Works by Linardopoulos, Spiros

Results: 16

Sensitization of (colon) cancer cells to death receptor related therapies.

Published in:

Cancer Biology & Therapy, 2012, v. 13, n. 7, p. 458, doi. 10.4161/cbt.19600

By:

Pintzas, Alexander;
Zhivotovsky, Boris;
Workman, Paul;
Clarke, Paul A.;
Linardopoulos, Spiros;
Martinou, Jean-Claude;
Lacal, Juan Carlos;
Robine, Sylvie;
Nasioulas, George;
Andera, Ladislav

Publication type:

Article

CCT245718, a dual FLT3/Aurora A inhibitor overcomes D835Y-mediated resistance to FLT3 inhibitors in acute myeloid leukaemia cells.

Published in:

British Journal of Cancer, 2021, v. 125, n. 7, p. 966, doi. 10.1038/s41416-021-01527-2

By:

Tariq, Muhammad Usama;
Furqan, Muhammad;
Parveen, Hira;
Ullah, Rahim;
Muddassar, Muhammad;
Saleem, Rahman Shah Zaib;
Bavetsias, Vassilios;
Linardopoulos, Spiros;
Faisal, Amir

Publication type:

Article

CCT245718, a dual FLT3/Aurora A inhibitor overcomes D835Y-mediated resistance to FLT3 inhibitors in acute myeloid leukaemia cells.

Published in:

2021

By:

Tariq, Muhammad Usama;
Furqan, Muhammad;
Parveen, Hira;
Ullah, Rahim;
Muddassar, Muhammad;
Saleem, Rahman Shah Zaib;
Bavetsias, Vassilios;
Linardopoulos, Spiros;
Faisal, Amir

Publication type:

journal article

RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.

Published in:

British Journal of Cancer, 2017, v. 117, n. 7, p. 954, doi. 10.1038/bjc.2017.277

By:

Dolly, Saoirse O;
Gurden, Mark D;
Drosopoulos, Konstantinos;
Clarke, Paul;
de Bono, Johann;
Kaye, Stan;
Workman, Paul;
Linardopoulos, Spiros

Publication type:

Article

RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.

Published in:

2017

By:

Dolly, Saoirse O;
Gurden, Mark D;
Drosopoulos, Konstantinos;
Clarke, Paul;
de Bono, Johann;
Kaye, Stan;
Workman, Paul;
Linardopoulos, Spiros

Publication type:

journal article

Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03283-z

By:

Patel, Nirmesh;
Weekes, Daniel;
Drosopoulos, Konstantinos;
Gazinska, Patrycja;
Noel, Elodie;
Rashid, Mamun;
Mirza, Hasan;
Quist, Jelmar;
Brasó-Maristany, Fara;
Mathew, Sumi;
Ferro, Riccardo;
Pereira, Ana Mendes;
Prince, Cynthia;
Noor, Farzana;
Francesch-Domenech, Erika;
Marlow, Rebecca;
de Rinaldis, Emanuele;
Grigoriadis, Anita;
Linardopoulos, Spiros;
Marra, Pierfrancesco

Publication type:

Article

Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.

Published in:

EMBO Molecular Medicine, 2010, v. 2, n. 4, p. 130, doi. 10.1002/emmm.201000068

By:

Sourisseau, Tony;
Maniotis, Despina;
McCarthy, Afshan;
Tang, Chan;
Lord, Christopher J.;
Ashworth, Alan;
Linardopoulos, Spiros

Publication type:

Article

Allele-specific loss or imbalance of chromosomes 9, 15, and 16 in B-cell tumors from interspecific F1 hybrid mice carrying eμ-c- myc or N- myc transgenes.

Published in:

International Journal of Cancer, 2000, v. 88, n. 6, p. 920, doi. 10.1002/1097-0215(20001215)88:6<920::AID-IJC13>3.0.CO;2-#

By:

Linardopoulos, Spiros;
Silva, Santiago;
Klein, George;
Balmain, Allan

Publication type:

Article

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human.

Published in:

Nature Genetics, 2003, v. 34, n. 4, p. 403, doi. 10.1038/ng1220

By:

Ewart-Toland, Amanda;
Briassouli, Paraskevi;
de Koning, John P.;
Jian-Hua Mao;
Jinwei Yuan;
Chan, Florence;
MacCarthy-Morrogh, Lucy;
Ponder, Bruce A.J.;
Nagase, Hiroki;
Burn, John;
Ball, Sarah;
Almeida, Maria;
Linardopoulos, Spiros;
Balmain, Allan

Publication type:

Article

Inhibition of Bromodomain Proteins Enhances Oncolytic HAdVC5 Replication and Efficacy in Pancreatic Ductal Adenocarcinoma (PDAC) Models.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 2, p. 1265, doi. 10.3390/ijms25021265

By:

Miao, Tizong;
Symonds, Alistair;
Hickman, Oliver J.;
Wu, Dongsheng;
Wang, Ping;
Lemoine, Nick;
Wang, Yaohe;
Linardopoulos, Spiros;
Halldén, Gunnel

Publication type:

Article

Aurora B expression directly correlates with prostate cancer malignancy and influence prostate cell proliferation.

Published in:

Prostate, 2006, v. 66, n. 3, p. 326, doi. 10.1002/pros.20345

By:

Paolo Chieffi;
Laura Cozzolino;
Annamaria Kisslinger;
Silvana Libertini;
Stefania Staibano;
Gelsomina Mansueto;
Gaetano De Rosa;
Antonia Villacci;
Mario Vitale;
Spiros Linardopoulos;
Giuseppe Portella;
Donatella Tramontano

Publication type:

Article

APC/C is an essential regulator of centrosome clustering.

Published in:

Nature Communications, 2014, v. 5, n. 4, p. 3686, doi. 10.1038/ncomms4686

By:

Drosopoulos, Konstantinos;
Tang, Chan;
Chao, William C. H.;
Linardopoulos, Spiros

Publication type:

Article

The N-terminal domain of the Aurora-A Phe-31 variant encodes an E3 ubiquitin ligase and mediates ubiquitination of IκBα.

Published in:

Human Molecular Genetics, 2006, v. 15, n. 22, p. 3343, doi. 10.1093/hmg/ddl410

By:

Briassouli, Paraskevi;
Chan, Florence;
Linardopoulos, Spiros

Publication type:

Article

New therapeutic perspectives in CCDC6 deficient lung cancer cells.

Published in:

International Journal of Cancer, 2015, v. 136, n. 9, p. 2146, doi. 10.1002/ijc.29263

By:

Morra, Francesco;
Luise, Chiara;
Visconti, Roberta;
Staibano, Stefania;
Merolla, Francesco;
Ilardi, Gennaro;
Guggino, Gianluca;
Paladino, Simona;
Sarnataro, Daniela;
Franco, Renato;
Monaco, Roberto;
Zitomarino, Federica;
Pacelli, Roberto;
Monaco, Guglielmo;
Rocco, Gaetano;
Cerrato, Aniello;
Linardopoulos, Spiros;
Muller, Mark T.;
Celetti, Angela

Publication type:

Article

Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation.

Published in:

2005

By:

Sorrentino, Rosanna;
Libertini, Silvana;
Pallante, Pier Lorenzo;
Troncone, Giancarlo;
Palombini, Lucio;
Bavetsias, Vassilios;
Spalletti-Cernia, Daniela;
Laccetti, Paolo;
Linardopoulos, Spiros;
Chieffi, Paolo;
Fusco, Alfredo;
Portella, Giuseppe

Publication type:

journal article

The Cyclin-Dependent Kinase Inhibitor Seliciclib (R-roscovitine; CYC202) Decreases the Expression of Mitotic Control Genes and Prevents Entry into Mitosis.

Published in:

Cell Cycle, 2007, v. 6, n. 24, p. 3114, doi. 10.4161/cc.6.24.5142

By:

Whittaker, Steven R.;
Te Poele, Robert H.;
Chan, Florence;
Linardopoulos, Spiros;
Walton, Michael I.;
Garrett, Michelle D.;
Workman, Paul

Publication type:

Article