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P4‐194: PLASMA NEUROFILAMENT LIGHT CHAIN IS ASSOCIATED WITH THE KYNURENINE PATHWAY METABOLITES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1351, doi. 10.1016/j.jalz.2019.06.3856
By:
- Chatterjee, Pratishtha;
- Goozee, Kathryn;
- Lim, Chai K.;
- Jacobs, Kelly;
- Sohrabi, Hamid;
- Shen, Kaikai;
- Shah, Tejal M.;
- Asih, Prita Riana;
- Dave, Preeti;
- Lovejoy, David;
- Guillemin, Gilles;
- Zetterberg, Henrik;
- Blennow, Kaj;
- Martins, Ralph N.
Publication type:
Article
P2‐283: ELEVATED KYNURENINE AND ANTHRANILIC ACID LEVELS IN ELDERLY FEMALES WITH HIGH NEOCORTICAL AMYLOID‐BETA LOAD.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P789, doi. 10.1016/j.jalz.2018.06.972
By:
- Chatterjee, Pratishtha;
- Goozee, Kathryn;
- Lim, Chai K.;
- James, Ian;
- Shen, Kaikai;
- Heng, Benjamin;
- Jacobs, Kelly;
- Sohrabi, Hamid R.;
- Shah, Tejal M.;
- Asih, Prita Riana;
- Dave, Preeti;
- ManYan, Candice;
- Taddei, Kevin;
- Lovejoy, David;
- Guillemin, Gilles;
- Chung, Roger;
- Martins, Ralph N.
Publication type:
Article
Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms.
Published in:
Neurotoxicity Research, 2019, v. 35, n. 3, p. 530, doi. 10.1007/s12640-019-9997-4
By:
- Castellano-Gonzalez, Gloria;
- Jacobs, Kelly R.;
- Don, Emily;
- Cole, Nicholas J.;
- Adams, Seray;
- Lim, Chai K.;
- Lovejoy, David B.;
- Guillemin, Gilles J.
Publication type:
Article
Neurotoxicity of the Cyanotoxin BMAA Through Axonal Degeneration and Intercellular Spreading.
Published in:
Neurotoxicity Research, 2018, v. 33, n. 1, p. 62, doi. 10.1007/s12640-017-9790-1
By:
- Tan, Vanessa X.;
- Lassus, Benjamin;
- Lim, Chai K.;
- Tixador, Philippe;
- Courte, Josquin;
- Bessede, Alban;
- Guillemin, Gilles J.;
- Peyrin, Jean-Michel
Publication type:
Article
The Kynurenine Pathway of Tryptophan Degradation is Activated During Osteoblastogenesis.
Published in:
Stem Cells, 2015, v. 33, n. 1, p. 111, doi. 10.1002/stem.1836
By:
- Vidal, Christopher;
- Li, Wei;
- Santner-Nanan, Brigitte;
- Lim, Chai K.;
- Guillemin, Gilles J.;
- Ball, Helen J.;
- Hunt, Nicholas H.;
- Nanan, Ralph;
- Duque, Gustavo
Publication type:
Article
Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression.
Published in:
2020
By:
- Sundaram, Gayathri;
- Lim, Chai K.;
- Brew, Bruce J.;
- Guillemin, Gilles J.
Publication type:
journal article
Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer's disease.
Published in:
2019
By:
- Chatterjee, Pratishtha;
- Zetterberg, Henrik;
- Goozee, Kathryn;
- Lim, Chai K.;
- Jacobs, Kelly R.;
- Ashton, Nicholas J.;
- Hye, Abdul;
- Pedrini, Steve;
- Sohrabi, Hamid R.;
- Shah, Tejal;
- Asih, Prita R.;
- Dave, Preeti;
- Shen, Kaikai;
- Taddei, Kevin;
- Lovejoy, David B.;
- Guillemin, Gilles J.;
- Blennow, Kaj;
- Martins, Ralph N.
Publication type:
journal article
Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression.
Published in:
Scientific Reports, 2017, p. 41473, doi. 10.1038/srep41473
By:
- Lim, Chai K.;
- Bilgin, Ayse;
- Lovejoy, David B.;
- Tan, Vanessa;
- Bustamante, Sonia;
- Taylor, Bruce V.;
- Bessede, Alban;
- Brew, Bruce J.;
- Guillemin, Gilles J.
Publication type:
Article
Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity.
Published in:
Autism Research: Official Journal of the International Society for Autism Research, 2016, v. 9, n. 6, p. 621, doi. 10.1002/aur.1565
By:
- Lim, Chai K.;
- Essa, Musthafa M.;
- de Paula Martins, Roberta;
- Lovejoy, David B.;
- Bilgin, Ayse A.;
- Waly, Mostafa I.;
- Al ‐ Farsi, Yahya M.;
- Al ‐ Sharbati, Marwan;
- Al ‐ Shaffae, Mohammed A.;
- Guillemin, Gilles J.
Publication type:
Article
Differential kynurenine pathway metabolism in highly metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression.
Published in:
2020
By:
- Heng, Benjamin;
- Bilgin, Ayse A.;
- Lovejoy, David B.;
- Tan, Vanessa X.;
- Milioli, Heloisa H.;
- Gluch, Laurence;
- Bustamante, Sonia;
- Sabaretnam, Tharani;
- Moscato, Pablo;
- Lim, Chai K.;
- Guillemin, Gilles J.
Publication type:
journal article
Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease.
Published in:
PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0131389
By:
- Jones, Simon P.;
- Franco, Nunzio F.;
- Varney, Bianca;
- Sundaram, Gayathri;
- Brown, David A.;
- de Bie, Josien;
- Lim, Chai K.;
- Guillemin, Gilles J.;
- Brew, Bruce J.
Publication type:
Article
Involvement of the Kynurenine Pathway in Human Glioma Pathophysiology.
Published in:
PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0112945
By:
- Adams, Seray;
- Teo, Charles;
- McDonald, Kerrie L.;
- Zinger, Anna;
- Bustamante, Sonia;
- Lim, Chai K.;
- Sundaram, Gayathri;
- Braidy, Nady;
- Brew, Bruce J.;
- Guillemin, Gilles J.
Publication type:
Article
Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain.
Published in:
PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0059749
By:
- Wu, Wei;
- Nicolazzo, Joseph A.;
- Wen, Li;
- Chung, Roger;
- Stankovic, Roger;
- Bao, Shisan S.;
- Lim, Chai K.;
- Brew, Bruce J.;
- Cullen, Karen M.;
- Guillemin, Gilles J.
Publication type:
Article
A Review of the Evidence for Tryptophan and the Kynurenine Pathway as a Regulator of Stem Cell Niches in Health and Disease.
Published in:
International Journal of Tryptophan Research, 2024, p. 1, doi. 10.1177/11786469241248287
By:
- Summers, Benjamin Sebastian;
- Thomas Broome, Sarah;
- Pang, Tsz Wai Rosita;
- Mundell, Hamish D;
- Koh Belic, Naomi;
- Tom, Nicole C;
- Ng, Mei Li;
- Yap, Maylin;
- Sen, Monokesh K;
- Sedaghat, Sara;
- Weible, Michael W;
- Castorina, Alessandro;
- Lim, Chai K;
- Lovelace, Michael D;
- Brew, Bruce J
Publication type:
Article
Normative Data on Serum and Plasma Tryptophan and Kynurenine Concentrations from 8089 Individuals Across 120 Studies: A Systematic Review and Meta-Analysis.
Published in:
International Journal of Tryptophan Research, 2023, p. 1, doi. 10.1177/11786469231211184
By:
- Metri, Najwa-Joelle;
- Butt, Ali S;
- Murali, Ava;
- Steiner-Lim, Genevieve Z;
- Lim, Chai K
Publication type:
Article
Normative Data on Serum and Plasma Tryptophan and Kynurenine Concentrations from 8089 Individuals Across 120 Studies: A Systematic Review and Meta-Analysis.
Published in:
International Journal of Tryptophan Research, 2023, v. 16, p. 1, doi. 10.1177/11786469231211184
By:
- Metri, Najwa-Joelle;
- Butt, Ali S.;
- Murali, Ava;
- Steiner-Lim, Genevieve Z.;
- Chai K. Lim
Publication type:
Article
Role of NAD<sup>+</sup>, Oxidative Stress, and Tryptophan Metabolism in Autism Spectrum Disorders.
Published in:
International Journal of Tryptophan Research, 2014, n. 6, p. 15, doi. 10.4137/IJTR.S11355
By:
- Mohamed Essa, Musthafa;
- Subash, Selvaraju;
- Braidy, Nady;
- Al-Adawi, Samir;
- Lim, Chai K.;
- Manivasagam, Tamilarasan;
- Guillemin, Gilles J.
Publication type:
Article
Role of NAD + , Oxidative Stress, and Tryptophan Metabolism in Autism Spectrum Disorders.
Published in:
International Journal of Tryptophan Research, 2013, n. 6, p. 1, doi. 10.4137/IJTR.S11355
By:
- Essa, Musthafa Mohamed;
- Subash, Selvaraju;
- Braidy, Nady;
- Al-Adawi, Samir;
- Lim, Chai K;
- Manivasagam, Tamilarasan;
- Guillemin, Gilles J
Publication type:
Article
Characterization of the Kynurenine Pathway in Human Neurons.
Published in:
Journal of Neuroscience, 2007, v. 27, n. 47, p. 12884, doi. 10.1523/JNEUROSCI.4101-07.2007
By:
- Guillemin, Gilles J.;
- Cullen, Karen M.;
- Lim, Chai K.;
- Smythe, George A.;
- Garner, Brett;
- Kapoor, Vimal;
- Takikawa, Osamu;
- Brew, Bruce J.
Publication type:
Article
Connecting inflammation with glutamate agonism in suicidality.
Published in:
Neuropsychopharmacology, 2013, v. 38, n. 5, p. 743, doi. 10.1038/npp.2012.248
By:
- Erhardt, Sophie;
- Lim, Chai K;
- Linderholm, Klas R;
- Janelidze, Shorena;
- Lindqvist, Daniel;
- Samuelsson, Martin;
- Lundberg, Kristina;
- Postolache, Teodor T;
- Träskman-Bendz, Lil;
- Guillemin, Gilles J;
- Brundin, Lena
Publication type:
Article
A brief diet intervention can reduce symptoms of depression in young adults – A randomised controlled trial.
Published in:
PLoS ONE, 2019, v. 14, n. 10, p. 1, doi. 10.1371/journal.pone.0222768
By:
- Francis, Heather M.;
- Stevenson, Richard J.;
- Chambers, Jaime R.;
- Gupta, Dolly;
- Newey, Brooklyn;
- Lim, Chai K.
Publication type:
Article
Eclipse Impact on a Remote Sensing Data Set: PAL NDVI 10-Day Composite from February 11 to 20 in 1999 for Western Australia.
Published in:
Remote Sensing, 2010, v. 2, n. 8, p. 1962, doi. 10.3390/rs2081962
By:
- Lim, Chai K.
Publication type:
Article
Current evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis.
Published in:
Frontiers in Immunology, 2016, p. 1, doi. 10.3389/fmmu.2016.00246
By:
- Lovelace, Michael D.;
- Varney, Bianca;
- Sundaram, Gayathri;
- Franco, Nunzio F.;
- Mei Li Ng;
- Pai, Saparna;
- K. Lim, Chai;
- Guillemin, Gilles J.;
- Brew, Bruce J.
Publication type:
Article
Characterization of the Kynurenine Pathway and Quinolinic Acid Production in Macaque Macrophages.
Published in:
International Journal of Tryptophan Research, 2013, n. 6, p. 7, doi. 10.4137/IJTR.S11789
By:
- Lim, Chai K.;
- Yap, Margaret M. C.;
- Kent, Stephen J.;
- Gras, Gabriel;
- Samah, Boubekeur;
- Batten, Jane C.;
- Rose, Robert De;
- Benjamin Heng;
- Brew, Bruce J.;
- Guillemin, Gilles J.
Publication type:
Article
Understanding the Roles of the Kynurenine Pathway in Multiple Sclerosis Progression.
Published in:
International Journal of Tryptophan Research, 2010, n. 3, p. 157, doi. 10.4137/IJTR.S4294
By:
- Lim, Chai K.;
- Brew, Bruce J.;
- Sundaram, Gayathri;
- Guillemin, Gilles J.
Publication type:
Article
A randomized, double‐blind, placebo‐controlled, parallel‐group 12‐week pilot phase II trial of SaiLuoTong (SLT) for cognitive function in older adults with mild cognitive impairment.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2023, v. 9, n. 4, p. 1, doi. 10.1002/trc2.12420
By:
- Steiner‐Lim, Genevieve Z.;
- Bensoussan, Alan;
- Andrews‐Marney, Elana R.;
- Al‐Dabbas, Mahmoud A.;
- Cave, Adele E.;
- Chiu, Christine L.;
- Christofides, Katerina;
- De Blasio, Frances M.;
- Dewsbury, Lauren S.;
- Fagan, Naomi L.;
- Fogarty, Jack S.;
- Hattom, Lena C.;
- Hohenberg, Mark I.;
- Jafar, Deyyan;
- Karamacoska, Diana;
- Lim, Chai K.;
- Liu, Jianxun;
- Metri, Najwa‐Joelle;
- Oxenham, D. Vincent;
- Ratajec, Holly
Publication type:
Article
Human regulatory macrophages are potent in suppression of the xenoimmune response via indoleamine-2,3-dioxygenase-involved mechanism(s).
Published in:
Xenotransplantation, 2017, v. 24, n. 5, p. n/a, doi. 10.1111/xen.12326
By:
- Guo, Fei;
- Hu, Min;
- Huang, Dandan;
- Zhao, Yuanfei;
- Heng, Benjamin;
- Guillemin, Gilles;
- Lim, Chai K.;
- Hawthorne, Wayne J.;
- Yi, Shounan
Publication type:
Article
Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.
Published in:
Journal of Neuroinflammation, 2015, v. 12, n. 1, p. 1, doi. 10.1186/s12974-015-0328-2
By:
- Yan, Edwin B.;
- Frugier, Tony;
- Chai K. Lim;
- Benjamin Heng;
- Sundaram, Gayathri;
- May Tan;
- Rosenfeld, Jeffrey V.;
- Walker, David W.;
- Guillemin, Gilles J.;
- Morganti-Kossmann, Maria Cristina
Publication type:
Article
Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.
Published in:
2015
By:
- Yan, Edwin B;
- Frugier, Tony;
- Lim, Chai K;
- Heng, Benjamin;
- Sundaram, Gayathri;
- Tan, May;
- Rosenfeld, Jeffrey V;
- Walker, David W;
- Guillemin, Gilles J;
- Morganti-Kossmann, Maria Cristina
Publication type:
journal article
Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies.
Published in:
Journal of Neuroinflammation, 2014, v. 11, n. 1, p. 114, doi. 10.1186/s12974-014-0204-5
By:
- Sundaram, Gayathri;
- Brew, Bruce J.;
- Jones, Simon P.;
- Adams, Seray;
- Lim, Chai K.;
- Guillemin, Gilles J.
Publication type:
Article
Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model.
Published in:
Molecular Autism, 2018, v. 9, n. 1, p. N.PAG, doi. 10.1186/s13229-018-0239-z
By:
- Haslinger, Denise;
- Waltes, Regina;
- Yousaf, Afsheen;
- Lindlar, Silvia;
- Schneider, Ines;
- Lim, Chai K.;
- Tsai, Meng-Miao;
- Garvalov, Boyan K.;
- Acker-Palmer, Amparo;
- Krezdorn, Nicolas;
- Rotter, Björn;
- Acker, Till;
- Guillemin, Gilles J.;
- Fulda, Simone;
- Freitag, Christine M.;
- Chiocchetti, Andreas G.
Publication type:
Article
Picolinic Acid, a Catabolite of Tryptophan, Has an Anabolic Effect on Bone In Vivo.
Published in:
Journal of Bone & Mineral Research, 2020, v. 35, n. 11, p. 2275, doi. 10.1002/jbmr.4125
By:
- Duque, Gustavo;
- Vidal, Christopher;
- Li, Wei;
- Al Saedi, Ahmed;
- Khalil, Mamdouh;
- Lim, Chai K;
- Myers, Damian E;
- Guillemin, Gilles J
Publication type:
Article
The Cytokines CXCL10 and CCL2 and the Kynurenine Metabolite Anthranilic Acid Accurately Predict Patients at Risk of Developing Dengue With Warning Signs.
Published in:
2022
By:
- Jusof, Felicita Fedelis;
- Lim, Chai K;
- Aziz, Fazidatul Nadhirah;
- Soe, Hui Jen;
- Raju, Chandramathi Samudi;
- Sekaran, Shamala Devi;
- Guillemin, Gilles J
Publication type:
journal article

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