Works by Lotta, Luca A.

Results: 42
    1

    The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis.

    Published in:
    2020
    By:
    • Zheng, Ju-Sheng;
    • Luan, Jian'an;
    • Sofianopoulou, Eleni;
    • Sharp, Stephen J.;
    • Day, Felix R.;
    • Imamura, Fumiaki;
    • Gundersen, Thomas E.;
    • Lotta, Luca A.;
    • Sluijs, Ivonne;
    • Stewart, Isobel D.;
    • Shah, Rupal L.;
    • van der Schouw, Yvonne T.;
    • Wheeler, Eleanor;
    • Ardanaz, Eva;
    • Boeing, Heiner;
    • Dorronsoro, Miren;
    • Dahm, Christina C.;
    • Dimou, Niki;
    • El-Fatouhi, Douae;
    • Franks, Paul W.
    Publication type:
    journal article
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    Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.

    Published in:
    2021
    By:
    • Zheng, Ju-Sheng;
    • Luan, Jian'an;
    • Sofianopoulou, Eleni;
    • Imamura, Fumiaki;
    • Stewart, Isobel D.;
    • Day, Felix R.;
    • Pietzner, Maik;
    • Wheeler, Eleanor;
    • Lotta, Luca A.;
    • Gundersen, Thomas E.;
    • Amiano, Pilar;
    • Ardanaz, Eva;
    • Chirlaque, María-Dolores;
    • Fagherazzi, Guy;
    • Franks, Paul W.;
    • Kaaks, Rudolf;
    • Laouali, Nasser;
    • Mancini, Francesca Romana;
    • Nilsson, Peter M.;
    • Onland-Moret, N. Charlotte
    Publication type:
    journal article
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    Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

    Published in:
    2016
    By:
    • Lotta, Luca A.;
    • Scott, Robert A.;
    • Sharp, Stephen J.;
    • Burgess, Stephen;
    • Luan, Jian’an;
    • Tillin, Therese;
    • Schmidt, Amand F.;
    • Imamura, Fumiaki;
    • Stewart, Isobel D.;
    • Perry, John R. B.;
    • Marney, Luke;
    • Koulman, Albert;
    • Karoly, Edward D.;
    • Forouhi, Nita G.;
    • Sjögren, Rasmus J. O.;
    • Näslund, Erik;
    • Zierath, Juleen R.;
    • Krook, Anna;
    • Savage, David B.;
    • Griffin, Julian L.
    Publication type:
    journal article
    6

    Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.

    Published in:
    PLoS Medicine, 2015, v. 12, n. 6, p. 1, doi. 10.1371/journal.pmed.1001841
    By:
    • Østergaard, Søren D.;
    • Mukherjee, Shubhabrata;
    • Sharp, Stephen J.;
    • Proitsi, Petroula;
    • Lotta, Luca A.;
    • Day, Felix;
    • Perry, John R. B.;
    • Boehme, Kevin L.;
    • Walter, Stefan;
    • Kauwe, John S.;
    • Gibbons, Laura E.;
    • null, null;
    • Larson, Eric B.;
    • Powell, John F.;
    • Langenberg, Claudia;
    • Crane, Paul K.;
    • Wareham, Nicholas J.;
    • Scott, Robert A.
    Publication type:
    Article
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    Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis.

    Published in:
    2015
    By:
    • Nead, Kevin T.;
    • Sharp, Stephen J.;
    • Thompson, Deborah J.;
    • Painter, Jodie N.;
    • Savage, David B.;
    • Semple, Robert K.;
    • Barker, Adam;
    • Perry, John R. B.;
    • Attia, John;
    • Dunning, Alison M.;
    • Easton, Douglas F.;
    • Holliday, Elizabeth;
    • Lotta, Luca A.;
    • O'Mara, Tracy;
    • McEvoy, Mark;
    • Pharoah, Paul D. P.;
    • Scott, Rodney J.;
    • Spurdle, Amanda B.;
    • Langenberg, Claudia;
    • Wareham, Nicholas J.
    Publication type:
    journal article
    16

    Assessing the causal association of glycine with risk of cardio-metabolic diseases.

    Published in:
    Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-08936-1
    By:
    • Wittemans, Laura B. L.;
    • Lotta, Luca A.;
    • Oliver-Williams, Clare;
    • Stewart, Isobel D.;
    • Surendran, Praveen;
    • Karthikeyan, Savita;
    • Day, Felix R.;
    • Koulman, Albert;
    • Imamura, Fumiaki;
    • Zeng, Lingyao;
    • Erdmann, Jeanette;
    • Schunkert, Heribert;
    • Khaw, Kay-Tee;
    • Griffin, Julian L.;
    • Forouhi, Nita G.;
    • Scott, Robert A.;
    • Wood, Angela M.;
    • Burgess, Stephen;
    • Howson, Joanna M. M.;
    • Danesh, John
    Publication type:
    Article
    17
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    Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.

    Published in:
    2016
    By:
    • Yaghootkar, Hanieh;
    • Lotta, Luca A.;
    • Tyrrell, Jessica;
    • Smit, Roelof A. J.;
    • Jones, Sam E.;
    • Donnelly, Louise;
    • Beaumont, Robin;
    • Campbell, Archie;
    • Tuke, Marcus A.;
    • Hayward, Caroline;
    • Ruth, Katherine S.;
    • Padmanabhan, Sandosh;
    • Wouter Jukema, J.;
    • Palmer, Colin C.;
    • Hattersley, Andrew;
    • Freathy, Rachel M.;
    • Langenberg, Claudia;
    • Wareham, Nicholas J.;
    • Wood, Andrew R.;
    • Murray, Anna
    Publication type:
    journal article
    19

    Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies.

    Published in:
    2022
    By:
    • Cavazos, Taylor B.;
    • Kachuri, Linda;
    • Graff, Rebecca E.;
    • Nierenberg, Jovia L.;
    • Thai, Khanh K.;
    • Alexeeff, Stacey;
    • Van Den Eeden, Stephen;
    • Corley, Douglas A.;
    • Kushi, Lawrence H.;
    • Regeneron Genetics Center;
    • Abecasis, Goncalo;
    • Baras, Aris;
    • Cantor, Michael;
    • Coppola, Giovanni;
    • Deubler, Andrew;
    • Economides, Aris;
    • Karalis, Katia;
    • Lotta, Luca A.;
    • Overton, John D.;
    • Reid, Jeffrey G.
    Publication type:
    journal article
    20
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    Hypoinsulinaemic, hypoketotic hypoglycaemia due to mosaic genetic activation of PI3-kinase.

    Published in:
    European Journal of Endocrinology, 2017, v. 177, n. 2, p. 175, doi. 10.1530/EJE-17-0132
    By:
    • Leiter, Sarah M.;
    • Parker, Victoria E. R.;
    • Welters, Alena;
    • Knox, Rachel;
    • Rocha, Nuno;
    • Clark, Graeme;
    • Payne, Felicity;
    • Lotta, Luca;
    • Harris, Julie;
    • Guerrero-Fernández, Julio;
    • González-Casado, Isabel;
    • García-Miñaur, Sixto;
    • Gordo, Gema;
    • Wareham, Nick;
    • Martínez-Glez, Víctor;
    • Allison, Michael;
    • O’Rahilly, Stephen;
    • Barroso, Inês;
    • Meissner, Thomas;
    • Davies, Susan
    Publication type:
    Article
    22

    Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes.

    Published in:
    Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-99091-5
    By:
    • Deaton, Aimee M.;
    • Parker, Margaret M.;
    • Ward, Lucas D.;
    • Flynn-Carroll, Alexander O.;
    • BonDurant, Lucas;
    • Hinkle, Gregory;
    • Akbari, Parsa;
    • Lotta, Luca A.;
    • Regeneron Genetics Center;
    • RGC Management and Leadership Team;
    • Abecasis, Goncalo;
    • Baras, Aris;
    • Cantor, Michael;
    • Coppola, Giovanni;
    • Economides, Aris;
    • Overton, John D.;
    • Reid, Jeffrey G.;
    • Shuldiner, Alan;
    • Karalis, Katia;
    • Deubler, Andrew
    Publication type:
    Article
    23
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    Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse.

    Published in:
    PLoS Genetics, 2024, v. 20, n. 3, p. 1, doi. 10.1371/journal.pgen.1011179
    By:
    • Smagris, Eriks;
    • Shihanian, Lisa M.;
    • Mintah, Ivory J.;
    • Bigdelou, Parnian;
    • Livson, Yuliya;
    • Brown, Heather;
    • Verweij, Niek;
    • Hunt, Charleen;
    • Johnson, Reid O'Brien;
    • Greer, Tyler J.;
    • Hartford, Suzanne A.;
    • Hindy, George;
    • Sun, Luanluan;
    • Nielsen, Jonas B.;
    • Halasz, Gabor;
    • Lotta, Luca A.;
    • Murphy, Andrew J.;
    • Sleeman, Mark W.;
    • Gusarova, Viktoria
    Publication type:
    Article
    25

    Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.

    Published in:
    Nature Communications, 2017, v. 8, n. 7, p. 16015, doi. 10.1038/ncomms16015
    By:
    • Willems, Sara M.;
    • Wright, Daniel J.;
    • Day, Felix R.;
    • Trajanoska, Katerina;
    • Joshi, Peter K.;
    • Morris, John A.;
    • Matteini, Amy M.;
    • Garton, Fleur C.;
    • Grarup, Niels;
    • Oskolkov, Nikolay;
    • Thalamuthu, Anbupalam;
    • Mangino, Massimo;
    • Liu, Jun;
    • Demirkan, Ayse;
    • Lek, Monkol;
    • Xu, Liwen;
    • Wang, Guan;
    • Oldmeadow, Christopher;
    • Gaulton, Kyle J.;
    • Lotta, Luca A.
    Publication type:
    Article
    26

    Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings.

    Published in:
    eLife, 2024, p. 1, doi. 10.7554/eLife.90419
    By:
    • Shek Man Chim;
    • Howell, Kristen;
    • Dronzek, John;
    • Weizhen Wu;
    • Van Hout, Cristopher;
    • Ferreira, Manuel A. R.;
    • Bin Ye;
    • Li, Alexander;
    • Brydges, Susannah;
    • Arunachalam, Vinayagam;
    • Marcketta, Anthony;
    • Locke, Adam E.;
    • Bovijn, Jonas;
    • Verweij, Niek;
    • De, Tanima;
    • Lotta, Luca;
    • Mitnaul, Lyndon;
    • LeBlanc, Michelle;
    • Center, Regeneron Genetics;
    • Carey, David J.
    Publication type:
    Article
    27

    Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.

    Published in:
    2018
    By:
    • Lotta, Luca A.;
    • Wittemans, Laura B. L.;
    • Zuber, Verena;
    • Stewart, Isobel D.;
    • Sharp, Stephen J.;
    • Luan, Jian'an;
    • Day, Felix R.;
    • Li, Chen;
    • Bowker, Nicholas;
    • Cai, Lina;
    • De Lucia Rolfe, Emanuella;
    • Khaw, Kay-Tee;
    • Perry, John R. B.;
    • O'Rahilly, Stephen;
    • Scott, Robert A.;
    • Savage, David B.;
    • Burgess, Stephen;
    • Wareham, Nicholas J.;
    • Langenberg, Claudia
    Publication type:
    journal article
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    Genome‐wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals.

    Published in:
    Genetic Epidemiology, 2021, v. 45, n. 6, p. 664, doi. 10.1002/gepi.22392
    By:
    • Gao, Chuan;
    • Marcketta, Anthony;
    • Backman, Joshua D.;
    • O'Dushlaine, Colm;
    • Staples, Jeffrey;
    • Ferreira, Manuel Allen Revez;
    • Lotta, Luca A.;
    • Overton, John D.;
    • Reid, Jeffrey G.;
    • Mirshahi, Tooraj;
    • Regeneron Genetics Center;
    • Geisinger Regeneron Discovehr Collaboration;
    • Baras, Aris;
    • Abecasis, Gonçalo;
    • Shuldiner, Alan R.;
    • Van Hout, Cristopher V.;
    • McCarthy, Shane
    Publication type:
    Article
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    GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms.

    Published in:
    Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24563-1
    By:
    • Ward, Lucas D.;
    • Tu, Ho-Chou;
    • Quenneville, Chelsea B.;
    • Tsour, Shira;
    • Flynn-Carroll, Alexander O.;
    • Parker, Margaret M.;
    • Deaton, Aimee M.;
    • Haslett, Patrick A. J.;
    • Lotta, Luca A.;
    • Verweij, Niek;
    • Ferreira, Manuel A. R.;
    • Regeneron Genetics Center;
    • RGC Management and Leadership Team;
    • Abecasis, Goncalo;
    • Cantor, Michael;
    • Coppola, Giovanni;
    • Reid, Jeffrey G.;
    • Shuldiner, Alan;
    • Karalis, Katia;
    • Siminovitch, Katherine
    Publication type:
    Article
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