Works matching AU LoRusso, Patricia M.

Results: 32

Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation.

Published in:

Oncologist, 2021, v. 26, n. 7, p. e1104, doi. 10.1002/onco.13758

By:

Kim, Joseph W.;
Cardin, Dana B.;
Vaishampayan, Ulka N.;
Kato, Shumei;
Grossman, Steven R.;
Glazer, Peter M.;
Shyr, Yu;
Ivy, S. Percy;
LoRusso, Patricia M.

Publication type:

Article

Targeted therapy and immunotherapy: Emerging biomarkers in metastatic melanoma.

Published in:

Pigment Cell & Melanoma Research, 2020, v. 33, n. 3, p. 390, doi. 10.1111/pcmr.12847

By:

LoRusso, Patricia M.;
Schalper, Kurt;
Sosman, Jeffrey

Publication type:

Article

A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies.

Published in:

2016

By:

Mateo, Joaquin;
Olmos, David;
Dumez, Herlinde;
Poondru, Srinivasu;
Samberg, Nancy L;
Barr, Sharon;
Van Tornout, Jan M;
Jie, Fei;
Sandhu, Shahneen;
Tan, Daniel S;
Moreno, Victor;
LoRusso, Patricia M;
Kaye, Stan B;
Schöffski, Patrick;
Schöffski, Patrick

Publication type:

journal article

A phase I dose-escalation study of selumetinib in combination with docetaxel or dacarbazine in patients with advanced solid tumors.

Published in:

2017

By:

LoRusso, Patricia M.;
Infante, Jeffrey R.;
Kim, Kevin B.;
Burris, Howard A.;
Curt, Gregory;
Ugochi Emeribe;
Clemett, Delyth;
Tomkinson, Helen K.;
Cohen, Roger B.;
Burris, Howard A 3rd;
Emeribe, Ugochi

Publication type:

journal article

Preclinical and first-in-human phase I studies of KW-2450, an oral tyrosine kinase inhibitor with insulin-like growth factor receptor-1/insulin receptor selectivity.

Published in:

Cancer Science, 2016, v. 107, n. 4, p. 499, doi. 10.1111/cas.12906

By:

Schwartz, Gary K.;
Dickson, Mark A.;
LoRusso, Patricia M.;
Sausville, Edward A.;
Maekawa, Yoshimi;
Watanabe, Yasuo;
Kashima, Naomi;
Nakashima, Daisuke;
Akinaga, Shiro

Publication type:

Article

AZD1480: A Phase I Study of a Novel JAK2 Inhibitor in Solid Tumors.

Published in:

Oncologist, 2013, v. 18, n. 7, p. 819, doi. 10.1634/theoncologist.2013-0198

By:

Plimack, Elizabeth R.;
LoRusso, Patricia M.;
McCoon, Patricia;
Tang, Weifeng;
Krebs, Annetta D.;
Curt, Gregory;
Eckhardt, S. Gail

Publication type:

Article

Assessment of effects of repeated oral doses of fedratinib on inhibition of cytochrome P450 activities in patients with solid tumors using a cocktail approach.

Published in:

Cancer Chemotherapy & Pharmacology, 2020, v. 86, n. 1, p. 87, doi. 10.1007/s00280-020-04102-3

By:

Ogasawara, Ken;
LoRusso, Patricia M.;
Olszanski, Anthony J.;
Rixe, Olivier;
Xu, Christine;
Yin, Jian;
Palmisano, Maria;
Krishna, Gopal

Publication type:

Article

A pharmacodynamically guided dose selection of PF-00337210 in a phase I study in patients with advanced solid tumors.

Published in:

2016

By:

Bruce, Justine;
LoRusso, Patricia;
Goncalves, Priscila;
Heath, Elisabeth;
Sadowski, Elizabeth;
Shalinsky, David;
Zhang, Yanwei;
Traynor, Anne;
Breazna, Aurora;
Ricart, Alejandro;
Tortorici, Michael;
Liu, Glenn;
Bruce, Justine Yang;
LoRusso, Patricia M;
Goncalves, Priscila H;
Heath, Elisabeth I;
Shalinsky, David R;
Traynor, Anne M;
Ricart, Alejandro D

Publication type:

journal article

Metabolic profile of XK469 (2( R)-[4-(7-chloro-2-quinoxalinyl)oxyphenoxy]-propionic acid; NSC698215) in patients and in vitro: low potential for active or toxic metabolites or for drug–drug interactions.

Published in:

Cancer Chemotherapy & Pharmacology, 2005, v. 56, n. 4, p. 351, doi. 10.1007/s00280-004-0962-3

By:

Anderson, Lawrence W.;
Collins, Jerry M.;
Klecker, Raymond W.;
Katki, Aspandiar G.;
Parchment, Ralph E.;
Boinpally, Ramesh R.;
LoRusso, Patricia M.;
Ivy, S. Percy

Publication type:

Article

Bioavailability and pharmacokinetics of the investigational anticancer agent XK469 (NSC 698215) in rats following oral and intravenous administration.

Published in:

2005

By:

Boinpally, Ramesh;
Sen-Lin Zhou;
LoRusso, Patricia;
Parchment, Ralph;
Boinpally, Ramesh R;
Zhou, Sen-Lin;
LoRusso, Patricia M;
Parchment, Ralph E

Publication type:

journal article

In vitro and in vivo effects of acetyldinaline on murine megakaryocytopoiesis.

Published in:

2004

By:

Volpe, Donna A.;
LoRusso, Patricia M.;
Foster, Brenda J.;
Parchment, Ralph E.

Publication type:

journal article

Improving Precision Oncology through Better Designs and Reporting of Biomarker-Driven Randomized Clinical Trials.

Published in:

JNCI: Journal of the National Cancer Institute, 2023, v. 115, n. 2, p. 122, doi. 10.1093/jnci/djac212

By:

LoRusso, Patricia M;
Freidlin, Boris

Publication type:

Article

The Role of Phosphoinositide 3-Kinase in Breast Cancer: An Overview.

Published in:

Clinical Breast Cancer, 2010, v. 10, p. S56, doi. 10.3816/CBC.2010.s.012

By:

LoRusso, Patricia M.;
Boerner, Scott A.

Publication type:

Article

Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 315, doi. 10.1007/s10637-018-0663-0

By:

Goff, Laura W.;
Azad, Nilofer S.;
Stein, Stacey;
Whisenant, Jennifer G.;
Koyama, Tatsuki;
Vaishampayan, Ulka;
Hochster, Howard;
Connolly, Roisin;
Weise, Amy;
LoRusso, Patricia M.;
Salaria, Safia N.;
El-Rifai, Wael;
Berlin, Jordan D.

Publication type:

Article

First-in-human study of the anti-HB-EGF antibody U3-1565 in subjects with advanced solid tumors.

Published in:

Investigational New Drugs, 2019, v. 37, n. 1, p. 147, doi. 10.1007/s10637-018-0646-1

By:

Moore, Kathleen N.;
Bendell, Johanna C.;
LoRusso, Patricia M.;
Olszanski, Anthony J.;
Zwick-Wallasch, Esther;
Jansen, Mendel;
Vandell, Alexander G.;
Senaldi, Giorgio

Publication type:

Article

Correction to: Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer.

Published in:

Investigational New Drugs, 2018, v. 36, n. 6, p. 1158, doi. 10.1007/s10637-018-0679-5

By:

Goff, Laura W.;
Azad, Nilofer S.;
Stein, Stacey;
Whisenant, Jennifer G.;
Koyama, Tatsuki;
Vaishampayan, Ulka;
Hochster, Howard;
Connolly, Roisin;
Weise, Amy;
LoRusso, Patricia M.;
Salaria, Safia N.;
El-Rifai, Wael;
Berlin, Jordan D.

Publication type:

Article

A phase I dose-escalation study of the safety and pharmacokinetics of a tablet formulation of voxtalisib, a phosphoinositide 3-kinase inhibitor, in patients with solid tumors.

Published in:

Investigational New Drugs, 2018, v. 36, n. 1, p. 36, doi. 10.1007/s10637-017-0467-7

By:

Mehnert, Janice M.;
Edelman, Gerald;
Stein, Mark;
Camisa, Heather;
Lager, Joanne;
Dedieu, Jean-François;
Ghuysen, Anne-Frédérique;
Sharma, Jyoti;
Liu, Li;
LoRusso, Patricia M.

Publication type:

Article

Phase I study of liposomal doxorubicin (Doxil) and cyclophosphamide in solid tumors.

Published in:

Investigational New Drugs, 2005, v. 23, n. 1, p. 57, doi. 10.1023/B:DRUG.0000047106.20104.a7

By:

Basil F. El-Rayes;
Dina Ibrahim;
Anthony F. Shields;
Patricia M. LoRusso;
Mark M. Zalupski;
Philip A. Philip

Publication type:

Article

Capecitabine and PPE Syndrome: A Case Report.

Published in:

Breast Journal, 2003, v. 9, n. 1, p. 64, doi. 10.1046/j.1524-4741.2003.09119.x

By:

LoRusso, Patricia M.

Publication type:

Article

An International Phase 2 Study of Pazopanib in Progressive and Metastatic Thyroglobulin Antibody Negative Radioactive Iodine Refractory Differentiated Thyroid Cancer.

Published in:

Thyroid, 2020, v. 30, n. 9, p. 1254, doi. 10.1089/thy.2019.0269

By:

Bible, Keith C.;
Menefee, Michael E.;
Lin, Chia-Chi (Josh);
Millward, Michael J.;
Maples, William J.;
Goh, Boon Cher;
Karlin, Nina J.;
Kane, Madeleine A.;
Adkins, Douglas R.;
Molina, Julian R.;
Donehower, Ross C.;
Lim, Wan-Teck;
Flynn, Patrick J.;
Richardson, Ronald L.;
Traynor, Anne M.;
Rubin, Joseph;
LoRusso, Patricia M.;
Smallridge, Robert C.;
Burton, Jill K.;
Suman, Vera J.

Publication type:

Article

Clinical responses to selumetinib (AZD6244; ARRY-142886)-based combination therapy stratified by gene mutations in patients with metastatic melanoma.

Published in:

Cancer (0008543X), 2013, v. 119, n. 4, p. 799, doi. 10.1002/cncr.27790

By:

Patel, Sapna P.;
Lazar, Alexander J.;
Papadopoulos, Nicholas E.;
Liu, Ping;
Infante, Jeffrey R.;
Glass, Michelle R.;
Vaughn, Carol S.;
LoRusso, Patricia M.;
Cohen, Roger B.;
Davies, Michael A.;
Kim, Kevin B.

Publication type:

Article

Phase 1b/2a study of trastuzumab emtansine (T-DM1), paclitaxel, and pertuzumab in HER2-positive metastatic breast cancer.

Published in:

2016

By:

Krop, Ian E.;
Modi, Shanu;
LoRusso, Patricia M.;
Pegram, Mark;
Guardino, Ellie;
Althaus, Betsy;
Lu, Dan;
Strasak, Alexander;
Elias, Anthony

Publication type:

journal article

Levels of 5-hydroxymethyl-2′-deoxyuridine in DNA from blood as a marker of breast cancer.

Published in:

Cancer (0008543X), 1996, v. 77, n. 4, p. 691, doi. 10.1002/(SICI)1097-0142(19960215)77:4<691::AID-CNCR15>3.0.CO;2-W

By:

Djuric, Zora;
Heilbrun, Lance K.;
Simon, Michael S.;
Smith, Daryn;
Luongo, Domenico A.;
LoRusso, Patricia M.;
Martino, Silvana

Publication type:

Article

Improved methods for RNAseq-based alternative splicing analysis.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-89938-2

By:

Halperin, Rebecca F.;
Hegde, Apurva;
Lang, Jessica D.;
Raupach, Elizabeth A.;
C4RCD Research Group;
Narayanan, Vinodh;
Huentelman, Matt;
Belnap, Newell;
Aziz, Anne-Marie;
Ramsey, Keri;
Legendre, Christophe;
Liang, Winnie S.;
LoRusso, Patricia M.;
Sekulic, Aleksandar;
Sosman, Jeffrey A.;
Trent, Jeffrey M.;
Rangasamy, Sampathkumar;
Pirrotte, Patrick;
Schork, Nicholas J.

Publication type:

Article

Protein Expression of DNA Damage Repair Proteins Dictates Response to Topoisomerase and PARP Inhibitors in Triple-Negative Breast Cancer.

Published in:

PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0119614

By:

Boerner, Julie L.;
Nechiporchik, Nicole;
Mueller, Kelly L.;
Polin, Lisa;
Heilbrun, Lance;
Boerner, Scott A.;
Zoratti, Gina L.;
Stark, Karri;
LoRusso, Patricia M.;
Burger, Angelika

Publication type:

Article

Qualitative Analysis of the Experience of Mental Fatigue of Family Caregivers of Patients With Cancer in Phase I Trials.

Published in:

Oncology Nursing Forum, 2016, v. 43, n. 4, p. E153, doi. 10.1188/16.ONF.E153-E160

By:

Weiss, Denise M.;
Northouse, Laurel L.;
Duffy, Sonia A.;
Ingersoll-Dayton, Berit;
Katapodi, Maria C.;
LoRusso, Patricia M.

Publication type:

Article

Genome-wide analysis of aberrant position and sequence of plasma DNA fragment ends in patients with cancer.

Published in:

Science Translational Medicine, 2023, v. 15, n. 678, p. 1, doi. 10.1126/scitranslmed.abm6863

By:

Budhraja, Karan K.;
McDonald, Bradon R.;
Stephens, Michelle D.;
Contente-Cuomo, Tania;
Markus, Havell;
Farooq, Maria;
Favaro, Patricia F.;
Connor, Sydney;
Byron, Sara A.;
Egan, Jan B.;
Ernst, Brenda;
McDaniel, Timothy K.;
Sekulic, Aleksandar;
Tran, Nhan L.;
Prados, Michael D.;
Borad, Mitesh J.;
Berens, Michael E.;
Pockaj, Barbara A.;
LoRusso, Patricia M.;
Bryce, Alan

Publication type:

Article

Identifying treatment options for BRAF<sup>V600</sup> wild-type metastatic melanoma: A SU2C/MRA genomics-enabled clinical trial.

Published in:

PLoS ONE, 2021, v. 16, n. 4, p. 1, doi. 10.1371/journal.pone.0248097

By:

LoRusso, Patricia M.;
Sekulic, Aleksandar;
Sosman, Jeffrey A.;
Liang, Winnie S.;
Carpten, John;
Craig, David W.;
Solit, David B.;
Bryce, Alan H.;
Kiefer, Jeffrey A.;
Aldrich, Jessica;
Nasser, Sara;
Halperin, Rebecca;
Byron, Sara A.;
Pilat, Mary Jo;
Boerner, Scott A.;
Durecki, Diane;
Hendricks, William P. D.;
Enriquez, Daniel;
Izatt, Tyler;
Keats, Jonathan

Publication type:

Article

Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase.

Published in:

Journal of Clinical Pharmacology, 2016, v. 56, n. 11, p. 1433, doi. 10.1002/jcph.751

By:

Li, Jing;
Kim, Seongho;
Shields, Anthony F.;
Douglas, Kirk A.;
McHugh, Christopher I.;
Lawhorn‐Crews, Jawana M.;
Wu, Jianmei;
Mangner, Thomas J.;
LoRusso, Patricia M.

Publication type:

Article

Assessment of the drug interaction potential and single- and repeat-dose pharmacokinetics of the BRAF inhibitor dabrafenib.

Published in:

Journal of Clinical Pharmacology, 2015, v. 55, n. 4, p. 392, doi. 10.1002/jcph.437

By:

Suttle, A. Benjamin;
Grossmann, Kenneth F.;
Ouellet, Daniele;
Richards‐Peterson, Lauren E.;
Aktan, Gursel;
Gordon, Michael S.;
LoRusso, Patricia M.;
Infante, Jeffrey R.;
Sharma, Sunil;
Kendra, Kari;
Patel, Manish;
Pant, Shubham;
Arkenau, Hendrik‐Tobias;
Middleton, Mark R.;
Blackman, Samuel C.;
Botbyl, Jeff;
Carson, Stanley W.

Publication type:

Article

Clinical Implications of Pathophysiological and Demographic Covariates on the Population Pharmacokinetics of Trastuzumab Emtansine, a HER2-Targeted Antibody-Drug Conjugate, in Patients With HER2-Positive Metastatic Breast Cancer.

Published in:

Journal of Clinical Pharmacology, 2012, v. 52, n. 5, p. 691, doi. 10.1177/0091270011403742

By:

Gupta, Manish;
LoRusso, Patricia M.;
Wang, Bei;
Yi, Joo-Hee;
Burris, Howard A.;
Beeram, Muralidhar;
Modi, Shanu;
Chu, Yu-Waye;
Agresta, Samuel;
Klencke, Barbara;
Joshi, Amita;
Girish, Sandhya

Publication type:

Article

Network Rewiring in Cancer: Applications to Melanoma Cell Lines and the Cancer Genome Atlas Patients.

Published in:

Frontiers in Genetics, 2018, p. N.PAG, doi. 10.3389/fgene.2018.00228

By:

Ding, Kuan-Fu;
Finlay, Darren;
Yin, Hongwei;
Hendricks, William P. D.;
Sereduk, Chris;
Kiefer, Jeffrey;
Sekulic, Aleksandar;
LoRusso, Patricia M.;
Vuori, Kristiina;
Trent, Jeffrey M.;
Schork, Nicholas J.

Publication type:

Article