- Liu, Shu;
- Vorberg, Ina;
- Bormans, Guy;
- Neyts, Johan
Publication type:
Article

Found: 24

Hidden Aggregation Hot-Spots on Human Apolipoprotein E: A Structural Study.

Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers.

Enhanced therapeutic window for antimicrobial Pept-ins by investigating their structure-activity relationship.

Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure.

Autonomous aggregation suppression by acidic residues explains why chaperones favour basic residues.

CORDAX web server: an online platform for the prediction and 3D visualization of aggregation motifs in protein sequences.

StAmP-DB: a platform for structures of polymorphic amyloid fibril cores.

Local structural preferences in shaping tau amyloid polymorphism.

Author Correction: Reverse engineering synthetic antiviral amyloids.

Structural Analysis of Peptide-Analogues of Human <i>Zona Pellucida</i> ZP1 Protein with Amyloidogenic Properties: Insights into Mammalian <i>Zona Pellucida</i> Formation.

Heterotypic interactions in amyloid function and disease.

A β-solenoid model of the Pmel17 repeat domain: insights to the formation of functional amyloid fibrils.

Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.

WALTZ-DB 2.0: an updated database containing structural information of experimentally determined amyloid-forming peptides.

Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis.

A common 'aggregation-prone' interface possibly participates in the self-assembly of human zona pellucida proteins.

An N-terminal pro-atrial natriuretic peptide (NT-proANP) ‘aggregation-prone’ segment involved in isolated atrial amyloidosis.

Arabidopsis thaliana Plant Natriuretic Peptide Active Domain Forms Amyloid-like Fibrils in a pH-Dependent Manner.

Unraveling the Aggregation Propensity of Human Insulin C-Peptide.

Identification of an amyloid fibril forming segment of human Pmel17 repeat domain ( RPT domain).

Structural studies and cytotoxicity assays of 'aggregation-prone' IAPP<sub>8-16</sub> and its non-amyloidogenic variants suggest its important role in fibrillogenesis and cytotoxicity of human amylin.

Structural studies of 'aggregation-prone' peptide-analogues of teleostean egg chorion ZPB proteins.

Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities.

Reverse engineering synthetic antiviral amyloids.