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Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.
Published in:
Nature Reviews Drug Discovery, 2013, v. 12, n. 7, p. 507, doi. 10.1038/nrd4024
By:
- Longo, Frank M.;
- Massa, Stephen M.
Publication type:
Article
Optimizing the use of CROs by academia and small companies.
Published in:
Nature Reviews Drug Discovery, 2013, v. 12, n. 7, p. 487, doi. 10.1038/nrd4057
By:
- Lane, Rachel F.;
- Friedman, Lauren G.;
- Keith, Curtis;
- Braithwaite, Steven P.;
- Frearson, Julie A.;
- Lowe, David A.;
- Longo, Frank M.;
- Refolo, Lorenzo M.;
- Watterson, D. Martin;
- Tsaioun, Katya;
- Shineman, Diana W.;
- Fillit, Howard M.
Publication type:
Article
Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice.
Published in:
Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40478-020-01034-0
By:
- Yang, Tao;
- Liu, Harry;
- Tran, Kevin C.;
- Leng, Albert;
- Massa, Stephen M.;
- Longo, Frank M.
Publication type:
Article
Neurotrophin-based strategies for neuroprotection.
Published in:
Journal of Alzheimer's Disease, 2004, v. 6, p. S13
By:
- Longo, Frank M.;
- Massa, Stephen M.
Publication type:
Article
Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau.
Published in:
2020
By:
- Wilson, Edward N;
- Swarovski, Michelle S;
- Linortner, Patricia;
- Shahid, Marian;
- Zuckerman, Abigail J;
- Wang, Qian;
- Channappa, Divya;
- Minhas, Paras S;
- Mhatre, Siddhita D;
- Plowey, Edward D;
- Quinn, Joseph F;
- Zabetian, Cyrus P;
- Tian, Lu;
- Longo, Frank M;
- Cholerton, Brenna;
- Montine, Thomas J;
- Poston, Kathleen L;
- Andreasson, Katrin I
Publication type:
journal article
Leukocyte Antigen-Related Protein Tyrosine Phosphatase Receptor: A Small Ectodomain Isoform Functions as a Homophilic Ligand and Promotes Neurite Outgrowth.
Published in:
Journal of Neuroscience, 2003, v. 23, n. 8, p. 3353, doi. 10.1523/JNEUROSCI.23-08-03353.2003
By:
- Tao Yang;
- Bernabeu, Ramon;
- Youmei Xie;
- Zhang, Juile S.;
- Massa, Stephen M.;
- Rempel, Hans C.;
- Longo, Frank M.
Publication type:
Article
A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity‐dependent synaptic and microglial transcriptomic changes in a late‐stage Alzheimer's mouse model.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 7, p. 4434, doi. 10.1002/alz.13857
By:
- Latif‐Hernandez, Amira;
- Yang, Tao;
- Butler, Robert R.;
- Losada, Patricia Moran;
- Minhas, Paras S.;
- White, Halle;
- Tran, Kevin C.;
- Liu, Harry;
- Simmons, Danielle A.;
- Langness, Vanessa;
- Andreasson, Katrin I.;
- Wyss‐Coray, Tony;
- Longo, Frank M.
Publication type:
Article
Modulation of the p75 neurotrophin receptor in the PS19 tauopathy mouse model regulates transcription profiles and inter‐cellular communication across multiple populations of non‐neuronal cells.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.080789
By:
- III, Robert R. Butler;
- Yang, Tao;
- Han, Crystal;
- Guen, Yann Le;
- Tran, Kevin C;
- Lallani, Shoeb;
- Liu, Harry;
- Leng, Song Albert;
- Massa, Stephen M.;
- Longo, Frank M.
Publication type:
Article
Neuronal stimulation‐regulated RNA splicing defects in tauopathies are corrected by treatment with a p75 NTR modulator.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.080548
By:
- Latif‐Hernandez, Amira;
- Moran‐Losada, Patricia;
- Yang, Tao;
- White, Halle;
- Tran, Kevin C;
- Liu, Harry;
- Massa, Stephen M.;
- Wyss‐Coray, Tony;
- Longo, Frank M.
Publication type:
Article
The Emory‐Sage‐SGC TREAT‐AD Center: Tool development for novel targets in Alzheimer's Disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.076912
By:
- Leal, Karina;
- Axtman, Alison D.;
- Betarbet, Ranjita;
- Brennan, Paul E;
- Carter, Gregory W;
- Fu, Haian;
- Greenwood, Anna K;
- Longo, Frank M.;
- Edwards, Aled M;
- Levey, Allan I.;
- Center, The Emory‐Sage‐SGC TREAT‐AD
Publication type:
Article
Age‐dependent effects of the p75 neurotrophin receptor modulator LM11A‐31 on Alzheimer's disease biomarkers in a 26‐week safety and exploratory endpoint trial.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.069079
By:
- Shanks, Hayley R. C.;
- Börjesson‐Hanson, Anne;
- Windisch, Manfred;
- Massa, Stephen M.;
- Longo, Frank M.;
- Schmitz, Taylor W.
Publication type:
Article
p75NTR modulation counteracts alterations in neuronal and glial activity‐dependent profiles of gene co‐expression networks in tauopathy mice.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.066948
By:
- Latif‐Hernandez, Amira;
- Moran‐Losada, Patricia;
- Yang, Tao;
- III, Robert R. Butler;
- Tran, Kevin C;
- Liu, Harry;
- Massa, Stephen M.;
- Wyss‐Coray, Tony;
- Longo, Frank M.
Publication type:
Article
Microglial state changes in response to LM11A‐31 promote recovery in a tauopathy mouse model of Alzheimer's Disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.066201
By:
- Butler, Robert R.;
- Yang, Tao;
- Tran, Kevin C;
- Johnson, William A;
- Liu, Harry;
- Leng, Song Albert;
- Massa, Stephen M.;
- Longo, Frank M.
Publication type:
Article
The Emory‐Sage‐SGC TREAT‐AD Center: Tool and probe development for emerging targets in Alzheimer's Disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.064748
By:
- Leal, Karina;
- Axtman, Alison D.;
- Betarbet, Ranjita;
- Brennan, Paul E;
- Carter, Gregory W;
- Frye, Stephen V.;
- Fu, Haian;
- Greenwood, Anna K;
- Longo, Frank M.;
- Pearce, Kenneth H.;
- Edwards, Aled M;
- Levey, Allan I.
Publication type:
Article
Diagnostic and Prognostic Performance of the Modified Lumipulse pTau 181 Assay in Plasma for Alzheimer's Disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.060879
By:
- Wilson, Edward N.;
- Young, Christina B;
- Benitez, Javier A. Ramos;
- Vandijck, Manu;
- Swarovski, Michelle S.;
- Shahid, Marian;
- Corso, Nicole;
- Kennedy, Gabriel;
- Trelle, Alexandra N;
- Channappa, Divya;
- Belnap, Malia;
- Lind, Betty;
- Bastard, Nathalie Le;
- Quinn, Joseph F;
- Nairn, Angus C;
- Kerchner, Geoffrey A.;
- Sha, Sharon;
- Wagner, Anthony D;
- Henderson, Victor;
- Longo, Frank M.
Publication type:
Article
CSF Biomarkers of Amyloid and Tau Pathologies in Participants Enrolled in the Stanford Alzheimer's Disease Research Center.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 5, p. 1, doi. 10.1002/alz.068261
By:
- Ramos Benitez, Javier A.;
- Wilson, Edward N.;
- Swarovski, Michelle S.;
- Shahid, Marian;
- Corso, Nicole;
- Channappa, Divya;
- Belnap, Malia;
- Tian, Lu;
- Kerchner, Geoffrey A.;
- Sha, Sharon;
- Henderson, Victor;
- Longo, Frank M.;
- Wyss‐Coray, Tony;
- Poston, Kathleen L;
- Mormino, Elizabeth C.;
- Andreasson, Katrin I.
Publication type:
Article
Activity‐dependent dysfunctional gene expression patterns are normalized by in vivo treatment of late‐stage Aβ pathology mice with a TrkB/C small molecule ligand.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.055861
By:
- Latif‐Hernandez, Amira;
- Moran‐Losada, Patricia;
- Yang, Tao;
- Tran, Kevin C;
- Liu, Harry;
- Butler, Robert R.;
- Massa, Stephen M.;
- Longo, Frank M.
Publication type:
Article
Integrating multimodal data to support Alzheimer's disease target prioritization.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.052334
By:
- Cary, Gregory A.;
- Gockley, Jake;
- Lehallier, Benoit;
- Leal, Karina;
- Greenwood, Anna K;
- Shulman, Joshua M;
- Longo, Frank M;
- Levey, Allan I;
- Mangravite, Lara M;
- Logsdon, Benjamin A;
- Carter, Gregory W
Publication type:
Article
Tool and chemical probe development for emerging targets in Alzheimer's disease: The Emory‐Sage‐SGC TREAT‐AD Center.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.051447
By:
- Mangravite, Lara M;
- Betarbet, Ranjita;
- Carter, Gregory W;
- Frye, Stephen V.;
- Fu, Haian;
- Gileadi, Opher;
- Greenwood, Anna K;
- Leal, Karina;
- Longo, Frank M.;
- Omberg, Larsson;
- Pearce, Kenneth H.;
- Edwards, Aled M;
- Levey, Allan I
Publication type:
Article
Elucidating emerging therapeutics: P75 receptor modulation reverts tauopathy associated alterations in synapse‐relevant gene expression signatures: Preclinical small‐molecule drug discovery.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045764
By:
- Latif‐Hernandez, Amira;
- Losada, Patricia Moran;
- Yang, Tao;
- Tran, Kevin C.;
- Liu, Harry;
- Lehallier, Benoit;
- Massa, Stephen M.;
- Longo, Frank M.
Publication type:
Article
P3‐212: A SMALL MOLECULE TRKB/TRKC NEUROTROPHIN RECEPTOR CO‐ACTIVATOR PREVENTS SYNAPTIC IMPAIRMENT IN AN AD MOUSE MODEL.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1011, doi. 10.1016/j.jalz.2019.06.3242
By:
- Latif-Hernandez, Amira;
- Yang, Tao;
- Tran, Kevin C.;
- Liu, Harry;
- Massa, Stephen M.;
- Longo, Frank M.
Publication type:
Article
S2‐02‐04: TARGETING THE P75 NEUROTROPHIN RECEPTOR: A NEW APPROACH FOR ALZHEIMER'S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P601, doi. 10.1016/j.jalz.2018.06.2609
By:
- Longo, Frank M.
Publication type:
Article
Modulation of p75 NTR on Mesenchymal Stem Cells Increases Their Vascular Protection in Retinal Ischemia-Reperfusion Mouse Model.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 2, p. 829, doi. 10.3390/ijms22020829
By:
- Elshaer, Sally L.;
- Park, Hang-soo;
- Pearson, Laura;
- Hill, William D.;
- Longo, Frank M.;
- El-Remessy, Azza B.
Publication type:
Article
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.
Published in:
2010
By:
- Massa, Stephen M.;
- Tao Yang;
- Youmei Xie;
- Jian Shi;
- Bilgen, Mehmet;
- Joyce, Jeffrey N.;
- Nehama, Dean;
- Rajadas, Jayakumar;
- Longo, Frank M.;
- Yang, Tao;
- Xie, Youmei;
- Shi, Jian
Publication type:
journal article
Heat Shock Proteins Used to Show that Haloperidol Prevents Neuronal Injury Produced by Ketamine, MK801, and Phencyclidinea.
Published in:
Annals of the New York Academy of Sciences, 1993, v. 679, n. 1, p. 288, doi. 10.1111/j.1749-6632.1993.tb18310.x
By:
- SHARP, FRANK R.;
- BUTMAN, MICHAEL;
- WANG, SHU;
- KOISTINAHO, JARI;
- GRAHAM, STEVEN H.;
- SAGAR, STEPHEN M.;
- BERGER, PAUL;
- LONGO, FRANK M.
Publication type:
Article
A Small Molecule p75NTR Ligand Protects Neurogenesis After Traumatic Brain Injury.
Published in:
Stem Cells, 2013, v. 31, n. 11, p. 2561, doi. 10.1002/stem.1516
By:
- Shi, Jian;
- Longo, Frank M.;
- Massa, Stephen M.
Publication type:
Article
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.
Published in:
Nature Medicine, 2014, v. 20, n. 6, p. 659, doi. 10.1038/nm.3569
By:
- Villeda, Saul A;
- Plambeck, Kristopher E;
- Middeldorp, Jinte;
- Castellano, Joseph M;
- Mosher, Kira I;
- Luo, Jian;
- Smith, Lucas K;
- Bieri, Gregor;
- Lin, Karin;
- Berdnik, Daniela;
- Wabl, Rafael;
- Udeochu, Joe;
- Wheatley, Elizabeth G;
- Zou, Bende;
- Simmons, Danielle A;
- Xie, Xinmin S;
- Longo, Frank M;
- Wyss-Coray, Tony
Publication type:
Article
A Candidate Chimeric Mammalian mRNA Transcript Is Derived from Distinct Chromosomes and Is Associated with Nonconsensus Splice Junction Motifs.
Published in:
DNA & Cell Biology, 2003, v. 22, n. 5, p. 303, doi. 10.1089/104454903322216653
By:
- Cheng Zhang;
- Youmei Xie;
- Martignetti, John A.;
- Yeo, Tracy T.;
- Massa, Stephen M.;
- Longo, Frank M.
Publication type:
Article
Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway.
Published in:
Diabetologia, 2019, v. 62, n. 8, p. 1488, doi. 10.1007/s00125-019-4885-2
By:
- Elshaer, Sally L.;
- Alwhaibi, Abdulrahman;
- Mohamed, Riyaz;
- Lemtalsi, Tahira;
- Coucha, Maha;
- Longo, Frank M.;
- El-Remessy, Azza B.
Publication type:
Article
Thy1-hAPPLond/Swe+ mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function.
Published in:
Brain & Behavior, 2012, v. 2, n. 2, p. 142, doi. 10.1002/brb3.41
By:
- Faizi, Mehrdad;
- Bader, Patrick L.;
- Saw, Nay;
- Nguyen, Thuy-Vi V.;
- Beraki, Simret;
- Wyss-Coray, Tony;
- Longo, Frank M.;
- Shamloo, Mehrdad
Publication type:
Article
A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression.
Published in:
PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0102136
By:
- Simmons, Danielle A.;
- Knowles, Juliet K.;
- Belichenko, Nadia P.;
- Banerjee, Gargi;
- Finkle, Carly;
- Massa, Stephen M.;
- Longo, Frank M.
Publication type:
Article
Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment.
Published in:
PLoS ONE, 2008, v. 3, n. 11, p. 1, doi. 10.1371/journal.pone.0003604
By:
- Tao Yang;
- Knowles, Juliet K.;
- Qun Lu;
- Hong Zhang;
- Arancio, Ottavio;
- Moore, Laura A.;
- Chang, Timothy;
- Qian Wang;
- Andreasson, Katrin;
- Rajadas, Jayakumar;
- Fuller, Gerald G.;
- Youmei Xie;
- Massa, Stephen M.;
- Longo, Frank M.
Publication type:
Article
Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia.
Published in:
Acta Neuropathologica Communications, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40478-018-0603-4
By:
- Nguyen, Thuy-Vi V.;
- Hayes, Megan;
- Zbesko, Jacob C.;
- Frye, Jennifer B.;
- Congrove, Nicole R.;
- Belichenko, Nadia P.;
- McKay, Brian S.;
- Longo, Frank M.;
- Doyle, Kristian P.
Publication type:
Article
Trinucleotide Repeats in Transgenic Mice: New Insights.
Published in:
Neuroscientist, 1997, v. 3, n. 5, p. 273, doi. 10.1177/107385849700300507
By:
- Longo, Frank M.;
- Massa, Stephen M.
Publication type:
Article
Transgenic mice: What are we learning about gene function and neurological disease?
Published in:
Neuroscientist, 1995, v. 1, n. 6, p. 309, doi. 10.1177/107385849500100601
By:
- Longo, Frank M.
Publication type:
Article
Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09744-3
By:
- Wong, Hoi Leong Xavier;
- Qin, Hong-yan;
- Tsang, Siu Wai;
- Zuo, Xiao;
- Che, Sijia;
- Chow, Chi Fung Willis;
- Li, Xi;
- Xiao, Hai-tao;
- Zhao, Ling;
- Huang, Tao;
- Lin, Cheng Yuan;
- Kwan, Hiu Yee;
- Yang, Tao;
- Longo, Frank M.;
- Lyu, Aiping;
- Bian, Zhao-xiang
Publication type:
Article
The p75 Neurotrophin Receptor Promotes Amyloid-β(1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo.
Published in:
Journal of Neuroscience, 2009, v. 29, n. 34, p. 10627, doi. 10.1523/JNEUROSCI.0620-09.2009
By:
- Knowles, Juliet K.;
- Rajadas, Jayakumar;
- Nguyen, Thuy-Vi V.;
- Tao Yang;
- LeMieux, Melburne C.;
- Griend, Lilith Vander;
- Ishikawa, Chihiro;
- Massa, Stephen M.;
- Wyss-Coray, Tony;
- Longo, Frank M.
Publication type:
Article
Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.
Published in:
Journal of Neuroscience, 2006, v. 26, n. 20, p. 5288, doi. 10.1523/JNEUROSCI.3547-05.2006
By:
- Massa, Stephen M.;
- Youmei Xie;
- Tao Yang;
- Harrington, Anthony W.;
- Mi Lyang Kim;
- Sung Ok Yoon;
- Kraemer, Rosemary;
- Moore, Laura A.;
- Hempstead, Barbara L.;
- Longo, Frank M.
Publication type:
Article
Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning.
Published in:
Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02727-8
By:
- Iweka, Chinyere Agbaegbu;
- Seigneur, Erica;
- Hernandez, Amira Latif;
- Paredes, Sur Herrera;
- Cabrera, Mica;
- Blacher, Eran;
- Pasternak, Connie Tsai;
- Longo, Frank M.;
- de Lecea, Luis;
- Andreasson, Katrin I.
Publication type:
Article
Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning.
Published in:
Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02727-8
By:
- Iweka, Chinyere Agbaegbu;
- Seigneur, Erica;
- Hernandez, Amira Latif;
- Paredes, Sur Herrera;
- Cabrera, Mica;
- Blacher, Eran;
- Pasternak, Connie Tsai;
- Longo, Frank M.;
- de Lecea, Luis;
- Andreasson, Katrin I.
Publication type:
Article
The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis.
Published in:
BMC Neuroscience, 2010, v. 11, p. 136, doi. 10.1186/1471-2202-11-136
By:
- Bernabeu, Ramon O.;
- Longo, Frank M.
Publication type:
Article
Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma.
Published in:
Carcinogenesis, 2000, v. 21, n. 2, p. 125, doi. 10.1093/carcin/21.2.125
By:
- Yang, Tao;
- Martignetti, John A.;
- Massa, Stephen M.;
- Longo, Frank M.
Publication type:
Article
PET Imaging of Translocator Protein (18 kDa) in a Mouse Model of Alzheimer's Disease Using N-(2,5-Dimethoxybenzyl)-2-18F-Fluoro-A- (2-Phenoxyphenyl) Acetamide.
Published in:
Journal of Nuclear Medicine, 2015, v. 56, n. 2, p. 311, doi. 10.2967/jnumed.114.141648
By:
- James, Michelle L.;
- Belichenko, Nadia P.;
- Thuy-Vi V. Nguyen;
- Andrews, Lauren E.;
- Zhaoqing Ding;
- Hongguang Liu;
- Bodapati, Deepika;
- Arksey, Natasha;
- Bin Shen;
- Zhen Cheng;
- Wyss-Coray, Tony;
- Gambhir, Sanjiv S.;
- Longo, Frank M.;
- Chin, Frederick T.
Publication type:
Article
Leukocyte common antigen-related tyrosine phosphatase receptor: Increased expression and neuronal-type splicing in breast cancer cells and tissue.
Published in:
Molecular Carcinogenesis, 1999, v. 25, n. 2, p. 139, doi. 10.1002/(SICI)1098-2744(199906)25:2<139::AID-MC9>3.0.CO;2-T
By:
- Yang, Tao;
- Zhang, Julie S.;
- Massa, Stephen M.;
- Han, Xiaoliang;
- Longo, Frank M.
Publication type:
Article
Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-77210-y
By:
- Yang, Tao;
- Tran, Kevin C.;
- Zeng, Anne Y.;
- Massa, Stephen M.;
- Longo, Frank M.
Publication type:
Article
TSPO–PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington’s disease: preclinical evidence with the p75NTR ligand LM11A-31.
Published in:
Human Molecular Genetics, 2018, v. 27, n. 16, p. 2893, doi. 10.1093/hmg/ddy202
By:
- Simmons, Danielle A;
- James, Michelle L;
- Belichenko, Nadia P;
- Semaan, Sarah;
- Condon, Christina;
- Kuan, Jason;
- Shuhendler, Adam J;
- Miao, Zheng;
- Chin, Frederick T;
- Longo, Frank M
Publication type:
Article
A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.
Published in:
Human Molecular Genetics, 2016, v. 25, n. 22, p. 4920, doi. 10.1093/hmg/ddw316
By:
- Simmons, Danielle A.;
- Belichenko, Nadia P.;
- Ford, Ellen C.;
- Semaan, Sarah;
- Monbureau, Marie;
- Aiyaswamy, Sruti;
- Holman, Cameron M.;
- Condon, Christina;
- Shamloo, Mehrdad;
- Massa, Stephen M.;
- Longo, Frank M.
Publication type:
Article
Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury.
Published in:
Cerebral Cortex, 2020, v. 30, n. 9, p. 5180, doi. 10.1093/cercor/bhz254
By:
- Gu, Feng;
- Parada, Isabel;
- Yang, Tao;
- Longo, Frank M;
- Prince, David A
Publication type:
Article
Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism.
Published in:
Journal of Neuroscience Research, 1997, v. 48, n. 1, p. 1, doi. 10.1002/(SICI)1097-4547(19970401)48:1<1::AID-JNR1>3.0.CO;2-K
By:
- Longo, Frank M.;
- Manthorpe, Marston;
- Xie, Youmei M.;
- Varon, Silvio
Publication type:
Article
Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation.
Published in:
Journal of Neuroscience Research, 1997, v. 47, n. 3, p. 348, doi. 10.1002/(SICI)1097-4547(19970201)47:3<348::AID-JNR13>3.0.CO;2-Y
By:
- Yeo, Tracy T.;
- Yang, Tao;
- Massa, Stephen M.;
- Zhang, Julie S.;
- Honkaniemi, Jari;
- Butcher, Larry L.;
- Longo, Frank M.
Publication type:
Article

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