Works matching AU Lim, Elaine T.

Results: 19
    1

    Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC.

    Published in:
    Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59596-3
    By:
    • Liu, Songlei;
    • Li, Li;
    • Zhang, Fan;
    • Garcia-Corral, Mariana;
    • Meyer, Katharina;
    • Fortuna, Patrick R. J.;
    • van Sambeek, Björn;
    • Appleton, Evan;
    • Ng, Alex H. M.;
    • Khoshakhlagh, Parastoo;
    • Lu, Yuancheng Ryan;
    • Cameron, James;
    • Ramirez, Ricardo N.;
    • Chen, Yuting;
    • Wu, Chun-Ting;
    • Huang, Jeremy Y.;
    • Tan, Yuqi;
    • Chao, George;
    • Aach, John;
    • Lim, Elaine T.
    Publication type:
    Article
    2

    Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder.

    Published in:
    Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30968-3
    By:
    • Lim, Elaine T.;
    • Chan, Yingleong;
    • Dawes, Pepper;
    • Guo, Xiaoge;
    • Erdin, Serkan;
    • Tai, Derek J. C.;
    • Liu, Songlei;
    • Reichert, Julia M.;
    • Burns, Mannix J.;
    • Chan, Ying Kai;
    • Chiang, Jessica J.;
    • Meyer, Katharina;
    • Zhang, Xiaochang;
    • Walsh, Christopher A.;
    • Yankner, Bruce A.;
    • Raychaudhuri, Soumya;
    • Hirschhorn, Joel N.;
    • Gusella, James F.;
    • Talkowski, Michael E.;
    • Church, George M.
    Publication type:
    Article
    3

    Mutational spectrum and phenotypic variability of Duchenne muscular dystrophy and related disorders in a Bangladeshi population.

    Published in:
    Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-48982-w
    By:
    • Sarker, Shaoli;
    • Eshaque, Tamannyat Binte;
    • Soorajkumar, Anjana;
    • Nassir, Nasna;
    • Zehra, Binte;
    • Kanta, Shayla Imam;
    • Rahaman, Md Atikur;
    • Islam, Amirul;
    • Akter, Shimu;
    • Ali, Mohammad Kawsar;
    • Mim, Rabeya Akter;
    • Uddin, K. M. Furkan;
    • Chowdhury, Mohammod Shah Jahan;
    • Shams, Nusrat;
    • Baqui, Md. Abdul;
    • Lim, Elaine T.;
    • Akter, Hosneara;
    • Woodbury-Smith, Marc;
    • Uddin, Mohammed
    Publication type:
    Article
    4

    Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus 10398A>G.

    Published in:
    Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-37541-y
    By:
    • Smullen, Molly;
    • Olson, Meagan N.;
    • Murray, Liam F.;
    • Suresh, Madhusoodhanan;
    • Yan, Guang;
    • Dawes, Pepper;
    • Barton, Nathaniel J.;
    • Mason, Jivanna N.;
    • Zhang, Yucheng;
    • Fernandez-Fontaine, Aria A.;
    • Church, George M.;
    • Mastroeni, Diego;
    • Wang, Qi;
    • Lim, Elaine T.;
    • Chan, Yingleong;
    • Readhead, Benjamin
    Publication type:
    Article
    5

    Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses.

    Published in:
    Science Translational Medicine, 2021, v. 13, n. 580, p. 1, doi. 10.1126/scitranslmed.abd3438
    By:
    • Chan, Ying Kai;
    • Wang, Sean K.;
    • Chu, Colin J.;
    • Copland, David A.;
    • Letizia, Alexander J.;
    • Costa Verdera, Helena;
    • Chiang, Jessica J.;
    • Sethi, Meher;
    • Wang, May K.;
    • Neidermyer, William J.;
    • Chan, Yingleong;
    • Lim, Elaine T.;
    • Graveline, Amanda R.;
    • Sanchez, Melinda;
    • Boyd, Ryan F.;
    • Vihtelic, Thomas S.;
    • Inciong, Rolando Gian Carlo O.;
    • Slain, Jared M.;
    • Alphonse, Priscilla J.;
    • Xue, Yunlu
    Publication type:
    Article
    6

    A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity.

    Published in:
    Annals of Neurology, 2015, v. 78, n. 1, p. 115, doi. 10.1002/ana.24429
    By:
    • Esposito, Federica;
    • Sorosina, Melissa;
    • Ottoboni, Linda;
    • Lim, Elaine T.;
    • Replogle, Joseph M.;
    • Raj, Towfique;
    • Brambilla, Paola;
    • Liberatore, Giuseppe;
    • Guaschino, Clara;
    • Romeo, Marzia;
    • Pertel, Thomas;
    • Stankiewicz, James M.;
    • Martinelli, Vittorio;
    • Rodegher, Mariaemma;
    • Weiner, Howard L.;
    • Brassat, David;
    • Benoist, Christophe;
    • Patsopoulos, Nikolaos A.;
    • Comi, Giancarlo;
    • Elyaman, Wassim
    Publication type:
    Article
    7

    Single‐cell spatial and non‐spatial RNA sequencing on herpes simplex virus 1 (HSV‐1) infected 2D and 3D cerebral organoids reveal molecular granularity on virus‐human gene interactions in Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.092866
    By:
    • Dawes, Pepper;
    • Barton, Nathaniel J;
    • Orszulak, Adrian R;
    • Chigas, Samantha M;
    • Tran, Khanh;
    • Sundstrom, Jonathan;
    • Olson, Meagan N;
    • Murray, Liam F;
    • Oh, HyungSuk;
    • Church, George M;
    • Knipe, David M;
    • Readhead, Benjamin;
    • Chan, Yingleong;
    • Lim, Elaine T
    Publication type:
    Article
    8

    Transcriptomics‐based investigation of herpes simplex virus 1 infections and acyclovir treatment in human cerebral organoids.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082321
    By:
    • Orszulak, Adrian R;
    • Chigas, Samantha M;
    • Tran, Khanh;
    • Dawes, Pepper;
    • Olson, Meagan N;
    • Murray, Liam F;
    • Barton, Nathaniel J;
    • Aylward, Aimee J;
    • Wang, Qi;
    • Oh, HyungSuk;
    • Church, George M;
    • Young‐Pearse, Tracy;
    • Knipe, David M;
    • Readhead, Benjamin;
    • Chan, Yingleong;
    • Lim, Elaine T
    Publication type:
    Article
    9
    10

    Whole exome sequencing uncovered highly penetrant recessive mutations for a spectrum of rare genetic pediatric diseases in Bangladesh.

    Published in:
    NPJ Genomic Medicine, 2021, v. 6, n. 1, p. 1, doi. 10.1038/s41525-021-00173-0
    By:
    • Akter, Hosneara;
    • Hossain, Mohammad Shahnoor;
    • Dity, Nushrat Jahan;
    • Rahaman, Md. Atikur;
    • Furkan Uddin, K. M.;
    • Nassir, Nasna;
    • Begum, Ghausia;
    • Hameid, Reem Abdel;
    • Islam, Muhammad Sougatul;
    • Tusty, Tahrima Arman;
    • Basiruzzaman, Mohammad;
    • Sarkar, Shaoli;
    • Islam, Mazharul;
    • Jahan, Sharmin;
    • Lim, Elaine T.;
    • Woodbury-Smith, Marc;
    • Stavropoulos, Dimitri James;
    • O'Rielly, Darren D.;
    • Berdeiv, Bakhrom K.;
    • Nurun Nabi, A. H. M.
    Publication type:
    Article
    11
    12

    Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases.

    Published in:
    Cells (2073-4409), 2024, v. 13, n. 23, p. 1978, doi. 10.3390/cells13231978
    By:
    • Sundstrom, Jonathan;
    • Vanderleeden, Emma;
    • Barton, Nathaniel J.;
    • Redick, Sambra D.;
    • Dawes, Pepper;
    • Murray, Liam F.;
    • Olson, Meagan N.;
    • Tran, Khanh;
    • Chigas, Samantha M.;
    • Orszulak, Adrian R.;
    • Church, George M.;
    • Readhead, Benjamin;
    • Oh, Hyung Suk;
    • Harlan, David M.;
    • Knipe, David M.;
    • Wang, Jennifer P.;
    • Chan, Yingleong;
    • Lim, Elaine T.
    Publication type:
    Article
    13

    Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia.

    Published in:
    Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46695-w
    By:
    • Funes, Salome;
    • Jung, Jonathan;
    • Gadd, Del Hayden;
    • Mosqueda, Michelle;
    • Zhong, Jianjun;
    • Shankaracharya;
    • Unger, Matthew;
    • Stallworth, Karly;
    • Cameron, Debra;
    • Rotunno, Melissa S.;
    • Dawes, Pepper;
    • Fowler-Magaw, Megan;
    • Keagle, Pamela J.;
    • McDonough, Justin A.;
    • Boopathy, Sivakumar;
    • Sena-Esteves, Miguel;
    • Nickerson, Jeffrey A.;
    • Lutz, Cathleen;
    • Skarnes, William C.;
    • Lim, Elaine T.
    Publication type:
    Article
    14
    15
    16

    oFlowSeq: a quantitative approach to identify protein coding mutations affecting cell type enrichment using mosaic CRISPR-Cas9 edited cerebral organoids.

    Published in:
    Human Genetics, 2023, v. 142, n. 8, p. 1281, doi. 10.1007/s00439-023-02534-4
    By:
    • Dawes, Pepper;
    • Murray, Liam F.;
    • Olson, Meagan N.;
    • Barton, Nathaniel J.;
    • Smullen, Molly;
    • Suresh, Madhusoodhanan;
    • Yan, Guang;
    • Zhang, Yucheng;
    • Fernandez-Fontaine, Aria;
    • English, Jay;
    • Uddin, Mohammed;
    • Pak, ChangHui;
    • Church, George M.;
    • Chan, Yingleong;
    • Lim, Elaine T.
    Publication type:
    Article
    17

    Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population.

    Published in:
    PLoS Genetics, 2014, v. 10, n. 7, p. 1, doi. 10.1371/journal.pgen.1004494
    By:
    • Lim, Elaine T.;
    • Würtz, Peter;
    • Havulinna, Aki S.;
    • Palta, Priit;
    • Tukiainen, Taru;
    • Rehnström, Karola;
    • Esko, Tõnu;
    • Mägi, Reedik;
    • Inouye, Michael;
    • Lappalainen, Tuuli;
    • Chan, Yingleong;
    • Salem, Rany M.;
    • Lek, Monkol;
    • Flannick, Jason;
    • Sim, Xueling;
    • Manning, Alisa;
    • Ladenvall, Claes;
    • Bumpstead, Suzannah;
    • Hämäläinen, Eija;
    • Aalto, Kristiina
    Publication type:
    Article
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