Works by Lingner, Joachim

Results: 50

Oxidative stress at telomeres triggers internal DNA loops, TRF1 dissociation, and TRF2-dependent R-loops Open Access.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 7, p. 1, doi. 10.1093/nar/gkaf285

By:

Nguyen, Trang Thu;
Mazzucco, Giulia;
Kyriacou, Eftychia;
Lunardi, Thomas;
Brandl, Leona;
Ahmed, Wareed;
Doksani, Ylli;
Lingner, Joachim

Publication type:

Article

Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 22, p. 7688, doi. 10.1093/nar/gkm912

By:

Luke, Brian;
Azzalin, Claus M.;
Hug, Nele;
Deplazes, Anna;
Peter, Matthias;
Lingner, Joachim

Publication type:

Article

Protein–RNA and protein–protein interactions mediate association of human EST1A/SMG6 with telomerase.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 20, p. 7011, doi. 10.1093/nar/gkm724

By:

Redon, Sophie;
Reichenbach, Patrick;
Lingner, Joachim

Publication type:

Article

Yeast telomerase is specialized for C/A‐rich RNA templates.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 6, p. 1646, doi. 10.1093/nar/gkg261

By:

Förstemann, Klaus;
Zaug, Arthur J.;
Cech, Thomas R.;
Lingner, Joachim

Publication type:

Article

Detection of promoter activity by flow cytometric analysis of GFP reporter expression.

Published in:

Nucleic Acids Research, 2002, v. 30, n. 14, p. e65, doi. 10.1093/nar/gnf064

By:

Ducrest, Anne‐Lyse;
Amacker, Mario;
Lingner, Joachim;
Nabholz, Markus

Publication type:

Article

Telomerase-dependent repeat divergence at the 3′ ends of yeast telomeres.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 14, p. 2690, doi. 10.1093/nar/28.14.2690

By:

Förstemann, Klaus;
Höss, Matthias;
Lingner, Joachim

Publication type:

Article

CST for the grand finale of telomere replication.

Published in:

Nucleus (1949-1034), 2013, v. 4, n. 4, p. 277, doi. 10.4161/nucl.25701

By:

Chen, Liuh-Yow;
Lingner, Joachim

Publication type:

Article

The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening.

Published in:

EMBO Journal, 2013, v. 32, n. 21, p. 2861, doi. 10.1038/emboj.2013.217

By:

Pfeiffer, Verena;
Crittin, Jérôme;
Grolimund, Larissa;
Lingner, Joachim

Publication type:

Article

TERRA: telomeric repeat-containing RNA.

Published in:

EMBO Journal, 2009, v. 28, n. 17, p. 2503, doi. 10.1038/emboj.2009.166

By:

Luke, Brian;
Lingner, Joachim

Publication type:

Article

Telomere length homeostasis requires that telomerase levels are limiting.

Published in:

EMBO Journal, 2006, v. 25, n. 3, p. 565, doi. 10.1038/sj.emboj.7600952

By:

Cristofari, Gaël;
Lingner, Joachim

Publication type:

Article

Structure of active dimeric human telomerase.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 4, p. 454, doi. 10.1038/nsmb.2530

By:

Sauerwald, Anselm;
Sandin, Sara;
Cristofari, Gaël;
Scheres, Sjors H W;
Lingner, Joachim;
Rhodes, Daniela

Publication type:

Article

The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 8, p. 734, doi. 10.1038/nsmb1126

By:

Eugster, Anne;
Lanzuolo, Chiara;
Bonneton, Manon;
Luciano, Pierre;
Pollice, Alessandra;
Pulitzer, John F;
Stegberg, Emma;
Berthiau, Anne-Sophie;
Förstemann, Klaus;
Corda, Yves;
Lingner, Joachim;
Géli, Vincent;
Gilson, Eric

Publication type:

Article

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.

Published in:

Nature Cell Biology, 2011, v. 13, n. 7, p. 867, doi. 10.1038/ncb2263

By:

Ferreira, Helder C.;
Luke, Brian;
Schober, Heiko;
Kalck, Véronique;
Lingner, Joachim;
Gasser, Susan M.

Publication type:

Article

Challenging endings: How telomeres prevent fragility.

Published in:

BioEssays, 2021, v. 43, n. 10, p. 1, doi. 10.1002/bies.202100157

By:

Glousker, Galina;
Lingner, Joachim

Publication type:

Article

Human shelterin protein POT1 prevents severe telomere instability induced by homology‐directed DNA repair.

Published in:

EMBO Journal, 2020, v. 39, n. 23, p. 1, doi. 10.15252/embj.2020104500

By:

Glousker, Galina;
Briod, Anna‐Sophia;
Quadroni, Manfredo;
Lingner, Joachim

Publication type:

Article

SMCHD1 promotes ATM‐dependent DNA damage signaling and repair of uncapped telomeres.

Published in:

EMBO Journal, 2020, v. 39, n. 7, p. 1, doi. 10.15252/embj.2019102668

By:

Vančevska, Aleksandra;
Ahmed, Wareed;
Pfeiffer, Verena;
Feretzaki, Marianna;
Boulton, Simon J;
Lingner, Joachim

Publication type:

Article

The human CST complex is a terminator of telomerase activity.

Published in:

Nature, 2012, v. 488, n. 7412, p. 540, doi. 10.1038/nature11269

By:

Chen, Liuh-Yow;
Redon, Sophie;
Lingner, Joachim

Publication type:

Article

Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast.

Published in:

EMBO Reports, 2011, v. 12, n. 6, p. 587, doi. 10.1038/embor.2011.73

By:

Iglesias, Nahid;
Redon, Sophie;
Pfeiffer, Verena;
Dees, Martina;
Lingner, Joachim;
Luke, Brian

Publication type:

Article

Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast.

Published in:

EMBO Reports, 2007, v. 8, n. 11, p. 1080, doi. 10.1038/sj.embor.7401082

By:

Arnerić, Milica;
Lingner, Joachim

Publication type:

Article

Telomerase limits the extent of base pairing between template RNA and telomeric DNA.

Published in:

EMBO Reports, 2005, v. 6, n. 4, p. 361, doi. 10.1038/sj.embor.7400374

By:

Förstemann, Klaus;
Lingner, Joachim

Publication type:

Article

Intracellular trafficking of yeast telomerase components.

Published in:

2002

By:

Teixeira, M. Teresa;
Förstemann, Klaus;
Gasser, Susan M.;
Lingner, Joachim

Publication type:

Report

Regulation of the human telomerase reverse transcriptase gene.

Published in:

Oncogene, 2002, v. 21, n. 4, p. 541, doi. 10.1038/sj.onc.1205081

By:

Ducrest, Anne-Lyse;
Szutorisz, Henrietta;
Lingner, Joachim;
Nabholz, Markus

Publication type:

Article

Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas.

Published in:

Oncogene, 2001, v. 20, n. 20, p. 2600, doi. 10.1038/sj.onc.1204346

By:

Szutorisz, Henrietta;
Palmqvist, Richard;
Roos, Göran;
Stenling, Roger;
Schorderet, Daniel F;
Reddel, Roger;
Lingner, Joachim;
Nabholz, Markus

Publication type:

Article

Direct activation of TERT transcription by c-MYC.

Published in:

Nature Genetics, 1999, v. 21, n. 2, p. 220, doi. 10.1038/6010

By:

Wu, Kou-Juey;
Grandori, Carla;
Amacker, Mario;
Simon-Vermot, Nathalie;
Polack, Axel;
Lingner, Joachim;
Dalla-Favera, Riccardo

Publication type:

Article

Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools.

Published in:

Genetics, 2013, v. 193, n. 4, p. 1095, doi. 10.1534/genetics.112.149120

By:

Gupta, Amitabha;
Sharma, Sushma;
Reichenbach, Patrick;
Marjavaara, Lisette;
Nilsson, Anna Karin;
Lingner, Joachim;
Chabes, Andrei;
Rothstein, Rodney;
Chang, Michael

Publication type:

Article

Telomerase Is Essential to Alleviate Pif1-Induced Replication Stress at Telomeres.

Published in:

Genetics, 2009, v. 183, n. 3, p. 779, doi. 10.1534/genetics.109.107631

By:

Chang, Michael;
Luke, Brian;
Kraft, Claudine;
Zhijian Li;
Peter, Matthias;
Lingner, Joachim;
Rothstein, Rodney

Publication type:

Article

CSL controls telomere maintenance and genome stability in human dermal fibroblasts.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11785-7

By:

Bottoni, Giulia;
Katarkar, Atul;
Tassone, Beatrice;
Ghosh, Soumitra;
Clocchiatti, Andrea;
Goruppi, Sandro;
Bordignon, Pino;
Jafari, Paris;
Tordini, Fabio;
Lunardi, Thomas;
Hoetzenecker, Wolfram;
Neel, Victor;
Lingner, Joachim;
Paolo Dotto, G.

Publication type:

Article

Method for determining RNA 34 ends and application to human telomerase RNA.

Published in:

Nucleic Acids Research, 1996, v. 24, n. 3, p. 532, doi. 10.1093/nar/24.3.532

By:

Zaug, Arthur J.;
Lingner, Joachim;
Cech, Thomas R.

Publication type:

Article

A highly selective telomerase inhibitor limiting human cancer cell proliferation.

Published in:

EMBO Journal, 2001, v. 20, n. 24, p. 6958, doi. 10.1093/emboj/20.24.6958

By:

Damm, Klaus;
Hemmann, Ulrike;
Garin-chesa, Pilar;
Hauel, Norbert;
Kauffmann, Iris;
Priepke, Henning;
Niestroj, Claudia;
Daiber, Christine;
Enenkel, Barbara;
Guilliard, Bernd;
Lauritsch, Ines;
Müller, Elfriede;
Pascolo, Emanuelle;
Sauter, Gabriele;
Pantic, Milena;
Martens, Uwe M.;
Wenz, Christian;
Lingner, Joachim;
Kraut, Norbert;
Rettig, Wolfgang J.

Publication type:

Article

A highly selective telomerase inhibitor limiting human cancer cell proliferation.

Published in:

EMBO Journal, 2001, v. 20, n. 24, p. 6958, doi. 10.1093/emboj/20.24.6958

By:

Damm, Klaus;
Hemmann, Ulrike;
Garin‐Chesa, Pilar;
Hauel, Norbert;
Kauffmann, Iris;
Priepke, Henning;
Niestroj, Claudia;
Daiber, Christine;
Enenkel, Barbara;
Guilliard, Bernd;
Lauritsch, Ines;
Müller, Elfriede;
Pascolo, Emanuelle;
Sauter, Gabriele;
Pantic, Milena;
Martens, Uwe M.;
Wenz, Christian;
Lingner, Joachim;
Kraut, Norbert;
Rettig, Wolfgang J.

Publication type:

Article

Human telomerase contains two cooperating telomerase RNA molecules.

Published in:

EMBO Journal, 2001, v. 20, n. 13, p. 3526, doi. 10.1093/emboj/20.13.3526

By:

Wenz, Christian;
Enenkel, Barbara;
Amacker, Mario;
Kelleher, Colleen;
Damm, Klaus;
Lingner, Joachim

Publication type:

Article

A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 5, p. 2365, doi. 10.3390/ijms22052365

By:

Mentegari, Elisa;
Bertoletti, Federica;
Kissova, Miroslava;
Zucca, Elisa;
Galli, Silvia;
Tagliavini, Giulia;
Garbelli, Anna;
Maffia, Antonio;
Bione, Silvia;
Ferrari, Elena;
d'Adda di Fagagna, Fabrizio;
Francia, Sofia;
Sabbioneda, Simone;
Chen, Liuh-Yow;
Lingner, Joachim;
Bergoglio, Valerie;
Hoffmann, Jean-Sébastien;
Hübscher, Ulrich;
Crespan, Emmanuele;
Maga, Giovanni

Publication type:

Article

human telomeric proteome during telomere replication.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 21, p. 12119, doi. 10.1093/nar/gkab1015

By:

Lin, Chih-Yi Gabriela;
Näger, Anna Christina;
Lunardi, Thomas;
Vančevska, Aleksandra;
Lossaint, Gérald;
Lingner, Joachim

Publication type:

Article

A three-state model for the regulation of telomerase by TERRA and hnRNPA1.

Published in:

Nucleic Acids Research, 2013, v. 41, n. 19, p. 9117, doi. 10.1093/nar/gkt695

By:

Redon, Sophie;
Zemp, Ivo;
Lingner, Joachim

Publication type:

Article

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase.

Published in:

Nucleic Acids Research, 2010, v. 38, n. 17, p. 5797, doi. 10.1093/nar/gkq296

By:

Redon, Sophie;
Reichenbach, Patrick;
Lingner, Joachim

Publication type:

Article

Functional characterization of the TERRA transcriptome at damaged telomeres.

Published in:

Nature Communications, 2014, v. 5, n. 10, p. 1, doi. 10.1038/ncomms6379

By:

Porro, Antonio;
Feuerhahn, Sascha;
Delafontaine, Julien;
Riethman, Harold;
Rougemont, Jacques;
Lingner, Joachim

Publication type:

Article

A quantitative telomeric chromatin isolation protocol identifies different telomeric states.

Published in:

Nature Communications, 2013, v. 4, n. 11, p. 2848, doi. 10.1038/ncomms3848

By:

Grolimund, Larissa;
Aeby, Eric;
Hamelin, Romain;
Armand, Florence;
Chiappe, Diego;
Moniatte, Marc;
Lingner, Joachim

Publication type:

Article

The makings of TERRA R-loops at chromosome ends.

Published in:

Cell Cycle, 2021, v. 20, n. 18, p. 1745, doi. 10.1080/15384101.2021.1962638

By:

Fernandes, Rita Valador;
Feretzaki, Marianna;
Lingner, Joachim

Publication type:

Article

Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from Microcystis aeruguinosa PCC 7806.

Published in:

Chemistry - A European Journal, 2013, v. 19, n. 14, p. 4596, doi. 10.1002/chem.201203296

By:

Makhlouf Brahmi, Malika;
Portmann, Cyril;
D'Ambrosio, Danilo;
Woods, Tom M.;
Banfi, Damiano;
Reichenbach, Patrick;
Da Silva, Laeticia;
Baudat, Emilie;
Turcatti, Gerardo;
Lingner, Joachim;
Gademann, Karl

Publication type:

Article

Molecular biology: Damage control.

Published in:

Nature, 2007, v. 448, n. 7157, p. 1001, doi. 10.1038/4481001a

By:

Azzalin, Claus M.;
Lingner, Joachim

Publication type:

Article

TERRA Promotes Telomere Shortening through Exonuclease 1--Mediated Resection of Chromosome Ends.

Published in:

PLoS Genetics, 2012, v. 8, n. 6, p. 1, doi. 10.1371/journal.pgen.1002747

By:

Pfeiffer, Verena;
Lingner, Joachim

Publication type:

Article

The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase<sup>+</sup> cells and telomeric recombination in ALT<sup>+</sup> cells.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 13, p. 6702, doi. 10.1093/nar/gkad448

By:

Fernandes, Rita Valador;
Lingner, Joachim

Publication type:

Article

TERRA biogenesis, turnover and implications for function

Published in:

FEBS Letters, 2010, v. 584, n. 17, p. 3812, doi. 10.1016/j.febslet.2010.07.032

By:

Feuerhahn, Sascha;
Iglesias, Nahid;
Panza, Andrea;
Porro, Antonio;
Lingner, Joachim

Publication type:

Article

Molecular Dissection of Telomeric Repeat-Containing RNA Biogenesis Unveils the Presence of Distinct and Multiple Regulatory Pathways.

Published in:

Molecular & Cellular Biology, 2010, v. 30, n. 20, p. 5, doi. 10.1128/MCB.00460-10

By:

Porro, Antonio;
Feuerhahn, Sascha;
Reichenbach, Patrick;
Lingner, Joachim

Publication type:

Article

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo.

Published in:

Molecular & Cellular Biology, 2010, v. 30, n. 12, p. 11, doi. 10.1128/MCB.00240-10

By:

Abreu, Eladio;
Aritonovska, Elena;
Reichenbach, Patrick;
Cristofari, Gaël;
Culp, Brad;
Terns, Rebecca M.;
Lingner, Joachim;
Terns, Michael P.

Publication type:

Article

Human Protection of Telomeres 1 (POT1) Is a Negative Regulator of Telomerase Activity In Vitro.

Published in:

Molecular & Cellular Biology, 2005, v. 25, n. 2, p. 808, doi. 10.1128/MCB.25.2.808-818.2005

By:

Kelleher, Colleen;
Kurth, Isabel;
Lingner, Joachim

Publication type:

Article

Telomeres.

Published in:

Cell Cycle, 2008, v. 7, n. 9, p. 1161, doi. 10.4161/cc.7.9.5836

By:

Azzalin, Claus M.;
Lingner, Joachim

Publication type:

Article

The Double Life of UPF1 in RNA and DNA Stability Pathways.

Published in:

Cell Cycle, 2006, v. 5, n. 14, p. 1496, doi. 10.4161/cc.5.14.3093

By:

Azzalin, Claus M.;
Lingner, Joachim

Publication type:

Article

Interplay of DNA polymerase lambda, Protection of Telomeres (Pot) 1 and TERRA in telomere elongation.

Published in:

FASEB Journal, 2013, v. 27, p. 538.4, doi. 10.1096/fasebj.27.1_supplement.538.4

By:

Maga, Giovanni;
Lingner, Joachim;
Hübscher, Ulrich

Publication type:

Article

Low- to high-throughput analysis of telomerase modulators with Telospot.

Published in:

Nature Methods, 2007, v. 4, n. 10, p. 851, doi. 10.1038/nmeth1099

By:

Cristofari, Gaël;
Reichenbach, Patrick;
Regamey, Pierre-Olivier;
Banfi, Damiano;
Chambon, Marc;
Turcatti, Gerardo;
Lingner, Joachim

Publication type:

Article