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Golexanolone reduces glial activation in the striatum and improves non-motor and some motor alterations in a rat model of Parkinson's disease.
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- Frontiers in Aging Neuroscience, 2024, p. 1, doi. 10.3389/fnagi.2024.1417938
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- Article
Preface for the Vicente Felipo Honorary Issue of Neurochemical Research.
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- Neurochemical Research, 2024, v. 49, n. 6, p. 1421, doi. 10.1007/s11064-024-04139-3
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- Article
Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats.
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- Biological Research, 2024, v. 57, n. 1, p. 1, doi. 10.1186/s40659-024-00504-2
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- Article
Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mechanisms and therapeutic implications.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1358323
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- Article
Golexanolone improves fatigue, motor incoordination and gait and memory in rats with bile duct ligation.
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- Liver International, 2024, v. 44, n. 2, p. 433, doi. 10.1111/liv.15782
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- Article
Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 24, p. 17251, doi. 10.3390/ijms242417251
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- Article
Patients who died with steatohepatitis or liver cirrhosis show neuroinflammation and neuronal loss in hippocampus.
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- European Journal of Neurology, 2023, v. 30, n. 10, p. 3032, doi. 10.1111/ene.15935
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- Article
Golexanolone, a GABA<sub>A</sub> receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation.
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- CNS Neuroscience & Therapeutics, 2022, v. 28, n. 11, p. 1861, doi. 10.1111/cns.13926
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- Article
Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11770, doi. 10.3390/ijms231911770
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- Article
Rifaximin Improves Spatial Learning and Memory Impairment in Rats with Liver Damage-Associated Neuroinflammation.
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- Biomedicines, 2022, v. 10, n. 6, p. 1263, doi. 10.3390/biomedicines10061263
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- Article
Hyperammonemia Enhances GABAergic Neurotransmission in Hippocampus: Underlying Mechanisms and Modulation by Extracellular cGMP.
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- Molecular Neurobiology, 2022, v. 59, n. 6, p. 3431, doi. 10.1007/s12035-022-02803-9
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- Article
The S1PR2‐CCL2‐BDNF‐TrkB pathway mediates neuroinflammation and motor incoordination in hyperammonaemia.
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- Neuropathology & Applied Neurobiology, 2022, v. 48, n. 4, p. 1, doi. 10.1111/nan.12799
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- Article
Potential Neuroprotective Role of Sugammadex: A Clinical Study on Cognitive Function Assessment in an Enhanced Recovery After Cardiac Surgery Approach and an Experimental Study.
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- Frontiers in Cellular Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fncel.2022.789796
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- Article
Rifaximin Prevents T-Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats with Mild Liver Damage.
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- Biomedicines, 2021, v. 9, n. 8, p. 1002, doi. 10.3390/biomedicines9081002
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- Article
The Dual Role of the GABA A Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 13, p. 6772, doi. 10.3390/ijms22136772
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- Article
A multi-omic study for uncovering molecular mechanisms associated with hyperammonemia-induced cerebellar function impairment in rats.
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- Cell Biology & Toxicology, 2021, v. 37, n. 1, p. 129, doi. 10.1007/s10565-020-09572-y
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- Article
Hyperammonemia alters the mismatch negativity in the auditory evoked potential by altering functional connectivity and neurotransmission.
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- Journal of Neurochemistry, 2020, v. 154, n. 1, p. 56, doi. 10.1111/jnc.14941
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- Article
Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway.
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- 2020
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- Publication type:
- journal article
Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications.
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- Acta Physiologica, 2019, v. 226, n. 2, p. N.PAG, doi. 10.1111/apha.13270
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- Article
Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors.
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- Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00132
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- Article
Inhibition of γ-Secretase Leads to an Increase in Presenilin-1.
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- Molecular Neurobiology, 2018, v. 55, n. 6, p. 5047, doi. 10.1007/s12035-017-0705-1
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- Article
Determination of selected neurotoxic insecticides in small amounts of animal tissue utilizing a newly constructed mini-extractor.
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- Analytical & Bioanalytical Chemistry, 2017, v. 409, n. 25, p. 6015, doi. 10.1007/s00216-017-0533-1
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- Article
Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy.
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- CNS Neuroscience & Therapeutics, 2017, v. 23, n. 5, p. 386, doi. 10.1111/cns.12688
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- Article
Sildenafil Treatment Eliminates Pruritogenesis and Thermal Hyperalgesia in Rats with Portacaval Shunts.
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- Neurochemical Research, 2017, v. 42, n. 3, p. 788, doi. 10.1007/s11064-016-1980-3
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- Article
Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy.
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- Frontiers in Molecular Neuroscience, 2016, v. 9, p. 1, doi. 10.3389/fnmol.2016.00106
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- Article
Extracellular cGMP Modulates Learning Biphasically by Modulating Glycine Receptors, CaMKII and Glutamate-Nitric Oxide-cGMP Pathway.
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- Scientific Reports, 2016, p. 33124, doi. 10.1038/srep33124
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- Article
Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy.
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- 2016
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- Publication type:
- journal article
Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia.
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- 2016
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- journal article
Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane.
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- 2016
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- journal article
Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms.
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- 2015
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- journal article
Cerebral oedema is not responsible for motor or cognitive deficits in rats with hepatic encephalopathy.
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- Liver International, 2014, v. 34, n. 3, p. 379, doi. 10.1111/liv.12258
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- Article
Chronic hyperammonemia, glutamatergic neurotransmission and neurological alterations.
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- Metabolic Brain Disease, 2013, v. 28, n. 2, p. 151, doi. 10.1007/s11011-012-9337-3
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- Article
Exploratory investigation on nitro- and phospho-proteome cerebellum changes in hyperammonemia and hepatic encephalopathy rat models.
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- Metabolic Brain Disease, 2012, v. 27, n. 1, p. 37, doi. 10.1007/s11011-011-9268-4
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- Article
Cerebellum Proteomics Addressing the Cognitive Deficit of Rats Perinatally Exposed to the Food-Relevant Polychlorinated Biphenyl 138.
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- Toxicological Sciences, 2011, v. 123, n. 1, p. 170, doi. 10.1093/toxsci/kfr156
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- Article
Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications.
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- Metabolic Brain Disease, 2010, v. 25, n. 1, p. 39, doi. 10.1007/s11011-010-9184-z
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- Article
Polychlorinated Biphenyls PCB 153 and PCB 126 Impair the Glutamate–Nitric Oxide–cGMP Pathway in Cerebellar Neurons in Culture by Different Mechanisms.
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- Neurotoxicity Research, 2009, v. 16, n. 2, p. 97, doi. 10.1007/s12640-009-9055-8
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- Article
Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy.
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- Metabolic Brain Disease, 2009, v. 24, n. 1, p. 69, doi. 10.1007/s11011-008-9115-4
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- Article
NMDA receptors in hyperammonemia and hepatic encephalopathy.
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- Metabolic Brain Disease, 2007, v. 22, n. 3/4, p. 321, doi. 10.1007/s11011-007-9067-0
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- Article
Chronic liver failure in rats impairs glutamatergic synaptic transmission and long-term potentiation in hippocampus and learning ability.
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- European Journal of Neuroscience, 2007, v. 25, n. 7, p. 2103, doi. 10.1111/j.1460-9568.2007.05444.x
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- Article
Motor activity is modulated via different neuronal circuits in rats with chronic liver failure than in normal rats.
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- European Journal of Neuroscience, 2007, v. 25, n. 7, p. 2112, doi. 10.1111/j.1460-9568.2007.05435.x
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- Article
Prenatal exposure to polybrominated diphenylether 99 enhances the function of the glutamate–nitric oxide–cGMP pathway in brain in vivo and in cultured neurons.
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- European Journal of Neuroscience, 2007, v. 25, n. 2, p. 373, doi. 10.1111/j.1460-9568.2006.05289.x
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- Article
Modulation of NMDA receptors in the cerebellum. 1. Properties of the NMDA receptor that modulate its function.
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- Cerebellum, 2005, v. 4, n. 3, p. 154, doi. 10.1080/14734220510007996
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- Article
Modulation of NMDA receptors in the cerebellum. II. Signaling pathways and physiological modulators regulating NMDA receptor function.
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- Cerebellum, 2005, v. 4, n. 3, p. 162, doi. 10.1080/14734220510008003
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- Article
Modulation of NMDA receptor function by cyclic AMP in cerebellar neurones in culture.
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- Journal of Neurochemistry, 2004, v. 91, n. 3, p. 591, doi. 10.1111/j.1471-4159.2004.02730.x
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- Article
NMDA-induced phosphorylation of the microtubule- associated protein MAP-2 is mediated by activation of nitric oxide synthase and MAP kinase.
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- European Journal of Neuroscience, 2001, v. 13, n. 7, p. 1283, doi. 10.1046/j.0953-816x.2001.01497.x
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- Article
Chronic Exposure to Ammonia Alters Pathways Modulating Phosphorylation of Microtubule-Associated Protein 2 in Cerebellar Neurons in Culture.
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- Journal of Neurochemistry, 1999, v. 73, n. 6, p. 2555, doi. 10.1046/j.1471-4159.1999.0732555.x
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- Article
Prenatal Exposure to Aluminum Reduces Expression of Neuronal Nitric Oxide Synthase and of Soluble Guanylate Cyclase and Impairs Glutamatergic Neurotransmission in Rat Cerebellum.
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- Journal of Neurochemistry, 1999, v. 73, n. 2, p. 712, doi. 10.1046/j.1471-4159.1999.0730712.x
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- Article
Chronic hyperammonemia impairs the glutamate–nitric oxide–cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo.
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- European Journal of Neuroscience, 1998, v. 10, n. 10, p. 3201, doi. 10.1046/j.1460-9568.1998.00329.x
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- Article