Works by Locasale, Jason W.

Results: 53

Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays.
Published in:
Angewandte Chemie, 2019, v. 131, n. 48, p. 17318, doi. 10.1002/ange.201905578
By:
- Guo, Zufeng;
- Cheng, Zhiqiang;
- Wang, Jingxin;
- Liu, Wukun;
- Peng, Hanjing;
- Wang, Yuefan;
- Rao, A. V. Subba;
- Li, Ruo‐jing;
- Ying, Xue;
- Korangath, Preethi;
- Liberti, Maria V.;
- Li, Yingjun;
- Xie, Yongmei;
- Hong, Sam Y.;
- Schiene‐Fischer, Cordelia;
- Fischer, Gunter;
- Locasale, Jason W.;
- Sukumar, Saraswati;
- Zhu, Heng;
- Liu, Jun O.
Publication type:
Article
PHGDH amplification and altered glucose metabolism in human melanoma.
Published in:
Pigment Cell & Melanoma Research, 2011, v. 24, n. 6, p. 1112, doi. 10.1111/j.1755-148X.2011.00919.x
By:
- Mullarky, Edouard;
- Mattaini, Katherine R.;
- Vander Heiden, Matthew G.;
- Cantley, Lewis C.;
- Locasale, Jason W.
Publication type:
Article
Cancer's insatiable appetite.
Published in:
Nature Biotechnology, 2009, v. 27, n. 10, p. 916, doi. 10.1038/nbt1009-916
By:
- Locasale, Jason W;
- Cantley, Lewis C;
- Heiden, Matthew G vander
Publication type:
Article
Genetic selection for enhanced serine metabolism in cancer development.
Published in:
Cell Cycle, 2011, v. 10, n. 22, p. 3812, doi. 10.4161/cc.10.22.18224
By:
- Locasale, Jason W.;
- Cantley, Lewis C.
Publication type:
Article
Rewiring of glycolysis in cancer cell metabolism.
Published in:
Cell Cycle, 2010, v. 9, n. 21, p. 4253, doi. 10.4161/cc.9.21.13925
By:
- Locasale, Jason W.;
- Vander Heiden, Matthew G.;
- Cantley, Lewis C.
Publication type:
Article
Scaffold Proteins Confer Diverse Regulatory Properties to Protein Kinase Cascades.
Published in:
FASEB Journal, 2007, v. 21, n. 5, p. A264, doi. 10.1096/fasebj.21.5.a264
By:
- Locasale, Jason W.;
- Chakraborty, Arup K.;
- Shaw, Andrey
Publication type:
Article
Metabolomics in cancer research and emerging applications in clinical oncology.
Published in:
CA: A Cancer Journal for Clinicians, 2021, v. 71, n. 4, p. 333, doi. 10.3322/caac.21670
By:
- Schmidt, Daniel R.;
- Patel, Rutulkumar;
- Kirsch, David G.;
- Lewis, Caroline A.;
- Vander Heiden, Matthew G.;
- Locasale, Jason W.
Publication type:
Article
Human pluripotent stem cells decouple respiration from energy production.
Published in:
EMBO Journal, 2011, v. 30, n. 24, p. 4851, doi. 10.1038/emboj.2011.436
By:
- Shyh-Chang, Ng;
- Zheng, Yuxiang;
- Locasale, Jason W;
- Cantley, Lewis C
Publication type:
Article
Altered metabolism in cancer.
Published in:
BMC Biology, 2010, v. 8, p. 88, doi. 10.1186/1741-7007-8-88
By:
- Locasale, Jason W.;
- Cantley, Lewis C.
Publication type:
Article
Morphomics, Survival, and Metabolites in Patients With Metastatic Pancreatic Cancer.
Published in:
JAMA Network Open, 2024, v. 7, n. 10, p. e2440047, doi. 10.1001/jamanetworkopen.2024.40047
By:
- Gunchick, Valerie;
- Brown, Edward;
- Liu, Juan;
- Locasale, Jason W.;
- Philip, Philip A.;
- Wang, Stewart C.;
- Su, Grace L.;
- Sahai, Vaibhav
Publication type:
Article
Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism.
Published in:
Nature Communications, 2016, v. 7, n. 12, p. 13666, doi. 10.1038/ncomms13666
By:
- Mehrmohamadi, Mahya;
- Mentch, Lucas K.;
- Clark, Andrew G.;
- Locasale, Jason W.
Publication type:
Article
Organization of Enzyme Concentration across the Metabolic Network in Cancer Cells.
Published in:
PLoS ONE, 2015, v. 10, n. 1, p. 1, doi. 10.1371/journal.pone.0117131
By:
- Madhukar, Neel S.;
- Warmoes, Marc O.;
- Locasale, Jason W.
Publication type:
Article
Estimating Relative Changes of Metabolic Fluxes.
Published in:
PLoS Computational Biology, 2014, v. 10, n. 11, p. 1, doi. 10.1371/journal.pcbi.1003958
By:
- Huang, Lei;
- Kim, Dongsung;
- Liu, Xiaojing;
- Myers, Christopher R.;
- Locasale, Jason W.
Publication type:
Article
Regulation of Signal Duration and the Statistical Dynamics of Kinase Activation by Scaffold Proteins.
Published in:
PLoS Computational Biology, 2008, v. 4, n. 6, p. 1, doi. 10.1371/journal.pcbi.1000099
By:
- Locasale, Jason W.;
- Chakraborty, Arup K.
Publication type:
Article
13C tracer analysis suggests extensive recycling of endogenous CO2 in vivo.
Published in:
Cancer & Metabolism, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40170-022-00287-8
By:
- Duan, Likun;
- Cooper, Daniel E.;
- Scheidemantle, Grace;
- Locasale, Jason W.;
- Kirsch, David G.;
- Liu, Xiaojing
Publication type:
Article
Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer.
Published in:
Cancer & Metabolism, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40170-018-0190-7
By:
- Lu, Min;
- Sanderson, Sydney M;
- Zessin, Amelia;
- Ashcraft, Kathleen A;
- Jones, Lee W;
- Dewhirst, Mark W;
- Locasale, Jason W;
- Hsu, David S
Publication type:
Article
Molecular features that predict the response to antimetabolite chemotherapies.
Published in:
Cancer & Metabolism, 2017, v. 5, p. 1, doi. 10.1186/s40170-017-0170-3
By:
- Mehrmohamadi, Mahya;
- Seong Ho Jeong;
- Locasale, Jason W.
Publication type:
Article
The rate of glycolysis quantitatively mediates specific histone acetylation sites.
Published in:
Cancer & Metabolism, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40170-015-0135-3
By:
- Cluntun, Ahmad A.;
- He Huang;
- Lunzhi Dai;
- Xiaojing Liu;
- Yingming Zhao;
- Locasale, Jason W.
Publication type:
Article
The rate of glycolysis quantitatively mediates specific histone acetylation sites.
Published in:
Cancer & Metabolism, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40170-015-0135-3
By:
- Cluntun, Ahmad A.;
- He Huang;
- Lunzhi Dai;
- Xiaojing Liu;
- Yingming Zhao;
- Locasale, Jason W.
Publication type:
Article
The rate of glycolysis quantitatively mediates specific histone acetylation sites.
Published in:
Cancer & Metabolism, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40170-015-0135-3
By:
- Cluntun, Ahmad A.;
- He Huang;
- Lunzhi Dai;
- Xiaojing Liu;
- Yingming Zhao;
- Locasale, Jason W.
Publication type:
Article
MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-08759-0
By:
- Yang, Ying;
- Ishak Gabra, Mari B.;
- Hanse, Eric A.;
- Lowman, Xazmin H.;
- Tran, Thai Q.;
- Li, Haiqing;
- Milman, Neta;
- Liu, Juan;
- Reid, Michael A.;
- Locasale, Jason W.;
- Gil, Ziv;
- Kong, Mei
Publication type:
Article
Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07868-6
By:
- Reid, Michael A.;
- Allen, Annamarie E.;
- Liu, Shiyu;
- Liberti, Maria V.;
- Liu, Pei;
- Liu, Xiaojing;
- Dai, Ziwei;
- Gao, Xia;
- Wang, Qian;
- Liu, Ying;
- Lai, Luhua;
- Locasale, Jason W.
Publication type:
Article
Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06406-8
By:
- Stone, Oliver A.;
- El-Brolosy, Mohamed;
- Wilhelm, Kerstin;
- Liu, Xiaojing;
- Romão, Ana M.;
- Grillo, Elisabetta;
- Lai, Jason K. H.;
- Günther, Stefan;
- Jeratsch, Sylvia;
- Kuenne, Carsten;
- Lee, I-Ching;
- Braun, Thomas;
- Santoro, Massimo M.;
- Locasale, Jason W.;
- Potente, Michael;
- Stainier, Didier Y. R.
Publication type:
Article
mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04392-5
By:
- Chapman, Nicole M.;
- Hu Zeng;
- Nguyen, Thanh-Long M.;
- Yanyan Wang;
- Vogel, Peter;
- Dhungana, Yogesh;
- Xiaojing Liu;
- Neale, Geoffrey;
- Locasale, Jason W.;
- Hongbo Chi
Publication type:
Article
Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04426-y
By:
- Ziwei Dai;
- Mentch, Samantha J.;
- Xia Gao;
- Nichenametla, Sailendra N.;
- Locasale, Jason W.
Publication type:
Article
Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors.
Published in:
Science Signaling, 2011, v. 4, n. 163, p. 1, doi. 10.1126/scisignal.2001518
By:
- Sasaki, Atsuo T.;
- Carracedo, Arkaitz;
- Locasale, Jason W.;
- Anastasiou, Dimitrios;
- Takeuchi, Koh;
- Kahoud, Emily Rose;
- Haviv, Sasson;
- Asara, John M.;
- Pandolfi, Pier Paolo;
- Cantley, Lewis C.
Publication type:
Article
Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays.
Published in:
Angewandte Chemie International Edition, 2019, v. 58, n. 48, p. 17158, doi. 10.1002/anie.201905578
By:
- Guo, Zufeng;
- Cheng, Zhiqiang;
- Wang, Jingxin;
- Liu, Wukun;
- Peng, Hanjing;
- Wang, Yuefan;
- Rao, A. V. Subba;
- Li, Ruo‐jing;
- Ying, Xue;
- Korangath, Preethi;
- Liberti, Maria V.;
- Li, Yingjun;
- Xie, Yongmei;
- Hong, Sam Y.;
- Schiene‐Fischer, Cordelia;
- Fischer, Gunter;
- Locasale, Jason W.;
- Sukumar, Saraswati;
- Zhu, Heng;
- Liu, Jun O.
Publication type:
Article
FOXO protects against age‐progressive axonal degeneration.
Published in:
Aging Cell, 2018, v. 17, n. 1, p. 1, doi. 10.1111/acel.12701
By:
- Hwang, Inah;
- Oh, Hwanhee;
- Santo, Evan;
- Kim, Do‐Yeon;
- Chen, John W.;
- Bronson, Roderick T.;
- Locasale, Jason W.;
- Na, Yoonmi;
- Lee, Jaclyn;
- Reed, Stewart;
- Toth, Miklos;
- Yu, Wai H.;
- Muller, Florian L.;
- Paik, Jihye
Publication type:
Article
Amino acid variability, tradeoffs and optimality in human diet.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34486-0
By:
- Dai, Ziwei;
- Zheng, Weiyan;
- Locasale, Jason W.
Publication type:
Article
Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
Published in:
2012
By:
- Locasale, Jason W.;
- Grassian, Alexandra;
- Beroukhim, Rameen;
- Meyerson, Matthew;
- Wagner, Gerhard;
- Asara, John M.;
- Brugge, Joan S.;
- Vander Heiden, Matthew G.;
- Cantley, Lewis C.
Publication type:
Abstract
RRmix: A method for simultaneous batch effect correction and analysis of metabolomics data in the absence of internal standards.
Published in:
PLoS ONE, 2017, v. 12, n. 6, p. 1, doi. 10.1371/journal.pone.0179530
By:
- Jr.Salerno, Stephen;
- Mehrmohamadi, Mahya;
- Liberti, Maria V.;
- Wan, Muting;
- Wells, Martin T.;
- Booth, James G.;
- Locasale, Jason W.
Publication type:
Article
Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.
Published in:
EMBO Journal, 2017, v. 36, n. 21, p. 3175, doi. 10.15252/embj.201796708
By:
- Tang, Shuang;
- Fang, Yi;
- Huang, Gang;
- Xu, Xiaojiang;
- Padilla‐Banks, Elizabeth;
- Fan, Wei;
- Xu, Qing;
- Sanderson, Sydney M;
- Foley, Julie F;
- Dowdy, Scotty;
- McBurney, Michael W;
- Fargo, David C;
- Williams, Carmen J;
- Locasale, Jason W;
- Guan, Ziqiang;
- Li, Xiaoling
Publication type:
Article
Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis.
Published in:
EMBO Reports, 2015, v. 16, n. 9, p. 1145, doi. 10.15252/embr.201540759
By:
- Chourasia, Aparajita H;
- Tracy, Kristin;
- Frankenberger, Casey;
- Boland, Michelle L;
- Sharifi, Marina N;
- Drake, Lauren E;
- Sachleben, Joseph R;
- Asara, John M;
- Locasale, Jason W;
- Karczmar, Gregory S;
- Macleod, Kay F
Publication type:
Article
Serine, glycine and one-carbon units: cancer metabolism in full circle.
Published in:
Nature Reviews Cancer, 2013, v. 13, n. 8, p. 572, doi. 10.1038/nrc3557
By:
- Locasale, Jason W.
Publication type:
Article
GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43889-6
By:
- Zhu, Qiang;
- Combs, Matthew E.;
- Liu, Juan;
- Bai, Xue;
- Wang, Wenbo B.;
- Herring, Laura E.;
- Liu, Jiandong;
- Locasale, Jason W.;
- Bowles, Dawn E.;
- Gross, Ryan T.;
- Pla, Michelle Mendiola;
- Mack, Christopher P.;
- Taylor, Joan M.
Publication type:
Article
Metabolomics: insights into plant‐based diets.
Published in:
EMBO Molecular Medicine, 2021, v. 13, n. 2, p. 1, doi. 10.15252/emmm.202013568
By:
- Allen, Annamarie E;
- Locasale, Jason W
Publication type:
Article
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
Published in:
Nature Genetics, 2011, v. 43, n. 9, p. 869, doi. 10.1038/ng.890
By:
- Locasale, Jason W.;
- Grassian, Alexandra R.;
- Melman, Tamar;
- Lyssiotis, Costas A.;
- Mattaini, Katherine R.;
- Bass, Adam J.;
- Heffron, Gregory;
- Metallo, Christian M.;
- Muranen, Taru;
- Sharfi, Hadar;
- Sasaki, Atsuo T.;
- Anastasiou, Dimitrios;
- Mullarky, Edouard;
- Vokes, Natalie I.;
- Sasaki, Mika;
- Beroukhim, Rameen;
- Stephanopoulos, Gregory;
- Ligon, Azra H.;
- Meyerson, Matthew;
- Richardson, Andrea L.
Publication type:
Article
Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.
Published in:
Annals of the New York Academy of Sciences, 2016, v. 1363, n. 1, p. 99, doi. 10.1111/nyas.13021
By:
- Niewiadomski, Julie;
- Zhou, James Q.;
- Roman, Heather B.;
- Liu, Xiaojing;
- Hirschberger, Lawrence L.;
- Locasale, Jason W.;
- Stipanuk, Martha H.
Publication type:
Article
One-carbon metabolism and epigenetics: understanding the specificity.
Published in:
Annals of the New York Academy of Sciences, 2016, v. 1363, n. 1, p. 91, doi. 10.1111/nyas.12956
By:
- Mentch, Samantha J.;
- Locasale, Jason W.
Publication type:
Article
Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-13168-4
By:
- Zurlo, Giada;
- Liu, Xijuan;
- Takada, Mamoru;
- Fan, Cheng;
- Simon, Jeremy M.;
- Ptacek, Travis S.;
- Rodriguez, Javier;
- von Kriegsheim, Alex;
- Liu, Juan;
- Locasale, Jason W.;
- Robinson, Adam;
- Zhang, Jing;
- Holler, Jessica M.;
- Kim, Baek;
- Zikánová, Marie;
- Bierau, Jörgen;
- Xie, Ling;
- Chen, Xian;
- Li, Mingjie;
- Perou, Charles M.
Publication type:
Article
Metabolic landscape of the tumor microenvironment at single cell resolution.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11738-0
By:
- Xiao, Zhengtao;
- Dai, Ziwei;
- Locasale, Jason W.
Publication type:
Article
Metabolic pattern formation in the tumor microenvironment.
Published in:
Molecular Systems Biology, 2017, v. 13, n. 2, p. n/a, doi. 10.15252/msb.20167518
By:
- Dai, Ziwei;
- Locasale, Jason W
Publication type:
Article
Metabolic rewiring drives resistance to targeted cancer therapy.
Published in:
Molecular Systems Biology, 2012, v. 8, n. 1, p. 1, doi. 10.1038/msb.2012.30
By:
- Locasale, Jason W
Publication type:
Article
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.
Published in:
2015
By:
- Gerriets, Valerie A;
- Kishton, Rigel J;
- Nichols, Amanda G;
- Macintyre, Andrew N;
- Inoue, Makoto;
- Ilkayeva, Olga;
- Winter, Peter S;
- Liu, Xiaojing;
- Priyadharshini, Bhavana;
- Slawinska, Marta E;
- Haeberli, Lea;
- Huck, Catherine;
- Turka, Laurence A;
- Wood, Kris C;
- Hale, Laura P;
- Smith, Paul A;
- Schneider, Martin A;
- MacIver, Nancie J;
- Locasale, Jason W;
- Newgard, Christopher B
Publication type:
journal article
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.
Published in:
Journal of Clinical Investigation, 2015, v. 125, n. 1, p. 194, doi. 10.1172/JCI76012
By:
- Cerriets, Valerie A.;
- Kishton, Rigel J.;
- Nichols, Amanda C.;
- Macintyre, Andrew N.;
- Makoto Inoue;
- Ilkayeva, Olga;
- Winter, Peter S.;
- Xiaojing Liu;
- Priyadharshini, Bhavana;
- Slawinska, Marta E.;
- Haeberli, Lea;
- Huck, Catherine;
- Turka, Laurence A.;
- Wood, Kris C.;
- Hale, Laura P.;
- Smith, Paul A.;
- Schneider, Martin A.;
- Maclver, Nancie J.;
- Locasale, Jason W.;
- Newgard, Christopher B.
Publication type:
Article
Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells.
Published in:
Science Immunology, 2019, v. 4, n. 31, p. 1, doi. 10.1126/sciimmunol.aap9520
By:
- Gemta, Lelisa F.;
- Siska, Peter J.;
- Nelson, Marin E.;
- Gao, Xia;
- Liu, Xiaojing;
- Locasale, Jason W.;
- Yagita, Hideo;
- Slingluff Jr., Craig L.;
- Hoehn, Kyle L.;
- Rathmell, Jeffrey C.;
- Bullock, Timothy N. J.
Publication type:
Article
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
Published in:
Nature Structural & Molecular Biology, 2013, v. 20, n. 1, p. 46, doi. 10.1038/nsmb.2430
By:
- Baker, Rachael;
- Lewis, Steven M;
- Sasaki, Atsuo T;
- Wilkerson, Emily M;
- Locasale, Jason W;
- Cantley, Lewis C;
- Kuhlman, Brian;
- Dohlman, Henrik G;
- Campbell, Sharon L
Publication type:
Article
Interactions between epigenetics and metabolism in cancers.
Published in:
Frontiers in Oncology, 2012, v. 2, p. 1, doi. 10.3389/fonc.2012.00163
By:
- Jihye Yun;
- Johnson, Jared L.;
- Hanigan, Christin L.;
- Locasale, Jason W.
Publication type:
Article
Interactions between epigenetics and metabolism in cancers.
Published in:
Frontiers in Oncology, 2012, v. 2, p. 1, doi. 10.3389/fonc.2012.00163
By:
- Jihye Yun;
- Johnson, Jared L.;
- Hanigan, Christin L.;
- Locasale, Jason W.
Publication type:
Article
Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20839-0
By:
- Hwang, Inah;
- Uchida, Hiroki;
- Dai, Ziwei;
- Li, Fei;
- Sanchez, Teresa;
- Locasale, Jason W.;
- Cantley, Lewis C.;
- Zheng, Hongwu;
- Paik, Jihye
Publication type:
Article