Works matching AU Llorca, Oscar

Results: 43

Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations.

Published in:

EMBO Journal, 2000, v. 19, n. 22, p. 5971, doi. 10.1093/emboj/19.22.5971

By:

Llorca, Oscar;
Martín-Benito, Jaime;
Ritco-Vonsovici, Monica;
Grantham, Julie;
Hynes, Gillian M.;
Willison, Keith R.;
Carrascosa, José L.;
Valpuesta, José M.

Publication type:

Article

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B.

Published in:

Nature, 2008, v. 455, n. 7209, p. 124, doi. 10.1038/nature07187

By:

Rehmann, Holger;
Arias-Palomo, Ernesto;
Hadders, Michael A.;
Schwede, Frank;
Llorca, Oscar;
Bos, Johannes L.

Publication type:

Article

RPAP3 C-Terminal Domain: A Conserved Domain for the Assembly of R2TP Co-Chaperone Complexes.

Published in:

Cells (2073-4409), 2020, v. 9, n. 5, p. 1139, doi. 10.3390/cells9051139

By:

Rodríguez, Carlos F.;
Llorca, Oscar

Publication type:

Article

Conformational transitions regulate the exposure of a DNA-binding domain in the RuvBL1–RuvBL2 complex.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 21, p. 11086, doi. 10.1093/nar/gks871

By:

López-Perrote, Andrés;
Muñoz-Hernández, Hugo;
Gil, David;
Llorca, Oscar

Publication type:

Article

Flexible tethering of primase and DNA Pol α in the eukaryotic primosome.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 10, p. 4726, doi. 10.1093/nar/gks431

By:

Núñez-Ramírez, Rafael;
Klinge, Sebastian;
Sauguet, Ludovic;
Melero, Roberto;
Recuero-Checa, María A.;
Kilkenny, Mairi;
Perera, Rajika L.;
García-Alvarez, Begoña;
Hall, Richard J.;
Nogales, Eva;
Pellegrini, Luca;
Llorca, Oscar

Publication type:

Article

Flexible tethering of primase and DNA Pol α in the eukaryotic primosome.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 18, p. 8187

By:

Núñez-Ramírez, Rafael;
Klinge, Sebastian;
Sauguet, Ludovic;
Melero, Roberto;
Recuero-Checa, María A.;
Kilkenny, Mairi;
Perera, Rajika L.;
García-Alvarez, Begoña;
Hall, Richard J.;
Nogales, Eva;
Pellegrini, Luca;
Llorca, Oscar

Publication type:

Article

Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 13, p. 5757, doi. 10.1093/nar/gkr146

By:

Morris, Edward P.;
Rivera-Calzada, Angel;
da Fonseca, Paula C. A.;
Llorca, Oscar;
Pearl, Laurence H.;
Spagnolo, Laura

Publication type:

Article

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 1, p. 347

By:

Fernández, Israel S.;
Yamashita, Akio;
Arias-Palomo, Ernesto;
Bamba, Yumi;
Bartolomé, Ruben A.;
Canales, M. Angeles;
Teixidó, Joaquín;
Ohno, Shigeo;
Llorca, Oscar

Publication type:

Article

Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 11, p. 3774, doi. 10.1093/nar/gkm336

By:

Torreira, Eva;
Schoehn, Guy;
Fernández, Yolanda;
Jorba, Núria;
Ruigrok, Rob W.H.;
Cusack, Stephen;
Ortín, Juan;
Llorca, Oscar

Publication type:

Article

Prediction of the structure of GroES and its interaction with GroEL.

Published in:

Proteins, 1995, v. 22, n. 3, p. 199, doi. 10.1002/prot.340220302

By:

Valencia, Alfonso;
Hubbard, Tim J.;
Muga, Arturo;
Bañuelos, Sonia;
Llorca, Oscar;
Carrascosa, José L.;
Valpuesta, José Marí

Publication type:

Article

C3 glomerulopathy--associated CFHR1 mutation alters FHR oligomerization and complement regulation.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 7, p. 2434, doi. 10.1172/JCI68280

By:

Tortajada, Agustín;
Yébenes, Hugo;
Abarrategui-Garrido, Cynthia;
Anter, Jaouad;
García-Fernández, Jesús M.;
Martínez-Barricarte, Rubén;
Alba-Domínguez, María;
Malik, Talat H.;
Bedoya, Rafael;
Pérez, Rocío Cabrera;
Trascasa, Margarita López;
Pickering, Matthew C.;
Harris, Claire L.;
Sánchez-Corral, Pilar;
Llorca, Oscar;
de Córdoba, Santiago Rodríguez

Publication type:

Article

C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.

Published in:

2013

By:

Tortajada, Agustín;
Yébenes, Hugo;
Abarrategui-Garrido, Cynthia;
Anter, Jaouad;
García-Fernández, Jesús M;
Martínez-Barricarte, Rubén;
Alba-Domínguez, María;
Malik, Talat H;
Bedoya, Rafael;
Cabrera Pérez, Rocío;
López Trascasa, Margarita;
Pickering, Matthew C;
Harris, Claire L;
Sánchez-Corral, Pilar;
Llorca, Oscar;
Rodríguez de Córdoba, Santiago

Publication type:

journal article

C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 6, p. 2334, doi. 10.1172/JCI68280

By:

Tortajada, Agustín;
Yébenes, Hugo;
Abarrategui-Garrido, Cynthia;
Anter, Jaouad;
García-Fernández, Jesús M.;
Martínez-Barricarte, Rubén;
Alba-Domínguez, María;
Pickering, Matthew C.;
Harris, Claire L.;
Sánchez-Corral, Pilar;
Llorca, Oscar;
de Córdoba, Santiago Rodríguez

Publication type:

Article

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.

Published in:

2010

By:

Martínez-Barricarte, Rubén;
Heurich, Meike;
Valdes-Cañedo, Francisco;
Vazquez-Martul, Eduardo;
Torreira, Eva;
Montes, Tamara;
Tortajada, Agustín;
Pinto, Sheila;
Lopez-Trascasa, Margarita;
Morgan, B. Paul;
Llorca, Oscar;
Harris, Claire L.;
de Córdoba, Santiago Rodríguez;
Martínez-Barricarte, Rubén;
Valdes-Cañedo, Francisco;
Tortajada, Agustín;
Rodríguez de Córdoba, Santiago

Publication type:

journal article

Functional and structural characterization of four mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic applications.

Published in:

European Journal of Immunology, 2017, v. 47, n. 3, p. 504, doi. 10.1002/eji.201646758

By:

Subías Hidalgo, Marta;
Yébenes, Hugo;
Rodríguez‐Gallego, César;
Martín‐Ambrosio, Adrián;
Domínguez, Mercedes;
Tortajada, Agustin;
Rodríguez de Córdoba, Santiago;
Llorca, Oscar

Publication type:

Article

Introduction to 3D reconstruction of macromolecules using single particle electron microscopy.

Published in:

Acta Pharmacologica Sinica, 2005, v. 26, n. 10, p. 1153, doi. 10.1111/j.1745-7254.2005.00203.x

By:

Llorca, Oscar

Publication type:

Article

Structural model of full-length human Ku70–Ku80 heterodimer and its recognition of DNA and DNA-PKcs.

Published in:

EMBO Reports, 2007, v. 8, n. 1, p. 56, doi. 10.1038/sj.embor.7400847

By:

Rivera-Calzada, Angel;
Spagnolo, Laura;
Pearl, Laurence H;
Llorca, Oscar

Publication type:

Article

Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180.

Published in:

2003

By:

Rivera-Calzada, Angel;
Robertson, David;
MacFadyen, John R.;
Boskovic, Jasminka;
Isacke, Calre M.;
Llorca, Oscar

Publication type:

Report

Three-dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particle.

Published in:

2001

By:

Martín-Benito, Jaime;
Area, Estela;
Ortega, Joaquín;
Llorca, Oscar;
Valpuesta, José M.;
Carrascosa, José L.;
Ortín, Juan

Publication type:

Report

Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM.

Published in:

eLife, 2020, p. 1, doi. 10.7554/eLife.63042

By:

Lopez-Perrote, Andres;
Hug, Nele;
Gonzalez-Corpas, Ana;
Rodrıguez, Carlos F.;
Serna, Marina;
Garcıa-Martın, Carmen;
Boskovic, Jasminka;
Fernandez-Leiro, Rafael;
Caceres, Javier F.;
Llorca, Oscar

Publication type:

Article

BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38116-1

By:

Gallisà-Suñé, Núria;
Sànchez-Fernàndez-de-Landa, Paula;
Zimmermann, Fabian;
Serna, Marina;
Regué, Laura;
Paz, Joel;
Llorca, Oscar;
Lüders, Jens;
Roig, Joan

Publication type:

Article

Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34843-z

By:

Rivera-Calzada, Angel;
Arribas-Bosacoma, Raquel;
Ruiz-Ramos, Alba;
Escudero-Bravo, Paloma;
Boskovic, Jasminka;
Fernandez-Leiro, Rafael;
Oliver, Antony W.;
Pearl, Laurence H.;
Llorca, Oscar

Publication type:

Article

Structural basis of Focal Adhesion Kinase activation on lipid membranes.

Published in:

EMBO Journal, 2020, v. 39, n. 19, p. 1, doi. 10.15252/embj.2020104743

By:

Acebrón, Iván;
Righetto, Ricardo D;
Schoenherr, Christina;
Buhr, Svenja;
Redondo, Pilar;
Culley, Jayne;
Rodríguez, Carlos F;
Daday, Csaba;
Biyani, Nikhil;
Llorca, Oscar;
Byron, Adam;
Chami, Mohamed;
Gräter, Frauke;
Boskovic, Jasminka;
Frame, Margaret C;
Stahlberg, Henning;
Lietha, Daniel

Publication type:

Article

Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-47385-3

By:

Rullo-Tubau, Josep;
Martinez-Molledo, Maria;
Bartoccioni, Paola;
Puch-Giner, Ignasi;
Arias, Ángela;
Saen-Oon, Suwipa;
Stephan-Otto Attolini, Camille;
Artuch, Rafael;
Díaz, Lucía;
Guallar, Víctor;
Errasti-Murugarren, Ekaitz;
Palacín, Manuel;
Llorca, Oscar

Publication type:

Article

The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.

Published in:

Nature Communications, 2016, v. 7, n. 2, p. 10585, doi. 10.1038/ncomms10585

By:

Melero, Roberto;
Hug, Nele;
López-Perrote, Andrés;
Yamashita, Akio;
Cáceres, Javier F.;
Llorca, Oscar

Publication type:

Article

3D reconstruction of the ATP-bound form of CCT reveals the asymmetric folding conformation of a type II chaperonin.

Published in:

Nature Structural Biology, 1999, v. 6, n. 7, p. 639

By:

Llorca, Oscar;
Smyth, Martin G.;
Carrascosa, José L.;
Willison, Keith R.;
Radermacher, Michael;
Steinbacher, Stefan;
Valpuesta, José M.

Publication type:

Article

The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity.

Published in:

Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.748103

By:

del Fresno, Carlos;
García-Arriaza, Juan;
Martínez-Cano, Sarai;
Heras-Murillo, Ignacio;
Jarit-Cabanillas, Aitor;
Amores-Iniesta, Joaquín;
Brandi, Paola;
Dunphy, Gillian;
Suay-Corredera, Carmen;
Pricolo, Maria Rosaria;
Vicente, Natalia;
López-Perrote, Andrés;
Cabezudo, Sofía;
González-Corpas, Ana;
Llorca, Oscar;
Alegre-Cebollada, Jorge;
Garaigorta, Urtzi;
Gastaminza, Pablo;
Esteban, Mariano;
Sancho, David

Publication type:

Article

Molecular architecture and oligomerization of Candida glabrata Cdc13 underpin its telomeric DNA-binding and unfolding activity.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 2, p. 668, doi. 10.1093/nar/gkac1261

By:

Coloma, Javier;
Gonzalez-Rodriguez, Nayim;
Balaguer, Francisco A;
Gmurczyk, Karolina;
Aicart-Ramos, Clara;
Nuero, Óscar M;
Luque-Ortega, Juan Román;
Calugaru, Kimberly;
Lue, Neal F;
Moreno-Herrero, Fernando;
Llorca, Oscar

Publication type:

Article

CryoEM of RUVBL1–RUVBL2–ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 2, p. 1128, doi. 10.1093/nar/gkab1267

By:

Serna, Marina;
González-Corpas, Ana;
Cabezudo, Sofía;
López-Perrote, Andrés;
Degliesposti, Gianluca;
Zarzuela, Eduardo;
Skehel, J Mark;
Muñoz, Javier;
Llorca, Oscar

Publication type:

Article

Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 4, p. 1909, doi. 10.1093/nar/gkv1527

By:

López-Perrote, Andrés;
ño, Raquel Casta;
Melero, Roberto;
Zamarro, Teresa;
Hitomi Kurosawa;
Tetsuo Ohnishi;
Akiko Uchiyama;
Kyoko Aoyagi;
Buchwald, Gretel;
Naoyuki Kataoka;
Akio Yamashita;
Llorca, Oscar

Publication type:

Article

Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05546-1

By:

Martino, Fabrizio;
Pal, Mohinder;
Muñoz-Hernández, Hugo;
Rodríguez, Carlos F.;
Núñez-Ramírez, Rafael;
Gil-Carton, David;
Degliesposti, Gianluca;
Skehel, J. Mark;
Roe, S. Mark;
Prodromou, Chrisostomos;
Pearl, Laurence H.;
Llorca, Oscar

Publication type:

Article

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03942-1

By:

Martino, Fabrizio;
Pal, Mohinder;
Muñoz-Hernández, Hugo;
Rodríguez, Carlos F.;
Núñez-Ramírez, Rafael;
Gil-Carton, David;
Degliesposti, Gianluca;
Skehel, J. Mark;
Roe, S. Mark;
Prodromou, Chrisostomos;
Pearl, Laurence H.;
Llorca, Oscar

Publication type:

Article

3D architecture of DNA Pol α reveals the functional core of multi-subunit replicative polymerases.

Published in:

EMBO Journal, 2009, v. 28, n. 13, p. 1978, doi. 10.1038/emboj.2009.150

By:

Klinge, Sebastian;
Núñez-Ramírez, Rafael;
Llorca, Oscar;
Pellegrini, Luca

Publication type:

Article

Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains.

Published in:

EMBO Journal, 2009, v. 28, n. 11, p. 1666, doi. 10.1038/emboj.2009.125

By:

Boer, D. Roeland;
Ruíz-Masó, José A.;
López-Blanco, José R.;
Blanco, Alexander G.;
Vives-Llàcer, Mireia;
Chacón, Pablo;
Usón, Isabel;
Gomis-Rüth, F. Xavier;
Espinosa, Manuel;
Llorca, Oscar;
del Solar, Gloria;
Coll, Miquel

Publication type:

Article

Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs.

Published in:

EMBO Journal, 2003, v. 22, n. 21, p. 5875, doi. 10.1093/emboj/cdg555

By:

Jasminka Boskovic;
Angel Rivera-Calzada;
Joseph D. Maman;
Pablo Chacón;
Keith R. Willison;
Laurence H. Pearl;
Oscar Llorca

Publication type:

Article

The 'sequential allosteric ring' mechanism in the eukaryotic chaperonin-assisted folding of actin and tubulin.

Published in:

EMBO Journal, 2001, v. 20, n. 15, p. 4065, doi. 10.1093/emboj/20.15.4065

By:

Llorca, Oscar;
Martín-Benito, Jaime;
Grantham, Julie;
Ritco-Vonsovici, Monica;
Willison, Keith R.;
Carrascosa, José L.;
Valpuesta, José M.

Publication type:

Article

The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3? end.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 5, p. 498, doi. 10.1038/nsmb.2287

By:

Melero, Roberto;
Buchwald, Gretel;
Castaño, Raquel;
Raabe, Monika;
Gil, David;
Lázaro, Melisa;
Urlaub, Henning;
Conti, Elena;
Llorca, Oscar

Publication type:

Article

Eukaryotic type II chaperonin CCT interacts with actin through specific subunits.

Published in:

Nature, 1999, v. 402, n. 6762, p. 693, doi. 10.1038/45294

By:

Llorca, Oscar;
McCormack, Elizabeth A.

Publication type:

Article

The C-Terminal SH3 Domain Contributes to the Intramolecular Inhibition of Vav Family Proteins.

Published in:

Science Signaling, 2014, v. 7, n. 321, p. 1, doi. 10.1126/scisignal.2004993

By:

Barreira, María;
Fabbiano, Salvatore;
Couceiro, José R.;
Torreira, Eva;
Martínez-Torrecuadrada, Jorge L.;
Montoya, Guillermo;
Llorca, Oscar;
Bustelo, Xosé R.

Publication type:

Article

TubZ filament assembly dynamics requires the flexible C-terminal tail.

Published in:

Scientific Reports, 2017, p. 43342, doi. 10.1038/srep43342

By:

Fuentes-Pérez, Maria E.;
Núñez-Ramírez, Rafael;
Martín-González, Alejandro;
Juan-Rodríguez, David;
Llorca, Oscar;
Moreno-Herrero, Fernando;
Oliva, Maria A.

Publication type:

Article

SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis.

Published in:

Cell Death & Disease, 2024, v. 15, n. 9, p. 1, doi. 10.1038/s41419-024-07106-6

By:

Murga, Matilde;
Lopez-Pernas, Gema;
Soliva, Robert;
Fueyo-Marcos, Elena;
Amor, Corina;
Faustino, Ignacio;
Serna, Marina;
Serrano, Alicia G.;
Díaz, Lucía;
Martínez, Sonia;
Blanco-Aparicio, Carmen;
Antón, Marta Elena;
Seashore-Ludlow, Brinton;
Pastor, Joaquín;
Jafari, Rozbeh;
Lafarga, Miguel;
Llorca, Oscar;
Orozco, Modesto;
Fernández-Capetillo, Oscar

Publication type:

Article

How novel structures inform understanding of complement function.

Published in:

Seminars in Immunopathology, 2018, v. 40, n. 1, p. 3, doi. 10.1007/s00281-017-0643-z

By:

de Jorge, Elena Goicoechea;
Yebenes, Hugo;
Serna, Marina;
Tortajada, Agustín;
Llorca, Oscar;
de Córdoba, Santiago Rodríguez

Publication type:

Article

Structural insights on complement activation.

Published in:

FEBS Journal, 2015, v. 282, n. 20, p. 3883, doi. 10.1111/febs.13399

By:

Alcorlo, Martín;
López‐Perrote, Andrés;
Delgado, Sandra;
Yébenes, Hugo;
Subías, Marta;
Rodríguez‐Gallego, César;
Rodríguez de Córdoba, Santiago;
Llorca, Oscar

Publication type:

Article