Works by Lesyk, Roman

Results: 102

Synthesis and anticancer activity of novel thiopyrano[2,3-d]thiazole-based compounds containing norbornane moiety.

Published in:

Journal of Sulfur Chemistry, 2008, v. 29, n. 2, p. 151, doi. 10.1080/17415990801911723

By:

Atamanyuk, Dmytro;
Zimenkovsky, Borys;
Lesyk, Roman

Publication type:

Article

Evaluation of thiopyrano[2,3‐d]thiazole derivatives as potential anticonvulsant agents.

Published in:

Archiv der Pharmazie, 2024, v. 357, n. 10, p. 1, doi. 10.1002/ardp.202400357

By:

Davydov, Eduard;
Hoidyk, Mykhailo;
Shtrygol', Sergiy;
Karkhut, Andriy;
Polovkovych, Svyatoslav;
Klyuchivska, Olga;
Karpenko, Olexandr;
Lesyk, Roman;
Holota, Serhii

Publication type:

Article

Anticancer 5‐arylidene‐2‐(4‐hydroxyphenyl)aminothiazol‐4(5H)‐ones as tubulin inhibitors.

Published in:

Archiv der Pharmazie, 2022, v. 355, n. 12, p. 1, doi. 10.1002/ardp.202200419

By:

Rehulka, Jiri;
Subtelna, Ivanna;
Kryshchyshyn‐Dylevych, Anna;
Cherniienko, Alina;
Ivanova, Aleksandra;
Matveieva, Mariia;
Polishchuk, Pavel;
Gurska, Sona;
Hajduch, Marian;
Zagrijtschuk, Oleh;
Dzubak, Petr;
Lesyk, Roman

Publication type:

Article

5‐Arylidene‐2‐(4‐hydroxyphenyl)aminothiazol‐4(5H)‐ones with selective inhibitory activity against some leukemia cell lines.

Published in:

Archiv der Pharmazie, 2021, v. 354, n. 4, p. 1, doi. 10.1002/ardp.202000342

By:

Subtelna, Ivanna;
Kryshchyshyn‐Dylevych, Anna;
Jia, Ruochen;
Lelyukh, Maryan;
Ringler, Anna;
Kubicek, Stefan;
Zagrijtschuk, Oleh;
Kralovics, Robert;
Lesyk, Roman

Publication type:

Article

Human Healthcare and Its Pharmacy Component from a Safety Point of View.

Published in:

Pharmacy, 2024, v. 12, n. 2, p. 64, doi. 10.3390/pharmacy12020064

By:

Tkachenko, Natalia;
Pankevych, Ostap;
Mahanova, Tamara;
Hromovyk, Bohdan;
Lesyk, Roman;
Lesyk, Lilia

Publication type:

Article

The Proapoptotic Action of Pyrrolidinedione–Thiazolidinone Hybrids towards Human Breast Carcinoma Cells Does Not Depend on Their Genotype.

Published in:

Cancers, 2024, v. 16, n. 16, p. 2924, doi. 10.3390/cancers16162924

By:

Finiuk, Nataliya;
Kozak, Yuliia;
Gornowicz, Agnieszka;
Czarnomysy, Robert;
Tynecka, Marlena;
Holota, Serhii;
Moniuszko, Marcin;
Stoika, Rostyslav;
Lesyk, Roman;
Bielawski, Krzysztof;
Bielawska, Anna

Publication type:

Article

Synthesis of New Schiff Bases and Polycyclic Fused Thiopyranothiazoles Containing 4,6-Dichloro-1,3,5-Triazine Moiety.

Published in:

Journal of Heterocyclic Chemistry, 2013, v. 50, n. 6, p. 1419, doi. 10.1002/jhet.890

By:

Polovkovych, Svyatoslav V.;
Karkhut, Andrew I.;
Marintsova, Natalia G.;
Lesyk, Roman B.;
Zimenkovsky, Borys S.;
Novikov, Volodymyr P.

Publication type:

Article

Synthesis and Anticancer and Antiviral Activities of New 2-Pyrazoline-Substituted 4-Thiazolidinones.

Published in:

Journal of Heterocyclic Chemistry, 2013, v. 50, p. E55, doi. 10.1002/jhet.1056

By:

Havrylyuk, Dmytro;
ZimENkovsky, Borys;
VasylENko, Olexandr;
Lesyk, Roman

Publication type:

Article

Synthesis and Anticancer Activity of Isatin-Based Pyrazolines and Thiazolidines Conjugates.

Published in:

Archiv der Pharmazie, 2011, v. 344, n. 8, p. 514, doi. 10.1002/ardp.201100055

By:

Havrylyuk, Dmytro;
Kovach, Natalya;
Zimenkovsky, Borys;
Vasylenko, Olexandr;
Lesyk, Roman

Publication type:

Article

1,4-Naphthoquinone Motif in the Synthesis of New Thiopyrano[2,3- d ]thiazoles as Potential Biologically Active Compounds.

Published in:

Molecules, 2022, v. 27, n. 21, p. 7575, doi. 10.3390/molecules27217575

By:

Lozynskyi, Andrii;
Senkiv, Julia;
Ivasechko, Iryna;
Finiuk, Nataliya;
Klyuchivska, Olga;
Kashchak, Nataliya;
Lesyk, Danylo;
Karkhut, Andriy;
Polovkovych, Svyatoslav;
Levytska, Oksana;
Karpenko, Olexandr;
Boshkayeva, Assyl;
Sayakova, Galiya;
Gzella, Andrzej;
Stoika, Rostyslav;
Lesyk, Roman

Publication type:

Article

Development of Novel Pyridine-Thiazole Hybrid Molecules as Potential Anticancer Agents.

Published in:

Molecules, 2022, v. 27, n. 19, p. 6219, doi. 10.3390/molecules27196219

By:

Ivasechko, Iryna;
Yushyn, Ihor;
Roszczenko, Piotr;
Senkiv, Julia;
Finiuk, Nataliya;
Lesyk, Danylo;
Holota, Serhii;
Czarnomysy, Robert;
Klyuchivska, Olga;
Khyluk, Dmytro;
Kashchak, Nataliya;
Gzella, Andrzej;
Bielawski, Krzysztof;
Bielawska, Anna;
Stoika, Rostyslav;
Lesyk, Roman

Publication type:

Article

Evaluation of Anticancer and Antibacterial Activity of Four 4-Thiazolidinone-Based Derivatives.

Published in:

Molecules, 2022, v. 27, n. 3, p. 894, doi. 10.3390/molecules27030894

By:

Skóra, Bartosz;
Lewińska, Anna;
Kryshchyshyn-Dylevych, Anna;
Kaminskyy, Danylo;
Lesyk, Roman;
Szychowski, Konrad A.

Publication type:

Article

Synthesis, Antibacterial and Antifungal Activity of New 3-Aryl-5 H -pyrrolo[1,2- a ]imidazole and 5 H -Imidazo[1,2- a ]azepine Quaternary Salts.

Published in:

Molecules, 2021, v. 26, n. 14, p. 4253, doi. 10.3390/molecules26144253

By:

Demchenko, Sergii;
Lesyk, Roman;
Yadlovskyi, Oleh;
Zuegg, Johannes;
Elliott, Alysha G.;
Drapak, Iryna;
Fedchenkova, Yuliia;
Suvorova, Zinaida;
Demchenko, Anatolii

Publication type:

Article

Synthesis and Anticancer Activity Evaluation of 5-[2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-thiazolidinones.

Published in:

Molecules, 2021, v. 26, n. 10, p. 3057, doi. 10.3390/molecules26103057

By:

Buzun, Kamila;
Kryshchyshyn-Dylevych, Anna;
Senkiv, Julia;
Roman, Olexandra;
Gzella, Andrzej;
Bielawski, Krzysztof;
Bielawska, Anna;
Lesyk, Roman;
Marchetti, Fabio

Publication type:

Article

Synthesis, Characterization and In Vitro Evaluation of Novel 5-Ene-thiazolo[3,2- b ][1,2,4]triazole-6(5 H)-ones as Possible Anticancer Agents.

Published in:

Molecules, 2021, v. 26, n. 4, p. 1162, doi. 10.3390/molecules26041162

By:

Holota, Serhii;
Komykhov, Sergiy;
Sysak, Stepan;
Gzella, Andrzej;
Cherkas, Andriy;
Lesyk, Roman;
Morak-Młodawska, Beata;
Muñoz-Torrero, Diego

Publication type:

Article

Anti-inflammatory hydrogen sulfide-releasing agents with reduced gastro- and enterotoxicity on the stress model in rats.

Published in:

Minerva Biotechnology & Biomolecular Research, 2021, v. 33, n. 2, p. 117, doi. 10.23736/S2724-542X.21.02758-9

By:

FOMENKO, Iryna;
LOZYNSKA, Iryna;
BONDARCHUK, Tetyana;
DENYSENKO, Natalia;
LESYK, Roman;
SKLYAROV, Alexander

Publication type:

Article

Introducing bromine in the molecular structure as a good strategy to the drug design.

Published in:

Journal of Medical Science, 2024, v. 93, n. 3, p. 227, doi. 10.20883/medical.e1128

By:

Potapskyi, Eduard;
Kustrzyńska, Karolina;
Łażewski, Dawid;
Skupin-Mrugalska, Paulina;
Lesyk, Roman

Publication type:

Article

Drug design: 4-thiazolidinones applications. Part 2. Pharmacological profiles.

Published in:

Journal of Medical Science, 2020, v. 89, n. 2, p. 1, doi. 10.20883/medical.e407

By:

Lesyk, Roman

Publication type:

Article

Drug design: 4-thiazolidinones applications. Part 1. Synthetic routes to the drug-like molecules.

Published in:

Journal of Medical Science, 2020, v. 89, n. 1, p. 1, doi. 10.20883/medical.406

By:

Lesyk, Roman

Publication type:

Article

Development of Predictive QSAR Models of 4‐Thiazolidinones Antitrypanosomal Activity Using Modern Machine Learning Algorithms.

Published in:

Molecular Informatics, 2018, v. 37, n. 5, p. 1, doi. 10.1002/minf.201700078

By:

Kryshchyshyn, Anna;
Devinyak, Oleg;
Kaminskyy, Danylo;
Grellier, Philippe;
Lesyk, Roman

Publication type:

Article

Computational Search for Possible Mechanisms of 4-Thiazolidinones Anticancer Activity: The Power of Visualization.

Published in:

Molecular Informatics, 2014, v. 33, n. 3, p. 216, doi. 10.1002/minf.201300086

By:

Devinyak, Oleg;
Havrylyuk, Dmytro;
Zimenkovsky, Borys;
Lesyk, Roman

Publication type:

Article

Fused Triazole-Azepine Hybrids as Potential Non-Steroidal Antiinflammatory Agents.

Published in:

Scientia Pharmaceutica, 2023, v. 91, n. 2, p. 26, doi. 10.3390/scipharm91020026

By:

Demchenko, Sergii;
Lesyk, Roman;
Yadlovskyi, Oleh;
Holota, Serhii;
Yarmoluk, Sergii;
Tsyhankov, Sergii;
Demchenko, Anatolii

Publication type:

Article

3-[5-(1 H -Indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl]-propionic Acid as a Potential Polypharmacological Agent.

Published in:

Scientia Pharmaceutica, 2023, v. 91, n. 1, p. 13, doi. 10.3390/scipharm91010013

By:

Konechnyi, Yulian;
Lozynskyi, Andrii;
Ivasechko, Iryna;
Dumych, Tetiana;
Paryzhak, Solomiya;
Hrushka, Oksana;
Partyka, Ulyana;
Pasichnyuk, Iryna;
Khylyuk, Dmytro;
Lesyk, Roman

Publication type:

Article

Detailing the Ten Main Professional Roles of a Pharmacist to Provide the Scope of Professional Functions.

Published in:

Scientia Pharmaceutica, 2023, v. 91, n. 1, p. 5, doi. 10.3390/scipharm91010005

By:

Kremin, Yuliia;
Lesyk, Lilia;
Lesyk, Roman;
Levytska, Oksana;
Hromovyk, Bohdan

Publication type:

Article

Evaluation of 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) as Potential Anticonvulsant Agent.

Published in:

Scientia Pharmaceutica, 2022, v. 90, n. 3, p. 56, doi. 10.3390/scipharm90030056

By:

Mishchenko, Mariia;
Shtrygol', Sergiy;
Lozynskyi, Andrii;
Hoidyk, Mykhailo;
Khyluk, Dmytro;
Gorbach, Tatyana;
Lesyk, Roman

Publication type:

Article

Compounding in Ukraine: Assessment of the Risks for the Ointment's Quality by the FMECA Method.

Published in:

Scientia Pharmaceutica, 2022, v. 90, n. 2, p. N.PAG, doi. 10.3390/scipharm90020025

By:

Savchenko, Lesia;
Pidpruzhnykov, Yuri;
Lesyk, Roman;
Ivanauskas, Liudas;
Kotvitska, Alla;
Georgiyants, Victoriya

Publication type:

Article

Synthesis and Biological Activity Evaluation of Novel 5-Methyl-7-phenyl-3H-thiazolo[4,5-b]pyridin-2-ones.

Published in:

Scientia Pharmaceutica, 2021, v. 89, n. 4, p. 1, doi. 10.3390/scipharm89040052

By:

Lozynskyi, Andrii;
Konechnyi, Yulian;
Senkiv, Julia;
Yushyn, Ihor;
Khyluk, Dmytro;
Karpenko, Olexandr;
Shepeta, Yulia;
Lesyk, Roman

Publication type:

Article

Characterization of Phytochemical Components of Crocus sativus Leaves: A New Attractive By-Product.

Published in:

Scientia Pharmaceutica, 2021, v. 89, n. 2, p. 1, doi. 10.3390/scipharm89020028

By:

Mykhailenko, Olha;
Ivanauskas, Liudas;
Bezruk, Ivan;
Sidorenko, Lyudmila;
Lesyk, Roman;
Georgiyants, Victoriya

Publication type:

Article

Evaluation of Anticonvulsant Activity of Dual COX-2/5-LOX Inhibitor Darbufelon and Its Novel Analogues.

Published in:

Scientia Pharmaceutica, 2021, v. 89, n. 2, p. 1, doi. 10.3390/scipharm89020022

By:

Mishchenko, Mariia;
Shtrygol, Sergiy;
Lozynskyi, Andrii;
Khomyak, Semen;
Novikov, Volodymyr;
Karpenko, Olexandr;
Holota, Serhii;
Lesyk, Roman

Publication type:

Article

Biodistribution and Anticancer Characteristics of Les-3833, A Novel 4-thiazolidinone-Based Lead Compound.

Published in:

Scientia Pharmaceutica, 2020, v. 88, n. 2, p. 1, doi. 10.3390/scipharm88020018

By:

Kobylinska, Lesya;
Lozynskii, Andrii;
Lesyk, Roman;
Stoika, Rostyslav;
Vari, Sandor G.

Publication type:

Article

Isothiochromenothiazoles--A Class of Fused Thiazolidinone Derivatives with Established Anticancer Activity That Inhibits Growth of Trypanosoma brucei brucei.

Published in:

Scientia Pharmaceutica, 2018, v. 86, n. 4, p. 1, doi. 10.3390/scipharm86040047

By:

Kryshchyshyn, Anna;
Kaminskyy, Danylo;
Nektegayev, Igor;
Grellier, Philippe;
Lesyk, Roman

Publication type:

Article

Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry.

Published in:

Scientia Pharmaceutica, 2018, v. 86, n. 2, p. 1, doi. 10.3390/scipharm86020026

By:

Kryshchyshyn, Anna;
Roman, Olexandra;
Lozynskyi, Andrii;
Lesyk, Roman

Publication type:

Article

Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy.

Published in:

Scientia Pharmaceutica, 2017, v. 85, n. 4, p. 1, doi. 10.3390/scipharm85040035

By:

Sklyarova, Yulia;
Fomenko, Iryna;
Lozynska, Iryna;
Lozynskyi, Andrii;
Lesyk, Roman;
Sklyarov, Alexandr

Publication type:

Article

Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides.

Published in:

Scientia Pharmaceutica, 2014, v. 82, n. 4, p. 723, doi. 10.3797/scipharm.1408-05

By:

LOZYNSKYI, Andrii;
ZIMENKOVSKY, Borys;
LESYK, Roman

Publication type:

Article

Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides.

Published in:

Scientia Pharmaceutica, 2014, v. 82, n. 4, p. 723, doi. 10.3797/scipharm.1408-05

By:

LOZYNSKYI, Andrii;
ZIMENKOVSKY, Borys;
LESYK, Roman

Publication type:

Article

Synthesis and Biological Activity of New Thiopyrano[2,3-d]thiazoles Containing a Naphthoquinone Moiety.

Published in:

Scientia Pharmaceutica, 2013, v. 81, n. 2, p. 423, doi. 10.3797/scipharm.1301-13

By:

ATAMANYUK, Dmytro;
ZIMENKOVSKY, Borys;
ATAMANYUK, Vasyl;
NEKTEGAYEV, Ihor;
LESYK, Roman

Publication type:

Article

Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents.

Published in:

Scientia Pharmaceutica, 2012, v. 80, n. 3, p. 509, doi. 10.3797/scipharm.1204-02

By:

Kryshchyshyn, Anna;
Atamanyuk, Dmytro;
Lesyk, Roman

Publication type:

Article

A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates.

Published in:

Scientia Pharmaceutica, 2011, v. 79, n. 4, p. 763, doi. 10.3797/scipharm.1109-14

By:

Kaminskyy, Danylo;
Khyluk, Dmytro;
Vasylenko, Olexandr;
Zaprutko, Lucjusz;
Lesyk, Roman

Publication type:

Article

2-((5-(3-(2-Fluorophenyl)acryloyl)-4-methylthiazol-2-yl)amino)isoindoline-1,3-dione.

Published in:

Molbank, 2024, v. 2024, n. 1, p. M1785, doi. 10.3390/M1785

By:

Fedusevych, Olha-Maria;
Lozynskyi, Andrii;
Sulyma, Marta;
Lesyk, Roman

Publication type:

Article

2-(Cyclopropylamino)-5-(4-methoxybenzylidene)thiazol-4(5 H)-one.

Published in:

Molbank, 2022, v. 2022, n. 4, p. M1478, doi. 10.3390/M1478

By:

Sydorenko, Ivan;
Holota, Serhii;
Lozynskyi, Andrii;
Konechnyi, Yulian;
Horishny, Volodymyr;
Karkhut, Andriy;
Polovkovych, Svyatoslav;
Karpenko, Olexandr;
Lesyk, Roman

Publication type:

Article

rel -2-[4-Chloro-2-[(5 R ,6 R ,7 S)-6-[5-(4-methoxyphenyl)-3-(2-naphthyl)-3,4-dihydropyrazole-2-carbonyl]-5-methyl-2-oxo-3,5,6,7-tetrahydrothiopyrano[2,3- d ]thiazol-7-yl]phenoxy]acetic Acid.

Published in:

Molbank, 2022, v. 2022, n. 3, p. M1410, doi. 10.3390/M1410

By:

Yushyn, Ihor;
Holota, Serhii;
Ivantsiv, Oksana;
Lesyk, Roman

Publication type:

Article

3-(2-Diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione.

Published in:

Molbank, 2022, v. 2022, n. 3, p. M1394, doi. 10.3390/M1394

By:

Holota, Serhii;
Yushyn, Ihor;
Gzella, Andrzej;
Lesyk, Roman

Publication type:

Article

2,2-Dichloro- N -[5-[2-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydro-2 H -pyrazol-2-yl]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]acetamide.

Published in:

Molbank, 2022, v. 2022, n. 1, p. M1328, doi. 10.3390/M1328

By:

Yushyn, Ihor;
Holota, Serhii;
Lesyk, Roman

Publication type:

Article

5-[4-(tert -Butyl)cyclohexylidene]-2-thioxothiazolidin-4-one.

Published in:

Molbank, 2021, v. 2021, n. 4, p. M1281, doi. 10.3390/M1281

By:

Holota, Serhii;
Lozynskyi, Andrii;
Konechnyi, Yulian;
Shepeta, Yulia;
Lesyk, Roman

Publication type:

Article

N -(3-Cyano-4,5,6,7-tetrahydrobenzothiophen-2-yl)-2-[[5-[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide.

Published in:

Molbank, 2021, v. 2021, n. 2, p. M1211, doi. 10.3390/M1211

By:

Holota, Serhii;
Yushyn, Ihor;
Khyluk, Dmytro;
Vynnytska, Renata;
Lesyk, Roman

Publication type:

Article

Synthesis of 4-(2H-[1,2,4]-Triazol-5-ylsulfanyl)-1,2-dihydropyrazol-3-one via Ring-Switching Hydrazinolysis of 5-Ethoxymethylidenethiazolo [3,2-b][1,2,4]triazol-6-one.

Published in:

Molbank, 2018, v. 2018, n. 4, p. M1022, doi. 10.3390/M1022

By:

Holota, Serhii;
Shylych, Yaroslav;
Derkach, Halyna;
Karpenko, Olexandr;
Gzella, Andrzej;
Lesyk, Roman

Publication type:

Article

Induction of Cyp450 enzymes by 4-thiazolidinone-based derivatives in 3T3-L1 cells in vitro.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2021, v. 394, n. 5, p. 915, doi. 10.1007/s00210-020-02025-7

By:

Szychowski, Konrad A.;
Skóra, Bartosz;
Kryshchyshyn-Dylevych, Anna;
Kaminskyy, Danylo;
Rybczyńska-Tkaczyk, Kamila;
Lesyk, Roman;
Gmiński, Jan

Publication type:

Article

Anticancer Properties of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Potential Agonists 4-Thiazolidinone-Pyrazoline Hybrids Les-4368 and Les-4370 in Colorectal Adenocarcinoma Cells In Vitro.

Published in:

Applied Sciences (2076-3417), 2024, v. 14, n. 17, p. 7692, doi. 10.3390/app14177692

By:

Kaleniuk, Edyta;
Holota, Serhii;
Skóra, Bartosz;
Khylyuk, Dmytro;
Tabęcka-Łonczyńska, Anna;
Lesyk, Roman;
Szychowski, Konrad A.

Publication type:

Article

BODIPY-Based Nanomaterials—Sensing and Biomedical Applications.

Published in:

Applied Sciences (2076-3417), 2022, v. 12, n. 15, p. 7815, doi. 10.3390/app12157815

By:

Koczorowski, Tomasz;
Glowacka-Sobotta, Arleta;
Sysak, Stepan;
Mlynarczyk, Dariusz T.;
Lesyk, Roman;
Goslinski, Tomasz;
Sobotta, Lukasz

Publication type:

Article

Changes in Energy Consumption, Economic Growth and Aspirations for Energy Independence: Sectoral Analysis of Uses of Natural Gas in Ukrainian Economy.

Published in:

Energies (19961073), 2019, v. 12, n. 24, p. 4724, doi. 10.3390/en12244724

By:

Yemelyanov, Olexandr;
Symak, Anastasiya;
Petrushka, Tetyana;
Zahoretska, Olena;
Kusiy, Myroslava;
Lesyk, Roman;
Lesyk, Lilia

Publication type:

Article