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Theme 7 Pre-clinical therapeutic strategies.
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- Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2019, v. 20, p. 217, doi. 10.1080/21678421.2019.1646995
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- Article
A common functional allele of the Nogo receptor gene, reticulon 4 receptor (RTN4R), is associated with sporadic amyotrophic lateral sclerosis in a French population.
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- Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2015, v. 16, n. 7/8, p. 490, doi. 10.3109/21678421.2015.1051988
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- Article
Spatial Memory Consolidation is Associated with Induction of Several Lysine-Acetyltransferase (Histone Acetyltransferase) Expression Levels and H2B/H4 Acetylation-Dependent Transcriptional Events in the Rat Hippocampus.
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- Neuropsychopharmacology, 2010, v. 35, n. 13, p. 2521, doi. 10.1038/npp.2010.117
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- Article
Caspase-dependent cleavage of the retinoblastoma protein is an early step in neuronal apoptosis.
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- Oncogene, 2000, v. 19, n. 18, p. 2171, doi. 10.1038/sj.onc.1203532
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- Article
The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca<sup>2+</sup>/calmodulin kinases II and IV activity.
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- Oncogene, 1999, v. 18, n. 17, p. 2762, doi. 10.1038/sj.onc.1202634
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- Article
Oxidative Stress and a Murine Superoxide Dismutase-1 Mutation Promoting Amyotrophic Lateral Sclerosis Alter Neurosecretion in the Hypothalamo-Neurohypophyseal Axis.
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- Neuroendocrinology, 1999, v. 69, n. 5, p. 377, doi. 10.1159/000054440
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- Article
Pituitary Adenylate Cyclase-Activating Polypeptide Transduces through cAMP/PKA and PKC Pathways and Stimulates Proopiomelanocortin Gene Transcription in Mouse Melanotropes.
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- Neuroendocrinology, 1996, v. 64, n. 1, p. 2, doi. 10.1159/000127091
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- Article
Dopamine Inhibition of Proopiomelanocortin Gene Expression in the Intermediate Lobe of the Pituitary.
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- Neuroendocrinology, 1988, v. 47, n. 2, p. 95, doi. 10.1159/000124898
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- Article
Influence of Calcium Ions on Proopiomelanocortin mRNA Levels in Clonal Anterior Pituitary Cells.
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- Neuroendocrinology, 1988, v. 47, n. 1, p. 32, doi. 10.1159/000124887
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- Article
Ca<sup>2+</sup>-Dependent Histaminergic Regulation of Proenkephalin mRNA Levels in Cultured Adrenal Chromaffin Cells.
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- Neuroendocrinology, 1987, v. 46, n. 1, p. 89, doi. 10.1159/000124801
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- Article
In vivo and in vitro Studies of GABAergic Inhibition of Prolactin Biosynthesis.
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- Neuroendocrinology, 1986, v. 43, n. 4, p. 504, doi. 10.1159/000124574
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- Article
Theβ-amyloid precursor protein controls a store-operated Ca<sup>2+</sup> entry in cortical neurons.
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- European Journal of Neuroscience, 2004, v. 20, n. 8, p. 2071, doi. 10.1111/j.1460-9568.2004.03680.x
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- Article
A mouse model of familial amyotrophic lateral sclerosis expressing a mutant superoxide dismutase 1 shows evidence of disordered transport in the vasopressin hypothalamo-neurohypophysial axis.
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- European Journal of Neuroscience, 1999, v. 11, n. 12, p. 4179, doi. 10.1046/j.1460-9568.1999.00840.x
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- Article
Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway.
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- European Journal of Neuroscience, 1999, v. 11, n. 2, p. 441, doi. 10.1046/j.1460-9568.1999.00451.x
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- Article
Melanocortin receptors and δ‐opioid receptor mediate opposite signalling actions of POMC‐derived peptides in CATH.a cells.
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- European Journal of Neuroscience, 1998, v. 10, n. 5, p. 1885, doi. 10.1046/j.1460-9568.1998.00199.x
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- Article
Up-regulation of mitochondrial uncoupling protein 3 reveals an early muscular metabolic defect in amyotrophic lateral sclerosis.
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- FASEB Journal, 2003, v. 17, n. 14, p. 2091, doi. 10.1096/fj.02-1182fje
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- Article
Amyotrophic lateral sclerosis: all roads lead to Rome.
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- Journal of Neurochemistry, 2007, v. 101, n. 5, p. 1153, doi. 10.1111/j.1471-4159.2006.04408.x
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- Article
Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis.
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- Journal of Neurochemistry, 2003, v. 84, n. 4, p. 814, doi. 10.1046/j.1471-4159.2003.01581.x
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- Article
Brain-Derived Neurotrophic Factor Exerts Opposing Effects on β<sub>2</sub>-Adrenergic Receptor According to Depolarization Status of Cerebellar Neurons.
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- Journal of Neurochemistry, 1999, v. 73, n. 4, p. 1467, doi. 10.1046/j.1471-4159.1999.0731467.x
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- Article
Continuous Activation of Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Elicits Antipodal Effects on Cyclic AMP and Inositol Phospholipid Signaling Pathways in CATH.a Cells: Role of Protein Synthesis and Protein Kinases.
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- Journal of Neurochemistry, 1998, v. 70, n. 4, p. 1431, doi. 10.1046/j.1471-4159.1998.70041431.x
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- Article
Pituitary Adenylate Cyclase-Activating Polypeptide Triggers Dual Transduction Signaling in CATH.a Cells and Transcriptionally Activates Tyrosine Hydroxylase and c- fos Expression.
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- Journal of Neurochemistry, 1997, v. 68, n. 4, p. 1696, doi. 10.1046/j.1471-4159.1997.68041696.x
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- Article
Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Proenkephalin Gene Transcription through API- and CREB-Dependent Mechanisms.
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- DNA & Cell Biology, 1998, v. 17, n. 2, p. 151, doi. 10.1089/dna.1998.17.151
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- Article
Gene Transfer Optimization with Lipospermine-Coated DNA.
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- DNA & Cell Biology, 1993, v. 12, n. 6, p. 553, doi. 10.1089/dna.1993.12.553
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- Article
Differentiation to a Neuronal Phenotype in Bovine Chromaffin Cells Is Repressed by Protein Kinase C and Is Not Dependent on c- fos Oncoproteins.
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- DNA & Cell Biology, 1990, v. 9, n. 5, p. 335, doi. 10.1089/dna.1990.9.335
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- Article
The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model.
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- EMBO Reports, 2006, v. 7, n. 11, p. 1162, doi. 10.1038/sj.embor.7400826
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- Article
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1<sup>G93A</sup> mice.
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- British Journal of Pharmacology, 2022, v. 179, n. 8, p. 1732, doi. 10.1111/bph.15738
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- Article
APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation.
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- FASEB Journal, 2016, v. 30, n. 5, p. 1696, doi. 10.1096/fj.15-278739
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- Article
Neuroendocrinology of Neurodegenerative Diseases.
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- Neuroendocrinology, 2003, v. 78, n. 5, p. 244, doi. 10.1159/000074445
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- Article
Blood Cell Palmitoleate-Palmitate Ratio Is an Independent Prognostic Factor for Amyotrophic Lateral Sclerosis.
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- PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0131512
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- Article
Systemic Down-Regulation of Delta-9 Desaturase Promotes Muscle Oxidative Metabolism and Accelerates Muscle Function Recovery following Nerve Injury.
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- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0064525
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- Article
Detection of Histone Acetylation Levels in the Dorsal Hippocampus Reveals Early Tagging on Specific Residues of H2B and H4 Histones in Response to Learning.
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- PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0057816
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- Article
Platelet Serotonin Level Predicts Survival in Amyotrophic Lateral Sclerosis.
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- PLoS ONE, 2010, v. 5, n. 10, p. 1, doi. 10.1371/journal.pone.0013346
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- Article
Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons.
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- PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005390
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- Article
The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis.
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- Brain Pathology, 2016, v. 26, n. 2, p. 227, doi. 10.1111/bpa.12350
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- Article
HP1α guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation.
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- EMBO Journal, 2007, v. 26, n. 15, p. 3616, doi. 10.1038/sj.emboj.7601789
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- Article
Electrophysiological studies in a mouse model of Schwartz-Jampel syndrome demonstrate muscle fiber hyperactivity of peripheral nerve origin.
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- Muscle & Nerve, 2009, v. 40, n. 1, p. 55, doi. 10.1002/mus.21253
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- Article
A transgenic mouse expressing CHMP2B<sup>intron5</sup> mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia.
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- Human Molecular Genetics, 2016, v. 25, n. 15, p. 3341, doi. 10.1093/hmg/ddw182
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- Article
Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.
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- Human Molecular Genetics, 2015, v. 24, n. 25, p. 7390, doi. 10.1093/hmg/ddv439
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- Article
Full-length PGC-1α salvages the phenotype of a mouse model of human neuropathy through mitochondrial proliferation.
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- Human Molecular Genetics, 2013, v. 22, n. 25, p. 5096, doi. 10.1093/hmg/ddt359
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- Article
A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis.
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- EMBO Molecular Medicine, 2015, v. 7, n. 5, p. 526, doi. 10.15252/emmm.201404433
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- Article
Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis.
- Published in:
- Frontiers in Pharmacology, 2019, p. 1, doi. 10.3389/fphar.2019.00883
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- Article
Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles.
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- Journal of Cachexia, Sarcopenia & Muscle, 2022, v. 13, n. 2, p. 1385, doi. 10.1002/jcsm.12945
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- Article
Sphingolipid Metabolism Is Dysregulated at Transcriptomic and Metabolic Levels in the Spinal Cord of an Animal Model of Amyotrophic Lateral Sclerosis.
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- Frontiers in Molecular Neuroscience, 2018, p. 1, doi. 10.3389/fnmol.2017.00433
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- Article
Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity.
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- Brain: A Journal of Neurology, 2013, v. 136, n. 2, p. 483, doi. 10.1093/brain/aws274
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- Article
Reply.
- Published in:
- Annals of Neurology, 2007, v. 62, n. 6, p. 677, doi. 10.1002/ana.21282
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- Article
Muscle Nogo-a expression is a prognostic marker in lower motor neuron syndromes.
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- Annals of Neurology, 2007, v. 62, n. 1, p. 15, doi. 10.1002/ana.21122
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- Article
Promoter Elements of the Rat Choline Acetyltransferase Gene Allowing Nerve Growth Factor Inducibility in Transfected Primary Cultured Cells.
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- Journal of Neurochemistry, 1992, v. 58, n. 4, p. 1580, doi. 10.1111/j.1471-4159.1992.tb11383.x
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- Article
Proenkephalin B Messenger RNA in Porcine Tissues: Characterization, Quantification, and Correlation with Opioid Peptides.
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- Journal of Neurochemistry, 1987, v. 48, n. 2, p. 586, doi. 10.1111/j.1471-4159.1987.tb04133.x
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- Article
Early Activation of Antioxidant Mechanisms in Muscle of Mutant Cu/Zn-Superoxide Dismutase-Linked Amyotrophic Lateral Sclerosis Mice.
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- Annals of the New York Academy of Sciences, 2004, v. 1010, n. 1, p. 552, doi. 10.1196/annals.1299.102
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- Article
Constitutive Repression of E2F1 Transcriptional Activity through HDAC Proteins Is Essential for Neuronal Survival.
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- Annals of the New York Academy of Sciences, 2002, v. 973, n. 1, p. 438, doi. 10.1111/j.1749-6632.2002.tb04679.x
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- Article