Works by Logothetis, Diomedes

Results: 50

A Computational Model Predicts That Gβγ Acts at a Cleft Between Channel Subunits to Activate GIRK1 Channels.

Published in:

Science Signaling, 2013, v. 6, n. 288, p. 1, doi. 10.1126/scisignal.2004075

By:

Mahajan, Rahul;
Junghoon Ha;
Miao Zhang;
Takeharu Kawano;
Tohru Kozasa;
Logothetis, Diomedes E.

Publication type:

Article

N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits.

Published in:

EMBO Journal, 2003, v. 22, n. 15, p. 3833, doi. 10.1093/emboj/cdg376

By:

Chan, Kim W.;
Hailin Zhang;
Logothetis, Diomedes E.

Publication type:

Article

Correction: Elucidation of molecular kinetic schemes from macroscopic traces using system identification.

Published in:

2018

By:

Fribourg, Miguel;
Logothetis, Diomedes E.;
González-Maeso, Javier;
Sealfon, Stuart C.;
Galocha-Iragüen, Belén;
Las-Heras Andrés, Fernando;
Brezina, Vladimir

Publication type:

Correction Notice

Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization.

Published in:

Nature Cell Biology, 2000, v. 2, n. 8, p. 507, doi. 10.1038/35019544

By:

Kobrinsky, Evgeny;
Mirshahi, Tooraj;
Zhang, Hailin;
Jin, Taihao;
Logothetis, Diomedes E.

Publication type:

Article

Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions.

Published in:

Nature Cell Biology, 1999, v. 1, n. 3, p. 183, doi. 10.1038/11103

By:

Zhang, Hailin;
He, Cheng;
Yan, Xixin;
Mirshahi, Tooraj;
Logothetis, Diomedes E.

Publication type:

Article

Endocytosis and Degradative Sorting of NMDA Receptors by Conserved Membrane-Proximal Signals.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 32, p. 7096, doi. 10.1523/JNEUROSCI.0780-04.2004

By:

Scott, Derek B.;
Michailidis, Ioannis;
Yuanyue Mu;
Logothetis, Diomedes;
Ehlers, Michael D.

Publication type:

Article

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50964-z

By:

Knight, Kevin M.;
Krumm, Brian E.;
Kapolka, Nicholas J.;
Ludlam, W. Grant;
Cui, Meng;
Mani, Sepehr;
Prytkova, Iya;
Obarow, Elizabeth G.;
Lefevre, Tyler J.;
Wei, Wenyuan;
Ma, Ning;
Huang, Xi-Ping;
Fay, Jonathan F.;
Vaidehi, Nagarajan;
Smrcka, Alan V.;
Slesinger, Paul A.;
Logothetis, Diomedes E.;
Martemyanov, Kirill A.;
Roth, Bryan L.;
Dohlman, Henrik G.

Publication type:

Article

Molecular mechanism of GIRK2 channel gating modulated by cholesteryl hemisuccinate.

Published in:

Frontiers in Physiology, 2024, p. 01, doi. 10.3389/fphys.2024.1486362

By:

Meng Cui;
Yongcheng Lu;
Xinyi Ma;
Logothetis, Diomedes E.

Publication type:

Article

A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 42, p. 14397, doi. 10.1523/JNEUROSCI.1415-15.2015

By:

Adney, Scott K.;
Junghoon Ha;
Xuan-Yu Meng;
Kawano, Takeharu;
Logothetis, Diomedes E.

Publication type:

Article

An analytical tool for elucidating ion-channel molecular mechanisms from macroscopic current traces.

Published in:

BMC Neuroscience, 2010, v. 11, p. 1, doi. 10.1186/1471-2202-11-S1-P149

By:

Fribourg, Miguel;
Galocha-Iragüen, Belén;
Las Heras-Andrés, Fernando;
Logothetis, Diomedes E.;
Brezina, Vladimir

Publication type:

Article

Cydlin D1 Overexpression and Response to Bortezomib Treatment in a Breast Cancer Model.

Published in:

JNCI: Journal of the National Cancer Institute, 2006, v. 98, n. 17, p. 1238, doi. 10.1093/jnci/djj334

By:

Ishii, Yuki;
Pirkmaier, Andreja;
Alvarez, James V.;
Frank, David A.;
Keselman, Inna;
Logothetis, Diomedes;
Mandeli, John;
Connell, Matthew J. O.;
Waxman, Samuel;
Germain, Doris

Publication type:

Article

Elucidation of molecular kinetic schemes from macroscopic traces using system identification.

Published in:

PLoS Computational Biology, 2017, v. 13, n. 2, p. 1, doi. 10.1371/journal.pcbi.1005376

By:

Fribourg, Miguel;
Logothetis, Diomedes E.;
González-Maeso, Javier;
Sealfon, Stuart C.;
Galocha-Iragüen, Belén;
Las-Heras Andrés, Fernando;
Brezina, Vladimir

Publication type:

Article

The I inhibitor DCPIB blocks Kir channels that possess weak affinity for PIP.

Published in:

Pflügers Archiv: European Journal of Physiology, 2016, v. 468, n. 5, p. 817, doi. 10.1007/s00424-016-1794-9

By:

Deng, Wu;
Mahajan, Rahul;
Baumgarten, Clive;
Logothetis, Diomedes

Publication type:

Article

Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells.

Published in:

Pflügers Archiv: European Journal of Physiology, 2016, v. 468, n. 5, p. 775, doi. 10.1007/s00424-015-1780-7

By:

Baki, Lia;
Fribourg, Miguel;
Younkin, Jason;
Eltit, Jose;
Moreno, Jose;
Park, Gyu;
Vysotskaya, Zhanna;
Narahari, Adishesh;
Sealfon, Stuart;
Gonzalez-Maeso, Javier;
Logothetis, Diomedes

Publication type:

Article

Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation.

Published in:

Pflügers Archiv: European Journal of Physiology, 2011, v. 461, n. 3, p. 387, doi. 10.1007/s00424-010-0904-3

By:

Michailidis, Ioannis;
Rusinova, Radda;
Georgakopoulos, Anastasios;
Chen, Yibang;
Iyengar, Ravi;
Robakis, Nikolaos;
Logothetis, Diomedes;
Baki, Lia

Publication type:

Article

Channelopathies linked to plasma membrane phosphoinositides.

Published in:

Pflügers Archiv: European Journal of Physiology, 2010, v. 460, n. 2, p. 321, doi. 10.1007/s00424-010-0828-y

By:

Logothetis, Diomedes E.;
Petrou, Vasileios I.;
Adney, Scott K.;
Mahajan, Rahul

Publication type:

Article

Mass spectrometric analysis reveals a functionally important PKA phosphorylation site in a Kir3 channel subunit.

Published in:

Pflügers Archiv: European Journal of Physiology, 2009, v. 458, n. 2, p. 303, doi. 10.1007/s00424-008-0628-9

By:

Rusinova, Radda;
Shen, Yu-Ming Albert;
Dolios, Georgia;
Padovan, Julio;
Yang, Heyi;
Kirchberger, Madeleine;
Wang, Rong;
Logothetis, Diomedes E.

Publication type:

Article

Identification of Sodium- and Chloride-Sensitive Sites in the Slack Channel.

Published in:

Journal of Neuroscience, 2023, v. 43, n. 15, p. 2665, doi. 10.1523/JNEUROSCI.1365-22.2023

By:

Jie Xu;
Yan-Tian Lv;
Xiao-Yun Zhao;
Jing-Jing Wang;
Zhong-Shan Shen;
Jian Li;
Fei-Fei Zhang;
Jing Liu;
Xiao-Hui Wang;
Yun Xu;
Qi Geng;
Yi-Tong Ding;
Jing-Jing Xu;
Meng-Jiao Tan;
Zhi-Xiao Li;
Ran Wang;
Jian Chen;
Wen Sun;
Meng Cui;
Logothetis, Diomedes E.

Publication type:

Article

Diverse Kir modulators act in close proximity to residues implicated in phosphoinositide binding.

Published in:

Journal of Physiology, 2007, v. 582, n. 3, p. 953, doi. 10.1113/jphysiol.2007.133157

By:

Logothetis, Diomedes E.;
Lupyan, Dmitry;
Rosenhouse-Dantsker, Avia

Publication type:

Article

PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels.

Published in:

Journal of Physiology, 2005, v. 564, n. 1, p. 117, doi. 10.1113/jphysiol.2004.081935

By:

Lopes, Coeli M. B.;
Rohács, Tibor;
Czirják, Gábor;
Balla, Tamás;
Enyedi, Péter;
Logothetis, Diomedes E.

Publication type:

Article

Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-01752-y

By:

Cui, Meng;
Chen, Bohan;
Xu, Keman;
Rigakou, Aimilia;
Diamantakos, Panagiotis;
Melliou, Eleni;
Logothetis, Diomedes E.;
Magiatis, Prokopios

Publication type:

Article

PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain.

Published in:

Nature Neuroscience, 2005, v. 8, n. 5, p. 626, doi. 10.1038/nn1451

By:

Rohács, Tibor;
Lopes, Coeli M. B.;
Michailidis, Ioannis;
Logothetis, Diomedes E.

Publication type:

Article

Ca -Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels.

Published in:

Channels (19336950), 2017, v. 11, n. 6, p. 686, doi. 10.1080/19336950.2017.1388478

By:

Tobelaim, William S.;
Dvir, Meidan;
Lebel, Guy;
Cui, Meng;
Buki, Tal;
Peretz, Asher;
Marom, Milit;
Haitin, Yoni;
Logothetis, Diomedes E.;
Hirsch, Joel A.;
Attali, Bernard

Publication type:

Article

Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini.

Published in:

Channels (19336950), 2013, v. 7, n. 4, p. 303, doi. 10.4161/chan.25437

By:

Rosenhouse-Dantsker, Avia;
Noskov, Sergei;
Logothetis, Diomedes E;
Levitan, Irena

Publication type:

Article

SLO-2 isoforms with unique Ca2+- and voltage-dependence characteristics confer sensitivity to hypoxia in C. elegans.

Published in:

Channels (19336950), 2013, v. 7, n. 3, p. 194, doi. 10.4161/chan.24492

By:

Zhang, Zhe;
Tang, Qiong-Yao;
Alaimo, Joseph T.;
Davies, Andrew G.;
Bettinger, Jill C.;
Logothetis, Diomedes E

Publication type:

Article

Comparative analysis of cholesterol sensitivity of Kir channels.

Published in:

Channels (19336950), 2010, v. 4, n. 1, p. 63, doi. 10.4161/chan.4.1.10366

By:

Rosenhouse-Dantsker, Avia;
Leal-Pinto, Edgar;
Logothetis, Diomedes E.;
Levitan, Irena

Publication type:

Article

Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 18, p. N.PAG, doi. 10.3390/ijms231810820

By:

Gazgalis, Dimitrios;
Cantwell, Lucas;
Xu, Yu;
Thakur, Ganesh A.;
Cui, Meng;
Guarnieri, Frank;
Logothetis, Diomedes E.

Publication type:

Article

Specificity of Gβγ Signaling Depends on Gα Subunit Coupling with G-Protein-Sensitive K Channels.

Published in:

Pharmacology, 2009, v. 84, n. 2, p. 82, doi. 10.1159/000227772

By:

Geng, Xian;
Du, Xiao-na;
Rusinova, Radda;
Liu, Bo-yi;
Li, Fang;
Zhang, Xuan;
Chen, Xing-juan;
Logothetis, Diomedes E.;
Zhang, Hai-lin

Publication type:

Article

Gating of G protein-sensitive inwardly rectifying K+ channels through phosphatidylinositol 4,5-bisphosphate.

Published in:

Journal of Physiology, 1999, v. 520, n. 3, p. 630, doi. 10.1111/j.1469-7793.1999.00630.x

By:

Logothetis, Diomedes E.;
Zhang, Hailin

Publication type:

Article

Characterization of a Ca2+-activated K+ current in insulin-secreting murine βTC-3 cells.

Published in:

Journal of Physiology, 1998, v. 509, n. 2, p. 355, doi. 10.1111/j.1469-7793.1998.355bn.x

By:

Kozak, J. Ashot;
Misler, Stanley;
Logothetis, Diomedes E.

Publication type:

Article

Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

Published in:

Science Signaling, 2016, v. 9, n. 410, p. 1, doi. 10.1126/scisignal.aab0467

By:

Moreno, José L.;
Miranda-Azpiazu, Patricia;
García-Bea, Aintzane;
Younkin, Jason;
Meng Cui;
Kozlenkov, Alexey;
Ben-Ezra, Ariel;
Voloudakis, Georgios;
Fakira, Amanda K.;
Baki, Lia;
Yongchao Ge;
Georgakopoulos, Anastasios;
Morón, José A.;
Milligan, Graeme;
López-Giménez, Juan F.;
Robakis, Nikolaos K.;
Logothetis, Diomedes E.;
Meana, J. Javier;
González-Maeso, Javier

Publication type:

Article

Side-chain interactions in the regulatory domain of human glutamate dehydrogenase determine basal activity and regulation.

Published in:

Journal of Neurochemistry, 2015, v. 133, n. 1, p. 73, doi. 10.1111/jnc.13019

By:

Mastorodemos, Vasileios;
Kanavouras, Konstantinos;
Sundaram, Shobana;
Providaki, Maria;
Petraki, Zoe;
Kokkinidis, Michael;
Zaganas, Ioannis;
Logothetis, Diomedes E.;
Plaitakis, Andreas

Publication type:

Article

Lick Rate and the Circadian Rhythm of Water Intake in the Rat: Effects of Deuterium Oxidea.

Published in:

Annals of the New York Academy of Sciences, 1984, v. 423, n. 1, p. 614, doi. 10.1111/j.1749-6632.1984.tb23472.x

By:

LOGOTHETIS, DIOMEDES E.;
BOULOS, ZIAD;
TERMAN, MICHAEL

Publication type:

Article

The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel.

Published in:

Scientific Reports, 2016, p. 29399, doi. 10.1038/srep29399

By:

Meng, Xuan-Yu;
Liu, Shengtang;
Cui, Meng;
Zhou, Ruhong;
Logothetis, Diomedes E.

Publication type:

Article

Identification of the Conformational transition pathway in PIP2 Opening Kir Channels.

Published in:

Scientific Reports, 2015, p. 11289, doi. 10.1038/srep11289

By:

Li, Junwei;
Lü, Shouqin;
Liu, Yuzhi;
Pang, Chunli;
Chen, Yafei;
Zhang, Suhua;
Yu, Hui;
Long, Mian;
Zhang, Hailin;
Logothetis, Diomedes E.;
Zhan, Yong;
An, Hailong

Publication type:

Article

Lack of Negatively Charged Residues at the External Mouth of Kir2.2 Channels Enable the Voltage-Dependent Block by External Mg2+.

Published in:

PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0111372

By:

Li, Junwei;
Xie, Xiaoxiao;
Liu, Jun;
Yu, Hui;
Zhang, Suhua;
Zhan, Yong;
Zhang, Hailin;
Logothetis, Diomedes E.;
An, Hailong

Publication type:

Article

Three pairs of weak interactions precisely regulate the G-loop gate of Kir2.1 channel.

Published in:

Proteins, 2016, v. 84, n. 12, p. 1929, doi. 10.1002/prot.25176

By:

Li, Junwei;
Xiao, Shaoying;
Xie, Xiaoxiao;
Zhou, Hui;
Pang, Chunli;
Li, Shanshan;
Zhang, Hailin;
Logothetis, Diomedes E.;
Zhan, Yong;
An, Hailong

Publication type:

Article

The RCK2 Domain Uses a Coordination Site Present in Kir Channels to Confer Sodium Sensitivity to Slo2.2 Channels.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 22, p. 7554, doi. 10.1523/JNEUROSCI.0525-10.2010

By:

Zhe Zhang;
Rosenhouse-Dantsker, Avia;
Qiong-Yao Tang;
Noskov, Sergei;
Logothetis, Diomedes E.

Publication type:

Article

Phosphoinositides Regulate P2X4 ATP-Gated Channels through Direct Interactions.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 48, p. 12938, doi. 10.1523/JNEUROSCI.3038-08.2008

By:

Bernier, Louis-Philippe;
Ase, Ariel R.;
Chevallier, Stéphanie;
Blais, Dominique;
Qi Zhao;
Boué-Grabot, Éric;
Logothetis, Diomedes;
Séguéla, Philippe

Publication type:

Article

Phosphatidylinositol-4,5-Bisphosphate Regulates NMDA Receptor Activity through α-Actinin.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 20, p. 5523, doi. 10.1523/JNEUROSCI.4378-06.2007

By:

Michailidis, Ioannis E.;
Helton, Thomas D.;
Petrou, Vasileios I.;
Mirshahi, Tooraj;
Ehlers, Michael D.;
Logothetis, Diomedes E.

Publication type:

Article

Regulation of ATP-gated P2X receptors by phosphoinositides.

Published in:

Pflügers Archiv: European Journal of Physiology, 2007, v. 455, n. 1, p. 181, doi. 10.1007/s00424-007-0271-x

By:

Qi Zhao;
Logothetis, Diomedes E.;
Séguéla, Philippe

Publication type:

Article

Molecular characteristics of phosphoinositide binding.

Published in:

Pflügers Archiv: European Journal of Physiology, 2007, v. 455, n. 1, p. 45, doi. 10.1007/s00424-007-0291-6

By:

Rosenhouse-Dantsker, Avia;
Logothetis, Diomedes E.

Publication type:

Article

Dynamic changes in phosphoinositide levels control ion channel activity.

Published in:

Pflügers Archiv: European Journal of Physiology, 2007, v. 455, n. 1, p. 1, doi. 10.1007/s00424-007-0311-6

By:

Logothetis, Diomedes E.;
Nilius, Bernd

Publication type:

Article

Phosphoinositide-mediated gating of inwardly rectifying K+ channels.

Published in:

Pflügers Archiv: European Journal of Physiology, 2007, v. 455, n. 1, p. 83, doi. 10.1007/s00424-007-0276-5

By:

Logothetis, Diomedes E.;
Taihao Jin;
Lupyan, Dmitry;
Rosenhouse-Dantsker, Avia

Publication type:

Article

Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex.

Published in:

Nature Chemical Biology, 2014, v. 10, n. 9, p. 753, doi. 10.1038/nchembio.1592

By:

Zhang, Miao;
Meng, Xuan-Yu;
Cui, Meng;
Pascal, John M;
Logothetis, Diomedes E;
Zhang, Ji-Fang

Publication type:

Article

A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P2.

Published in:

Nature Chemical Biology, 2008, v. 4, n. 10, p. 624, doi. 10.1038/nchembio.112

By:

Rosenhouse-Dantsker, Avia;
Sui, Jin L.;
Qi Zhao;
Rusinova, Radda;
Rodríguez-Menchaca, Aldo A.;
Zhe Zhang;
Logothetis, Diomedes E.

Publication type:

Article

Cloning and characterization of G protein-gated inward rectifier K+ channel (GIRK1) isoforms from heart and brain.

Published in:

Journal of Molecular Neuroscience, 2001, v. 16, n. 1, p. 21, doi. 10.1385/JMN:16:1:21

By:

Zhu, Liangxue;
Wu, Xiaying;
Wu, Michael;
Chan, Kim;
Logothetis, Diomedes;
Thornhill, William

Publication type:

Article

Molecular Dynamics (MD) Simulations Provide Insights into the Activation Mechanisms of 5-HT 2A Receptors.

Published in:

Molecules, 2024, v. 29, n. 20, p. 4935, doi. 10.3390/molecules29204935

By:

Cui, Meng;
Lu, Yongcheng;
Mezei, Mihaly;
Logothetis, Diomedes E.

Publication type:

Article

G protein opening of K+ channels.

Published in:

Nature, 1987, v. 327, n. 6117, p. 22, doi. 10.1038/327022a0

By:

LOGOTHETIS, DIOMEDES E.;
KURACHI, YOSHIHISA;
GALPER, JONAS;
NEER, EVA J.;
CLAPHAM, DAVID E.

Publication type:

Article

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.

Published in:

Nature, 1987, v. 325, n. 6102, p. 321, doi. 10.1038/325321a0

By:

Logothetis, Diomedes E.;
Kurachi, Yoshihisa;
Galper, Jonas;
Neer, Eva J.;
Clapham, David E.

Publication type:

Article