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A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function.
Published in:
Cardiovascular Toxicology, 2012, v. 12, n. 4, p. 298, doi. 10.1007/s12012-012-9169-8
By:
- Kuka, Janis;
- Makrecka, Marina;
- Grinberga, Solveiga;
- Pugovics, Osvalds;
- Liepinsh, Edgars;
- Dambrova, Maija
Publication type:
Article
Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers.
Published in:
Journal of Pharmacy & Pharmacology, 2011, v. 63, n. 9, p. 1195, doi. 10.1111/j.2042-7158.2011.01325.x
By:
- Liepinsh, Edgars;
- Konrade, Ilze;
- Skapare, Elina;
- Pugovics, Osvalds;
- Grinberga, Solveiga;
- Kuka, Janis;
- Kalvinsh, Ivars;
- Dambrova, Maija
Publication type:
Article
Acylcarnitines in health and disease: biomarkers and drug targets.
Published in:
Macedonian Pharmaceutical Bulletin / Makedonsko Farmacevtski Bilten, 2022, v. 68, p. 19, doi. 10.33320/maced.pharm.bull.2022.68.03.006
By:
- Dambrova, Maija;
- Liepinsh, Edgars
Publication type:
Article
Innovative drug discovery projects in the Latvian Institute of Organic Synthesis: from meldonium to new cardioprotective drug methyl-GBB.
Published in:
Macedonian Pharmaceutical Bulletin / Makedonsko Farmacevtski Bilten, 2016, v. 62, p. 533
By:
- Dambrova, Maija;
- Liepinsh, Edgars
Publication type:
Article
Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus.
Published in:
Journal of Physiological Sciences, 2012, v. 62, n. 6, p. 469, doi. 10.1007/s12576-012-0224-9
By:
- Skapare, Elina;
- Konrade, Ilze;
- Liepinsh, Edgars;
- Makrecka, Marina;
- Zvejniece, Liga;
- Svalbe, Baiba;
- Vilskersts, Reinis;
- Dambrova, Maija
Publication type:
Article
Heart-Type Fatty Acid Binding Protein Binds Long-Chain Acylcarnitines and Protects against Lipotoxicity.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5528, doi. 10.3390/ijms24065528
By:
- Zelencova-Gopejenko, Diana;
- Videja, Melita;
- Grandane, Aiga;
- Pudnika-Okinčica, Linda;
- Sipola, Anda;
- Vilks, Karlis;
- Dambrova, Maija;
- Jaudzems, Kristaps;
- Liepinsh, Edgars
Publication type:
Article
Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 1, p. 45, doi. 10.3390/ijms23010045
By:
- Vilskersts, Reinis;
- Kigitovica, Dana;
- Korzh, Stanislava;
- Videja, Melita;
- Vilks, Karlis;
- Cirule, Helena;
- Skride, Andris;
- Makrecka-Kuka, Marina;
- Liepinsh, Edgars;
- Dambrova, Maija
Publication type:
Article
Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 12, p. 6470, doi. 10.3390/ijms22126470
By:
- Vilks, Karlis;
- Videja, Melita;
- Makrecka-Kuka, Marina;
- Katkevics, Martins;
- Sevostjanovs, Eduards;
- Grandane, Aiga;
- Dambrova, Maija;
- Liepinsh, Edgars
Publication type:
Article
Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria.
Published in:
Biochemical Journal, 2016, v. 473, n. 9, p. 1191, doi. 10.1042/BCJ20160164
By:
- Liepinsh, Edgars;
- Makrecka-Kuka, Marina;
- Volska, Kristine;
- Kuka, Janis;
- Makarova, Elina;
- Antone, Unigunde;
- Sevostjanovs, Eduards;
- Vilskersts, Reinis;
- Strods, Arnis;
- Tars, Kaspars;
- Dambrova, Maija
Publication type:
Article
Excretion of the Polymyxin Derivative NAB739 in Murine Urine.
Published in:
Antibiotics (2079-6382), 2020, v. 9, n. 4, p. 143, doi. 10.3390/antibiotics9040143
By:
- Vaara, Martti;
- Vaara, Timo;
- Kuka, Janis;
- Sevostjanovs, Eduards;
- Grinberga, Solveiga;
- Dambrova, Maija;
- Liepinsh, Edgars
Publication type:
Article
Rats with congenital hydronephrosis show increased susceptibility to renal ischemia‐reperfusion injury.
Published in:
Physiological Reports, 2020, v. 8, n. 22, p. 1, doi. 10.14814/phy2.14638
By:
- Vilskersts, Reinis;
- Vilks, Karlis;
- Videja, Melita;
- Cirule, Helena;
- Zharkova‐Malkova, Olga;
- Sevostjanovs, Eduards;
- Dambrova, Maija;
- Liepinsh, Edgars
Publication type:
Article
Low‐intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults.
Published in:
Physiological Reports, 2020, v. 8, n. 12, p. 1, doi. 10.14814/phy2.14489
By:
- Liepinsh, Edgars;
- Makarova, Elina;
- Plakane, Liga;
- Konrade, Ilze;
- Liepins, Kaspars;
- Videja, Melita;
- Sevostjanovs, Eduards;
- Grinberga, Solveiga;
- Makrecka‐Kuka, Marina;
- Dambrova, Maija
Publication type:
Article
Knockout of Tmlhe in mice is not associated with autism spectrum disorder phenotypes or motor dysfunction despite low carnitine levels.
Published in:
Molecular Autism, 2023, v. 14, n. 1, p. 1, doi. 10.1186/s13229-023-00560-7
By:
- Liepinsh, Edgars;
- Svalbe, Baiba;
- Stelfa, Gundega;
- Grinberga, Solveiga;
- Zvejniece, Liga;
- Schiöth, Helgi B.;
- Dambrova, Maija
Publication type:
Article
Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats.
Published in:
Oxidative Medicine & Cellular Longevity, 2021, p. 1, doi. 10.1155/2021/7493190
By:
- Kuka, Janis;
- Makrecka-Kuka, Marina;
- Vilks, Karlis;
- Korzh, Stanislava;
- Cirule, Helena;
- Sevostjanovs, Eduards;
- Grinberga, Solveiga;
- Dambrova, Maija;
- Liepinsh, Edgars
Publication type:
Article
Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity.
Published in:
Frontiers in Endocrinology, 2019, v. 10, p. 1, doi. 10.3389/fendo.2019.00870
By:
- Makarova, Elina;
- Makrecka-Kuka, Marina;
- Vilks, Karlis;
- Volska, Kristine;
- Sevostjanovs, Eduards;
- Grinberga, Solveiga;
- Zarkova-Malkova, Olga;
- Dambrova, Maija;
- Liepinsh, Edgars
Publication type:
Article
Mildronate, a Regulator of Energy Metabolism, Reduces Atherosclerosis in apoE/LDLR Mice.
Published in:
Pharmacology, 2009, v. 83, n. 5, p. 287, doi. 10.1159/000210015
By:
- Vilskersts, Reinis;
- Liepinsh, Edgars;
- Mateuszuk, Lukasz;
- Grinberga, Solveiga;
- Kalvinsh, Ivars;
- Chlopicki, Stefan;
- Dambrova, Maija
Publication type:
Article
Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion.
Published in:
Naunyn-Schmiedeberg's Archives of Pharmacology, 2013, v. 386, n. 6, p. 541, doi. 10.1007/s00210-013-0849-0
By:
- Liepinsh, Edgars;
- Skapare, Elina;
- Kuka, Janis;
- Makrecka, Marina;
- Cirule, Helena;
- Vavers, Edijs;
- Sevostjanovs, Eduards;
- Grinberga, Solveiga;
- Pugovics, Osvalds;
- Dambrova, Maija
Publication type:
Article
The methylester of γ-butyrobetaine, but not γ-butyrobetaine itself, induces muscarinic receptor-dependent vasodilatation.
Published in:
Naunyn-Schmiedeberg's Archives of Pharmacology, 2004, v. 369, n. 5, p. 533, doi. 10.1007/s00210-004-0925-6
By:
- Dambrova, Maija;
- Chlopicki, Stefan;
- Liepinsh, Edgars;
- Kirjanova, Olga;
- Gorshkova, Olga;
- Kozlovski, Valery I.;
- Uhlen, Staffan;
- Liepina, Inta;
- Petrovska, Ramona;
- Kalvinsh, Ivars
Publication type:
Article
Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia.
Published in:
Journal of Cellular & Molecular Medicine, 2020, v. 24, n. 20, p. 11903, doi. 10.1111/jcmm.15809
By:
- Makrecka‐Kuka, Marina;
- Korzh, Stanislava;
- Videja, Melita;
- Vilskersts, Reinis;
- Sevostjanovs, Eduards;
- Zharkova‐Malkova, Olga;
- Arsenyan, Pavel;
- Kuka, Janis;
- Dambrova, Maija;
- Liepinsh, Edgars
Publication type:
Article
Cardiac metabolism as a driver and therapeutic target of myocardial infarction.
Published in:
Journal of Cellular & Molecular Medicine, 2020, v. 24, n. 11, p. 5937, doi. 10.1111/jcmm.15180
By:
- Zuurbier, Coert J.;
- Bertrand, Luc;
- Beauloye, Christoph R.;
- Andreadou, Ioanna;
- Ruiz‐Meana, Marisol;
- Jespersen, Nichlas R.;
- Kula‐Alwar, Duvaraka;
- Prag, Hiran A.;
- Eric Botker, Hans;
- Dambrova, Maija;
- Montessuit, Christophe;
- Kaambre, Tuuli;
- Liepinsh, Edgars;
- Brookes, Paul S.;
- Krieg, Thomas
Publication type:
Article
Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.
Published in:
Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 4, p. 1063, doi. 10.1002/cpt.2104
By:
- Sou, Tomás;
- Hansen, Jon;
- Liepinsh, Edgars;
- Backlund, Maria;
- Ercan, Onur;
- Grinberga, Solveiga;
- Cao, Sha;
- Giachou, Paraskevi;
- Petersson, Anna;
- Tomczak, Magdalena;
- Urbas, Malgorzata;
- Zabicka, Dorota;
- Vingsbo Lundberg, Carina;
- Hughes, Diarmaid;
- Hobbie, Sven N.;
- Friberg, Lena E.
Publication type:
Article
Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria.
Published in:
Molecular & Cellular Biochemistry, 2014, v. 395, n. 1/2, p. 1, doi. 10.1007/s11010-014-2106-3
By:
- Makrecka, Marina;
- Kuka, Janis;
- Volska, Kristine;
- Antone, Unigunde;
- Sevostjanovs, Eduards;
- Cirule, Helena;
- Grinberga, Solveiga;
- Pugovics, Osvalds;
- Dambrova, Maija;
- Liepinsh, Edgars
Publication type:
Article
Determination of trimethylamine- N-oxide in combination with l-carnitine and γ-butyrobetaine in human plasma by UPLC/MS/MS.
Published in:
Biomedical Chromatography, 2015, v. 29, n. 11, p. 1670, doi. 10.1002/bmc.3477
By:
- Grinberga, Solveiga;
- Dambrova, Maija;
- Latkovskis, Gustavs;
- Strele, Ieva;
- Konrade, Ilze;
- Hartmane, Dace;
- Sevostjanovs, Eduards;
- Liepinsh, Edgars;
- Pugovics, Osvalds
Publication type:
Article
Quantitative analysis of phenibut in rat brain tissue extracts by liquid chromatography-tandem mass spectrometry.
Published in:
Biomedical Chromatography, 2008, v. 22, n. 12, p. 1321, doi. 10.1002/bmc.1059
By:
- Grinberga, Solveiga;
- Zvejniece, Liga;
- Liepinsh, Edgars;
- Dambrova, Maija;
- Pugovics, Osvalds
Publication type:
Article
Effects of Long-Term Mildronate Treatment on Cardiac and Liver Functions in Rats.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2009, v. 105, n. 6, p. 387, doi. 10.1111/j.1742-7843.2009.00461.x
By:
- Liepinsh, Edgars;
- Kuka, Janis;
- Svalbe, Baiba;
- Vilskersts, Reinis;
- Skapare, Elina;
- Cirule, Helena;
- Pugovics, Osvalds;
- Kalvinsh, Ivars;
- Dambrova, Maija
Publication type:
Article
Functional Evaluation of THIQ, a Melanocortin 4 Receptor Agonist, in Models of Food Intake and Inflammation.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2007, v. 101, n. 6, p. 416, doi. 10.1111/j.1742-7843.2007.00133.x
By:
- Muceniece, Ruta;
- Zvejniece, Liga;
- Vilskersts, Reinis;
- Liepinsh, Edgars;
- Baumane, Larisa;
- Kalvinsh, Ivars;
- Wikberg, Jarl E.;
- Dambrova, Maija
Publication type:
Article
Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-71470-4
By:
- Kuka, Janis;
- Videja, Melita;
- Makrecka-Kuka, Marina;
- Liepins, Janis;
- Grinberga, Solveiga;
- Sevostjanovs, Eduards;
- Vilks, Karlis;
- Liepinsh, Edgars;
- Dambrova, Maija
Publication type:
Article
Off‐target effects of statins: molecular mechanisms, side effects and the emerging role of kinases.
Published in:
British Journal of Pharmacology, 2024, v. 181, n. 20, p. 3799, doi. 10.1111/bph.17309
By:
- Lagunas‐Rangel, Francisco Alejandro;
- Liepinsh, Edgars;
- Fredriksson, Robert;
- Alsehli, Ahmed M.;
- Williams, Michael J.;
- Dambrova, Maija;
- Jönsson, Jörgen;
- Schiöth, Helgi B.
Publication type:
Article
Hydroxymethylglutaryl‐CoA reductase activity is essential for mitochondrial β‐oxidation of fatty acids to prevent lethal accumulation of long‐chain acylcarnitines in the mouse liver.
Published in:
British Journal of Pharmacology, 2024, v. 181, n. 16, p. 2750, doi. 10.1111/bph.16363
By:
- Liepinsh, Edgars;
- Zvejniece, Liga;
- Clemensson, Laura;
- Ozola, Melita;
- Vavers, Edijs;
- Cirule, Helena;
- Korzh, Stanislava;
- Skuja, Sandra;
- Groma, Valerija;
- Briviba, Monta;
- Grinberga, Solveiga;
- Liu, Wen;
- Olszewski, Paweł;
- Gentreau, Mélissa;
- Fredriksson, Robert;
- Dambrova, Maija;
- Schiöth, Helgi B.
Publication type:
Article
Altered mitochondrial metabolism in the insulin‐resistant heart.
Published in:
Acta Physiologica, 2020, v. 228, n. 3, p. 1, doi. 10.1111/apha.13430
By:
- Makrecka‐Kuka, Marina;
- Liepinsh, Edgars;
- Murray, Andrew J.;
- Lemieux, Hélène;
- Dambrova, Maija;
- Tepp, Kersti;
- Puurand, Marju;
- Käämbre, Tuuli;
- Han, Woo H.;
- de Goede, Paul;
- O'Brien, Katie A.;
- Turan, Belma;
- Tuncay, Erkan;
- Olgar, Yusuf;
- Rolo, Anabela P.;
- Palmeira, Carlos M.;
- Boardman, Neoma T.;
- Wüst, Rob C. I.;
- Larsen, Terje S.
Publication type:
Article
Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload.
Published in:
Cardiovascular Drugs & Therapy, 2020, v. 34, n. 6, p. 791, doi. 10.1007/s10557-020-06989-9
By:
- Makrecka-Kuka, Marina;
- Korzh, Stanislava;
- Videja, Melita;
- Vilks, Karlis;
- Cirule, Helena;
- Kuka, Janis;
- Dambrova, Maija;
- Liepinsh, Edgars
Publication type:
Article
The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine.
Published in:
Journal of Cardiovascular Pharmacology & Therapeutics, 2012, v. 17, n. 2, p. 215, doi. 10.1177/1074248411419502
By:
- Kuka, Janis;
- Vilskersts, Reinis;
- Cirule, Helena;
- Makrecka, Marina;
- Pugovics, Osvalds;
- Kalvinsh, Ivars;
- Dambrova, Maija;
- Liepinsh, Edgars
Publication type:
Article
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.
Published in:
2009
By:
- Liepinsh, Edgars;
- Vilskersts, Reinis;
- Zvejniece, Liga;
- Svalbe, Baiba;
- Skapare, Elina;
- Kuka, Janis;
- Cirule, Helena;
- Grinberga, Solveiga;
- Kalvinsh, Ivars;
- Dambrova, Maija
Publication type:
journal article
Seasonal Iodine Deficiency in Latvian School Children.
Published in:
Thyroid, 2012, v. 22, n. 10, p. 1088, doi. 10.1089/thy.2011.0506
By:
- Konrade, Ilze;
- Dambrova, Maija;
- Makrecka, Marina;
- Neimane, Lolita;
- Strele, Ieva;
- Liepinsh, Edgars;
- Lejnieks, Aivars;
- Vevere, Parsla;
- Gruntmanis, Ugis;
- Pirags, Valdis
Publication type:
Article
Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling.
Published in:
Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.941822
By:
- Papatheodorou, Ioanna;
- Makrecka-Kuka, Marina;
- Kuka, Janis;
- Liepinsh, Edgars;
- Dambrova, Maija;
- Lazou, Antigone
Publication type:
Article
Letter to the Editor: "Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris".
Published in:
2018
By:
- Liepinsh, Edgars;
- Dambrova, Maija
Publication type:
Letter
Flow cytometric analysis of glyoxalase-1 expression in human leukocytes.
Published in:
Cell Biochemistry & Function, 2011, v. 29, n. 2, p. 171, doi. 10.1002/cbf.1723
By:
- Skapare, Elina;
- Riekstina, Una;
- Liepinsh, Edgars;
- Konrade, Ilze;
- Makrecka, Marina;
- Maurina, Baiba;
- Dambrova, Maija
Publication type:
Article
Innovative Approach to Enhance Bioavailability of Birch Bark Extracts: Novel Method of Oleogel Development Contrasted with Other Dispersed Systems.
Published in:
Plants (2223-7747), 2024, v. 13, n. 1, p. 145, doi. 10.3390/plants13010145
By:
- Andze, Laura;
- Vitolina, Sanita;
- Berzins, Rudolfs;
- Rizikovs, Janis;
- Godina, Daniela;
- Teresko, Arturs;
- Grinberga, Solveiga;
- Sevostjanovs, Eduards;
- Cirule, Helena;
- Liepinsh, Edgars;
- Paze, Aigars
Publication type:
Article
Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl- GBB.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2017, v. 121, n. 2, p. 106, doi. 10.1111/bcpt.12775
By:
- Kuka, Janis;
- Makrecka‐Kuka, Marina;
- Cirule, Helena;
- Grinberga, Solveiga;
- Sevostjanovs, Eduards;
- Dambrova, Maija;
- Liepinsh, Edgars
Publication type:
Article
Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium due to Competition for OCTN2-mediated Transport.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2017, v. 120, n. 5, p. 450, doi. 10.1111/bcpt.12729
By:
- Liepinsh, Edgars;
- Makarova, Elina;
- Sevostjanovs, Eduards;
- Hartmane, Dace;
- Cirule, Helena;
- Zharkova‐Malkova, Olga;
- Grinberga, Solveiga;
- Dambrova, Maija
Publication type:
Article
Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice.
Published in:
Biofactors, 2017, v. 43, n. 5, p. 718, doi. 10.1002/biof.1378
By:
- Liepinsh, Edgars;
- Makrecka-Kuka, Marina;
- Makarova, Elina;
- Volska, Kristine;
- Vilks, Karlis;
- Sevostjanovs, Eduards;
- Antone, Unigunde;
- Kuka, Janis;
- Vilskersts, Reinis;
- Lola, Daina;
- Loza, Einars;
- Grinberga, Solveiga;
- Dambrova, Maija
Publication type:
Article
Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers.
Published in:
Nutrients, 2022, v. 14, n. 5, p. N.PAG, doi. 10.3390/nu14051093
By:
- Videja, Melita;
- Sevostjanovs, Eduards;
- Upmale-Engela, Sabine;
- Liepinsh, Edgars;
- Konrade, Ilze;
- Dambrova, Maija
Publication type:
Article

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