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Rare Mutations in Cancer Drug Resistance and Implications for Therapy.
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- Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 3, p. 437, doi. 10.1002/cpt.1938
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- Article
Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype.
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- Scientific Reports, 2017, p. 44081, doi. 10.1038/srep44081
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- Article
Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer.
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- Genome Medicine, 2016, v. 8, p. 1, doi. 10.1186/s13073-016-0286-z
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- Article
Detection of Ultra-Rare Mitochondrial Mutations in Breast Stem Cells by Duplex Sequencing.
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- PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0136216
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- Article
Sequencing small genomic targets with high efficiency and extreme accuracy.
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- Nature Methods, 2015, v. 12, n. 5, p. 423, doi. 10.1038/nmeth.3351
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- Article
Corrigendum: Detecting ultralow-frequency mutations by Duplex Sequencing.
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- Nature Protocols, 2014, v. 9, n. 12, p. 2903, doi. 10.1038/nprot.2014.170
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- Article
Cancer: One cell at a time.
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- Nature, 2014, v. 512, n. 7513, p. 143, doi. 10.1038/nature13650
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- Article
A Rapid Assay for Measuring Nucleotide Excision Repair by Oligonucleotide Retrieval.
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- Scientific Reports, 2014, p. 1, doi. 10.1038/srep04894
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- Article
Do mutator mutations fuel tumorigenesis?
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- Cancer & Metastasis Reviews, 2013, v. 32, n. 3/4, p. 353, doi. 10.1007/s10555-013-9426-8
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- Article
APOBEC3B mutagenesis in cancer.
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- Nature Genetics, 2013, v. 45, n. 9, p. 964, doi. 10.1038/ng.2736
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- Article
Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage.
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- PLoS Genetics, 2013, v. 9, n. 9, p. 1, doi. 10.1371/journal.pgen.1003794
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- Article
An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy.
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- Nature Genetics, 2013, v. 45, n. 8, p. 947, doi. 10.1038/ng.2670
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- Article
DNA polymerase delta in dna replication and genome maintenance.
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- Environmental & Molecular Mutagenesis, 2012, v. 53, n. 9, p. 666, doi. 10.1002/em.21745
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- Article
Implications of genetic heterogeneity in cancer.
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- Annals of the New York Academy of Sciences, 2012, v. 1267, n. 1, p. 110, doi. 10.1111/j.1749-6632.2012.06590.x
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- Article
The Werner Syndrome Protein Is Distinguished from the Bloom Syndrome Protein by Its Capacity to Tightly Bind Diverse DNA Structures.
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- PLoS ONE, 2012, v. 7, n. 1, p. 1, doi. 10.1371/journal.pone.0030189
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- Article
Roles of DNA polymerase I in leading and lagging-strand replication defined by a high-resolution mutation footprint of ColE1 plasmid replication.
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- Nucleic Acids Research, 2011, v. 39, n. 16, p. 7020, doi. 10.1093/nar/gkr157
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- Article
Human cancers express mutator phenotypes: origin, consequences and targeting.
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- 2011
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- Publication type:
- review
A random mutation capture assay to detect genomic point mutations in mouse tissue.
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- Nucleic Acids Research, 2011, v. 39, n. 11, p. e73, doi. 10.1093/nar/gkr142
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- Article
Mutation of HIV-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside KP1461.
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- PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0015135
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- Article
A Mitochondrial view of aging, reactive oxygen species and metastatic cancer.
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- Aging Cell, 2010, v. 9, n. 4, p. 462, doi. 10.1111/j.1474-9726.2010.00579.x
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- Article
Mitochondrial mutagenesis induced by tumor-specific radiation bystander effects.
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- Journal of Molecular Medicine, 2010, v. 88, n. 7, p. 701, doi. 10.1007/s00109-010-0616-3
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- Article
Werner syndrome gene variants in human sarcomas.
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- Molecular Carcinogenesis, 2010, v. 49, n. 2, p. 166, doi. 10.1002/mc.20586
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- Article
DNA polymerases and human disease.
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- Nature Reviews Genetics, 2008, v. 9, n. 8, p. 594, doi. 10.1038/nrg2345
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- Article
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.
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- Nature Genetics, 2008, v. 40, n. 4, p. 392, doi. 10.1038/ng.95
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- Article
Mitochondrial point mutations do not limit the natural lifespan of mice.
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- Nature Genetics, 2007, v. 39, n. 4, p. 540, doi. 10.1038/ng1988
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- Article
Mutations in DNA polymerase η are not detected in squamous cell carcinoma of the skin.
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- International Journal of Cancer, 2006, v. 119, n. 9, p. 2225, doi. 10.1002/ijc.22099
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- Article
Negative Clonal Selection in Tumor Evolution.
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- Genetics, 2005, v. 171, n. 4, p. 2123, doi. 10.1534/genetics.105.040840
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- Article
Quantification of random genomic mutations.
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- Nature Methods, 2005, v. 2, n. 4, p. 285, doi. 10.1038/nmeth751
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- Article
Mutator phenotype in cancer: Timing and perspectivesInvited article: 25th anniversary of Environmental and Molecular Mutagenesis.
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- Environmental & Molecular Mutagenesis, 2005, v. 45, n. 2/3, p. 206
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- Publication type:
- Article
Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)n is mediated by homolog-conserved domains in three members of the hnRNP family.
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- Nucleic Acids Research, 2004, v. 32, n. 14, p. 4145, doi. 10.1093/nar/gkh745
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- Article
Ageing: Mice and mitochondria.
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- Nature, 2004, v. 429, n. 6990, p. 357, doi. 10.1038/429357a
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- Article
Insertion of the T3 DNA polymerase thioredoxin binding domain enhances the processivity and fidelity of Taq DNA polymerase.
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- Nucleic Acids Research, 2003, v. 31, n. 16, p. 4702, doi. 10.1093/nar/gkg667
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- Article
Mutations in human DNA polymerase η motif II alter bypass of DNA lesions.
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- EMBO Journal, 2001, v. 20, n. 24, p. 7303, doi. 10.1093/emboj/20.24.7303
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- Article
Mutations in human DNA polymerase ?motif II alter bypass of DNA lesions.
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- EMBO Journal, 2001, v. 20, n. 24, p. 7303, doi. 10.1093/emboj/20.24.7303
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- Article
Getting a grip on how DNA polymerases function.
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- Nature Structural Biology, 2001, v. 8, n. 8, p. 656, doi. 10.1038/90344
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- Article
Enzymatic properties of rat DNA polymerase β mutants obtained by randomized mutagenesis.
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- Nucleic Acids Research, 2001, v. 29, n. 11, p. 2418, doi. 10.1093/nar/29.11.2418
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- Article
Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.
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- Nucleic Acids Research, 2000, v. 28, n. 17, p. 3260, doi. 10.1093/nar/28.17.3260
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- Article
Enhanced in vivo repair of O4-methylthymine by a mutant human DNA alkyltransferase.
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- Carcinogenesis, 2000, v. 21, n. 7, p. 1397, doi. 10.1093/carcin/21.5.397
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- Article
Significance of multiple mutations in cancer.
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- Carcinogenesis, 2000, v. 21, n. 3, p. 379, doi. 10.1093/carcin/21.3.379
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- Article
Human O6-alkylguanine-DNA alkyltransferase: protection against alkylating agents and sensitization to dibromoalkanes.
- Published in:
- Carcinogenesis, 1999, v. 20, n. 11, p. 2089, doi. 10.1093/carcin/20.11.2089
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- Article
Tolerance of 5-fluorodeoxyuridine resistant human thymidylate synthases to alterations in active site residues.
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- Nucleic Acids Research, 1999, v. 27, n. 18, p. 3702, doi. 10.1093/nar/27.18.3702
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- Article
Improving enzymes for cancer gene therapy.
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- Nature Biotechnology, 1999, v. 17, n. 2, p. 143, doi. 10.1038/6142
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- Article
The three faces of the WS helicase.
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- Nature Genetics, 1998, v. 19, n. 4, p. 308, doi. 10.1038/1188
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- Article
Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A.
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- Nucleic Acids Research, 1998, v. 26, n. 12, p. 2879, doi. 10.1093/nar/26.12.2879
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- Article
The mutation rate and cancer.
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- Genetics, 1998, v. 148, n. 4, p. 1483, doi. 10.1093/genetics/148.4.1483
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- Article
Tolerance of different proteins for amino acid diversity.
- Published in:
- Molecular Diversity, 1996, v. 2, n. 1/2, p. 111, doi. 10.1007/BF01718708
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- Article
In Vitro Expansion of GGC:GCC Repeats: Identification of the Preferred Strand of Expansion.
- Published in:
- Nucleic Acids Research, 1996, v. 24, n. 14, p. 2835
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- Publication type:
- Article
Multi-stage proofreading in DNA replication.
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- Quarterly Reviews of Biophysics, 1993, v. 26, n. 3, p. 225, doi. 10.1017/S0033583500002869
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- Article
Innovative funding for cancer research: California's antismoking initiative.
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- Molecular Carcinogenesis, 1990, v. 3, n. 6, p. 323, doi. 10.1002/mc.2940030602
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- Publication type:
- Article
Fidelity of DNA Polymerase-β in Neurons from Young and Very Aged Mice.
- Published in:
- Journal of Neurochemistry, 1985, v. 45, n. 4, p. 1273, doi. 10.1111/j.1471-4159.1985.tb05553.x
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- Article