Works matching AU Llinás, Manuel

Results: 51

Sexual development in Plasmodium parasites: knowing when it's time to commit.

Published in:

Nature Reviews Microbiology, 2015, v. 13, n. 9, p. 573, doi. 10.1038/nrmicro3519

By:

Josling, Gabrielle A.;
Llinás, Manuel

Publication type:

Article

Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium.

Published in:

Briefings in Functional Genomics, 2019, v. 18, n. 5, p. 281, doi. 10.1093/bfgp/elz012

By:

Lee, Marcus C S;
Lindner, Scott E;
Lopez-Rubio, Jose-Juan;
Llinás, Manuel

Publication type:

Article

Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.

Published in:

PLoS Pathogens, 2022, v. 18, n. 10, p. 1, doi. 10.1371/journal.ppat.1010926

By:

Okombo, John;
Mok, Sachel;
Qahash, Tarrick;
Yeo, Tomas;
Bath, Jade;
Orchard, Lindsey M.;
Owens, Edward;
Koo, Imhoi;
Albert, Istvan;
Llinás, Manuel;
Fidock, David A.

Publication type:

Article

Structural characterization of the ACDC domain from ApiAP2 proteins, a potential molecular target against apicomplexan parasites.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2025, v. 81, n. 1, p. 38, doi. 10.1107/S2059798324012518

By:

Le Berre, Marine;
Tubiana, Thibault;
Reuterswärd Waldner, Philippa;
Lazar, Noureddine;
Li de la Sierra-Gallay, Ines;
Santos, Joana M.;
Llinás, Manuel;
Nessler, Sylvie

Publication type:

Article

Re-Envisioning Anti-Apicomplexan Parasite Drug Discovery Approaches.

Published in:

Frontiers in Cellular & Infection Microbiology, 2021, v. 11, p. 1, doi. 10.3389/fcimb.2021.691121

By:

Rangel, Gabriel W.;
Llinás, Manuel

Publication type:

Article

Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 4, p. 1166, doi. 10.1093/nar/gkj517

By:

Llinás, Manuel;
Bozdech, Zbynek;
Wong, Edith D.;
Adai, Alex T.;
DeRisi, Joseph L.

Publication type:

Article

Author Correction: Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development.

Published in:

2022

By:

Painter, Heather J.;
Chung, Neo Christopher;
Sebastian, Aswathy;
Albert, Istvan;
Storey, John D.;
Llinás, Manuel

Publication type:

Correction Notice

The Kringle of Life.

Published in:

Protein Journal, 2021, v. 40, n. 4, p. 454, doi. 10.1007/s10930-021-10009-6

By:

Llinás, Manuel

Publication type:

Article

Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation.

Published in:

BMC Genomics, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s12864-019-6322-9

By:

van Biljon, Riëtte;
van Wyk, Roelof;
Painter, Heather J.;
Orchard, Lindsey;
Reader, Janette;
Niemand, Jandeli;
Llinás, Manuel;
Birkholtz, Lyn-Marie

Publication type:

Article

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism.

Published in:

PLoS Genetics, 2014, v. 10, n. 1, p. 1, doi. 10.1371/journal.pgen.1004085

By:

Lewis, Ian A.;
Wacker, Mark;
Olszewski, Kellen L.;
Cobbold, Simon A.;
Baska, Katelynn S.;
Tan, Asako;
Ferdig, Michael T.;
Llinás, Manuel

Publication type:

Article

The G9a Histone Methyltransferase Inhibitor BIX-01294 Modulates Gene Expression during Plasmodium falciparum Gametocyte Development and Transmission.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 20, p. 5087, doi. 10.3390/ijms20205087

By:

Ngwa, Che Julius;
Kiesow, Meike Jutta;
Orchard, Lindsey Marie;
Farrukh, Afia;
Llinás, Manuel;
Pradel, Gabriele

Publication type:

Article

A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum.

Published in:

PLoS Pathogens, 2018, v. 14, n. 8, p. 1, doi. 10.1371/journal.ppat.1007249

By:

Bennink, Sandra;
von Bohl, Andreas;
Ngwa, Che J.;
Henschel, Leonie;
Kuehn, Andrea;
Pilch, Nicole;
Weißbach, Tim;
Rosinski, Alina N.;
Scheuermayer, Matthias;
Repnik, Urska;
Przyborski, Jude M.;
Minns, Allen M.;
Orchard, Lindsey M.;
Griffiths, Gareth;
Lindner, Scott E.;
Llinás, Manuel;
Pradel, Gabriele

Publication type:

Article

Anti-inflammation and antimalarial profile of 5-pyridin-2-yl-1H-[1,2,4]triazole-3-carboxylic acid ethyl ester as a low molecular intermediate for hybrid drug synthesis.

Published in:

Research on Chemical Intermediates, 2022, v. 48, n. 2, p. 885, doi. 10.1007/s11164-021-04607-3

By:

Eya'ane Meva, Francois;
Prior, Timothy J.;
Evans, David J.;
Shah, Sachin;
Tamngwa, Cynthia Fake;
Belengue, Herschelle Guyenne Lagrange;
Mang, Roland Emmanuel;
Munro, Justin;
Qahash, Tarrick;
Llinás, Manuel

Publication type:

Article

Simultaneous genome-wide gene expression and transcript isoform profiling in the human malaria parasite.

Published in:

PLoS ONE, 2017, v. 12, n. 11, p. 1, doi. 10.1371/journal.pone.0187595

By:

Turnbull, Lindsey B.;
Siwo, Geoffrey H.;
Button-Simons, Katrina A.;
Tan, Asako;
Checkley, Lisa A.;
Painter, Heather J.;
Llinás, Manuel;
Ferdig, Michael T.

Publication type:

Article

Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1.

Published in:

BMC Genomics, 2015, v. 16, p. 1, doi. 10.1186/s12864-015-2320-8

By:

Adjalley, Sophie H.;
Scanfeld, Daniel;
Kozlowski, Elyse;
Llinás, Manuel;
Fidock, David A.

Publication type:

Article

An Erythrocyte Vesicle Protein Exported by the Malaria Parasite Promotes Tubovesicular Lipid Import from the Host Cell Surface.

Published in:

PLoS Pathogens, 2008, v. 4, n. 8, p. 1, doi. 10.1371/journal.ppat.1000118

By:

Tamez, Pamela A.;
Bhattacharjee, Souvik;
van Ooij, Christiaan;
Hiller, N. Luisa;
Llinás, Manuel;
Balu, Bharath;
Adams, John H.;
Haldar, Kasturi

Publication type:

Article

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-34964-w

By:

van Biljon, Riëtte;
Niemand, Jandeli;
van Wyk, Roelof;
Clark, Katherine;
Verlinden, Bianca;
Abrie, Clarissa;
von Grüning, Hilde;
Smidt, Werner;
Smit, Annél;
Reader, Janette;
Painter, Heather;
Llinás, Manuel;
Doerig, Christian;
Birkholtz, Lyn-Marié

Publication type:

Article

The PfAP2‐G2 transcription factor is a critical regulator of gametocyte maturation.

Published in:

Molecular Microbiology, 2021, v. 115, n. 5, p. 1005, doi. 10.1111/mmi.14676

By:

Singh, Suprita;
Santos, Joana M.;
Orchard, Lindsey M.;
Yamada, Naomi;
Biljon, Riëtte;
Painter, Heather J.;
Mahony, Shaun;
Llinás, Manuel

Publication type:

Article

Pf SR1 controls alternative splicing and steady-state RNA levels in P lasmodium falciparum through preferential recognition of specific RNA motifs.

Published in:

Molecular Microbiology, 2015, v. 96, n. 6, p. 1283, doi. 10.1111/mmi.13007

By:

Eshar, Shiri;
Altenhofen, Lindsey;
Rabner, Alona;
Ross, Phil;
Fastman, Yair;
Mandel‐Gutfreund, Yael;
Karni, Rotem;
Llinás, Manuel;
Dzikowski, Ron

Publication type:

Article

New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Published in:

Molecular Microbiology, 2010, v. 76, n. 1, p. 12, doi. 10.1111/j.1365-2958.2009.07026.x

By:

Otto, Thomas D.;
Wilinski, Daniel;
Assefa, Sammy;
Keane, Thomas M.;
Sarry, Louis R.;
Böhme, Ulrike;
Lemieux, Jacob;
Barrell, Bart;
Pain, Arnab;
Berriman, Matthew;
Newbold, Chris;
Llinás, Manuel

Publication type:

Article

Clonally variant gene families in Plasmodium falciparum share a common activation factor.

Published in:

Molecular Microbiology, 2009, v. 73, n. 6, p. 1171, doi. 10.1111/j.1365-2958.2009.06846.x

By:

Howitt, Cali A.;
Wilinski, Daniel;
Llinás, Manuel;
Templeton, Thomas J.;
Dzikowski, Ron;
Deitsch, Kirk W.

Publication type:

Article

The energetics of T4 lysozyme reveal a hierarchy of conformations.

Published in:

Nature Structural Biology, 1999, v. 6, n. 11, p. 1072

By:

Llinás, Manuel;
Gillespie, Blake;
Dahlquist, Frederick W.;
Marqusee, Susan

Publication type:

Article

Using context to improve protein domain identification.

Published in:

BMC Bioinformatics, 2011, v. 12, n. 1, p. 90, doi. 10.1186/1471-2105-12-90

By:

Ochoa, Alejandro;
Llinás, Manuel;
Singh, Mona

Publication type:

Article

Beyond the E-Value: Stratified Statistics for Protein Domain Prediction.

Published in:

PLoS Computational Biology, 2015, v. 11, n. 11, p. 1, doi. 10.1371/journal.pcbi.1004509

By:

Ochoa, Alejandro;
Storey, John D.;
Llinás, Manuel;
Singh, Mona

Publication type:

Article

Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite Plasmodium falciparum.

Published in:

Frontiers in Cellular & Infection Microbiology, 2017, v. 7, p. 1, doi. 10.3389/fcimb.2017.00320

By:

Ngwa, Che J.;
Kiesow, Meike J.;
Papst, Olga;
Orchard, Lindsey M.;
Filarsky, Michael;
Rosinski, Alina N.;
Voss, Till S.;
Llinás, Manuel;
Pradel, Gabriele

Publication type:

Article

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast.

Published in:

Cellular Microbiology, 2017, v. 19, n. 1, p. n/a, doi. 10.1111/cmi.12633

By:

Shears, Melanie J.;
MacRae, James I.;
Mollard, Vanessa;
Goodman, Christopher D.;
Sturm, Angelika;
Orchard, Lindsey M.;
Llinás, Manuel;
McConville, Malcolm J.;
Botté, Cyrille Y.;
McFadden, Geoffrey I.

Publication type:

Article

Sequestration and metabolism of host cell arginine by the intraerythrocytic malaria parasite Plasmodium falciparum.

Published in:

Cellular Microbiology, 2016, v. 18, n. 6, p. 820, doi. 10.1111/cmi.12552

By:

Cobbold, Simon A;
Llinás, Manuel;
Kirk, Kiaran

Publication type:

Article

Epigenetic switches in clag3 genes mediate blasticidin S resistance in malaria parasites.

Published in:

Cellular Microbiology, 2013, v. 15, n. 11, p. 1913, doi. 10.1111/cmi.12162

By:

Mira‐Martínez, Sofía;
Rovira‐Graells, Núria;
Crowley, Valerie M.;
Altenhofen, Lindsey M.;
Llinás, Manuel;
Cortés, Alfred

Publication type:

Article

DNA sequence and chromatin differentiate sequence-specific transcription factor binding in the human malaria parasite Plasmodium falciparum.

Published in:

Nucleic Acids Research, 2024, v. 52, n. 17, p. 10161, doi. 10.1093/nar/gkae585

By:

Bonnell, Victoria A;
Zhang, Yuning;
Brown, Alan S;
Horton, John;
Josling, Gabrielle A;
Chiu, Tsu-Pei;
Rohs, Remo;
Mahony, Shaun;
Gordân, Raluca;
Llinás, Manuel

Publication type:

Article

The Cryptosporidium parvum ApiAP2 gene family: insights into the evolution of apicomplexan AP2 regulatory systems.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 13, p. 8271, doi. 10.1093/nar/gku500

By:

Oberstaller, Jenna;
Pumpalova, Yoanna;
Schieler, Ariel;
Llinás, Manuel;
Kissinger, Jessica C.

Publication type:

Article

Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development.

Published in:

Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-04966-3

By:

Painter, Heather J.;
Chung, Neo Christopher;
Sebastian, Aswathy;
Albert, Istvan;
Storey, John D.;
Llinás, Manuel

Publication type:

Article

A Novel Antiparasitic Compound Kills Ring-Stage Plasmodium falciparum and Retains Activity Against Artemisinin-Resistant Parasites.

Published in:

2020

By:

Clements, Rebecca L;
Streva, Vincent;
Dumoulin, Peter;
Huang, Weigang;
Owens, Edward;
Raj, Dipak K;
Burleigh, Barbara;
Llinás, Manuel;
Winzeler, Elizabeth A;
Zhang, Qisheng;
Dvorin, Jeffrey D

Publication type:

journal article

Identifying the Components of Acidosis in Patients With Severe Plasmodium falciparum Malaria Using Metabolomics.

Published in:

2019

By:

Leopold, Stije J;
Ghose, Aniruddha;
Allman, Erik L;
Kingston, Hugh W F;
Hossain, Amir;
Dutta, Asok Kumar;
Plewes, Katherine;
Chotivanich, Kesinee;
Day, Nicholas P J;
Tarning, Joel;
Winterberg, Markus;
White, Nicholas J;
Llinás, Manuel;
Dondorp, Arjen M

Publication type:

journal article

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases.

Published in:

Nature Methods, 2012, v. 9, n. 10, p. 993, doi. 10.1038/nmeth.2143

By:

Straimer, Judith;
Lee, Marcus C S;
Lee, Andrew H;
Zeitler, Bryan;
Williams, April E;
Pearl, Jocelynn R;
Zhang, Lei;
Rebar, Edward J;
Gregory, Philip D;
Llinás, Manuel;
Urnov, Fyodor D;
Fidock, David A

Publication type:

Article

Refining the transcriptome of the human malaria parasite Plasmodium falciparum using amplification-free RNA-seq.

Published in:

BMC Genomics, 2020, v. 21, n. 1, p. 1, doi. 10.1186/s12864-020-06787-5

By:

Chappell, Lia;
Ross, Philipp;
Orchard, Lindsey;
Russell, Timothy J.;
Otto, Thomas D.;
Berriman, Matthew;
Rayner, Julian C.;
Llinás, Manuel

Publication type:

Article

Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network.

Published in:

Molecular Systems Biology, 2010, v. 6, n. 1, p. 1, doi. 10.1038/msb.2010.60

By:

Plata, Germán;
Hsiao, Tzu‐Lin;
Olszewski, Kellen L;
Llinás, Manuel;
Vitkup, Dennis

Publication type:

Article

The natural function of the malaria parasite's chloroquine resistance transporter.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17781-6

By:

Shafik, Sarah H.;
Cobbold, Simon A.;
Barkat, Kawthar;
Richards, Sashika N.;
Lancaster, Nicole S.;
Llinás, Manuel;
Hogg, Simon J.;
Summers, Robert L.;
McConville, Malcolm J.;
Martin, Rowena E.

Publication type:

Article

Dissecting the role of PfAP2-G in malaria gametocytogenesis.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15026-0

By:

Josling, Gabrielle A.;
Russell, Timothy J.;
Venezia, Jarrett;
Orchard, Lindsey;
van Biljon, Riëtte;
Painter, Heather J.;
Llinás, Manuel

Publication type:

Article

H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum.

Published in:

Epigenetics & Chromatin, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13072-021-00393-9

By:

Connacher, Jessica;
Josling, Gabrielle A.;
Orchard, Lindsey M.;
Reader, Janette;
Llinás, Manuel;
Birkholtz, Lyn-Marié

Publication type:

Article

Targeting NAD+ Metabolism in the Human Malaria Parasite Plasmodium falciparum.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0094061

By:

O'Hara, Jessica K.;
Kerwin, Lewis J.;
Cobbold, Simon A.;
Tai, Jonathan;
Bedell, Thomas A.;
Reider, Paul J.;
Llinás, Manuel

Publication type:

Article

Comment on 'Emerging Functions of Transcription Factors in Malaria Parasite'.

Published in:

2012

By:

Painter, Heather J.;
Llinás, Manuel

Publication type:

Journal Article

Comment on "Emerging Functions of Transcription Factors in Malaria Parasite".

Published in:

2012

By:

Painter, Heather J.;
Llinás, Manuel

Publication type:

Letter

A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium.

Published in:

Nature, 2014, v. 507, n. 7491, p. 253, doi. 10.1038/nature12970

By:

Sinha, Abhinav;
Hughes, Katie R.;
Modrzynska, Katarzyna K.;
Otto, Thomas D.;
Pfander, Claudia;
Dickens, Nicholas J.;
Religa, Agnieszka A.;
Bushell, Ellen;
Graham, Anne L.;
Cameron, Rachael;
Kafsack, Bjorn F. C.;
Williams, April E.;
Llinás, Manuel;
Berriman, Matthew;
Billker, Oliver;
Waters, Andrew P.

Publication type:

Article

A transcriptional switch underlies commitment to sexual development in malaria parasites.

Published in:

Nature, 2014, v. 507, n. 7491, p. 248, doi. 10.1038/nature12920

By:

Kafsack, Björn F. C.;
Rovira-Graells, Núria;
Clark, Taane G.;
Bancells, Cristina;
Crowley, Valerie M.;
Campino, Susana G.;
Williams, April E.;
Drought, Laura G.;
Kwiatkowski, Dominic P.;
Baker, David A.;
Cortés, Alfred;
Llinás, Manuel

Publication type:

Article

Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Published in:

Nature, 2013, v. 497, n. 7451, p. 652, doi. 10.1038/nature12164

By:

Olszewski, Kellen L.;
Mather, Michael W.;
Morrisey, Joanne M.;
Garcia, Benjamin A.;
Vaidya, Akhil B.;
Rabinowitz, Joshua D.;
Llinás, Manuel

Publication type:

Article

Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Published in:

2011

By:

Olszewski, Kellen L.;
Mather, Michael W.;
Morrisey, Joanne M.;
Garcia, Benjamin A.;
Vaidya, Akhil B.;
Rabinowitz, Joshua D.;
Llinás, Manuel

Publication type:

Correction Notice

Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Published in:

Nature, 2010, v. 466, n. 7307, p. 774, doi. 10.1038/nature09301

By:

Olszewski, Kellen L.;
Mather, Michael W.;
Morrisey, Joanne M.;
Garcia, Benjamin A.;
Vaidya, Akhil B.;
Rabinowitz, Joshua D.;
Llinás, Manuel

Publication type:

Article

Cripowellins Pause Plasmodium falciparum Intraerythrocytic Development at the Ring Stage.

Published in:

Molecules, 2023, v. 28, n. 6, p. 2600, doi. 10.3390/molecules28062600

By:

Butler, Joshua H.;
Painter, Heather J.;
Bremers, Emily K.;
Krai, Priscilla;
Llinás, Manuel;
Cassera, Maria B.

Publication type:

Article

Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite.

Published in:

Scientific Reports, 2016, p. 19722, doi. 10.1038/srep19722

By:

Cobbold, Simon A.;
Santos, Joana M.;
Ochoa, Alejandro;
Perlman, David H.;
Llinás, Manuel

Publication type:

Article

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.

Published in:

Scientific Reports, 2015, p. 14552, doi. 10.1038/srep14552

By:

Pulcini, Serena;
Staines, Henry M.;
Lee, Andrew H.;
Shafik, Sarah H.;
Bouyer, Guillaume;
Moore, Catherine M.;
Daley, Daniel A.;
Hoke, Matthew J.;
Altenhofen, Lindsey M.;
Painter, Heather J.;
Mu, Jianbing;
Ferguson, David J. P.;
Llinás, Manuel;
Martin, Rowena E.;
Fidock, David A.;
Cooper, Roland A.;
Krishna, Sanjeev

Publication type:

Article