Works by Lewinsohn, Deborah A.

Results: 33

Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists.

Published in:

PLoS Pathogens, 2025, v. 21, n. 7, p. 1, doi. 10.1371/journal.ppat.1012632

By:

Chengalroyen, Melissa D.;
Oketade, Nurudeen;
Worley, Aneta;
Lucas, Megan;
Ramirez, Luisa Maria Nieto;
Raphela, Mabule L.;
Swarbrick, Gwendolyn M.;
Soma, Paul S.;
Zuma, Mandisa;
Warner, Digby F.;
Lewinsohn, Deborah A.;
Mehaffy, Carolina;
Adams, Erin J.;
Hildebrand, William;
Dobos, Karen M.;
Mizrahi, Valerie;
Lewinsohn, David M.

Publication type:

Article

Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.

Published in:

2019

By:

Keshavjee, Salmaan;
Amanullah, Farhana;
Cattamanchi, Adithya;
Chaisson, Richard;
Dobos, Karen M;
Fox, Gregory J;
Gendelman, Howard E;
Gordon, Richard;
Hesseling, Anneke;
Le Van, Hoi;
Kampmann, Beate;
Kana, Bavesh;
Khuller, Gopal;
Lewinsohn, David M;
Lewinsohn, Deborah A;
Lin, Philiana Ling;
Lu, Lenette Lin;
Maartens, Gary;
Owen, Andrew;
Protopopova, Marina

Publication type:

journal article

Clonal enrichments of Vδ2- γδ T cells in Mycobacterium tuberculosis-infected human lungs.

Published in:

2020

By:

Kulicke, Corinna A.;
Lewinsohn, Deborah A.;
Lewinsohn, David M.

Publication type:

journal article

Clonal enrichments of Vδ2- γδ T cells in Mycobacterium tuberculosis-infected human lungs.

Published in:

Journal of Clinical Investigation, 2020, v. 130, n. 1, p. 68, doi. 10.1172/JCI133119

By:

Kulicke, Corinna A.;
Lewinsohn, Deborah A.;
Lewinsohn, David M.

Publication type:

Article

Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-26259-y

By:

Jin, Haihong;
Ladd, Nicole A.;
Peev, Andrew M.;
Swarbrick, Gwendolyn M.;
Cansler, Meghan;
Null, Megan;
Boughter, Christopher T.;
McMurtrey, Curtis;
Nilsen, Aaron;
Dobos, Karen M.;
Hildebrand, William H.;
Lewinsohn, Deborah A.;
Adams, Erin J.;
Lewinsohn, David M.;
Harriff, Melanie J.

Publication type:

Article

T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells.

Published in:

PLoS ONE, 2017, v. 12, n. 11, p. 1, doi. 10.1371/journal.pone.0188288

By:

McMurtrey, Curtis;
Harriff, Melanie J.;
Swarbrick, Gwendolyn M.;
Duncan, Amanda;
Cansler, Meghan;
Null, Megan;
Bardet, Wilfried;
Jackson, Kenneth W.;
Lewinsohn, Deborah A.;
Hildebrand, William;
Lewinsohn, David M.

Publication type:

Article

CD8+ T Cells Provide an Immunologic Signature of Tuberculosis in Young Children.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2012, v. 185, n. 2, p. 206, doi. 10.1164/rccm.201107-1355OC

By:

Lancioni, Christina;
Nyendak, Melissa;
Kiguli, Sarah;
Zalwango, Sarah;
Mori, Tomi;
Mayanja-Kizza, Harriet;
Balyejusa, Stephen;
Null, Megan;
Baseke, Joy;
Mulindwa, Deo;
Byrd, Laura;
Swarbrick, Gwendolyn;
Scott, Christine;
Johnson, Denise F.;
Malone, LaShaunda;
Mudido-Musoke, Philipa;
Boom, W. Henry;
Lewinsohn, David M.;
Lewinsohn, Deborah A.

Publication type:

Article

Online Supplement – Extra Detail Regarding Experimental Methods for Mycobacterium tuberculosis–specific CD8+ T Cells Preferentially Recognize Heavily Infected Cells.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2003, v. 168, n. 11, p. 21, doi. 10.1164/rccm.200306-837oc

By:

Lewinsohn, Deborah A.;
Heinzel, Amy S.;
Gardner, James M.;
Liqing Zhu;
Alderson, Mark R.;
Lewinsohn, David M.

Publication type:

Article

Mycobacterium tuberculosis–specific CD8+ T Cells Preferentially Recognize Heavily Infected Cells.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2003, v. 168, n. 11, p. 1346, doi. 10.1164/rccm.200306-837OC

By:

Lewinsohn, Deborah A.;
Heinzel, Amy S.;
Gardner, James M.;
Liqing Zhu;
Alderson, Mark R.;
Lewinsohn, David M.

Publication type:

Article

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children.

Published in:

Clinical Infectious Diseases, 2017, v. 64, n. 2, p. e1, doi. 10.1093/cid/ciw694

By:

Lewinsohn, David M.;
Leonard, Michael K.;
LoBue, Philip A.;
Cohn, David L.;
Daley, Charles L.;
Desmond, Ed;
Keane, Joseph;
Lewinsohn, Deborah A.;
Loeffler, Ann M.;
Mazurek, Gerald H.;
O'Brien, Richard J.;
Pai, Madhukar;
Richeldi, Luca;
Salfinger, Max;
Shinnick, Thomas M.;
Sterling, Timothy R.;
Warshauer, David M.;
Woods, Gail L.

Publication type:

Article

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children.

Published in:

Clinical Infectious Diseases, 2017, v. 64, n. 2, p. 111, doi. 10.1093/cid/ciw778

By:

Lewinsohn, David M.;
Leonard, Michael K.;
LoBue, Philip A.;
Cohn, David L.;
Daley, Charles L.;
Desmond, Ed;
Keane, Joseph;
Lewinsohn, Deborah A.;
Loeffler, Ann M.;
Mazurek, Gerald H.;
O'Brien, Richard J.;
Pai, Madhukar;
Richeldi, Luca;
Salfinger, Max;
Shinnick, Thomas M.;
Sterling, Timothy R.;
Warshauer, David M.;
Woods, Gail L.

Publication type:

Article

In vivo migration and function of transferred HIV-1-specific cytotoxic T cells.

Published in:

Nature Medicine, 1999, v. 5, n. 1, p. 34, doi. 10.1038/4716

By:

Brodie, Scott J.;
Lewinsohn, Deborah A.;
Patterson, Bruce K.;
Jiyamapa, Daniel;
Krieger, John;
Corey, Lawrence;
Greenberg, Philip D.;
Riddell, Stanley R.

Publication type:

Article

The Mycobacterium tuberculosis Phagosome Is a HLA-I Processing Competent Organelle.

Published in:

PLoS Pathogens, 2009, v. 5, n. 4, p. 1, doi. 10.1371/journal.ppat.1000374

By:

Grotzke, Jeff E.;
Harriff, Melanie J.;
Siler, Anne C.;
Nolt, Dawn;
Delepine, Jacob;
Lewinsohn, Deborah A.;
Lewinsohn, David M.

Publication type:

Article

Human Innate Mycobacterium tuberculosis-Reactive αβTCR+ Thymocytes.

Published in:

PLoS Pathogens, 2008, v. 4, n. 2, p. 0001, doi. 10.1371/journal.ppat.0040039

By:

Gold, Marielle C.;
Ehlinger, Heather D.;
Cook, Matthew S.;
Smyk-Pearson, Susan K.;
Wille, Paul T.;
Ungerleider, Ross M.;
Lewinsohn, Deborah A.;
Lewinsohn, David M.

Publication type:

Article

Immunodominant Tuberculosis CD8 Antigens Preferentially Restricted by HLA-B.

Published in:

PLoS Pathogens, 2007, v. 3, n. 9, p. 1240, doi. 10.1371/journal.ppat.0030127

By:

Lewinsohn, Deborah A.;
Winata, Ervina;
Swarbrick, Gwendolyn M.;
Tanner, Katie E.;
Cook, Matthew S.;
Null, Megan D.;
Cansler, Meghan E.;
Sette, Alessandro;
Sidney, John;
Lewinsohn, David M.

Publication type:

Article

High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells.

Published in:

Immunology, 2015, v. 145, n. 3, p. 443, doi. 10.1111/imm.12461

By:

Sharma, Prabhat K.;
Wong, Emily B.;
Napier, Ruth J.;
Bishai, William R.;
Ndung'u, Thumbi;
Kasprowicz, Victoria O.;
Lewinsohn, Deborah A.;
Lewinsohn, David M.;
Gold, Marielle C.

Publication type:

Article

Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-05912-4

By:

Kulicke, Corinna A.;
Swarbrick, Gwendolyn M.;
Ladd, Nicole A.;
Cansler, Meghan;
Null, Megan;
Worley, Aneta;
Lemon, Chance;
Ahmed, Tania;
Bennett, Joshua;
Lust, Taylor N.;
Heisler, Chelsea M.;
Huber, Megan E.;
Krawic, Jason R.;
Ankley, Laurisa M.;
McBride, Savannah K.;
Tafesse, Fikadu G.;
Olive, Andrew J.;
Hildebrand, William H.;
Lewinsohn, Deborah A.;
Adams, Erin J.

Publication type:

Article

Views of immunology: effector T cells.

Published in:

Immunological Reviews, 2011, v. 240, n. 1, p. 25, doi. 10.1111/j.1600-065X.2010.00997.x

By:

Lewinsohn, Deborah A.;
Gold, Marielle C.;
Lewinsohn, David M.

Publication type:

Article

Functional and Activation Profiles of Mucosal-Associated Invariant T Cells in Patients With Tuberculosis and HIV in a High Endemic Setting.

Published in:

Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2021.648216

By:

Balfour, Avuyonke;
Schutz, Charlotte;
Goliath, Rene;
Wilkinson, Katalin A.;
Sayed, Sumaya;
Sossen, Bianca;
Kanyik, Jean-Paul;
Ward, Amy;
Ndzhukule, Rhandzu;
Gela, Anele;
Lewinsohn, David M.;
Lewinsohn, Deborah A.;
Meintjes, Graeme;
Shey, Muki

Publication type:

Article

Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans.

Published in:

Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.556695

By:

Swarbrick, Gwendolyn M.;
Gela, Anele;
Cansler, Meghan E.;
Null, Megan D.;
Duncan, Rowan B.;
Nemes, Elisa;
Shey, Muki;
Nsereko, Mary;
Mayanja-Kizza, Harriet;
Kiguli, Sarah;
Koh, Jeffrey;
Hanekom, Willem A.;
Hatherill, Mark;
Lancioni, Christina;
Lewinsohn, David M.;
Scriba, Thomas J.;
Lewinsohn, Deborah A.

Publication type:

Article

Comprehensive definition of human immunodominant CD8 antigens in tuberculosis.

Published in:

NPJ Vaccines, 2017, v. 2, n. 1, p. N.PAG, doi. 10.1038/s41541-017-0008-6

By:

Lewinsohn, Deborah A.;
Swarbrick, Gwendolyn M.;
Park, Byung;
Cansler, Meghan E.;
Null, Megan D.;
Toren, Katelynne G.;
Baseke, Joy;
Zalwango, Sarah;
Mayanja-Kizza, Harriet;
Malone, LaShaunda L.;
Nyendak, Melissa;
Wu, Guanming;
Guinn, Kristi;
McWeeney, Shannon;
Mori, Tomi;
Chervenak, Keith A.;
Sherman, David R.;
Boom, W. Henry;
Lewinsohn, David M.

Publication type:

Article

MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage.

Published in:

Science Immunology, 2018, v. 3, n. 25, p. 1, doi. 10.1126/sciimmunol.aao2556

By:

Harriff, Melanie J.;
McMurtrey, Curtis;
Froyd, Cara A.;
Haihong Jin;
Cansler, Meghan;
Null, Megan;
Worley, Aneta;
Meermeier, Erin W.;
Swarbrick, Gwendolyn;
Nilsen, Aaron;
Lewinsohn, Deborah A.;
Hildebrand, William;
Adams, Erin J.;
Lewinsohn, David M.

Publication type:

Article

Polyfunctional CD4+ T Cells As Targets for Tuberculosis vaccination.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01262

By:

Lewinsohn, Deborah A.;
Lewinsohn, David M.;
Scriba, Thomas J.

Publication type:

Article

Childhood Tuberculosis in Northern Viet Nam: A Review of 103 Cases.

Published in:

PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0097267

By:

Blount, Robert J.;
Tran, Bao;
Jarlsberg, Leah G.;
Phan, Ha;
Thanh Hoang, Van;
Nguyen, Nhung Viet;
Lewinsohn, Deborah A.;
Nahid, Payam

Publication type:

Article

Mycobacterium tuberculosis Specific CD8+ T Cells Rapidly Decline with Antituberculosis Treatment.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0081564

By:

Nyendak, Melissa R.;
Park, Byung;
Null, Megan D.;
Baseke, Joy;
Swarbrick, Gwendolyn;
Mayanja-Kizza, Harriet;
Nsereko, Mary;
Johnson, Denise F.;
Gitta, Phineas;
Okwera, Alphonse;
Goldberg, Stefan;
Bozeman, Lorna;
Johnson, John L.;
Boom, W. Henry;
Lewinsohn, Deborah A.;
Lewinsohn, David M.

Publication type:

Article

TAP Mediates Import of Mycobacterium tuberculosis-Derived Peptides into Phagosomes and Facilitates Loading onto HLA-I.

Published in:

PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0079571

By:

Harriff, Melanie J.;
Burgdorf, Sven;
Kurts, Christian;
Wiertz, Emmanuel J. H. J.;
Lewinsohn, Deborah A.;
Lewinsohn, David M.

Publication type:

Article

Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library.

Published in:

PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0067016

By:

Lewinsohn, David M.;
Swarbrick, Gwendolyn M.;
Cansler, Meghan E.;
Null, Megan D.;
Rajaraman, Veena;
Frieder, Marisa M.;
Sherman, David R.;
McWeeney, Shannon;
Lewinsohn, Deborah A.

Publication type:

Article

Whole Blood Interferon-Gamma Responses to Mycobacterium tuberculosis Antigens in Young Household Contacts of Persons with Tuberculosis in Uganda.

Published in:

PLoS ONE, 2008, v. 3, n. 10, p. 1, doi. 10.1371/journal.pone.0003407

By:

Lewinsohn, Deborah A.;
Zalwango, Sarah;
Stein, Catherine M.;
Mayanja-Kizza, Harriet;
Okwera, Alphonse;
Boom, W. Henry;
Mugerwa, Roy D.;
Whalen, Christopher C.

Publication type:

Article

Production of Proinflammatory Cytokines by CD4+ and CD8+ T Cells in Response to Mycobacterial Antigens among Children and Adults with Tuberculosis.

Published in:

Pathogens, 2023, v. 12, n. 11, p. 1353, doi. 10.3390/pathogens12111353

By:

Morrow, Erin;
Liu, Qijia;
Kiguli, Sarah;
Swarbrick, Gwendolyn;
Nsereko, Mary;
Null, Megan D.;
Cansler, Meghan;
Mayanja-Kizza, Harriet;
Boom, W. Henry;
Chheng, Phalkun;
Nyendak, Melissa R.;
Lewinsohn, David M.;
Lewinsohn, Deborah A.;
Lancioni, Christina L.

Publication type:

Article

Evaluation of Tuberculosis Diagnostics in Children: 2. Methodological Issues for Conducting and Reporting Research Evaluations of Tuberculosis Diagnostics for Intrathoracic Tuberculosis in Children. Consensus From an Expert Panela.

Published in:

Journal of Infectious Diseases, 2012, v. 205, n. suppl_2, p. S209, doi. 10.1093/infdis/jir879

By:

Cuevas, Luis E.;
Browning, Renee;
Bossuyt, Patrick;
Casenghi, Martina;
Cotton, Mark F.;
Cruz, Andrea T.;
Dodd, Lori E.;
Drobniewski, Francis;
Gale, Marianne;
Graham, Stephen M.;
Grzemska, Malgosia;
Heinrich, Norbert;
Hesseling, Anneke C.;
Huebner, Robin;
Jean-Philippe, Patrick;
Kabra, Sushil Kumar;
Kampmann, Beate;
Lewinsohn, Deborah;
Li, Meijuan;
Lienhardt, Christian

Publication type:

Article

Evaluation of tuberculosis diagnostics in children: 2. Methodological issues for conducting and reporting research evaluations of tuberculosis diagnostics for intrathoracic tuberculosis in children. Consensus from an expert panel.

Published in:

2012

By:

Cuevas, Luis E;
Browning, Renee;
Bossuyt, Patrick;
Casenghi, Martina;
Cotton, Mark F;
Cruz, Andrea T;
Dodd, Lori E;
Drobniewski, Francis;
Gale, Marianne;
Graham, Stephen M;
Grzemska, Malgosia;
Heinrich, Norbert;
Hesseling, Anneke C;
Huebner, Robin;
Jean-Philippe, Patrick;
Kabra, Sushil Kumar;
Kampmann, Beate;
Lewinsohn, Deborah;
Li, Meijuan;
Lienhardt, Christian

Publication type:

journal article

Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine.

Published in:

Scientific Reports, 2016, p. 36355, doi. 10.1038/srep36355

By:

Nyendak, Melissa;
Swarbrick, Gwendolyn M.;
Duncan, Amanda;
Cansler, Meghan;
Huff, Ervina Winata;
Hokey, David;
Evans, Tom;
Barker, Lewellys;
Blatner, Gretta;
Sadoff, Jerald;
Douoguih, Macaya;
Pau, Maria Grazia;
Lewinsohn, Deborah A.;
Lewinsohn, David M.

Publication type:

Article

The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.869057

By:

Lewinsohn, David Michael;
Lewinsohn, Deborah Anne

Publication type:

Article

Works by Lewinsohn, Deborah A.

Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists.

Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.

Clonal enrichments of Vδ2- γδ T cells in Mycobacterium tuberculosis-infected human lungs.

Clonal enrichments of Vδ2- γδ T cells in Mycobacterium tuberculosis-infected human lungs.

Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells.

T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells.

CD8<sup>+</sup> T Cells Provide an Immunologic Signature of Tuberculosis in Young Children.

Online Supplement – Extra Detail Regarding Experimental Methods for Mycobacterium tuberculosis–specific CD8<sup>+</sup> T Cells Preferentially Recognize Heavily Infected Cells.

Mycobacterium tuberculosis–specific CD8<sup>+</sup> T Cells Preferentially Recognize Heavily Infected Cells.

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children.

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children.

In vivo migration and function of transferred HIV-1-specific cytotoxic T cells.

The Mycobacterium tuberculosis Phagosome Is a HLA-I Processing Competent Organelle.

Human Innate Mycobacterium tuberculosis-Reactive αβTCR<sup>+</sup> Thymocytes.

Immunodominant Tuberculosis CD8 Antigens Preferentially Restricted by HLA-B.

High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells.

Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation.

Views of immunology: effector T cells.

Functional and Activation Profiles of Mucosal-Associated Invariant T Cells in Patients With Tuberculosis and HIV in a High Endemic Setting.

Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans.

Comprehensive definition of human immunodominant CD8 antigens in tuberculosis.

MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage.

Polyfunctional CD4<sup>+</sup> T Cells As Targets for Tuberculosis vaccination.

Childhood Tuberculosis in Northern Viet Nam: A Review of 103 Cases.

<i>Mycobacterium tuberculosis</i> Specific CD8<sup>+</sup> T Cells Rapidly Decline with Antituberculosis Treatment.

TAP Mediates Import of <i>Mycobacterium tuberculosis</i>-Derived Peptides into Phagosomes and Facilitates Loading onto HLA-I.

Human <i>Mycobacterium tuberculosis</i> CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library.

Whole Blood Interferon-Gamma Responses to Mycobacterium tuberculosis Antigens in Young Household Contacts of Persons with Tuberculosis in Uganda.

Production of Proinflammatory Cytokines by CD4+ and CD8+ T Cells in Response to Mycobacterial Antigens among Children and Adults with Tuberculosis.

Evaluation of Tuberculosis Diagnostics in Children: 2. Methodological Issues for Conducting and Reporting Research Evaluations of Tuberculosis Diagnostics for Intrathoracic Tuberculosis in Children. Consensus From an Expert Panela.

Evaluation of tuberculosis diagnostics in children: 2. Methodological issues for conducting and reporting research evaluations of tuberculosis diagnostics for intrathoracic tuberculosis in children. Consensus from an expert panel.

Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine.

The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell.