Found: 17

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  • Therapeutic Targeting of Fumaryl Acetoacetate Hydrolase in Hereditary Tyrosinemia Type I.

    Published in:
    International Journal of Molecular Sciences, 2021, v. 22, n. 4, p. 1789, doi. 10.3390/ijms22041789
    By:
    • Gil-Martínez, Jon;
    • Macias, Iratxe;
    • Unione, Luca;
    • Bernardo-Seisdedos, Ganeko;
    • Lopitz-Otsoa, Fernando;
    • Fernandez-Ramos, David;
    • Lain, Ana;
    • Sanz-Parra, Arantza;
    • Mato, José M;
    • Millet, Oscar;
    • Kang, Congbao
    Publication type:
    Article

  • Multi-Omics Integration Highlights the Role of Ubiquitination in CCl 4 -Induced Liver Fibrosis.

    Published in:
    International Journal of Molecular Sciences, 2020, v. 21, n. 23, p. 9043, doi. 10.3390/ijms21239043
    By:
    • Mercado-Gómez, Maria;
    • Lopitz-Otsoa, Fernando;
    • Azkargorta, Mikel;
    • Serrano-Maciá, Marina;
    • Lachiondo-Ortega, Sofia;
    • Goikoetxea-Usandizaga, Naroa;
    • Rodríguez-Agudo, Rubén;
    • Fernández-Ramos, David;
    • Bizkarguenaga, Maider;
    • Juan, Virginia Gutiérrez-de;
    • Lectez, Benoît;
    • Aloria, Kerman;
    • Arizmendi, Jesus M.;
    • Simon, Jorge;
    • Alonso, Cristina;
    • Lozano, Juan J.;
    • Avila, Matias A.;
    • Banales, Jesus M.;
    • Marin, Jose J. G.;
    • Beraza, Naiara
    Publication type:
    Article

  • Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities.

    Published in:
    EMBO Reports, 2009, v. 10, n. 11, p. 1250, doi. 10.1038/embor.2009.192
    By:
    • Hjerpe, Roland;
    • Aillet, Fabienne;
    • Lopitz-Otsoa, Fernando;
    • Lang, Valerie;
    • England, Patrick;
    • Rodriguez, Manuel S
    Publication type:
    Article

  • Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease.

    Published in:
    Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28201-2
    By:
    • Barbier-Torres, Lucía;
    • Murray, Ben;
    • Yang, Jin Won;
    • Wang, Jiaohong;
    • Matsuda, Michitaka;
    • Robinson, Aaron;
    • Binek, Aleksandra;
    • Fan, Wei;
    • Fernández-Ramos, David;
    • Lopitz-Otsoa, Fernando;
    • Luque-Urbano, Maria;
    • Millet, Oscar;
    • Mavila, Nirmala;
    • Peng, Hui;
    • Ramani, Komal;
    • Gottlieb, Roberta;
    • Sun, Zhaoli;
    • Liangpunsakul, Suthat;
    • Seki, Ekihiro;
    • Van Eyk, Jennifer E.
    Publication type:
    Article

  • O-GlcNAcylated p53 in the liver modulates hepatic glucose production.

    Published in:
    Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25390-0
    By:
    • Gonzalez-Rellan, Maria J.;
    • Fondevila, Marcos F.;
    • Fernandez, Uxia;
    • Rodríguez, Amaia;
    • Varela-Rey, Marta;
    • Veyrat-Durebex, Christelle;
    • Seoane, Samuel;
    • Bernardo, Ganeko;
    • Lopitz-Otsoa, Fernando;
    • Fernández-Ramos, David;
    • Bilbao, Jon;
    • Iglesias, Cristina;
    • Novoa, Eva;
    • Ameneiro, Cristina;
    • Senra, Ana;
    • Beiroa, Daniel;
    • Cuñarro, Juan;
    • DP Chantada-Vazquez, Maria;
    • Garcia-Vence, Maria;
    • Bravo, Susana B.
    Publication type:
    Article

  • Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity.

    Published in:
    PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0051672
    By:
    • Aillet, Fabienne;
    • Lopitz-Otsoa, Fernando;
    • Egaña, Isabel;
    • Hjerpe, Roland;
    • Fraser, Paul;
    • Hay, Ron T.;
    • Rodriguez, Manuel S.;
    • Lang, Valérie
    Publication type:
    Article

  • Evolution of SUMO Function and Chain Formation in Insects.

    Published in:
    Molecular Biology & Evolution, 2016, v. 33, n. 2, p. 568, doi. 10.1093/molbev/msv242
    By:
    • Ureña, Enric;
    • Pirone, Lucia;
    • Chafino, Silvia;
    • Pérez, Coralia;
    • Sutherland, James D.;
    • Lang, Valérie;
    • Rodriguez, Manuel S.;
    • Lopitz-Otsoa, Fernando;
    • Blanco, Francisco J.;
    • Barrio, Rosa;
    • Martín, David
    Publication type:
    Article

  • Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen.

    Published in:
    Antioxidants, 2022, v. 11, n. 5, p. 897, doi. 10.3390/antiox11050897
    By:
    • Rodríguez-Agudo, Rubén;
    • Goikoetxea-Usandizaga, Naroa;
    • Serrano-Maciá, Marina;
    • Fernández-Tussy, Pablo;
    • Fernández-Ramos, David;
    • Lachiondo-Ortega, Sofía;
    • González-Recio, Irene;
    • Gil-Pitarch, Clàudia;
    • Mercado-Gómez, María;
    • Morán, Laura;
    • Bizkarguenaga, Maider;
    • Lopitz-Otsoa, Fernando;
    • Petrov, Petar;
    • Bravo, Miren;
    • Van Liempd, Sebastiaan Martijn;
    • Falcon-Perez, Juan Manuel;
    • Zabala-Letona, Amaia;
    • Carracedo, Arkaitz;
    • Castell, Jose Vicente;
    • Jover, Ramiro
    Publication type:
    Article

  • Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity.

    Published in:
    Cell Death & Disease, 2021, v. 12, n. 6, p. 1, doi. 10.1038/s41419-021-03827-0
    By:
    • Fernández-Tussy, Pablo;
    • Rodríguez-Agudo, Rubén;
    • Fernández-Ramos, David;
    • Barbier-Torres, Lucía;
    • Zubiete-Franco, Imanol;
    • Davalillo, Sergio López de;
    • Herraez, Elisa;
    • Goikoetxea-Usandizaga, Naroa;
    • Lachiondo-Ortega, Sofia;
    • Simón, Jorge;
    • Lopitz-Otsoa, Fernando;
    • Juan, Virginia Gutiérrez-de;
    • McCain, Misti V.;
    • Perugorria, Maria J.;
    • Mabe, Jon;
    • Navasa, Nicolás;
    • Rodrigues, Cecilia M. P.;
    • Fabregat, Isabel;
    • Boix, Loreto;
    • Sapena, Victor
    Publication type:
    Article

  • MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis.

    Published in:
    Cell Death & Disease, 2018, v. 9, n. 10, p. 1, doi. 10.1038/s41419-018-1014-y
    By:
    • Fernández-Ramos, David;
    • Fernández-Tussy, Pablo;
    • Lopitz-Otsoa, Fernando;
    • Gutiérrez-de-Juan, Virginia;
    • Navasa, Nicolás;
    • Barbier-Torres, Lucía;
    • Zubiete-Franco, Imanol;
    • Simón, Jorge;
    • Fernández, Agustín F.;
    • Arbelaiz, Ander;
    • Aransay, Ana M.;
    • Lavín, José Luis;
    • Beraza, Naiara;
    • Perugorria, María J.;
    • Banales, Jesus M.;
    • Villa, Erica;
    • Fraga, Mario F.;
    • Anguita, Juan;
    • Avila, Matias A.;
    • Berasain, Carmen
    Publication type:
    Article

  • Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis.

    Published in:
    Cells (2073-4409), 2019, v. 8, n. 12, p. 1575, doi. 10.3390/cells8121575
    By:
    • Lachiondo-Ortega, Sofia;
    • Mercado-Gómez, Maria;
    • Serrano-Maciá, Marina;
    • Lopitz-Otsoa, Fernando;
    • Salas-Villalobos, Tanya B;
    • Varela-Rey, Marta;
    • Delgado, Teresa C.;
    • Martínez-Chantar, María Luz
    Publication type:
    Article

  • The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.

    Published in:
    Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01970-x
    By:
    • Barbier-Torres, Lucía;
    • Fernández-Ramos, David;
    • Delgado, Teresa C.;
    • Taibo, Daniel;
    • Guitiérrez-de-Juan, Virginia;
    • Varela-Rey, Marta;
    • Fernández-Tussy, Pablo;
    • Zubiete-Franco, Imanol;
    • Simon, Jorge;
    • Lopitz-Otsoa, Fernando;
    • Lachiondo-Ortega, Sofia;
    • Mato, José M.;
    • Martínez-Chantar, María Luz;
    • Iruzubieta, Paula;
    • Lu, Shelly C.;
    • Rincón, Mercedes;
    • Crespo, Javier;
    • Azkargorta, Mikel;
    • Elortza, Felix;
    • Navasa, Nicolas
    Publication type:
    Article

  • Scavenger Receptors Mediate the Role of SUMO and Ftz-f1 in Drosophila Steroidogenesis.

    Published in:
    PLoS Genetics, 2013, v. 9, n. 4, p. 1, doi. 10.1371/journal.pgen.1003473
    By:
    • Talamillo, Ana;
    • Herboso, Leire;
    • Pirone, Lucia;
    • Pérez, Coralia;
    • Gonzalez, Monika;
    • Sánchez, Jonatan;
    • Mayor, Ugo;
    • Lopitz-Otsoa, Fernando;
    • Rodriguez, Manuel S.;
    • Sutherland, James D.;
    • Barrio, Rosa
    Publication type:
    Article

  • One Carbon Metabolism and S -Adenosylmethionine in Non-Alcoholic Fatty Liver Disease Pathogenesis and Subtypes.

    Published in:
    Livers, 2022, v. 2, n. 4, p. 243, doi. 10.3390/livers2040020
    By:
    • Fernández-Ramos, David;
    • Lopitz-Otsoa, Fernando;
    • Millet, Oscar;
    • Alonso, Cristina;
    • Lu, Shelly C.;
    • Mato, José M.
    Publication type:
    Article

  • Strategies to Identify Recognition Signals and Targets of SUMOylation.

    Published in:
    Biotechnology Research International, 2012, p. 1, doi. 10.1155/2012/875148
    By:
    • Silva-Ferrada, Elisa Da;
    • Lopitz-Otsoa, Fernando;
    • Lang, Valérie;
    • Rodríguez, Manuel S.;
    • Matthiesen, Rune
    Publication type:
    Article

  • A morphological method for ammonia detection in liver.

    Published in:
    PLoS ONE, 2017, v. 12, n. 3, p. 1, doi. 10.1371/journal.pone.0173914
    By:
    • Gutiérrez-de-Juan, Virginia;
    • López de Davalillo, Sergio;
    • Fernández-Ramos, David;
    • Barbier-Torres, Lucía;
    • Zubiete-Franco, Imanol;
    • Fernández-Tussy, Pablo;
    • Simon, Jorge;
    • Lopitz-Otsoa, Fernando;
    • de las Heras, Javier;
    • Iruzubieta, Paula;
    • Arias-Loste, María Teresa;
    • Villa, Erica;
    • Crespo, Javier;
    • Andrade, Raúl;
    • Lucena, M. Isabel;
    • Varela-Rey, Marta;
    • Lu, Shelly C.;
    • Mato, José M.;
    • Delgado, Teresa Cardoso;
    • Martínez-Chantar, María-Luz
    Publication type:
    Article

  • Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity.

    Published in:
    Molecular Oncology, 2014, v. 8, n. 5, p. 1026, doi. 10.1016/j.molonc.2014.04.002
    By:
    • Lang, Valérie;
    • Pallara, Chiara;
    • Zabala, Amaia;
    • Lobato-Gil, Sofia;
    • Lopitz-Otsoa, Fernando;
    • Farrás, Rosa;
    • Hjerpe, Roland;
    • Torres-Ramos, Monica;
    • Zabaleta, Lorea;
    • Blattner, Christine;
    • Hay, Ronald T.;
    • Barrio, Rosa;
    • Carracedo, Arkaitz;
    • Fernandez-Recio, Juan;
    • Rodríguez, Manuel S.;
    • Aillet, Fabienne
    Publication type:
    Article