Works by Lisa L. Von Moltke

Results: 63

Mechanism of cytochrome P450-3A inhibition by ketoconazole.

Published in:

Journal of Pharmacy & Pharmacology, 2011, v. 63, n. 2, p. 214, doi. 10.1111/j.2042-7158.2010.01202.x

By:

Greenblatt, David J.;
Zhao, Yanli;
Venkatakrishnan, Karthik;
Duan, Su X.;
Harmatz, Jerold S.;
Parent, Sarah J.;
Court, Michael H.;
von Moltke, Lisa L.

Publication type:

Article

Induction of P-glycoprotein expression and activity by ritonavir in bovine brain microvessel endothelial cells.

Published in:

Journal of Pharmacy & Pharmacology, 2007, v. 59, n. 7, p. 947, doi. 10.1211/jpp.59.7.0006

By:

Michael D. Perloff;
Lisa L. von Moltke;
Jeanne M. Fahey;
David J. Greenblatt

Publication type:

Article

Ethanol inhibits in-vitro metabolism of nifedipine, triazolam and testosterone in human liver microsomes.

Published in:

Journal of Pharmacy & Pharmacology, 2004, v. 56, n. 8, p. 963

By:

Kiran C. Patki;
David J. Greenblatt;
Lisa L. von Moltke

Publication type:

Article

Inhibition of human cytochromes P450 by components of Ginkgo biloba.

Published in:

Journal of Pharmacy & Pharmacology, 2004, v. 56, n. 8, p. 1039

By:

Lisa L. von Moltke;
James L. Weemhoff;
Erdal Bedir;
Ikhlas A. Khan;
Jerold S. Harmatz;
Peter Goldman;
David J. Greenblatt

Publication type:

Article

Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats.

Published in:

Journal of Pharmacy & Pharmacology, 2004, v. 56, n. 6, p. 819

By:

Jill S. Warrington;
Michael H. Court;
David J. Greenblatt;
Lisa L. von Moltke

Publication type:

Article

Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats.

Published in:

Journal of Pharmacy & Pharmacology, 2004, v. 56, n. 6, p. 819

By:

Jill S. Warrington;
Michael H. Court;
David J. Greenblatt;
Lisa L. von Moltke

Publication type:

Article

Effect of bupropion on CYP2B6 and CYP3A4 catalytic activity, immunoreactive protein and mRNA levels in primary human hepatocytes: comparison with rifampicin.

Published in:

Journal of Pharmacy & Pharmacology, 2003, v. 55, n. 9, p. 1229

By:

Leah M. Hesse;
Daesety Vishnuvardhan;
Lisa L. Von Moltke;
David J. Greenblatt;
Yumiko Sakai;
Albert P. Li

Publication type:

Article

Predicting interactions between conventional medications and botanical products on the basis of in vitro investigations.

Published in:

Molecular Nutrition & Food Research, 2008, v. 52, n. 7, p. 747, doi. 10.1002/mnfr.200700159

By:

Markowitz, John S.;
von Moltke, Lisa L.;
Donovan, Jennifer L.

Publication type:

Article

Pharmacokinetics, safety and tolerability of mipomersen in healthy Japanese volunteers and comparison with Western subjects.

Published in:

International Journal of Clinical Pharmacology & Therapeutics, 2014, v. 52, n. 4, p. 314, doi. 10.5414/CP201975

By:

Zhaoyang Li;
Hard, Marjie L.;
Andersen, Grit;
Pabst, Günther;
Wagener, Gilbert;
Singh, Tejdip;
Wai Chin;
Culm-Merdek, Kerry;
Boltje, Ingrid;
von Moltke, Lisa L.

Publication type:

Article

Inhibition of Human Cytochrome P450 Isoforms by Nonnucleoside Reverse Transcriptase Inhibitors.

Published in:

Journal of Clinical Pharmacology, 2001, v. 41, n. 1, p. 85, doi. 10.1177/009127000104100i110

By:

von Moltke, Lisa L.;
Greenblatt, David J.;
Granda, Brian W.;
Giancarlo, Gina M.;
Duan, Su Xiang;
Daily, Johanna P.;
Harmatz, Jerold S.;
Shader, Richard I.

Publication type:

Article

Unusually Low Clearance of Two CYP3A Substrates, Alprazolam and Trazodone, in a Volunteer Subject with Wild-Type CYP3A4 Promoter Region.

Published in:

Journal of Clinical Pharmacology, 2000, v. 40, n. 2, p. 200, doi. 10.1177/009127000004000212

By:

von Moltke, Lisa L.;
Tran, Thanh Huu;
Cotreau, Monette M.;
Greenblatt, David J.

Publication type:

Article

Nortriptyline E-10-Hydroxylation in Vitro Is Mediated by Human CYP2D6 (High Affinity) and CYP3A4 (Low Affinity): Implications for Interactions with Enzyme-Inducing Drugs.

Published in:

Journal of Clinical Pharmacology, 1999, v. 39, n. 6, p. 567, doi. 10.1177/009127009903900603

By:

Venkatakrishnan, Karthik;
von Moltke, Lisa L.;
Greenblatt, David J.

Publication type:

Article

A randomized, placebo-controlled study of the pharmacokinetics, pharmacodynamics, and tolerability of the oral JAK2 inhibitor fedratinib ( SAR302503) in healthy volunteers.

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 4, p. 415, doi. 10.1002/jcph.218

By:

Zhang, Meng;
Xu, Christine R.;
Shamiyeh, Elias;
Liu, Feng;
Yin, Jian Y.;
von Moltke, Lisa L.;
Smith, William B.

Publication type:

Article

Gender Has a Small but Statistically Significant Effect on Clearance of CYP3A Substrate Drugs.

Published in:

Journal of Clinical Pharmacology, 2008, v. 48, n. 11, p. 1350, doi. 10.1177/0091270008323754

By:

Greenblatt, David J.;
von Moltke, Lisa L.

Publication type:

Article

Human Pregnane X Receptor: Genetic Polymorphisms, Alternative mRNA Splice Variants, and Cytochrome P450 3A Metabolic Activity.

Published in:

Journal of Clinical Pharmacology, 2006, v. 46, n. 11, p. 1356, doi. 10.1177/0091270006292125

By:

He, Ping;
Court, Michael H.;
Greenblatt, David J.;
von Moltke, Lisa L.

Publication type:

Article

Updates for The Journal of Clinical Pharmacology.

Published in:

Journal of Clinical Pharmacology, 2006, v. 46, n. 7, p. 714, doi. 10.1177/0091270006290856

By:

von Moltke, Lisa L.

Publication type:

Article

Ritonavir Has Minimal Impact on the Pharmacokinetic Disposition of a Single Dose of Bupropion Administered to Human Volunteers.

Published in:

Journal of Clinical Pharmacology, 2006, v. 46, n. 5, p. 567, doi. 10.1177/0091270006286981

By:

Hesse, Leah M.;
Greenblatt, David J.;
von Moltke, Lisa L.;
Court, Michael H.

Publication type:

Article

Ginkgo biloba Does Not Alter Clearance of Flurbiprofen, a Cytochrome P450-2C9 Substrate.

Published in:

Journal of Clinical Pharmacology, 2006, v. 46, n. 2, p. 214, doi. 10.1177/0091270005283465

By:

Greenblatt, David J.;
von Moltke, Lisa L.;
Luo, Yan;
Perloff, Elke S.;
Horan, Kelly A.;
Bruce, Allison;
Reynolds, Robyn C.;
Harmatz, Jerold S.;
Avula, Bharathi;
Khan, Ikhlas A.;
Goldman, Peter

Publication type:

Article

Clinical Pharmacology and Drug Safety.

Published in:

Journal of Clinical Pharmacology, 2005, v. 45, n. 4, p. 370, doi. 10.1177/0091270005275480

By:

von Moltke, Lisa L.

Publication type:

Article

A Few Thoughts From the New Editor.

Published in:

Journal of Clinical Pharmacology, 2005, v. 45, n. 2, p. 126, doi. 10.1177/0091270004273509

By:

von Moltke, Lisa L.

Publication type:

Article

Interaction of Warfarin With Drugs, Natural Substances, and Foods.

Published in:

Journal of Clinical Pharmacology, 2005, v. 45, n. 2, p. 127, doi. 10.1177/0091270004271404

By:

Greenblatt, David J.;
von Moltke, Lisa L.

Publication type:

Article

From the Editors.

Published in:

Journal of Clinical Pharmacology, 2004, v. 44, n. 7, p. 679

By:

Deborah L. Keefe;
Lisa L. von Moltke

Publication type:

Article

Short-Term Exposure to Low-Dose Ritonavir Impairs Clearance and Enhances Adverse Effects of Trazodone.

Published in:

Journal of Clinical Pharmacology, 2003, v. 43, n. 4, p. 414

By:

David J. Greenblatt;
Lisa L. von Moltke;
Jerold S. Harmatz;
Steven M. Fogelman;
Gengsheng Chen;
Jennifer A. Graf;
Polyxane Mertzanis;
Susan Byron;
Kerry E. Culm;
Brian W. Granda;
Johanna P. Daily;
Richard I. Shader

Publication type:

Article

Fexofenadine Transport in Caco-2 Cells: Inhibition with Verapamil and Ritonavir.

Published in:

Journal of Clinical Pharmacology, 2002, v. 42, n. 11, p. 1269, doi. 10.1177/0091270002238770

By:

Perloff, Michael D.;
von Moltke, Lisa L.;
Greenblatt, David J.

Publication type:

Article

Zolpidem Pharmacokinetic Properties in Young Females: Influence of Smoking and Oral Contraceptive Use.

Published in:

Journal of Clinical Pharmacology, 2002, v. 42, n. 10, p. 1142, doi. 10.1177/009127002237988

By:

Olubodun, Joel O.;
Ochs, Hermann R.;
Trüten, Volker;
Klein, Arno;
von Moltke, Lisa L.;
Harmatz, Jerold S.;
Shader, Richard I.;
Greenblatt, David J.

Publication type:

Article

Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro Models.

Published in:

Journal of Clinical Pharmacology, 2001, v. 41, n. 11, p. 1149, doi. 10.1177/009127000104101101

By:

Venkatakrishnan, Karthik;
von Moltke, Lisa L.;
Greenblatt, David J.

Publication type:

Article

Relative Contribution of CYP3A to Amitriptyline Clearance in Humans: in Vitro and in Vivo Studies.

Published in:

Journal of Clinical Pharmacology, 2001, v. 41, n. 10, p. 1043, doi. 10.1177/009127000104101001

By:

Venkatakrishnan, Karthik;
Schmider, Jürgen;
Harmatz, Jerold S.;
Ehrenberg, Bruce L.;
von Moltke, Lisa L.;
Graf, Jennifer A.;
Mertzanis, Polyxane;
Corbett, Kathleen E.;
Rodriguez, Molly C.;
Shader, Richard I.;
Greenblatt, David J.

Publication type:

Article

P-glycoprotein Interactions of Nefazodone and Trazodone in Cell Culture.

Published in:

Journal of Clinical Pharmacology, 2001, v. 41, n. 7, p. 708, doi. 10.1177/009127000104100702

By:

Störmer, Elke;
von Moltke, Lisa L.;
Perloff, Michael D.;
Greenblatt, David J.

Publication type:

Article

Clinically Important Drug Interactions with Zopiclone, Zolpidem and Zaleplon.

Published in:

CNS Drugs, 2003, v. 17, n. 7, p. 513, doi. 10.2165/00023210-200317070-00004

By:

Hesse, Leah M.;
von Moltke, Lisa L.;
Greenblatt, David J.

Publication type:

Article

Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: Comparison with ritonavir*.

Published in:

Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 3, p. 243, doi. 10.1016/j.clpt.2005.11.009

By:

Culm-Merdek, Kerry E.;
von Moltke, Lisa L.;
Lu Gan;
Horan, Kelly A.;
Reynolds, Robyn;
Harmatz, Jerold S.;
Court, Michael H.;
Greenblatt, David J.

Publication type:

Article

Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: In vitro and clinical studies*.

Published in:

Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 1, p. 125, doi. 10.1016/j.clpt.2005.09.014

By:

Greenblatt, David J.;
von Moltke, Lisa L.;
Perloff, Elke Störmer;
Yan Luo;
Harmatz, Jerold S.;
Zinny, Miguel A.

Publication type:

Article

Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo.

Published in:

Clinical Pharmacology & Therapeutics, 2005, v. 77, n. 5, p. 373

By:

Ping He;
Court, Michael H.;
Greenblatt, David J.;
von Moltke, Lisa L.

Publication type:

Article

Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate*.

Published in:

Clinical Pharmacology & Therapeutics, 2004, v. 76, n. 5, p. 467, doi. 10.1016/j.clpt.2004.07.009

By:

Greenblatt, David J.;
Harmatz, Jerold S.;
von Moltke, Lisa L.;
Wright, C. Eugene;
Shader, Richard I.

Publication type:

Article

Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice*.

Published in:

Clinical Pharmacology & Therapeutics, 2003, v. 74, n. 2, p. 121, doi. 10.1016/S0009-9236(03)00118-8

By:

Greenblatt, David J.;
von Moltke, Lisa L.;
Harmatz, Jerold S.;
Chen, Gengsheng;
Weemhoff, James L.;
Jen, Cheng;
Kelley, Charles J.;
LeDuc, Barbara W.;
Zinny, Miguel A.

Publication type:

Article

Alprazolam-ritonavir interaction: Implications for product labeling*.

Published in:

Clinical Pharmacology & Therapeutics, 2000, v. 67, n. 4, p. 335, doi. 10.1067/mcp.2000.105757

By:

Greenblatt, David J.;
von Moltke, Lisa L.;
Harmatz, Jerold S.;
Durol, Anna Liza B.;
Daily, Johanna P.;
Graf, Jennifer A.;
Mertzanis, Polyxane;
Hoffman, Jonathan L.;
Shader, Richard I.

Publication type:

Article

Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: Effect of ketoconazole*.

Published in:

Clinical Pharmacology & Therapeutics, 1999, v. 66, n. 5, p. 461, doi. 10.1016/S0009-9236(99)70009-3

By:

Tsunoda, Shirley M.;
Velez, Rebecca L.;
von Moltke, Lisa L.;
Greenblatt, David J.

Publication type:

Article

The substrate-independence assumption of the relative activity factor (RAF) approach.

Published in:

Clinical Pharmacology & Therapeutics, 1999, v. 65, n. 2, p. 121, doi. 10.1016/S0009-9236(99)80016-2

By:

Venkatakrishnan, Karthik;
Von Moltke, Lisa L.;
Greenblatt, David J.

Publication type:

Article

Kinetic and dynamic interaction study of zolpidem with ketoconazole, itraconazole, and fluconazole*.

Published in:

Clinical Pharmacology & Therapeutics, 1998, v. 64, n. 6, p. 661, doi. 10.1016/S0009-9236(98)90057-1

By:

Greenblatt, David J.;
von Moltke, Lisa L.;
Harmatz, Jerold S.;
Mertzanis, Polyxane;
Graf, Jennifer A.;
Durol, Anna Liza B.;
Counihan, Molly;
Roth-Schechter, Barbara;
Shader, Richard I.

Publication type:

Article

Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo*.

Published in:

Clinical Pharmacology & Therapeutics, 1998, v. 64, n. 5, p. 553, doi. 10.1016/S0009-9236(98)90139-4

By:

Greenblatt, David J.;
Harmatz, Jerold S.;
von Moltke, Lisa L.;
Ehrenberg, Bruce L.;
Harrel, Lisa;
Corbett, Kate;
Counihan, Molly;
Graf, Jennifer A.;
Darwish, Mona;
Mertzanis, Polyxane;
Martin, Patrick T.;
Cevallos, William H.;
Shader, Richard I.

Publication type:

Article

Ketoconazole inhibition of triazolam and alprazolam clearance: Differential kinetic and dynamic consequences*.

Published in:

Clinical Pharmacology & Therapeutics, 1998, v. 64, n. 3, p. 237, doi. 10.1016/S0009-9236(98)90172-2

By:

Greenblatt, David J.;
Wright, C. Eugene;
von Moltke, Lisa L.;
Harmatz, Jerold S.;
Ehrenberg, Bruce L.;
Harrel, Lisa M.;
Corbett, Kate;
Counihan, Molly;
Tobias, Sara;
Shader, Richard I.

Publication type:

Article

Inhibition of triazolam clearance by macrolide antimicrobial agents: In vitro correlates and dynamic consequences*.

Published in:

Clinical Pharmacology & Therapeutics, 1998, v. 64, n. 3, p. 278, doi. 10.1016/S0009-9236(98)90176-X

By:

Greenblatt, David J.;
von Moltke, Lisa L.;
Harmatz, Jerold S.;
Counihan, Molly;
Graf, Jennifer A.;
Durol, Anna Liza B.;
Mertzanis, Polyxane;
Duan, Su Xiang;
Wright, C. Eugene;
Shader, Richard I.

Publication type:

Article

Molecular and Pharmacokinetic Evaluation of Rat Hepatic and Gastrointestinal Cytochrome P450 Induction by Tamoxifen.

Published in:

Pharmacology, 2001, v. 63, n. 4, p. 210, doi. 10.1159/000056136

By:

Cotreau, Monette M.;
von Moltke, Lisa L.;
Harmatz, Jerold S.;
Greenblatt, David J.

Publication type:

Article

Characterization of Six in vitro Reactions Mediated by Human Cytochrome P450: Application to the Testing of Cytochrome P450-Directed Antibodies.

Published in:

Pharmacology, 1996, v. 52, n. 2, p. 125, doi. 10.1159/000139376

By:

Schmider, Jürgen;
Greenblatt, David J.;
von Moltke, Lisa L.;
Harmatz, Jerold S.;
Duan, Su X.;
Karsov, Dmitry;
Shader, Richard I.

Publication type:

Article

Alprazolam Metabolism in vitro: Studies of Human, Monkey, Mouse, and Rat Liver Microsomes.

Published in:

Pharmacology, 1993, v. 47, n. 4, p. 268, doi. 10.1159/000139107

By:

von Moltke, Lisa L.;
Greenblatt, David J.;
Harmatz, Jerold S.;
Shader, Richard I.

Publication type:

Article

Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 6, p. 2909, doi. 10.1111/bcp.15229

By:

Dijkstra, Francis M.;
Zuiker, Rob G. J. A.;
Siebenga, Pieter S.;
Leigh‐Pemberton, Richard A.;
Sun, Lei;
Manthis, Joan D.;
de Kam, Marieke L.;
Lin, Richard;
von Moltke, Lisa L.;
Rezendes, David;
van Gerven, Joop M. A.

Publication type:

Article

Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics.

Published in:

British Journal of Clinical Pharmacology, 2005, v. 60, n. 5, p. 486, doi. 10.1111/j.1365-2125.2005.02467.x

By:

Culm-Merdek, Kerry E.;
von Moltke, Lisa L.;
Harmatz, Jerold S.;
Greenblatt, David J.

Publication type:

Article

Effect of zolpidem on human Cytochrome P450 activity, and on transport mediated by P-glycoprotein.

Published in:

Biopharmaceutics & Drug Disposition, 2002, v. 23, n. 9, p. 361, doi. 10.1002/bdd.329

By:

von Moltke, Lisa L.;
Weemhoff, James L.;
Perloff, Michael D.;
Hesse, Leah M.;
Harmatz, Jerold S.;
Roth-Schechter, Barbara F.;
Greenblatt, David J.

Publication type:

Article

Evaluation of SupermixTM as an in vitro model of human liver microsomal drug metabolism.

Published in:

Biopharmaceutics & Drug Disposition, 2002, v. 23, n. 5, p. 183, doi. 10.1002/bdd.307

By:

Venkatakrishnan, Karthik;
von Moltke, Lisa L.;
Greenblatt, David J.

Publication type:

Article

Inhibition of human cytochrome P450 isoforms in vitro by zafirlukast.

Published in:

Biopharmaceutics & Drug Disposition, 1999, v. 20, n. 8, p. 385, doi. 10.1002/1099-081X(199911)20:8<385::AID-BDD203>3.0.CO;2-7

By:

Shader, Richard I.;
Granda, Brian W.;
von Moltke, Lisa L.;
Giancarlo, Gina M.;
Greenblatt, David J.

Publication type:

Article

Biotransformation of Chlorzoxazone by Heptatic Microsomes from Humans and Ten Other Mammalian Species.

Published in:

Biopharmaceutics & Drug Disposition, 1997, v. 18, n. 3, p. 213, doi. 10.1002/(SICI)1099-081X(199704)18:3<213::AID-BDD15>3.0.CO;2-0

By:

COURT, MICHAEL H.;
VON MOLTKE, LISA L.;
SHADER, RICHARD I.;
GREENBLATT, DAVID J.

Publication type:

Article